| Lynx1 Capital Management LP | 8,963,500 | $92,772 |
| MPM BioImpact LLC | 7,648,268 | $79,160 |
| BVF INC/IL | 5,750,683 | $59,520 |
| BlackRock, Inc. | 4,400,296 | $45,543 |
| VANGUARD GROUP INC | 3,298,504 | $34,140 |
| Kynam Capital Management, LP | 3,114,132 | $32,231 |
| Blue Owl Capital Holdings LP | 2,350,972 | $24,333 |
| STATE STREET CORP | 2,197,338 | $22,742 |
| Affinity Asset Advisors, LLC | 1,932,106 | $19,997 |
| RTW INVESTMENTS, LP | 1,705,960 | $17,657 |
| VR Adviser, LLC | 1,379,965 | $14,283 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,302,262 | $13,481 |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,237,043 | $12,803 |
| Siren, L.L.C. | 1,193,410 | $12,352 |
| Nextech Invest, Ltd. | 1,141,145 | $11,811 |
| DIMENSIONAL FUND ADVISORS LP | 848,769 | $8,783 |
| MORGAN STANLEY | 766,934 | $7,938 |
| GOLDMAN SACHS GROUP INC | 721,864 | $7,471 |
| GREAT POINT PARTNERS LLC | 634,032 | $6,562 |
| RENAISSANCE TECHNOLOGIES LLC | 631,706 | $6,538 |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 595,489 | $6,163 |
| DEUTSCHE BANK AG\ | 586,636 | $6,072 |
| Nuveen, LLC | 579,095 | $5,994 |
| TWO SIGMA INVESTMENTS, LP | 470,526 | $4,870 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 436,273 | $4,515 |
| NORTHERN TRUST CORP | 421,635 | $4,364 |
| MARSHALL WACE, LLP | 414,359 | $4,289 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 386,169 | $3,997 |
| Trexquant Investment LP | 381,535 | $3,949 |
| Jump Financial, LLC | 364,889 | $3,777 |
| MILLENNIUM MANAGEMENT LLC | 362,495 | $3,752 |
| Point72 Asset Management, L.P. | 360,162 | $3,728 |
| BANK OF AMERICA CORP /DE/ | 346,307 | $3,584 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 343,667 | $3,409 |
| Elmind Capital, LP | 310,000 | $3,209 |
| AQR CAPITAL MANAGEMENT LLC | 281,483 | $2,913 |
| UBS Group AG | 271,736 | $2,812 |
| ORBIMED ADVISORS LLC | 270,006 | $2,795 |
| BARCLAYS PLC | 269,655 | $2,791 |
| Connor, Clark & Lunn Investment Management Ltd. | 244,022 | $2,526 |
| CITIGROUP INC | 240,457 | $2,489 |
| Susquehanna Portfolio Strategies, LLC | 233,842 | $2,420 |
| PFM Health Sciences, LP | 227,003 | $2,349 |
| JANE STREET GROUP, LLC | 186,844 | $1,934 |
| ALGERT GLOBAL LLC | 162,501 | $2 |
| WELLINGTON MANAGEMENT GROUP LLP | 159,751 | $1,653 |
| Assenagon Asset Management S.A. | 158,753 | $1,643 |
| JPMORGAN CHASE & CO | 147,055 | $1,522 |
| Bank of New York Mellon Corp | 144,927 | $1,500 |
| AMERICAN CENTURY COMPANIES INC | 142,761 | $1,478 |
| Invesco Ltd. | 130,323 | $1,349 |
| TWO SIGMA ADVISERS, LP | 129,809 | $1,344 |
| XTX Topco Ltd | 121,257 | $1,255 |
| Qube Research & Technologies Ltd | 119,292 | $1,235 |
| CITADEL ADVISORS LLC | 110,317 | $1,142 |
| HRT FINANCIAL LP | 84,067 | $1 |
| Squarepoint Ops LLC | 75,820 | $785 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 73,755 | $763 |
| Engineers Gate Manager LP | 69,343 | $718 |
| RHUMBLINE ADVISERS | 67,240 | $696 |
| Rafferty Asset Management, LLC | 61,671 | $638 |
| WELLS FARGO & COMPANY/MN | 60,514 | $626 |
| Swiss National Bank | 58,300 | $603 |
| ADAR1 Capital Management, LLC | 50,000 | $518 |
| Voleon Capital Management LP | 49,663 | $514 |
| Mariner, LLC | 49,131 | $508 |
| UBS ASSET MANAGEMENT AMERICAS INC | 48,051 | $497 |
| Quantinno Capital Management LP | 48,001 | $497 |
| ALLIANCEBERNSTEIN L.P. | 47,630 | $493 |
| KENNEDY CAPITAL MANAGEMENT LLC | 47,266 | $489 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 47,187 | $0 |
| Creative Planning | 39,890 | $413 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,822 | $412 |
| BNP PARIBAS ARBITRAGE, SA | 39,451 | $408 |
| NEOS Investment Management LLC | 37,519 | $388 |
| TEMA ETFS LLC | 36,964 | $383 |
| Aquatic Capital Management LLC | 30,923 | $320 |
| MetLife Investment Management, LLC | 30,816 | $319 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,799 | $319 |
| ExodusPoint Capital Management, LP | 30,487 | $316 |
| AlphaQuest LLC | 28,950 | $300 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 28,659 | $295 |
| Legal & General Group Plc | 28,628 | $296 |
| INTECH INVESTMENT MANAGEMENT LLC | 27,937 | $289 |
| GSA CAPITAL PARTNERS LLP | 27,303 | $0 |
| Russell Investments Group, Ltd. | 24,409 | $253 |
| EntryPoint Capital, LLC | 23,788 | $246 |
| PROFUND ADVISORS LLC | 23,282 | $241 |
| Virtus Investment Advisers, LLC | 22,318 | $231 |
| FOX RUN MANAGEMENT, L.L.C. | 21,204 | $219 |
| Birchview Capital, LP | 20,000 | $207 |
| Pale Fire Capital SE | 19,318 | $200 |
| AlphaCentric Advisors LLC | 19,041 | $197 |
| JANUS HENDERSON GROUP PLC | 18,528 | $191 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,822 | $174 |
| Schonfeld Strategic Advisors LLC | 16,638 | $172 |
| SG Americas Securities, LLC | 15,631 | $0 |
| Police & Firemen's Retirement System of New Jersey | 14,996 | $155 |
| D. E. Shaw & Co., Inc. | 14,365 | $149 |
| Compass Ion Advisors, LLC | 13,904 | $144 |
| 52 other institutions | 176,909 | $1,756 |