| Affinity Asset Advisors, LLC | 6,484,558 | $58,556 |
| MORGAN STANLEY | 4,292,951 | $38,765 |
| VANGUARD GROUP INC | 3,943,566 | $35,610 |
| BlackRock, Inc. | 3,142,440 | $28,376 |
| TANG CAPITAL MANAGEMENT LLC | 2,814,000 | $25,410 |
| BAKER BROS. ADVISORS LP | 2,349,280 | $21,214 |
| BRAIDWELL LP | 1,920,255 | $17,340 |
| D. E. Shaw & Co., Inc. | 1,665,474 | $15,039 |
| MPM BioImpact LLC | 1,639,061 | $14,801 |
| CITADEL ADVISORS LLC | 1,563,611 | $14,119 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,203,997 | $10,872 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,118,275 | $10,098 |
| Point72 Asset Management, L.P. | 1,056,520 | $9,540 |
| 683 Capital Management, LLC | 1,040,000 | $9,391 |
| MILLENNIUM MANAGEMENT LLC | 989,917 | $8,939 |
| Ikarian Capital, LLC | 958,704 | $8,657 |
| JANE STREET GROUP, LLC | 941,067 | $8,498 |
| GOLDMAN SACHS GROUP INC | 837,602 | $7,564 |
| ACADIAN ASSET MANAGEMENT LLC | 773,512 | $7 |
| DIMENSIONAL FUND ADVISORS LP | 742,544 | $6,702 |
| BALYASNY ASSET MANAGEMENT L.P. | 735,711 | $6,643 |
| GEODE CAPITAL MANAGEMENT, LLC | 722,355 | $6,526 |
| Artia Global Partners LP | 695,982 | $6,285 |
| TUDOR INVESTMENT CORP ET AL | 583,611 | $5,270 |
| STATE STREET CORP | 548,743 | $4,955 |
| RENAISSANCE TECHNOLOGIES LLC | 538,071 | $4,859 |
| BNP PARIBAS ARBITRAGE, SA | 452,310 | $4,084 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 430,000 | $3,883 |
| Squadron Capital Management LLC | 410,000 | $3,702 |
| Sio Capital Management, LLC | 387,751 | $3,501 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 383,231 | $3,461 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | $3,386 |
| TWO SIGMA INVESTMENTS, LP | 359,930 | $3,250 |
| BANK OF AMERICA CORP /DE/ | 316,856 | $2,861 |
| TCG Crossover Management, LLC | 316,195 | $2,855 |
| Qube Research & Technologies Ltd | 273,444 | $2,469 |
| Moody Aldrich Partners LLC | 262,938 | $2,374 |
| BOOTHBAY FUND MANAGEMENT, LLC | 251,994 | $2,276 |
| Opaleye Management Inc. | 251,932 | $2,275 |
| ING GROEP NV | 239,000 | $2,158 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 233,600 | $2,109 |
| WELLINGTON MANAGEMENT GROUP LLP | 227,229 | $2,052 |
| DIADEMA PARTNERS LP | 200,000 | $1,806 |
| SPHERA FUNDS MANAGEMENT LTD. | 180,114 | $1,626 |
| GSA CAPITAL PARTNERS LLP | 172,363 | $2 |
| Susquehanna Portfolio Strategies, LLC | 168,884 | $1,525 |
| TWO SIGMA ADVISERS, LP | 155,600 | $1,405 |
| Prospera Financial Services Inc | 151,570 | $1,369 |
| CITIZENS FINANCIAL GROUP INC/RI | 142,193 | $1,284 |
| NORTHERN TRUST CORP | 135,422 | $1,223 |
| BARCLAYS PLC | 118,702 | $1,072 |
| EAM Investors, LLC | 111,398 | $1,006 |
| Hudson Bay Capital Management LP | 102,357 | $924 |
| Birchview Capital, LP | 100,827 | $910 |
| Squarepoint Ops LLC | 99,559 | $899 |
| AMERICAN CENTURY COMPANIES INC | 99,499 | $898 |
| SECTORAL ASSET MANAGEMENT INC | 96,945 | $875 |
| HighTower Advisors, LLC | 85,972 | $776 |
| ADAR1 Capital Management, LLC | 81,600 | $737 |
| SEI INVESTMENTS CO | 78,703 | $711 |
| Jump Financial, LLC | 76,200 | $688 |
| UBS Group AG | 68,216 | $616 |
| XTX Topco Ltd | 67,361 | $608 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 57,437 | $519 |
| CITIGROUP INC | 56,344 | $509 |
| Persistent Asset Partners Ltd | 53,642 | $484 |
| ExodusPoint Capital Management, LP | 50,009 | $452 |
| Ashton Thomas Private Wealth, LLC | 48,316 | $436 |
| Vanguard Personalized Indexing Management, LLC | 46,561 | $420 |
| LPL Financial LLC | 46,005 | $415 |
| GLENMEDE TRUST CO NA | 42,055 | $380 |
| Lion Point Capital, LP | 41,500 | $375 |
| Schonfeld Strategic Advisors LLC | 40,027 | $361 |
| Velan Capital Investment Management LP | 40,000 | $361 |
| BROWN ADVISORY INC | 37,160 | $336 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,977 | $0 |
| COMMONWEALTH EQUITY SERVICES, LLC | 32,630 | $295 |
| Virtus Investment Advisers, LLC | 32,483 | $293 |
| Graham Capital Management, L.P. | 32,381 | $292 |
| FOX RUN MANAGEMENT, L.L.C. | 32,361 | $292 |
| Quadrature Capital Ltd | 31,501 | $284 |
| Cannell & Spears LLC | 31,000 | $280 |
| Man Group plc | 28,621 | $258 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 28,453 | $257 |
| ENVESTNET ASSET MANAGEMENT INC | 28,229 | $255 |
| OMERS ADMINISTRATION Corp | 26,200 | $237 |
| AQR CAPITAL MANAGEMENT LLC | 25,768 | $233 |
| Jefferies Financial Group Inc. | 23,750 | $214 |
| ALGERT GLOBAL LLC | 23,050 | $0 |
| China Universal Asset Management Co., Ltd. | 21,628 | $195 |
| BANK OF NOVA SCOTIA | 19,534 | $176 |
| EntryPoint Capital, LLC | 17,708 | $160 |
| Voya Investment Management LLC | 17,475 | $158 |
| J. Goldman & Co LP | 17,406 | $157 |
| Bank of New York Mellon Corp | 14,638 | $132 |
| PROFUND ADVISORS LLC | 14,560 | $131 |
| Rafferty Asset Management, LLC | 13,638 | $123 |
| Scientech Research LLC | 13,174 | $119 |
| Lighthouse Investment Partners, LLC | 12,660 | $114 |
| Entropy Technologies, LP | 11,663 | $105 |
| 38 other institutions | 114,774 | $995 |