Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: Feb 14, 2022
Total Value: $20.55B (99.2% shares, 0.8% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 46,893,364 | $7.25B | 35.3% | $195.69 | — | COM | 81181C104 |
| ONC | BeiGene, Ltd. | 11,668,897 | $3.161B | 15.4% | $136.93 | — | SPONSORED ADR | 07725L102 |
| INCY | Incyte Corporation | 33,618,063 | $2.468B | 12.0% | $72.80 | -7.4% | COM | 45337C102 |
| KOD | Kodiak Sciences Inc. | 14,681,304 | $1.245B | 6.1% | $31.75 | +220.4% | COM | 50015M109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,910,704 | $978M | 4.8% | $18.86 | +6.7% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,620,494 | $673M | 3.3% | $81.02 | +1.8% | COM | 09061G101 |
| ASND | Ascendis Pharma A/S | 4,541,604 | $611M | 3.0% | $73.24 | — | SPONSORED ADR | 04351P101 |
| ARGX | argenx SE | 1,119,557 | $392M | 1.9% | $79.01 | — | SPONSORED ADR | 04016X101 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $207M | 1.0% | $22.85 | — | COM | 60468T105 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $176M | 0.9% | $6.35 | +108.3% | COM | 09058V103 |
| KYMR | Kymera Therapeutics, Inc. | 2,384,742 | $151M | 0.7% | $35.42 | +64.4% | COM | 501575104 |
| — | Invitae Corporation | 9,873,488 | $151M | 0.7% | $25.40 | — | COM | 46185L103 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $149M | 0.7% | $45.73 | -66.8% | COM | 00288U106 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,499,213 | $127M | 0.6% | $104.81 | -21.6% | COM | 558868105 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $126M | 0.6% | $28.24 | -42.4% | COM | 74065P101 |
| LEGN | Legend Biotech Corporation | 2,489,003 | $116M | 0.6% | $44.07 | — | SPONSORED ADS | 52490G102 |
| PACB | Pacific Biosciences of California, Inc. | 5,444,963 | $111M | 0.5% | $15.59 | +54.8% | COM | 69404D108 |
| — | Global Blood Therapeutics, Inc. | 3,314,765 | $97.02M | 0.5% | $44.35 | — | COM | 37890U108 |
| CERS | Cerus Corporation | 13,713,195 | $93.39M | 0.5% | $4.64 | +45.1% | COM | 157085101 |
| — | IGM Biosciences, Inc. | 3,156,102 | $92.57M | 0.5% | $17.75 | — | COM | 449585108 |
| IMCR | Immunocore Holdings plc | 2,520,730 | $86.31M | 0.4% | $42.57 | — | ADS | 45258D105 |
| TVTX | Travere Therapeutics, Inc. | 2,669,054 | $82.85M | 0.4% | $21.33 | +32.0% | COM | 89422G107 |
| TRDA | Entrada Therapeutics, Inc. | 4,704,419 | $80.54M | 0.4% | $17.12 | — | COM | 29384C108 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $74.24M | 0.4% | $17.29 | -40.9% | COM | 427746102 |
| — | Amarin Corporation plc | 21,169,805 | $71.34M | 0.3% | $8.93 | — | SPONSORED ADR | 023111206 |
| NRIX | Nurix Therapeutics, Inc. | 2,454,082 | $71.05M | 0.3% | $28.63 | +5.9% | COM | 67080M103 |
| — | Instil Bio, Inc. | 3,893,700 | $66.62M | 0.3% | $25.08 | — | COM | 45783C101 |
| — | Merus N.V. | 2,037,469 | $64.79M | 0.3% | $10.77 | — | COM | N5749R100 |
