| BML Capital Management, LLC | 5,292,000 | $6,615 |
| ORBIMED ADVISORS LLC | 4,975,291 | $6,219 |
| TANG CAPITAL MANAGEMENT LLC | 4,940,000 | $6,175 |
| ArrowMark Colorado Holdings LLC | 3,090,093 | $3,863 |
| Sio Capital Management, LLC | 2,636,548 | $3,296 |
| Euclidean Capital LLC | 2,627,643 | $3,285 |
| VANGUARD GROUP INC | 2,170,310 | $2,713 |
| ACADIAN ASSET MANAGEMENT LLC | 2,015,770 | $3 |
| Stonepine Capital Management, LLC | 1,150,759 | $1,438 |
| BlackRock, Inc. | 1,094,883 | $1,369 |
| TWO SIGMA ADVISERS, LP | 874,100 | $1,093 |
| TWO SIGMA INVESTMENTS, LP | 706,061 | $883 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 524,350 | $655 |
| JANE STREET GROUP, LLC | 498,641 | $623 |
| Aldebaran Capital, LLC | 477,988 | $597 |
| MARSHALL WACE, LLP | 465,086 | $581 |
| GEODE CAPITAL MANAGEMENT, LLC | 446,140 | $558 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 428,853 | $536 |
| NORTHERN TRUST CORP | 382,088 | $478 |
| Walleye Capital LLC | 335,694 | $420 |
| BANK OF AMERICA CORP /DE/ | 240,138 | $300 |
| STATE STREET CORP | 183,178 | $229 |
| RBF Capital, LLC | 162,200 | $203 |
| Assenagon Asset Management S.A. | 140,468 | $176 |
| EVOKE WEALTH, LLC | 133,122 | $166 |
| GOLDMAN SACHS GROUP INC | 127,041 | $159 |
| CITADEL ADVISORS LLC | 118,593 | $148 |
| XTX Topco Ltd | 104,485 | $131 |
| ADAR1 Capital Management, LLC | 101,008 | $126 |
| MORGAN STANLEY | 98,875 | $124 |
| Ikarian Capital, LLC | 89,136 | $111 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,784 | $98 |
| PNC Financial Services Group, Inc. | 73,211 | $92 |
| AMERIPRISE FINANCIAL INC | 65,114 | $81 |
| Seven Fleet Capital Management LP | 63,498 | $79 |
| ALGERT GLOBAL LLC | 62,020 | $0 |
| Rangeley Capital, LLC | 45,500 | $57 |
| Velan Capital Investment Management LP | 35,000 | $44 |
| HSBC HOLDINGS PLC | 30,891 | $39 |
| Point72 Asset Management, L.P. | 28,744 | $36 |
| SIMPLEX TRADING, LLC | 27,862 | $35 |
| BARCLAYS PLC | 27,536 | $34 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,434 | $34 |
| BOOTHBAY FUND MANAGEMENT, LLC | 27,126 | $34 |
| Squarepoint Ops LLC | 26,502 | $33 |
| TWO SIGMA SECURITIES, LLC | 23,369 | $29 |
| CITIGROUP INC | 19,296 | $24 |
| Quadrature Capital Ltd | 18,428 | $23 |
| Pathstone Holdings, LLC | 17,487 | $22 |
| BAILARD, INC. | 17,069 | $21 |
| NINE MASTS CAPITAL Ltd | 16,607 | $21 |
| Virtu Financial LLC | 12,842 | $0 |
| Independent Advisor Alliance | 12,500 | $16 |
| GTS SECURITIES LLC | 10,002 | $13 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,790 | $11 |
| Silver Grove Financial Group, Inc. | 5,082 | $6 |
| Torren Management, LLC | 4,716 | $6 |
| Tower Research Capital LLC (TRC) | 3,905 | $5 |
| UBS Group AG | 1,098 | $1 |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 518 | $1 |
| JPMORGAN CHASE & CO | 214 | $0 |
| ROYAL BANK OF CANADA | 72 | $0 |