| JANUS HENDERSON GROUP PLC | 6,307,636 | $38,807 |
| 5AM Venture Management, LLC | 5,869,091 | $35,978 |
| FMR LLC | 4,918,243 | $30,149 |
| Vivo Capital, LLC | 4,246,568 | $26,031 |
| Enavate Sciences GP, LLC | 3,035,825 | $18,610 |
| BALYASNY ASSET MANAGEMENT L.P. | 2,436,900 | $14,938 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,181,679 | $13,374 |
| a16z Capital Management, L.L.C. | 2,125,339 | $13,028 |
| Trails Edge Capital Partners, LP | 1,983,986 | $12,162 |
| VANGUARD GROUP INC | 1,672,960 | $10,255 |
| HARBOURVEST PARTNERS LLC | 1,271,948 | $7,797 |
| BlackRock, Inc. | 390,160 | $2,392 |
| GEODE CAPITAL MANAGEMENT, LLC | 336,293 | $2,063 |
| EcoR1 Capital, LLC | 325,000 | $1,992 |
| Stonepine Capital Management, LLC | 228,894 | $1,403 |
| Alyeska Investment Group, L.P. | 200,000 | $1,226 |
| 683 Capital Management, LLC | 126,363 | $775 |
| TWO SIGMA INVESTMENTS, LP | 94,531 | $579 |
| VICTORY CAPITAL MANAGEMENT INC | 82,790 | $508 |
| NORTHERN TRUST CORP | 74,509 | $457 |
| BARCLAYS PLC | 73,601 | $451 |
| STATE STREET CORP | 39,700 | $243 |
| ExodusPoint Capital Management, LP | 34,720 | $213 |
| JANE STREET GROUP, LLC | 25,534 | $157 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | $153 |
| CITIGROUP INC | 21,403 | $131 |
| GOLDMAN SACHS GROUP INC | 18,823 | $115 |
| OMERS ADMINISTRATION Corp | 18,800 | $115 |
| Bank of New York Mellon Corp | 18,718 | $115 |
| Mariner, LLC | 15,371 | $94 |
| Jefferies Financial Group Inc. | 11,361 | $70 |
| MILLENNIUM MANAGEMENT LLC | 10,102 | $62 |
| China Universal Asset Management Co., Ltd. | 10,000 | $61 |
| MORGAN STANLEY | 9,914 | $61 |
| UBS Group AG | 5,145 | $32 |
| Tower Research Capital LLC (TRC) | 406 | $2 |
| BNP PARIBAS ARBITRAGE, SA | 33 | $0 |
| BANK OF AMERICA CORP /DE/ | 22 | $0 |
| ROYAL BANK OF CANADA | 18 | $0 |
| SBI Securities Co., Ltd. | 10 | $0 |