| Redmile Group, LLC | 12,872,946 | $12,649 |
| BlackRock, Inc. | 10,176,487 | $9,999 |
| VANGUARD GROUP INC | 8,971,347 | $8,819 |
| JOHNSON & JOHNSON | 3,379,064 | $3,320 |
| ACADIAN ASSET MANAGEMENT LLC | 2,931,893 | $3 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,468,348 | $2,426 |
| RENAISSANCE TECHNOLOGIES LLC | 2,360,881 | $2,320 |
| STATE STREET CORP | 2,265,217 | $2,226 |
| TWO SIGMA INVESTMENTS, LP | 1,734,064 | $1,704 |
| Vestal Point Capital, LP | 1,725,000 | $1,695 |
| TWO SIGMA ADVISERS, LP | 1,651,700 | $1,623 |
| DIMENSIONAL FUND ADVISORS LP | 1,577,478 | $1,550 |
| Point72 Asset Management, L.P. | 1,527,986 | $1,501 |
| GOLDMAN SACHS GROUP INC | 1,435,040 | $1,410 |
| TANG CAPITAL MANAGEMENT LLC | 1,167,773 | $1,147 |
| AQR CAPITAL MANAGEMENT LLC | 1,162,005 | $1,142 |
| MORGAN STANLEY | 916,946 | $901 |
| JANE STREET GROUP, LLC | 842,807 | $828 |
| Monaco Asset Management SAM | 830,000 | $816 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 784,628 | $771 |
| CITADEL ADVISORS LLC | 749,336 | $736 |
| NORTHERN TRUST CORP | 732,670 | $720 |
| Bruce & Co., Inc. | 729,188 | $717 |
| DAFNA Capital Management LLC | 550,000 | $540 |
| MILLENNIUM MANAGEMENT LLC | 522,617 | $514 |
| UBS Group AG | 403,524 | $397 |
| Invesco Ltd. | 379,025 | $372 |
| Privium Fund Management B.V. | 369,100 | $363 |
| Knott David M Jr | 365,000 | $359 |
| XTX Topco Ltd | 364,738 | $358 |
| Woodline Partners LP | 356,650 | $350 |
| Nuveen, LLC | 336,872 | $331 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 310,191 | $305 |
| BARCLAYS PLC | 308,542 | $303 |
| Bank of New York Mellon Corp | 307,597 | $302 |
| Quadrature Capital Ltd | 298,082 | $293 |
| Man Group plc | 261,172 | $257 |
| GSA CAPITAL PARTNERS LLP | 213,645 | $0 |
| Graham Capital Management, L.P. | 195,579 | $192 |
| Schonfeld Strategic Advisors LLC | 192,682 | $189 |
| ALLIANCEBERNSTEIN L.P. | 187,700 | $184 |
| WELLS FARGO & COMPANY/MN | 172,283 | $169 |
| BANK OF AMERICA CORP /DE/ | 151,107 | $148 |
| Assenagon Asset Management S.A. | 148,653 | $146 |
| RHUMBLINE ADVISERS | 146,761 | $144 |
| LPL Financial LLC | 144,816 | $142 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 135,000 | $133 |
| IEQ CAPITAL, LLC | 121,501 | $119 |
| Connor, Clark & Lunn Investment Management Ltd. | 111,227 | $109 |
| HSBC HOLDINGS PLC | 97,684 | $96 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 95,185 | $123 |
| DEUTSCHE BANK AG\ | 91,679 | $90 |
| State of Tennessee, Department of Treasury | 90,000 | $107 |
| Leo Wealth, LLC | 70,439 | $69 |
| Shay Capital LLC | 70,000 | $69 |
| Virtu Financial LLC | 68,871 | $0 |
| SEI INVESTMENTS CO | 67,643 | $66 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 54,470 | $0 |
| Cerity Partners LLC | 52,489 | $52 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 52,373 | $51 |
| CWM, LLC | 51,789 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 51,660 | $51 |
| Vanguard Personalized Indexing Management, LLC | 50,947 | $50 |
| HRT FINANCIAL LP | 48,544 | $0 |
| JPMORGAN CHASE & CO | 43,436 | $43 |
| SG Americas Securities, LLC | 38,913 | $0 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,658 | $35 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 34,925 | $35 |
| Thrivent Financial for Lutherans | 34,105 | $0 |
| HighTower Advisors, LLC | 32,219 | $32 |
| Focus Partners Wealth | 31,966 | $31 |
| Corient Private Wealth LLC | 29,830 | $29 |
| BNP PARIBAS ARBITRAGE, SA | 29,295 | $29 |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,015 | $28 |
| CITIGROUP INC | 27,459 | $27 |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,548 | $26 |
| FPC INVESTMENT ADVISORY, INC. | 26,456 | $26 |
| CAPTRUST FINANCIAL ADVISORS | 25,534 | $25 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 24,419 | $0 |
| Creative Planning | 23,891 | $23 |
| PRUDENTIAL FINANCIAL INC | 23,160 | $23 |
| Bronte Capital Management Pty Ltd. | 22,853 | $22 |
| Voya Investment Management LLC | 22,502 | $22 |
| Police & Firemen's Retirement System of New Jersey | 20,768 | $20 |
| Quinn Opportunity Partners LLC | 20,000 | $20 |
| ProShare Advisors LLC | 19,872 | $20 |
| NINE MASTS CAPITAL Ltd | 19,445 | $19 |
| Parametrica Management Ltd | 18,472 | $18 |
| TIAA TRUST, NATIONAL ASSOCIATION | 17,592 | $17 |
| Sagewood Asset Management LP | 15,003 | $15 |
| Mariner, LLC | 14,889 | $15 |
| Pallas Capital Advisors LLC | 14,674 | $14 |
| Parcion Private Wealth LLC | 14,057 | $14 |
| NEUBERGER BERMAN GROUP LLC | 13,950 | $14 |
| MERCER GLOBAL ADVISORS INC /ADV | 13,918 | $14 |
| FMR LLC | 12,756 | $13 |
| Narwhal Capital Management | 12,700 | $12 |
| AlphaCore Capital LLC | 12,689 | $12 |
| VICTORY CAPITAL MANAGEMENT INC | 12,628 | $12 |
| Tower Research Capital LLC (TRC) | 11,029 | $11 |
| 43 other institutions | 114,011 | $109 |