Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q2 2022 (← Previous) (Next →)
Filing Date: Aug 15, 2022
Total Value: $17.63B (99.6% shares, 0.4% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 46,912,266 | $8.301B | 47.1% | $195.69 | — | COM | 81181C104 |
| INCY | Incyte Corporation | 36,154,117 | $2.747B | 15.6% | $72.80 | +4.3% | COM | 45337C102 |
| ONC | BeiGene, Ltd. | 11,668,897 | $1.889B | 10.7% | $136.93 | — | SPONSORED ADR | 07725L102 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,620,494 | $632M | 3.6% | $81.02 | -1.7% | COM | 09061G101 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,923,486 | $591M | 3.4% | $18.86 | -1.0% | COM | 004225108 |
| ASND | Ascendis Pharma A/S | 4,852,655 | $451M | 2.6% | $74.51 | — | SPONSORED ADR | 04351P101 |
| ARGX | argenx SE | 1,119,557 | $424M | 2.4% | $79.01 | — | SPONSORED ADR | 04016X101 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $134M | 0.8% | $6.35 | +62.4% | COM | 09058V103 |
| KOD | Kodiak Sciences Inc. | 17,310,490 | $132M | 0.8% | $30.30 | -76.8% | COM | 50015M109 |
| — | Global Blood Therapeutics, Inc. | 3,732,502 | $119M | 0.7% | $42.96 | — | COM | 37890U108 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $111M | 0.6% | $45.73 | -81.5% | COM | 00288U106 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,499,213 | $107M | 0.6% | $104.81 | -29.9% | COM | 558868105 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $94.64M | 0.5% | $22.85 | — | COM | 60468T105 |
| IMCR | Immunocore Holdings plc | 2,520,730 | $94.05M | 0.5% | $42.57 | — | ADS | 45258D105 |
| — | Horizon Therapeutics Public Ltd Co | 1,148,504 | $91.61M | 0.5% | $77.79 | — | SHS | G46188101 |
| CERS | Cerus Corporation | 16,067,558 | $85M | 0.5% | $4.69 | +6.4% | COM | 157085101 |
| TVTX | Travere Therapeutics, Inc. | 3,300,009 | $79.96M | 0.5% | $22.33 | +12.6% | COM | 89422G107 |
| REPL | Replimune Group, Inc. | 3,591,081 | $62.77M | 0.4% | $19.04 | -13.7% | COM | 76029N106 |
| TRDA | Entrada Therapeutics, Inc. | 4,865,819 | $59.27M | 0.3% | $16.96 | — | COM | 29384C108 |
| — | IGM Biosciences, Inc. | 3,156,102 | $56.91M | 0.3% | $17.75 | — | COM | 449585108 |
| KYMR | Kymera Therapeutics, Inc. | 2,879,825 | $56.7M | 0.3% | $33.35 | -30.0% | COM | 501575104 |
| KRYS | Krystal Biotech, Inc. | 807,735 | $53.04M | 0.3% | $34.45 | +80.6% | COM | 501147102 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $52.85M | 0.3% | $28.24 | -82.0% | COM | 74065P101 |
| NRIX | Nurix Therapeutics, Inc. | 3,882,125 | $49.19M | 0.3% | $22.27 | -49.1% | COM | 67080M103 |
| LEGN | Legend Biotech Corporation | 856,658 | $47.12M | 0.3% | $44.07 | — | SPONSORED ADS | 52490G102 |
| ALKS | Alkermes plc | 1,500,000 | $44.69M | 0.3% | $23.65 | +21.4% | SHS | G01767105 |
| — | ChemoCentryx, Inc. | 1,792,657 | $44.42M | 0.3% | $28.90 | — | COM | 16383L106 |
| — | Chinook Therapeutics, Inc. | 2,534,102 | $44.32M | 0.3% | $14.83 | — | COM | 16961L106 |
| INSM | Insmed Incorporated | 2,156,001 | $42.52M | 0.2% | $22.18 | -5.5% | COM PAR $.01 | 457669307 |
| IMTX | Immatics N.V. | 4,423,731 | $38.53M | 0.2% | $11.08 | -28.6% | SHS | N44445109 |
| — | DBV Technologies S.A. | 14,614,264 | $37.27M | 0.2% | $19.06 | — | SPONSORED ADR | 23306J101 |
| — | Sarepta Therapeutics, Inc. | 29,174,000 | $36.58M | 0.2% | $1.31 | — | DBCV 1.5% 11/15/2024 | 803607AB6 |
| — | Insmed Incorporated | 40,000,000 | $33.28M | 0.2% | $1.10 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| — | Aerovate Therapeutics, Inc. | 2,070,010 | $32.35M | 0.2% | $21.15 | — | COM | 008064107 |
