| Opaleye Management Inc. | 2,860,000 | $48,363 |
| EcoR1 Capital, LLC | 2,030,544 | $34,336 |
| BlackRock, Inc. | 1,738,907 | $29,405 |
| VANGUARD GROUP INC | 1,348,668 | $22,806 |
| Nantahala Capital Management, LLC | 1,175,951 | $19,885 |
| GEODE CAPITAL MANAGEMENT, LLC | 565,051 | $9,557 |
| STATE STREET CORP | 501,925 | $8,488 |
| MORGAN STANLEY | 493,914 | $8,352 |
| Westside Investment Management, Inc. | 470,940 | $7,963 |
| OBERWEIS ASSET MANAGEMENT INC/ | 431,300 | $7,293 |
| THOMPSON SIEGEL & WALMSLEY LLC | 408,541 | $7 |
| BNP PARIBAS ARBITRAGE, SA | 277,458 | $4,692 |
| NORTHERN TRUST CORP | 231,849 | $3,921 |
| CANNELL CAPITAL LLC | 216,917 | $3,668 |
| RENAISSANCE TECHNOLOGIES LLC | 205,700 | $3,478 |
| GOLDMAN SACHS GROUP INC | 196,263 | $3,319 |
| Diametric Capital, LP | 193,155 | $3,266 |
| JPMORGAN CHASE & CO | 185,439 | $3,136 |
| Lumbard & Kellner, LLC | 174,944 | $2,958 |
| Aristides Capital LLC | 161,436 | $2,730 |
| Bank of New York Mellon Corp | 127,700 | $2,159 |
| UBS Group AG | 126,674 | $2,142 |
| Jefferies Financial Group Inc. | 118,300 | $2,000 |
| BANK OF AMERICA CORP /DE/ | 104,796 | $1,772 |
| Woodline Partners LP | 95,487 | $1,615 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 84,020 | $1,421 |
| WELLINGTON MANAGEMENT GROUP LLP | 81,201 | $1,373 |
| MILLENNIUM MANAGEMENT LLC | 79,331 | $1,341 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,212 | $1,306 |
| TWO SIGMA INVESTMENTS, LP | 76,602 | $1,295 |
| Connor, Clark & Lunn Investment Management Ltd. | 76,586 | $1,295 |
| CITADEL ADVISORS LLC | 74,144 | $1,254 |
| Nuveen, LLC | 58,917 | $996 |
| JANE STREET GROUP, LLC | 58,056 | $982 |
| BARCLAYS PLC | 51,448 | $870 |
| Russell Investments Group, Ltd. | 49,694 | $840 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 45,325 | $766 |
| ANCHOR CAPITAL ADVISORS LLC | 40,668 | $688 |
| XTX Topco Ltd | 32,527 | $550 |
| BLAIR WILLIAM & CO/IL | 32,400 | $548 |
| RHUMBLINE ADVISERS | 30,436 | $515 |
| WELLS FARGO & COMPANY/MN | 28,293 | $478 |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,615 | $416 |
| Aquatic Capital Management LLC | 22,802 | $386 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 20,182 | $341 |
| Invesco Ltd. | 19,691 | $333 |
| JUNCTURE WEALTH STRATEGIES, LLC | 18,996 | $321 |
| Bridge City Capital, LLC | 18,600 | $315 |
| DEUTSCHE BANK AG\ | 18,249 | $309 |
| CHICAGO TRUST Co NA | 16,700 | $282 |
| Voleon Capital Management LP | 15,582 | $263 |
| MetLife Investment Management, LLC | 15,537 | $263 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,369 | $0 |
| D. E. Shaw & Co., Inc. | 15,331 | $259 |
| PDT Partners, LLC | 14,891 | $252 |
| TWO SIGMA ADVISERS, LP | 14,700 | $249 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,631 | $267 |
| Squarepoint Ops LLC | 13,482 | $228 |
| Point72 Asset Management, L.P. | 12,925 | $219 |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,500 | $211 |
| INTECH INVESTMENT MANAGEMENT LLC | 12,421 | $210 |
| RAYMOND JAMES FINANCIAL INC | 12,250 | $207 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,864 | $201 |
| Quantum Private Wealth, LLC | 11,500 | $194 |
| ENVESTNET ASSET MANAGEMENT INC | 10,944 | $185 |
| Jump Financial, LLC | 10,551 | $178 |
| Man Group plc | 10,473 | $177 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 10,000 | $169 |
| Quantbot Technologies LP | 9,357 | $158 |
| State of Wyoming | 8,161 | $138 |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,100 | $137 |
| Police & Firemen's Retirement System of New Jersey | 7,209 | $122 |
| State of Alaska, Department of Revenue | 6,943 | $0 |
| SG Americas Securities, LLC | 6,471 | $0 |
| China Universal Asset Management Co., Ltd. | 4,370 | $74 |
| AlphaQuest LLC | 4,149 | $70 |
| FMR LLC | 3,076 | $52 |
| Tower Research Capital LLC (TRC) | 2,994 | $51 |
| Caitong International Asset Management Co., Ltd | 2,939 | $50 |
| Legal & General Group Plc | 2,731 | $46 |
| Ameritas Investment Partners, Inc. | 2,167 | $37 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,578 | $27 |
| CITIGROUP INC | 1,451 | $25 |
| Mirae Asset Global Investments Co., Ltd. | 1,303 | $22 |
| Truvestments Capital LLC | 1,183 | $20 |
| ROYAL BANK OF CANADA | 1,018 | $17 |
| AMALGAMATED BANK | 805 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 527 | $9 |
| GROUP ONE TRADING, L.P. | 500 | $8 |
| JONES FINANCIAL COMPANIES LLLP | 221 | $4 |
| OSAIC HOLDINGS, INC. | 200 | $3 |
| Sterling Capital Management LLC | 167 | $3 |
| Vermillion & White Wealth Management Group, LLC | 150 | $3 |
| Farther Finance Advisors, LLC | 146 | $2 |
| Daiwa Securities Group Inc. | 89 | $0 |
| US BANCORP \DE\ | 54 | $1 |
| PNC Financial Services Group, Inc. | 51 | $1 |
| CWM, LLC | 26 | $0 |
| GAMMA Investing LLC | 23 | $0 |
| SBI Securities Co., Ltd. | 10 | $0 |
| 2 other institutions | 8 | $0 |