| WELLINGTON MANAGEMENT GROUP LLP | 8,079,608 | $219,442 |
| Kynam Capital Management, LP | 5,943,180 | $161,417 |
| BlackRock, Inc. | 5,451,815 | $148,071 |
| FMR LLC | 4,907,469 | $133,287 |
| VANGUARD GROUP INC | 4,027,407 | $109,384 |
| Bellevue Group AG | 3,617,669 | $98,256 |
| STATE STREET CORP | 3,397,713 | $92,282 |
| Commodore Capital LP | 2,565,000 | $69,665 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,039,705 | $55 |
| Deep Track Capital, LP | 1,900,738 | $51,624 |
| BRAIDWELL LP | 1,858,109 | $50,466 |
| Point72 Asset Management, L.P. | 1,758,357 | $47,757 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,642,559 | $44,607 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,627,529 | $44,211 |
| Eversept Partners, LP | 1,434,725 | $38,967 |
| MILLENNIUM MANAGEMENT LLC | 1,212,705 | $32,937 |
| Novo Holdings A/S | 1,200,000 | $32,592 |
| Vestal Point Capital, LP | 1,165,000 | $31,641 |
| GOLDMAN SACHS GROUP INC | 1,068,131 | $29,010 |
| Polar Capital Holdings Plc | 1,008,163 | $27,382 |
| Pictet Asset Management Holding SA | 968,616 | $26,308 |
| Fisher Asset Management, LLC | 937,158 | $25,453 |
| Elmind Capital, LP | 865,000 | $23,493 |
| AMERICAN CENTURY COMPANIES INC | 855,226 | $23,228 |
| Rock Springs Capital Management LP | 692,538 | $18,809 |
| BAKER BROS. ADVISORS LP | 665,370 | $18,071 |
| DIMENSIONAL FUND ADVISORS LP | 651,716 | $17,700 |
| ADAR1 Capital Management, LLC | 646,767 | $17,566 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 550,729 | $14,958 |
| NORTHERN TRUST CORP | 549,998 | $14,938 |
| SEGALL BRYANT & HAMILL, LLC | 514,531 | $13,975 |
| Woodline Partners LP | 500,127 | $13,583 |
| 5AM Venture Management, LLC | 497,270 | $13,506 |
| BANK OF AMERICA CORP /DE/ | 414,888 | $11,268 |
| TSP Capital Management Group, LLC | 375,127 | $10,188 |
| Affinity Asset Advisors, LLC | 350,000 | $9,506 |
| Logos Global Management LP | 350,000 | $9,506 |
| UBS Group AG | 326,462 | $8,867 |
| MORGAN STANLEY | 285,535 | $7,755 |
| Redmile Group, LLC | 283,308 | $7,695 |
| Tetragon Partners GP Ltd | 243,800 | $6,622 |
| BARCLAYS PLC | 240,594 | $6,535 |
| SPHERA FUNDS MANAGEMENT LTD. | 239,764 | $6,512 |
| Corient Private Wealth LLC | 234,328 | $6,210 |
| BNP PARIBAS ARBITRAGE, SA | 230,662 | $6,265 |
| Nuveen, LLC | 200,696 | $5,451 |
| Bank of New York Mellon Corp | 194,552 | $5,284 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 191,074 | $5,190 |
| JPMORGAN CHASE & CO | 173,677 | $4,717 |
| Mirador Capital Partners LP | 170,659 | $4,635 |
| GordonMD Global Investments LP | 170,307 | $4,626 |
| Propel Bio Management, LLC | 154,300 | $4,191 |
| Jump Financial, LLC | 145,164 | $3,943 |
| DEUTSCHE BANK AG\ | 136,485 | $3,707 |
| D. E. Shaw & Co., Inc. | 136,324 | $3,703 |
| PFM Health Sciences, LP | 133,161 | $3,617 |
| TWO SIGMA INVESTMENTS, LP | 132,533 | $3,600 |
| BNP Paribas Investment Partners S.A. | 123,165 | $3 |
| RENAISSANCE TECHNOLOGIES LLC | 118,488 | $3,218 |
| Connor, Clark & Lunn Investment Management Ltd. | 118,205 | $3,210 |
| Swiss National Bank | 117,900 | $3,202 |
| UBS ASSET MANAGEMENT AMERICAS INC | 117,589 | $3,194 |
| Rafferty Asset Management, LLC | 114,230 | $3,102 |
| ALGERT GLOBAL LLC | 98,847 | $3 |
| PDT Partners, LLC | 97,822 | $2,657 |
| WELLS FARGO & COMPANY/MN | 91,599 | $2,488 |
| Invesco Ltd. | 90,144 | $2,448 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 88,308 | $2,398 |
| RHUMBLINE ADVISERS | 87,264 | $2,370 |
| Simplify Asset Management Inc. | 85,000 | $2,309 |
| HRT FINANCIAL LP | 77,640 | $2 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,130 | $2,007 |
| DAFNA Capital Management LLC | 68,518 | $1,861 |
| TD Asset Management Inc | 66,570 | $1,808 |
| ALLIANCEBERNSTEIN L.P. | 65,540 | $1,780 |
| Legal & General Group Plc | 62,599 | $1,700 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,397 | $1,586 |
| CITADEL ADVISORS LLC | 55,101 | $1,497 |
| ALPS ADVISORS INC | 54,559 | $1,482 |
| HighVista Strategies LLC | 51,805 | $1,407 |
| XTX Topco Ltd | 51,523 | $1,399 |
| ENVESTNET ASSET MANAGEMENT INC | 49,076 | $1,333 |
| SG Americas Securities, LLC | 47,340 | $1 |
| Hennion & Walsh Asset Management, Inc. | 46,965 | $1,276 |
| SummitTX Capital, L.P. | 43,324 | $1,177 |
| PROFUND ADVISORS LLC | 42,454 | $1,153 |
| FIRST TRUST ADVISORS LP | 38,313 | $1,041 |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,066 | $1,034 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,066 | $1,002 |
| MetLife Investment Management, LLC | 37,012 | $1,005 |
| INTECH INVESTMENT MANAGEMENT LLC | 33,499 | $910 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 33,098 | $1 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,263 | $876 |
| Creative Planning | 31,404 | $853 |
| VICTORY CAPITAL MANAGEMENT INC | 27,429 | $745 |
| Handelsbanken Fonder AB | 25,900 | $1 |
| JANUS HENDERSON GROUP PLC | 25,642 | $697 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 25,317 | $688 |
| DekaBank Deutsche Girozentrale | 25,000 | $1 |
| ArrowMark Colorado Holdings LLC | 25,000 | $679 |
| 86 other institutions | 383,904 | $9,890 |