| — | Horizon Therapeutics Public Ltd Co | 599,110 | $64.56M | 0.3% | $63.26 | — | SHS | G46188101 |
| IMTX | Immatics N.V. | 4,423,731 | $59.45M | 0.3% | $11.08 | +12.8% | SHS | N44445109 |
| — | ChemoCentryx, Inc. | 1,631,266 | $59.39M | 0.3% | $32.84 | — | COM | 16383L106 |
| INSM | Insmed Incorporated | 2,156,001 | $58.73M | 0.3% | $22.18 | +28.9% | COM PAR $.01 | 457669307 |
| NBIX | Neurocrine Biosciences, Inc. | 676,975 | $57.66M | 0.3% | $62.87 | +46.3% | COM | 64125C109 |
| KRYS | Krystal Biotech, Inc. | 807,735 | $56.5M | 0.3% | $34.45 | +69.0% | COM | 501147102 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $52.23M | 0.3% | $60.25 | — | COM | 92539P101 |
| — | Apellis Pharmaceuticals, Inc. | 31,754,000 | $47.97M | 0.2% | $1.43 | — | Note 3.5% 9/15/2026 | 03753UAB2 |
| — | Verastem, Inc. | 21,491,630 | $44.06M | 0.2% | $2.64 | — | COM | 92337C104 |
| — | Insmed Incorporated | 40,000,000 | $43.34M | 0.2% | $1.10 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| — | Sarepta Therapeutics, Inc. | 29,174,000 | $42.7M | 0.2% | $1.31 | — | DBCV 1.5% 11/15/2024 | 803607AB6 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 3,863,239 | $38.55M | 0.2% | $26.76 | -58.0% | COM | 76243J105 |
| — | Chinook Therapeutics, Inc. | 2,334,102 | $38.07M | 0.2% | $14.60 | — | COM | 16961L106 |
| RARE | Ultragenyx Pharmaceutical Inc. | 444,444 | $37.37M | 0.2% | $118.63 | -31.4% | COM | 90400D108 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $36.87M | 0.2% | $5.77 | — | SPONSORED ADR | 00653A107 |
| ALKS | Alkermes plc | 1,500,000 | $34.89M | 0.2% | $23.65 | +11.2% | SHS | G01767105 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $32.95M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| DSGN | Design Therapeutics, Inc. | 1,436,636 | $30.76M | 0.1% | $31.14 | -44.9% | COM | 25056L103 |
| — | Talis Biomedical Corporation | 7,624,835 | $30.58M | 0.1% | $12.85 | — | COM | 87424L108 |
| — | Forma Therapeutics Holdings, Inc. | 2,024,876 | $28.79M | 0.1% | $45.04 | — | SHS | 34633R104 |
| — | Zymeworks Inc. | 1,708,472 | $28M | 0.1% | $14.76 | — | COM | 98985W102 |
| — | bluebird bio, Inc. | 2,499,715 | $24.97M | 0.1% | $22.65 | — | COM | 09609G100 |
| — | Aligos Therapeutics, Inc. | 2,076,400 | $24.65M | 0.1% | $24.92 | — | COM | 01626L105 |
| OPTEY | Opthea Limited | 3,196,191 | $24.11M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 827,480 | $23.51M | 0.1% | $17.99 | +37.1% | COM | 22663K107 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $23.48M | 0.1% | $13.09 | +128.3% | COM | 98420N105 |
| — | DBV Technologies S.A. | 14,614,264 | $23.38M | 0.1% | $19.06 | — | SPONSORED ADR | 23306J101 |
| AXSM | Axsome Therapeutics, Inc. | 610,970 | $23.08M | 0.1% | $24.97 | +47.4% | COM | 05464T104 |
| — | Aerovate Therapeutics, Inc. | 1,831,789 | $21.6M | 0.1% | $21.52 | — | COM | 008064107 |
| — | 2seventy bio, Inc. | 833,236 | $21.36M | 0.1% | $25.63 | — | COMMON STOCK | 901384107 |
