Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2014 (← Previous) (Next →)

Filing Date: Feb 17, 2015

Total Value: $1.704B (100.0% shares, 0.0% debt)

Holdings (46)

UTHR UNITED THERAPEUTICS CORP DEL 10.7%

Value $182M Shares 1,403,128 Est. Cost $75.71 Unrealized +70.2%

— AUXILIUM PHARMACEUTICALS INC 9.9%

Value $169M Shares 4,915,931 Est. Cost $17.66 Unrealized —

— CUBIST PHARMACEUTICALS INC 7.7%

Value $131M Shares 1,303,668 Est. Cost $59.40 Unrealized —

— CLOVIS ONCOLOGY INC 6.9%

Value $118M Shares 2,102,857 Est. Cost $47.24 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 6.9%

Value $118M Shares 1,302,197 Est. Cost $64.35 Unrealized +29.2%

— ABIOMED INC 5.5%

Value $93.63M Shares 2,460,124 Est. Cost $21.84 Unrealized —

— CYBERONICS INC 5.3%

Value $89.54M Shares 1,608,101 Est. Cost $52.15 Unrealized —

— AMAG PHARMACEUTICALS INC 5.0%

Value $84.99M Shares 1,994,200 Est. Cost $26.16 Unrealized —

— ANACOR PHARMACEUTICALS INC 4.8%

Value $81.33M Shares 2,521,822 Est. Cost $13.71 Unrealized —

INSM INSMED INC 4.2%

Value $71.56M Shares 4,625,648 Est. Cost $14.64 Unrealized -3.1%

— WRIGHT MED GROUP INC 3.2%

Value $54.81M Shares 2,039,751 Est. Cost $28.27 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.2%

Value $54.23M Shares 3,786,908 Est. Cost $8.33 Unrealized +42.1%

— NPS PHARMACEUTICALS INC 2.5%

Value $42.58M Shares 1,190,263 Est. Cost $27.84 Unrealized —

— KYTHERA BIOPHARMACEUTICALS I 2.3%

Value $38.91M Shares 1,121,884 Est. Cost $37.65 Unrealized —

— SEQUENOM INC 2.2%

Value $36.73M Shares 9,925,742 Est. Cost $3.91 Unrealized —

— CELLADON CORP 1.6%

Value $27.42M Shares 1,403,800 Est. Cost $11.92 Unrealized —

— CELGENE CORP 1.4%

Value $24.11M Shares 215,500 Est. Cost $92.73 Unrealized —

STAA STAAR SURGICAL CO 1.4%

Value $23.96M Shares 2,629,622 Est. Cost $8.11 Unrealized +19.3%

GILD GILEAD SCIENCES INC 1.3%

Value $22.11M Shares 234,600 Est. Cost $59.95 Unrealized +19.9%

— SHIRE PLC 1.1%

Value $18.19M Shares 85,600 Est. Cost $227.79 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.0%

Value $17.52M Shares 1,455,176 Est. Cost $14.44 Unrealized —

— ALIMERA SCIENCES INC 1.0%

Value $16.7M Shares 3,013,793 Est. Cost $4.88 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.0%

Value $16.28M Shares 1,956,376 Est. Cost $3.07 Unrealized +123.3%

— MEDIVATION INC 0.9%

Value $16.07M Shares 161,300 Est. Cost $82.41 Unrealized —

— ARIAD PHARMACEUTICALS INC 0.9%

Value $15.33M Shares 2,231,717 Est. Cost $6.82 Unrealized —

PRTA PROTHENA CORP PLC 0.8%

Value $14.35M Shares 691,218 Est. Cost $22.18 Unrealized -5.9%

— ACELRX PHARMACEUTICALS INC 0.8%

Value $14.32M Shares 2,128,539 Est. Cost $5.78 Unrealized —

— INTUITIVE SURGICAL INC 0.8%

Value $13.78M Shares 26,050 Est. Cost $433.70 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.8%

