| BAKER BROS. ADVISORS LP | 27,525,640 | $94,138 |
| Capital World Investors | 13,361,096 | $45,695 |
| UBS ASSET MANAGEMENT AMERICAS INC | 7,876,629 | $26,938 |
| TWO SIGMA INVESTMENTS, LP | 5,810,985 | $19,874 |
| TWO SIGMA ADVISERS, LP | 4,878,000 | $16,683 |
| GOLDMAN SACHS GROUP INC | 4,344,485 | $14,858 |
| ArrowMark Colorado Holdings LLC | 4,105,095 | $14,039 |
| BlackRock, Inc. | 3,865,896 | $13,221 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,771,999 | $12,900 |
| MORGAN STANLEY | 3,001,850 | $10,266 |
| BANK OF AMERICA CORP /DE/ | 2,632,872 | $9,004 |
| RENAISSANCE TECHNOLOGIES LLC | 2,389,229 | $8,171 |
| UBS Group AG | 1,939,409 | $6,633 |
| CITADEL ADVISORS LLC | 1,834,508 | $6,274 |
| TUDOR INVESTMENT CORP ET AL | 1,796,010 | $6,142 |
| Guardian Partners Inc. | 1,786,414 | $5,819 |
| MILLENNIUM MANAGEMENT LLC | 1,773,539 | $6,066 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,524,563 | $5,214 |
| JANE STREET GROUP, LLC | 1,397,088 | $4,778 |
| Point72 Asset Management, L.P. | 976,507 | $3,340 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 695,796 | $2,380 |
| STATE STREET CORP | 694,114 | $2,374 |
| HRT FINANCIAL LP | 548,431 | $2 |
| Intellectus Partners, LLC | 523,383 | $1,790 |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 400,000 | $1,368 |
| ROYAL BANK OF CANADA | 373,856 | $1,279 |
| XTX Topco Ltd | 363,251 | $1,242 |
| OSAIC HOLDINGS, INC. | 347,321 | $1,188 |
| SOFTBANK GROUP CORP. | 345,161 | $1,180 |
| Skandinaviska Enskilda Banken AB (publ) | 340,267 | $1,164 |
| LAZARD ASSET MANAGEMENT LLC | 328,717 | $1,124 |
| GEODE CAPITAL MANAGEMENT, LLC | 313,467 | $1,072 |
| Voleon Capital Management LP | 265,325 | $907 |
| CITIZENS FINANCIAL GROUP INC/RI | 261,890 | $896 |
| Graham Capital Management, L.P. | 257,838 | $882 |
| Walleye Capital LLC | 249,050 | $852 |
| RAYMOND JAMES FINANCIAL INC | 247,050 | $845 |
| IEQ CAPITAL, LLC | 245,963 | $841 |
| BNP PARIBAS ARBITRAGE, SA | 211,281 | $723 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 209,925 | $718 |
| NORTHERN TRUST CORP | 208,072 | $712 |
| Quadrature Capital Ltd | 205,095 | $701 |
| Headlands Technologies LLC | 188,787 | $646 |
| Intesa Sanpaolo S.p.A. | 182,471 | $617 |
| Virtu Financial LLC | 181,031 | $1 |
| NORGES BANK | 176,386 | $603 |
| BANK OF MONTREAL /CAN/ | 146,359 | $501 |
| Aquatic Capital Management LLC | 141,885 | $485 |
| Squarepoint Ops LLC | 133,069 | $455 |
| GROUP ONE TRADING, L.P. | 128,999 | $441 |
| Qube Research & Technologies Ltd | 122,592 | $419 |
| HSBC HOLDINGS PLC | 117,031 | $401 |
| ArchPoint Investors | 115,055 | $393 |
| AMERICAN CENTURY COMPANIES INC | 113,760 | $389 |
| ExodusPoint Capital Management, LP | 113,068 | $387 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 109,000 | $373 |
| PIER 88 INVESTMENT PARTNERS LLC | 105,730 | $362 |
| POLEN CAPITAL MANAGEMENT LLC | 102,508 | $351 |
| DekaBank Deutsche Girozentrale | 87,000 | $0 |
| STIFEL FINANCIAL CORP | 85,169 | $291 |
| Jump Financial, LLC | 81,271 | $278 |
| HighTower Advisors, LLC | 79,963 | $273 |
| Handelsbanken Fonder AB | 79,300 | $0 |
| D. E. Shaw & Co., Inc. | 77,776 | $266 |
| JPMORGAN CHASE & CO | 77,614 | $265 |
| Virtus Investment Advisers, LLC | 73,488 | $251 |
| TWO SIGMA SECURITIES, LLC | 68,284 | $234 |
| Erste Asset Management GmbH | 62,000 | $215 |
| Resolute Advisors LLC | 57,526 | $197 |
| Invesco Ltd. | 54,603 | $187 |
| Cerity Partners LLC | 52,057 | $178 |
| China Universal Asset Management Co., Ltd. | 48,777 | $167 |
| LPL Financial LLC | 48,704 | $167 |
| Tradition Wealth Management, LLC | 47,110 | $161 |
| XML Financial, LLC | 42,025 | $144 |
| Creative Planning | 41,844 | $143 |
| Federation des caisses Desjardins du Quebec | 39,862 | $136 |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 35,668 | $122 |
| nVerses Capital, LLC | 35,446 | $121 |
| BARCLAYS PLC | 33,547 | $115 |
| MOR Wealth Management, LLC | 33,000 | $113 |
| Advisory Services Network, LLC | 29,664 | $101 |
| BRANDYWINE MANAGERS, LLC | 28,488 | $97 |
| Green Alpha Advisors, LLC | 27,592 | $94 |
| HBK Sorce Advisory LLC | 24,956 | $79 |
| OneDigital Investment Advisors LLC | 24,000 | $82 |
| Stratos Wealth Advisors, LLC | 23,000 | $79 |
| TD Waterhouse Canada Inc. | 22,412 | $76 |
| CIBC WORLD MARKET INC. | 20,706 | $71 |
| Tower Research Capital LLC (TRC) | 20,075 | $69 |
| Schonfeld Strategic Advisors LLC | 19,580 | $67 |
| Scientech Research LLC | 18,988 | $65 |
| HB Wealth Management, LLC | 18,981 | $65 |
| Ballentine Partners, LLC | 18,603 | $64 |
| Farther Finance Advisors, LLC | 16,645 | $57 |
| SCOTIA CAPITAL INC. | 15,943 | $55 |
| WELLS FARGO & COMPANY/MN | 14,900 | $51 |
| OXFORD ASSET MANAGEMENT LLP | 14,875 | $51 |
| Mirae Asset Global Investments Co., Ltd. | 14,546 | $50 |
| ROTHSCHILD INVESTMENT LLC | 14,495 | $50 |
| 44 other institutions | 276,008 | $916 |