| FLGT | Fulgent Genetics, Inc. | 201,444 | $20.26M | 0.1% | $11.30 | +678.1% | COM | 359664109 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $18.42M | 0.1% | $3.87 | — | COM | 64049K104 |
| — | Otonomy, Inc. | 7,844,692 | $16.32M | 0.1% | $2.50 | — | COM | 68906L105 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $16.2M | 0.1% | $7.84 | — | COM | 00773J103 |
| BCAB | BioAtla, Inc. | 825,000 | $16.2M | 0.1% | $33.43 | -23.5% | COM | 09077B104 |
| — | Surrozen, Inc. | 2,500,000 | $16.1M | 0.1% | $7.08 | — | COM | 86889P109 |
| REPL | Replimune Group, Inc. | 593,395 | $16.08M | 0.1% | $28.04 | +6.7% | COM | 76029N106 |
| — | DICE Therapeutics, Inc. | 588,235 | $14.89M | 0.1% | $32.75 | — | COM | 23345J104 |
| ANAB | AnaptysBio, Inc. | 427,179 | $14.84M | 0.1% | $26.06 | +21.7% | COM | 032724106 |
| — | Tricida, Inc. | 27,500,000 | $14.83M | 0.1% | $0.36 | — | Note 3.5% 5/15/2027 | 89610FAB7 |
| — | Affimed N.V. | 2,653,169 | $14.64M | 0.1% | $5.57 | — | COM | N01045108 |
| — | Achilles Therapeutics plc | 2,591,366 | $12.98M | 0.1% | $16.55 | — | SPONSORED ADS | 00449L102 |
| CNTA | Centessa Pharmaceuticals plc | 1,127,273 | $12.69M | 0.1% | $18.65 | — | SPONSORED ADS | 152309100 |
| — | Tricida, Inc. | 1,285,014 | $12.29M | 0.1% | $6.82 | — | COM | 89610F101 |
| RLMD | Relmada Therapeutics, Inc. | 495,113 | $11.15M | 0.1% | $25.31 | -12.1% | COM | 75955J402 |
| SRPT | Sarepta Therapeutics, Inc. | 123,456 | $11.12M | 0.1% | $85.49 | 0.0% | COM | 803607100 |
| — | Atreca, Inc. | 3,532,760 | $10.7M | 0.1% | $18.84 | — | CL A COM | 04965G109 |
| — | Athira Pharma, Inc. | 806,367 | $10.51M | 0.1% | $18.46 | — | COM | 04746L104 |
| ALT | Altimmune, Inc. | 1,072,038 | $9.82M | 0.0% | $9.32 | +14.0% | COM | 02155H200 |
| — | Invitae Corporation | 10,300,000 | $9.623M | 0.0% | $1.64 | — | Note 2.0% 9/1/2024 | 46185LAB9 |
| — | Cyteir Therapeutics, Inc. | 812,640 | $9.24M | 0.0% | $21.40 | — | COM | 23284P103 |
| — | Karuna Therapeutics, Inc. | 69,966 | $9.166M | 0.0% | $91.25 | — | COM | 48576A100 |
| TNGX | Tango Therapeutics, Inc. | 750,000 | $8.205M | 0.0% | $11.99 | +0.3% | COM | 87583X109 |
| — | FibroGen, Inc. | 580,150 | $8.18M | 0.0% | $14.10 | — | COM | 31572Q808 |
| EWTX | Edgewise Therapeutics, Inc. | 500,000 | $7.64M | 0.0% | $32.43 | -44.5% | COM | 28036F105 |
| — | CymaBay Therapeutics, Inc. | 2,170,464 | $7.336M | 0.0% | $5.48 | — | COM | 23257D103 |
| MGNX | MacroGenics, Inc. | 442,579 | $7.103M | 0.0% | $23.60 | -20.3% | COM | 556099109 |
| — | Iteos Therapeutics, Inc. | 150,346 | $7M | 0.0% | $24.67 | — | COM | 46565G104 |
| NVAX | Novavax, Inc. | 48,168 | $6.891M | 0.0% | $38.25 | +349.2% | COM | 670002401 |
| — | Allakos Inc. | 703,050 | $6.883M | 0.0% | $62.02 | — | COM | 01671P100 |
| TCRX | TScan Therapeutics, Inc. | 1,425,000 | $6.413M | 0.0% | $9.27 | -22.1% | COM | 89854M101 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $5.906M | 0.0% | $138.99 | — | CL A | 75615P103 |
