Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2014 (← Previous) (Next →)

Filing Date: Nov 13, 2014

Total Value: $1.338B (100.0% shares, 0.0% debt)

Holdings (43)

UTHR UNITED THERAPEUTICS CORP DEL 12.5%

Value $167M Shares 1,298,828 Est. Cost $71.44 Unrealized +44.3%

— AUXILIUM PHARMACEUTICALS INC 10.8%

Value $145M Shares 4,854,631 Est. Cost $17.45 Unrealized —

— CUBIST PHARMACEUTICALS INC 9.1%

Value $122M Shares 1,843,688 Est. Cost $59.40 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 6.8%

Value $91.24M Shares 1,264,397 Est. Cost $63.78 Unrealized +3.0%

— CYBERONICS INC 6.2%

Value $82.94M Shares 1,621,101 Est. Cost $52.15 Unrealized —

— CLOVIS ONCOLOGY INC 5.8%

Value $78.1M Shares 1,721,757 Est. Cost $45.31 Unrealized —

— ABIOMED INC 4.5%

Value $60.33M Shares 2,429,524 Est. Cost $21.63 Unrealized —

— ANACOR PHARMACEUTICALS INC 3.9%

Value $51.8M Shares 2,116,665 Est. Cost $10.16 Unrealized —

— AMAG PHARMACEUTICALS INC 3.8%

Value $51.52M Shares 1,614,536 Est. Cost $22.29 Unrealized —

INSM INSMED INC 3.8%

Value $50.79M Shares 3,892,199 Est. Cost $14.73 Unrealized +2.4%

— NPS PHARMACEUTICALS INC 3.3%

Value $44.19M Shares 1,699,562 Est. Cost $27.84 Unrealized —

— KYTHERA BIOPHARMACEUTICALS I 2.7%

Value $36.11M Shares 1,102,181 Est. Cost $37.70 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.5%

Value $34.08M Shares 3,283,124 Est. Cost $7.79 Unrealized +68.3%

— SEQUENOM INC 2.2%

Value $29.14M Shares 9,810,442 Est. Cost $3.91 Unrealized —

STAA STAAR SURGICAL CO 2.1%

Value $27.63M Shares 2,599,553 Est. Cost $8.10 Unrealized +46.8%

— WRIGHT MED GROUP INC 1.9%

Value $25.23M Shares 832,729 Est. Cost $30.30 Unrealized —

GILD GILEAD SCIENCES INC 1.3%

Value $17.83M Shares 167,500 Est. Cost $55.18 Unrealized +23.3%

— MOMENTA PHARMACEUTICALS INC 1.2%

Value $16.5M Shares 1,455,176 Est. Cost $14.44 Unrealized —

— SHIRE PLC 1.2%

Value $16.5M Shares 63,700 Est. Cost $233.03 Unrealized —

— ALIMERA SCIENCES INC 1.2%

Value $16.48M Shares 3,040,260 Est. Cost $4.88 Unrealized —

— CELGENE CORP 1.2%

Value $16.26M Shares 171,600 Est. Cost $87.84 Unrealized —

— CELLADON CORP 1.1%

Value $15.24M Shares 1,457,200 Est. Cost $11.92 Unrealized —

EXAS EXACT SCIENCES CORP 1.1%

Value $15.07M Shares 777,676 Est. Cost $12.83 Unrealized +42.9%

PRTA PROTHENA CORP PLC 1.1%

Value $14.93M Shares 673,818 Est. Cost $22.22 Unrealized -4.6%

— MEDIVATION INC 1.0%

Value $12.86M Shares 130,100 Est. Cost $78.28 Unrealized —

— ARIAD PHARMACEUTICALS INC 0.9%

Value $12.05M Shares 2,231,717 Est. Cost $6.82 Unrealized —

FOLD AMICUS THERAPEUTICS INC 0.9%

Value $11.64M Shares 1,956,376 Est. Cost $3.07 Unrealized +70.5%

ALGN ALIGN TECHNOLOGY INC 0.8%

Value $11.01M Shares 213,100 Est. Cost $52.58 Unrealized +3.6%

— INTUITIVE SURGICAL INC 0.8%

Value $10.74M Shares 23,250 Est. Cost $422.23 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.8%

Value $10.05M Shares 5,180,101 Est. Cost $3.43 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.7%

Value $8.908M Shares 1,622,654 Est. Cost $5.49 Unrealized —

— QLT INC 0.6%

Value $8.344M Shares 1,846,075 Est. Cost $4.40 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.6%

Value $8.227M Shares 1,931,324 Est. Cost $6.46 Unrealized —

— ZELTIQ AESTHETICS INC 0.5%

Value $6.433M Shares 284,249 Est. Cost $22.63 Unrealized —

— XOMA CORP DEL 0.2%

Value $2.631M Shares 624,900 Est. Cost $4.20 Unrealized —

GERN GERON CORP 0.2%

Value $2.323M Shares 1,161,400 Est. Cost $2.85 Unrealized -13.6%

— HYPERION THERAPEUTICS INC 0.1%

Value $1.581M Shares 62,700 Est. Cost $22.00 Unrealized —

— REVANCE THERAPEUTICS INC 0.1%

Value $1.554M Shares 80,369 Est. Cost $31.50 Unrealized —

— BIOSPECIFICS TECHNOLOGIES CO 0.1%

Value $1.247M Shares 35,336 Est. Cost $32.67 Unrealized —

— AVEO PHARMACEUTICALS INC 0.1%

Value $1.063M Shares 958,026 Est. Cost $2.50 Unrealized —

— SOPHIRIS BIO INC 0.1%

Value $858K Shares 292,900 Est. Cost $3.88 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $435K Shares 123,686 Est. Cost $6.71 Unrealized -37.4%

