CAMP4 THERAPEUTICS CORP

Institution	Shares	Value ($000)
Stonepine Capital Management, LLC	228,894	$1,403
EcoR1 Capital, LLC	325,000	$1,992
683 Capital Management, LLC	126,363	$775
BALYASNY ASSET MANAGEMENT L.P.	2,436,900	$14,938
China Universal Asset Management Co., Ltd.	10,000	$61
ExodusPoint Capital Management, LP	34,720	$213
BARCLAYS PLC	73,601	$451
OMERS ADMINISTRATION Corp	18,800	$115
JANE STREET GROUP, LLC	25,534	$157
CITIGROUP INC	21,403	$131
GOLDMAN SACHS GROUP INC	18,823	$115
Bank of New York Mellon Corp	18,718	$115
Jefferies Financial Group Inc.	11,361	$70

Increased Positions (10)

Vivo Capital, LLC

Value ($000) $26,031 (+121.3%) Shares 4,246,568 (+8.3%)

JANUS HENDERSON GROUP PLC

Value ($000) $38,807 (+178.7%) Shares 6,307,636 (+35.9%)

FMR LLC

Value ($000) $30,149 (+232.4%) Shares 4,918,243 (+62.7%)

VANGUARD GROUP INC

Value ($000) $10,255 (+990.4%) Shares 1,672,960 (+433.6%)

ADAGE CAPITAL PARTNERS GP, L.L.C.

Value ($000) $13,374 (+127.4%) Shares 2,181,679 (+11.3%)

BlackRock, Inc.

Value ($000) $2,392 (+6870.6%) Shares 390,160 (+3311.4%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $2,063 (+1038.8%) Shares 336,293 (+457.0%)

NORTHERN TRUST CORP

Value ($000) $457 (+941.7%) Shares 74,509 (+409.8%)

STATE STREET CORP

Value ($000) $243 (+212.0%) Shares 39,700 (+52.7%)

MORGAN STANLEY

Value ($000) $61 (+675155.6%) Shares 9,914 (+330366.7%)

Institution	Prev Shares	Curr Shares	Change
Vivo Capital, LLC	3,921,568	4,246,568	+325,000 (+8.3%)
JANUS HENDERSON GROUP PLC	4,640,970	6,307,636	+1,666,666 (+35.9%)
FMR LLC	3,023,434	4,918,243	+1,894,809 (+62.7%)
VANGUARD GROUP INC	313,506	1,672,960	+1,359,454 (+433.6%)
ADAGE CAPITAL PARTNERS GP, L.L.C.	1,960,784	2,181,679	+220,895 (+11.3%)
BlackRock, Inc.	11,437	390,160	+378,723 (+3311.4%)
GEODE CAPITAL MANAGEMENT, LLC	60,371	336,293	+275,922 (+457.0%)
NORTHERN TRUST CORP	14,615	74,509	+59,894 (+409.8%)
STATE STREET CORP	26,000	39,700	+13,700 (+52.7%)
MORGAN STANLEY	3	9,914	+9,911 (+330366.7%)

Decreased Positions (10)

Enavate Sciences GP, LLC

Value ($000) $18,610 (+63.9%) Shares 3,035,825 (-19.8%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $62 (-78.3%) Shares 10,102 (-89.4%)

Tower Research Capital LLC (TRC)

Value ($000) $2 (-85.3%) Shares 406 (-92.8%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $579 (+98.4%) Shares 94,531 (-2.9%)

Mariner, LLC

Value ($000) $94 (+81.6%) Shares 15,371 (-11.1%)

UBS Group AG

Value ($000) $32 (+49.3%) Shares 5,145 (-26.9%)

ROYAL BANK OF CANADA

Value ($000) $0 (-100.0%) Shares 18 (-98.1%)

BANK OF AMERICA CORP /DE/

Value ($000) $0 (-84.1%) Shares 22 (-92.2%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $0 (-13.7%) Shares 33 (-57.7%)

SBI Securities Co., Ltd.

Value ($000) $0 (+35.6%) Shares 10 (-33.3%)

Institution	Prev Shares	Curr Shares	Change
Enavate Sciences GP, LLC	3,785,802	3,035,825	-749,977 (-19.8%)
MILLENNIUM MANAGEMENT LLC	95,071	10,102	-84,969 (-89.4%)
Tower Research Capital LLC (TRC)	5,649	406	-5,243 (-92.8%)
TWO SIGMA INVESTMENTS, LP	97,371	94,531	-2,840 (-2.9%)
Mariner, LLC	17,298	15,371	-1,927 (-11.1%)
UBS Group AG	7,043	5,145	-1,898 (-26.9%)
ROYAL BANK OF CANADA	953	18	-935 (-98.1%)
BANK OF AMERICA CORP /DE/	283	22	-261 (-92.2%)
BNP PARIBAS ARBITRAGE, SA	78	33	-45 (-57.7%)
SBI Securities Co., Ltd.	15	10	-5 (-33.3%)

Exited Positions (2)

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $1,961 Shares 653,594

CWM, LLC

Value ($000) $0 Shares 5

Institution	Prev Shares	Prev Value ($000)
SILVERARC CAPITAL MANAGEMENT, LLC	653,594	$1,961
CWM, LLC	5	$0