Value $13.1M Shares 234,300 Est. Cost $52.61 Unrealized +0.5%

— RIGEL PHARMACEUTICALS INC 0.7%

Value $11.75M Shares 5,176,319 Est. Cost $3.43 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.7%

Value $11.7M Shares 1,931,324 Est. Cost $6.46 Unrealized —

— ZELTIQ AESTHETICS INC 0.6%

Value $11.01M Shares 394,486 Est. Cost $24.11 Unrealized —

EXAS EXACT SCIENCES CORP 0.6%

Value $10.74M Shares 391,276 Est. Cost $12.83 Unrealized +89.6%

— SALIX PHARMACEUTICALS INC 0.5%

Value $8.816M Shares 76,700 Est. Cost $114.94 Unrealized —

— THORATEC CORP 0.5%

Value $8.727M Shares 268,861 Est. Cost $32.46 Unrealized —

— QLT INC 0.4%

Value $6.95M Shares 1,733,208 Est. Cost $4.40 Unrealized —

— HISTOGENICS CORP 0.3%

Value $5M Shares 454,545 Est. Cost $11.00 Unrealized —

— XOMA CORP DEL 0.2%

Value $2.852M Shares 794,500 Est. Cost $4.07 Unrealized —

— BIOSPECIFICS TECHNOLOGIES CO 0.1%

Value $1.948M Shares 50,436 Est. Cost $34.45 Unrealized —

— HYPERION THERAPEUTICS INC 0.1%

Value $1.505M Shares 62,700 Est. Cost $22.00 Unrealized —

— INTREXON CORP 0.1%

Value $1.203M Shares 43,700 Est. Cost $27.53 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $991K Shares 123,686 Est. Cost $6.71 Unrealized -36.1%