— MALLINCKRODT PUB LTD CO 0.0%

Value $323K Shares 3,588 Est. Cost $90.02 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,298,828	$167M	12.5%	$71.44	+44.3%	COM	91307C102
—	AUXILIUM PHARMACEUTICALS INC	4,854,631	$145M	10.8%	$17.45	—	COM	05334D107
—	CUBIST PHARMACEUTICALS INC	1,843,688	$122M	9.1%	$59.40	—	COM	229678107
BMRN	BIOMARIN PHARMACEUTICAL INC	1,264,397	$91.24M	6.8%	$63.78	+3.0%	COM	09061G101
—	CYBERONICS INC	1,621,101	$82.94M	6.2%	$52.15	—	COM	23251P102
—	CLOVIS ONCOLOGY INC	1,721,757	$78.1M	5.8%	$45.31	—	COM	189464100
—	ABIOMED INC	2,429,524	$60.33M	4.5%	$21.63	—	COM	003654100
—	ANACOR PHARMACEUTICALS INC	2,116,665	$51.8M	3.9%	$10.16	—	COM	032420101
—	AMAG PHARMACEUTICALS INC	1,614,536	$51.52M	3.8%	$22.29	—	COM	00163U106
INSM	INSMED INC	3,892,199	$50.79M	3.8%	$14.73	+2.4%	COM PAR $.01	457669307
—	NPS PHARMACEUTICALS INC	1,699,562	$44.19M	3.3%	$27.84	—	COM	62936P103
—	KYTHERA BIOPHARMACEUTICALS I	1,102,181	$36.11M	2.7%	$37.70	—	COM	501570105
VNDA	VANDA PHARMACEUTICALS INC	3,283,124	$34.08M	2.5%	$7.79	+68.3%	COM	921659108
—	SEQUENOM INC	9,810,442	$29.14M	2.2%	$3.91	—	COM NEW	817337405
STAA	STAAR SURGICAL CO	2,599,553	$27.63M	2.1%	$8.10	+46.8%	COM PAR $0.01	852312305
—	WRIGHT MED GROUP INC	832,729	$25.23M	1.9%	$30.30	—	COM	98235T107
GILD	GILEAD SCIENCES INC	167,500	$17.83M	1.3%	$55.18	+23.3%	COM	375558103
—	MOMENTA PHARMACEUTICALS INC	1,455,176	$16.5M	1.2%	$14.44	—	COM	60877T100
—	SHIRE PLC	63,700	$16.5M	1.2%	$233.03	—	SPONSORED ADR	82481R106
—	ALIMERA SCIENCES INC	3,040,260	$16.48M	1.2%	$4.88	—	COM	016259103
—	CELGENE CORP	171,600	$16.26M	1.2%	$87.84	—	COM	151020104
—	CELLADON CORP	1,457,200	$15.24M	1.1%	$11.92	—	COM	15117E107
EXAS	EXACT SCIENCES CORP	777,676	$15.07M	1.1%	$12.83	+42.9%	COM	30063P105
PRTA	PROTHENA CORP PLC	673,818	$14.93M	1.1%	$22.22	-4.6%	SHS	G72800108
—	MEDIVATION INC	130,100	$12.86M	1.0%	$78.28	—	COM	58501N101
—	ARIAD PHARMACEUTICALS INC	2,231,717	$12.05M	0.9%	$6.82	—	COM	04033A100
FOLD	AMICUS THERAPEUTICS INC	1,956,376	$11.64M	0.9%	$3.07	+70.5%	COM	03152W109
ALGN	ALIGN TECHNOLOGY INC	213,100	$11.01M	0.8%	$52.58	+3.6%	COM	016255101
—	INTUITIVE SURGICAL INC	23,250	$10.74M	0.8%	$422.23	—	COM NEW	46120e602
—	RIGEL PHARMACEUTICALS INC	5,180,101	$10.05M	0.8%	$3.43	—	COM NEW	766559603
—	ACELRX PHARMACEUTICALS INC	1,622,654	$8.908M	0.7%	$5.49	—	COM	00444T100
—	QLT INC	1,846,075	$8.344M	0.6%	$4.40	—	COM	746927102
—	OREXIGEN THERAPEUTICS INC	1,931,324	$8.227M	0.6%	$6.46	—	COM	686164104
—	ZELTIQ AESTHETICS INC	284,249	$6.433M	0.5%	$22.63	—	COM	98933Q108
—	XOMA CORP DEL	624,900	$2.631M	0.2%	$4.20	—	COM	98419J107
GERN	GERON CORP	1,161,400	$2.323M	0.2%	$2.85	-13.6%	COM	374163103
—	HYPERION THERAPEUTICS INC	62,700	$1.581M	0.1%	$22.00	—	COM	44915N101
—	REVANCE THERAPEUTICS INC	80,369	$1.554M	0.1%	$31.50	—	COM	761330109
—	BIOSPECIFICS TECHNOLOGIES CO	35,336	$1.247M	0.1%	$32.67	—	COM	090931106
—	AVEO PHARMACEUTICALS INC	958,026	$1.063M	0.1%	$2.50	—	COM	053588109
—	SOPHIRIS BIO INC	292,900	$858K	0.1%	$3.88	—	COM NEW	83578Q209
CYTK	CYTOKINETICS INC	123,686	$435K	0.0%	$6.71	-37.4%	COM NEW	23282W605
—	MALLINCKRODT PUB LTD CO	3,588	$323K	0.0%	$90.02	—	SHS	G5785G107