| — | Amarin Corporation plc | 21,169,805 | $31.54M | 0.2% | $8.93 | — | SPONSORED ADR | 023111206 |
| — | Verastem, Inc. | 26,988,898 | $31.31M | 0.2% | $2.39 | — | COM | 92337C104 |
| RARE | Ultragenyx Pharmaceutical Inc. | 470,974 | $28.1M | 0.2% | $115.41 | -46.7% | COM | 90400D108 |
| — | 2seventy bio, Inc. | 2,062,744 | $27.23M | 0.2% | $20.52 | — | COMMON STOCK | 901384107 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $27.13M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| BMEA | Biomea Fusion, Inc. | 2,104,559 | $25.21M | 0.1% | $8.56 | -31.6% | COM | 09077A106 |
| ALT | Altimmune, Inc. | 2,075,403 | $24.28M | 0.1% | $7.80 | -20.9% | COM | 02155H200 |
| — | Invitae Corporation | 9,873,488 | $24.09M | 0.1% | $25.40 | — | COM | 46185L103 |
| PACB | Pacific Biosciences of California, Inc. | 5,444,963 | $24.07M | 0.1% | $15.59 | -61.0% | COM | 69404D108 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $22.86M | 0.1% | $13.09 | +131.1% | COM | 98420N105 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $22.69M | 0.1% | $17.29 | -76.8% | COM | 427746102 |
| — | Merus N.V. | 995,397 | $22.54M | 0.1% | $10.77 | — | COM | N5749R100 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $21.64M | 0.1% | $60.25 | — | COM | 92539P101 |
| DSGN | Design Therapeutics, Inc. | 1,436,636 | $20.11M | 0.1% | $31.14 | -56.6% | COM | 25056L103 |
| — | Affimed N.V. | 6,596,830 | $18.27M | 0.1% | $4.50 | — | COM | N01045108 |
| — | Instil Bio, Inc. | 3,893,700 | $17.99M | 0.1% | $25.08 | — | COM | 45783C101 |
| — | Otonomy, Inc. | 8,412,634 | $17.5M | 0.1% | $2.47 | — | COM | 68906L105 |
| DNLI | Denali Therapeutics Inc. | 588,738 | $17.33M | 0.1% | $25.39 | +3.2% | COM | 24823R105 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 4,125,062 | $17.12M | 0.1% | $25.62 | -78.6% | COM | 76243J105 |
| OPTEY | Opthea Limited | 2,696,191 | $16.99M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $16.71M | 0.1% | $5.77 | — | SPONSORED ADR | 00653A107 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 827,480 | $15.43M | 0.1% | $17.99 | +10.9% | COM | 22663K107 |
| — | Tricida, Inc. | 1,503,090 | $14.55M | 0.1% | $7.18 | — | COM | 89610F101 |
| — | Forma Therapeutics Holdings, Inc. | 2,024,876 | $13.95M | 0.1% | $45.04 | — | SHS | 34633R104 |
| FLGT | Fulgent Genetics, Inc. | 201,444 | $10.98M | 0.1% | $11.30 | +386.5% | COM | 359664109 |
| — | bluebird bio, Inc. | 2,499,715 | $10.35M | 0.1% | $22.65 | — | COM | 09609G100 |
| RLMD | Relmada Therapeutics, Inc. | 495,113 | $9.402M | 0.1% | $25.31 | -13.8% | COM | 75955J402 |
| — | DICE Therapeutics, Inc. | 588,235 | $9.129M | 0.1% | $32.75 | — | COM | 23345J104 |
| — | Zymeworks Inc. | 1,708,472 | $9.055M | 0.1% | $14.76 | — | COM | 98985W102 |
| — | Karuna Therapeutics, Inc. | 69,966 | $8.851M | 0.1% | $91.25 | — | COM | 48576A100 |
| TCRX | TScan Therapeutics, Inc. | 2,784,792 | $8.758M | 0.0% | $6.08 | -55.0% | COM | 89854M101 |
| ANAB | AnaptysBio, Inc. | 427,179 | $8.672M | 0.0% | $26.06 | -15.0% | COM | 032724106 |
| — | FibroGen, Inc. | 815,718 | $8.614M | 0.0% | $13.08 | — | COM | 31572Q808 |
| — | Invitae Corporation | 10,300,000 | $8.087M | 0.0% | $1.64 | — | Note 2.0% 9/1/2024 | 46185LAB9 |
| — | Cyteir Therapeutics, Inc. | 2,643,640 | $7.904M | 0.0% | $8.65 | — | COM | 23284P103 |
| — | Surrozen, Inc. | 2,500,000 | $7.5M | 0.0% | $7.08 | — | COM | 86889P109 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $6.807M | 0.0% | $138.99 | — | CL A | 75615P103 |
