| BlackRock, Inc. | 9,010,793 | $93,622 |
| BVF INC/IL | 8,617,162 | $89,532 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,575,422 | $89,099 |
| VANGUARD GROUP INC | 5,507,627 | $57,224 |
| ARMISTICE CAPITAL, LLC | 4,936,000 | $51,285 |
| STATE STREET CORP | 4,931,090 | $51,234 |
| AQR CAPITAL MANAGEMENT LLC | 3,062,212 | $31,816 |
| Prosight Management, LP | 2,529,600 | $26,283 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,028,618 | $21,082 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,022,333 | $21,012 |
| GOLDMAN SACHS GROUP INC | 1,837,264 | $19,089 |
| RENAISSANCE TECHNOLOGIES LLC | 1,830,566 | $19,020 |
| MILLENNIUM MANAGEMENT LLC | 1,584,399 | $16,462 |
| ALETHEA CAPITAL MANAGEMENT, LLC | 1,422,682 | $14,782 |
| MORGAN STANLEY | 1,389,828 | $14,440 |
| Qube Research & Technologies Ltd | 1,333,523 | $13,855 |
| Assenagon Asset Management S.A. | 1,145,016 | $11,897 |
| AMERICAN CENTURY COMPANIES INC | 1,117,042 | $11,606 |
| DIMENSIONAL FUND ADVISORS LP | 1,077,818 | $11,197 |
| UBS Group AG | 1,060,025 | $11,014 |
| NAN FUNG TRINITY (HK) LTD | 964,880 | $10,025 |
| ACADIAN ASSET MANAGEMENT LLC | 886,579 | $9 |
| Rhenman & Partners Asset Management AB | 872,000 | $9,060 |
| BANK OF AMERICA CORP /DE/ | 842,128 | $8,750 |
| NORTHERN TRUST CORP | 723,217 | $7,514 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 710,882 | $7,386 |
| Connor, Clark & Lunn Investment Management Ltd. | 618,571 | $6,427 |
| JANE STREET GROUP, LLC | 477,145 | $4,958 |
| Fisher Asset Management, LLC | 471,993 | $4,904 |
| TWO SIGMA INVESTMENTS, LP | 471,794 | $4,902 |
| SECTOR GAMMA AS | 455,841 | $4,736 |
| 1492 Capital Management LLC | 452,638 | $4,703 |
| Pale Fire Capital SE | 452,245 | $4,699 |
| Jump Financial, LLC | 422,443 | $4,389 |
| IEQ CAPITAL, LLC | 398,455 | $4,140 |
| BARCLAYS PLC | 394,605 | $4,100 |
| Susquehanna Portfolio Strategies, LLC | 392,817 | $4,081 |
| CITADEL ADVISORS LLC | 390,672 | $4,059 |
| GREAT LAKES ADVISORS, LLC | 390,231 | $4,055 |
| AMERIPRISE FINANCIAL INC | 346,676 | $3,602 |
| FMR LLC | 306,602 | $3,186 |
| SPHERA FUNDS MANAGEMENT LTD. | 295,522 | $3,070 |
| Hennion & Walsh Asset Management, Inc. | 294,805 | $3,063 |
| FRANKLIN RESOURCES INC | 281,115 | $2,921 |
| Bank of New York Mellon Corp | 258,427 | $2,685 |
| Man Group plc | 241,539 | $2,510 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 241,095 | $2,505 |
| DAFNA Capital Management LLC | 235,868 | $2,451 |
| Trexquant Investment LP | 227,382 | $2,362 |
| Invesco Ltd. | 209,370 | $2,175 |
| Creative Planning | 198,785 | $2,065 |
| Rafferty Asset Management, LLC | 187,391 | $1,947 |
| DARK FOREST CAPITAL MANAGEMENT LP | 183,505 | $1,907 |
| SEI INVESTMENTS CO | 183,448 | $1,906 |
| Moody Aldrich Partners LLC | 179,728 | $1,867 |
| Russell Investments Group, Ltd. | 160,031 | $1,663 |
| CWM, LLC | 156,544 | $2 |
| TWO SIGMA ADVISERS, LP | 152,600 | $1,586 |
| SG Americas Securities, LLC | 151,715 | $2 |
| Nuveen, LLC | 151,070 | $1,570 |
| Woodline Partners LP | 145,704 | $1,514 |
| Swiss National Bank | 145,600 | $1,513 |
| Cerity Partners LLC | 134,311 | $1,395 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 133,357 | $1,386 |
| Mariner, LLC | 125,920 | $1,306 |
| Xcel Wealth Management, LLC | 118,846 | $1,235 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,513 | $1,211 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 115,307 | $1,100 |
| UBS ASSET MANAGEMENT AMERICAS INC | 106,889 | $1,111 |
| RHUMBLINE ADVISERS | 104,447 | $1,085 |
| Rangeley Capital, LLC | 102,900 | $1,069 |
| Rosalind Advisors, Inc. | 100,000 | $1,039 |
| HRT FINANCIAL LP | 98,029 | $1 |
| DekaBank Deutsche Girozentrale | 95,000 | $2 |
| PRUDENTIAL FINANCIAL INC | 92,200 | $958 |
| WELLS FARGO & COMPANY/MN | 91,514 | $951 |
| POLEN CAPITAL MANAGEMENT LLC | 90,847 | $944 |
| GSA CAPITAL PARTNERS LLP | 88,395 | $1 |
| ALLIANCEBERNSTEIN L.P. | 84,800 | $881 |
| DEUTSCHE BANK AG\ | 80,809 | $840 |
| Legal & General Group Plc | 78,258 | $813 |
| STATE OF WISCONSIN INVESTMENT BOARD | 75,702 | $787 |
| ACT CAPITAL MANAGEMENT, LLC | 73,900 | $768 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 72,051 | $749 |
| ALPS ADVISORS INC | 71,447 | $742 |
| PROFUND ADVISORS LLC | 69,124 | $718 |
| Aaron Wealth Advisors LLC | 67,142 | $698 |
| Virtus Investment Advisers, LLC | 66,870 | $695 |
| GROUP ONE TRADING, L.P. | 65,012 | $675 |
| Squarepoint Ops LLC | 64,675 | $672 |
| SECTORAL ASSET MANAGEMENT INC | 54,110 | $562 |
| HSBC HOLDINGS PLC | 52,003 | $536 |
| MERCER GLOBAL ADVISORS INC /ADV | 50,080 | $520 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 48,366 | $501 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,363 | $482 |
| Lion Point Capital, LP | 46,000 | $478 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,727 | $0 |
| HARBOR CAPITAL ADVISORS, INC. | 45,610 | $0 |
| Brevan Howard Capital Management LP | 44,843 | $466 |
| MetLife Investment Management, LLC | 44,625 | $464 |
| 112 other institutions | 1,538,766 | $14,970 |