| RVMD | Revolution Medicines, Inc. | 222,222 | $5.593M | 0.0% | $44.84 | -37.2% | COM | 76155X100 |
| HRMY | Harmony Biosciences Holdings, Inc. | 123,600 | $5.27M | 0.0% | $36.46 | +9.3% | COM | 413197104 |
| — | NGM Biopharmaceuticals, Inc. | 291,801 | $5.168M | 0.0% | $23.80 | — | COM | 62921N105 |
| ALEC | Alector, Inc. | 239,228 | $4.94M | 0.0% | $25.49 | -11.5% | COM | 014442107 |
| ATYR | aTyr Pharma, Inc. | 625,000 | $4.669M | 0.0% | $5.98 | +39.5% | COM | 002120202 |
| KURA | Kura Oncology, Inc. | 304,158 | $4.258M | 0.0% | $18.84 | -14.0% | COM | 50127T109 |
| DNLI | Denali Therapeutics Inc. | 88,738 | $3.958M | 0.0% | $20.86 | +127.1% | COM | 24823R105 |
| BMEA | Biomea Fusion, Inc. | 524,617 | $3.908M | 0.0% | $15.49 | -31.7% | COM | 09077A106 |
| — | TCR2 Therapeutics Inc. | 753,064 | $3.509M | 0.0% | $8.48 | — | COM | 87808K106 |
| — | Genetron Holdings Limited | 455,306 | $2.777M | 0.0% | $13.55 | — | ADS | 37186H100 |
| CABA | Cabaletta Bio, Inc. | 662,063 | $2.509M | 0.0% | $11.75 | -9.2% | COM | 12674W109 |
| — | Akero Therapeutics, Inc. | 118,378 | $2.504M | 0.0% | $30.79 | — | COM | 00973Y108 |
| — | Vincerx Pharma, Inc. | 241,379 | $2.46M | 0.0% | $16.17 | — | COM | 92731L106 |
| — | Albireo Pharma, Inc. | 104,521 | $2.434M | 0.0% | $24.96 | — | COM | 01345P106 |
| SNDX | Syndax Pharmaceuticals, Inc. | 110,729 | $2.424M | 0.0% | $16.66 | +10.9% | COM | 87164F105 |
| — | Kezar Life Sciences, Inc. | 139,676 | $2.335M | 0.0% | $5.18 | — | COM | 49372L100 |
| — | Burning Rock Biotech Limited | 209,131 | $1.993M | 0.0% | $27.01 | — | SPONSORED ADS | 12233L107 |
| — | Leap Therapeutics, Inc. | 559,705 | $1.813M | 0.0% | $1.17 | — | COM | 52187K101 |
| — | HOOKIPA Pharma Inc. | 700,481 | $1.632M | 0.0% | $6.73 | — | COM | 43906K100 |
| — | Gamida Cell Ltd. | 610,626 | $1.551M | 0.0% | $6.83 | — | SHS | M47364100 |
| SERA | Sera Prognostics, Inc. | 201,562 | $1.385M | 0.0% | $10.38 | -3.2% | CLASS A COM | 81749D107 |
| — | NexImmune, Inc. | 294,117 | $1.356M | 0.0% | $19.08 | — | COM | 65344D109 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $1.348M | 0.0% | $30.96 | -77.7% | COM STK | 74365U107 |
| — | Oyster Point Pharma, Inc. | 61,424 | $1.122M | 0.0% | $28.88 | — | COM | 69242L106 |
| — | LogicBio Therapeutics, Inc. | 451,478 | $1.043M | 0.0% | $7.63 | — | COM | 54142F102 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $1.03M | 0.0% | $14.37 | 0.0% | COM | 344174107 |
| — | Evofem Biosciences, Inc. | 2,697,110 | $1.013M | 0.0% | $2.13 | — | COM | 30048L104 |
| SRZNW | Surrozen, Inc. | 833,333 | $958K | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |
| — | Passage Bio, Inc. | 117,161 | $744K | 0.0% | $15.75 | — | COM | 702712100 |
| — | Inozyme Pharma, Inc. | 106,999 | $730K | 0.0% | $26.29 | — | COM | 45790W108 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $371K | 0.0% | $4.71 | — | COM | 079481404 |