— AVEO PHARMACEUTICALS INC 0.0%

Value $562K Shares 669,449 Est. Cost $2.50 Unrealized —

— NXSTAGE MEDICAL INC 0.0%

Value $362K Shares 20,200 Est. Cost $17.92 Unrealized —

— MALLINCKRODT PUB LTD CO 0.0%

Value $355K Shares 3,588 Est. Cost $90.02 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $103K Shares 191,600 Est. Cost $3.88 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,403,128	$182M	10.7%	$75.71	+70.2%	COM	91307C102
—	AUXILIUM PHARMACEUTICALS INC	4,915,931	$169M	9.9%	$17.66	—	COM	05334D107
—	CUBIST PHARMACEUTICALS INC	1,303,668	$131M	7.7%	$59.40	—	COM	229678107
—	CLOVIS ONCOLOGY INC	2,102,857	$118M	6.9%	$47.24	—	COM	189464100
BMRN	BIOMARIN PHARMACEUTICAL INC	1,302,197	$118M	6.9%	$64.35	+29.2%	COM	09061G101
—	ABIOMED INC	2,460,124	$93.63M	5.5%	$21.84	—	COM	003654100
—	CYBERONICS INC	1,608,101	$89.54M	5.3%	$52.15	—	COM	23251P102
—	AMAG PHARMACEUTICALS INC	1,994,200	$84.99M	5.0%	$26.16	—	COM	00163U106
—	ANACOR PHARMACEUTICALS INC	2,521,822	$81.33M	4.8%	$13.71	—	COM	032420101
INSM	INSMED INC	4,625,648	$71.56M	4.2%	$14.64	-3.1%	COM PAR $.01	457669307
—	WRIGHT MED GROUP INC	2,039,751	$54.81M	3.2%	$28.27	—	COM	98235T107
VNDA	VANDA PHARMACEUTICALS INC	3,786,908	$54.23M	3.2%	$8.33	+42.1%	COM	921659108
—	NPS PHARMACEUTICALS INC	1,190,263	$42.58M	2.5%	$27.84	—	COM	62936P103
—	KYTHERA BIOPHARMACEUTICALS I	1,121,884	$38.91M	2.3%	$37.65	—	COM	501570105
—	SEQUENOM INC	9,925,742	$36.73M	2.2%	$3.91	—	COM NEW	817337405
—	CELLADON CORP	1,403,800	$27.42M	1.6%	$11.92	—	COM	15117E107
—	CELGENE CORP	215,500	$24.11M	1.4%	$92.73	—	COM	151020104
STAA	STAAR SURGICAL CO	2,629,622	$23.96M	1.4%	$8.11	+19.3%	COM PAR $0.01	852312305
GILD	GILEAD SCIENCES INC	234,600	$22.11M	1.3%	$59.95	+19.9%	COM	375558103
—	SHIRE PLC	85,600	$18.19M	1.1%	$227.79	—	SPONSORED ADR	82481R106
—	MOMENTA PHARMACEUTICALS INC	1,455,176	$17.52M	1.0%	$14.44	—	COM	60877T100
—	ALIMERA SCIENCES INC	3,013,793	$16.7M	1.0%	$4.88	—	COM	016259103
FOLD	AMICUS THERAPEUTICS INC	1,956,376	$16.28M	1.0%	$3.07	+123.3%	COM	03152W109
—	MEDIVATION INC	161,300	$16.07M	0.9%	$82.41	—	COM	58501N101
—	ARIAD PHARMACEUTICALS INC	2,231,717	$15.33M	0.9%	$6.82	—	COM	04033A100
PRTA	PROTHENA CORP PLC	691,218	$14.35M	0.8%	$22.18	-5.9%	SHS	G72800108
—	ACELRX PHARMACEUTICALS INC	2,128,539	$14.32M	0.8%	$5.78	—	COM	00444T100
—	INTUITIVE SURGICAL INC	26,050	$13.78M	0.8%	$433.70	—	COM NEW	46120e602
ALGN	ALIGN TECHNOLOGY INC	234,300	$13.1M	0.8%	$52.61	+0.5%	COM	016255101
—	RIGEL PHARMACEUTICALS INC	5,176,319	$11.75M	0.7%	$3.43	—	COM NEW	766559603
—	OREXIGEN THERAPEUTICS INC	1,931,324	$11.7M	0.7%	$6.46	—	COM	686164104
—	ZELTIQ AESTHETICS INC	394,486	$11.01M	0.6%	$24.11	—	COM	98933Q108
EXAS	EXACT SCIENCES CORP	391,276	$10.74M	0.6%	$12.83	+89.6%	COM	30063P105
—	SALIX PHARMACEUTICALS INC	76,700	$8.816M	0.5%	$114.94	—	COM	795435106
—	THORATEC CORP	268,861	$8.727M	0.5%	$32.46	—	COM NEW	885175307
—	QLT INC	1,733,208	$6.95M	0.4%	$4.40	—	COM	746927102
—	HISTOGENICS CORP	454,545	$5M	0.3%	$11.00	—	COM	43358V109
—	XOMA CORP DEL	794,500	$2.852M	0.2%	$4.07	—	COM	98419J107
—	BIOSPECIFICS TECHNOLOGIES CO	50,436	$1.948M	0.1%	$34.45	—	COM	090931106
—	HYPERION THERAPEUTICS INC	62,700	$1.505M	0.1%	$22.00	—	COM	44915N101
—	INTREXON CORP	43,700	$1.203M	0.1%	$27.53	—	COM	46122T102
CYTK	CYTOKINETICS INC	123,686	$991K	0.1%	$6.71	-36.1%	COM NEW	23282W605
—	AVEO PHARMACEUTICALS INC	669,449	$562K	0.0%	$2.50	—	COM	053588109
—	NXSTAGE MEDICAL INC	20,200	$362K	0.0%	$17.92	—	COM	67072V103
—	MALLINCKRODT PUB LTD CO	3,588	$355K	0.0%	$90.02	—	SHS	G5785G107
—	SOPHIRIS BIO INC	191,600	$103K	0.0%	$3.88	—	COM NEW	83578Q209