| — | Achilles Therapeutics plc | 2,591,366 | $6.53M | 0.0% | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | CymaBay Therapeutics, Inc. | 2,170,464 | $6.403M | 0.0% | $5.48 | — | COM | 23257D103 |
| — | Atreca, Inc. | 3,532,760 | $6.324M | 0.0% | $18.84 | — | CL A COM | 04965G109 |
| — | Talis Biomedical Corporation | 7,624,835 | $6.191M | 0.0% | $12.85 | — | COM | 87424L108 |
| HRMY | Harmony Biosciences Holdings, Inc. | 123,600 | $6.028M | 0.0% | $36.46 | +23.5% | COM | 413197104 |
| — | Atara Biotherapeutics, Inc. | 744,186 | $5.797M | 0.0% | $7.79 | — | COM | 046513107 |
| — | Vor Biopharma Inc. | 1,138,768 | $5.66M | 0.0% | $4.97 | — | COM | 929033108 |
| CNTA | Centessa Pharmaceuticals plc | 1,127,273 | $5.49M | 0.0% | $18.65 | — | SPONSORED ADS | 152309100 |
| NKTX | Nkarta, Inc. | 400,000 | $4.928M | 0.0% | $13.12 | 0.0% | COM | 65487U108 |
| VERA | Vera Therapeutics, Inc. | 333,333 | $4.537M | 0.0% | $21.52 | -18.9% | CL A | 92337R101 |
| RVMD | Revolution Medicines, Inc. | 222,222 | $4.331M | 0.0% | $44.84 | -56.6% | COM | 76155X100 |
| EWTX | Edgewise Therapeutics, Inc. | 500,000 | $3.98M | 0.0% | $32.43 | -76.7% | COM | 28036F105 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $3.936M | 0.0% | $3.87 | — | COM | 64049K104 |
| — | HOOKIPA Pharma Inc. | 2,400,481 | $3.913M | 0.0% | $3.58 | — | COM | 43906K100 |
| NTRA | Natera, Inc. | 100,000 | $3.544M | 0.0% | $37.02 | 0.0% | COM | 632307104 |
| TNGX | Tango Therapeutics, Inc. | 750,000 | $3.398M | 0.0% | $11.99 | -49.5% | COM | 87583X109 |
| — | Athira Pharma, Inc. | 1,040,834 | $3.175M | 0.0% | $14.99 | — | COM | 04746L104 |
| — | iTeos Therapeutics, Inc. | 150,346 | $3.097M | 0.0% | $24.67 | — | COM | 46565G104 |
| — | Evofem Biosciences, Inc. | 2,583,616 | $2.919M | 0.0% | $1.13 | — | COM | 30048L203 |
| MGNX | MacroGenics, Inc. | 892,579 | $2.633M | 0.0% | $14.35 | -63.4% | COM | 556099109 |
| — | Aligos Therapeutics, Inc. | 2,076,400 | $2.512M | 0.0% | $24.92 | — | COM | 01626L105 |
| ALEC | Alector, Inc. | 239,228 | $2.431M | 0.0% | $25.49 | -60.9% | COM | 014442107 |
| BCAB | BioAtla, Inc. | 825,000 | $2.351M | 0.0% | $33.43 | -90.5% | COM | 09077B104 |
| — | Allakos Inc. | 703,050 | $2.201M | 0.0% | $62.02 | — | COM | 01671P100 |
| — | TCR2 Therapeutics Inc. | 753,064 | $2.184M | 0.0% | $8.48 | — | COM | 87808K106 |
| SNDX | Syndax Pharmaceuticals, Inc. | 110,729 | $2.13M | 0.0% | $16.66 | -0.0% | COM | 87164F105 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $1.722M | 0.0% | $7.84 | — | COM | 00773J103 |
| — | Epizyme, Inc. | 1,000,000 | $1.47M | 0.0% | $1.15 | — | COM | 29428V104 |
| — | Akero Therapeutics, Inc. | 118,378 | $1.119M | 0.0% | $30.79 | — | COM | 00973Y108 |
| ATYR | aTyr Pharma, Inc. | 374,395 | $1.06M | 0.0% | $5.98 | -39.6% | COM | 002120202 |
| — | Genetron Holdings Limited | 455,306 | $774K | 0.0% | $13.55 | — | ADS | 37186H100 |
| — | NGM Biopharmaceuticals, Inc. | 55,294 | $709K | 0.0% | $23.80 | — | COM | 62921N105 |
| CABA | Cabaletta Bio, Inc. | 662,063 | $702K | 0.0% | $11.75 | -88.0% | COM | 12674W109 |
| — | Leap Therapeutics, Inc. | 559,705 | $644K | 0.0% | $1.17 | — | COM | 52187K101 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $612K | 0.0% | $14.37 | -10.2% | COM | 344174107 |
| — | Burning Rock Biotech Limited | 209,131 | $609K | 0.0% | $27.01 | — | SPONSORED ADS | 12233L107 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $585K | 0.0% | $30.96 | -88.2% | COM STK | 74365U107 |
| — | Kezar Life Sciences, Inc. | 61,946 | $512K | 0.0% | $5.18 | — | COM | 49372L100 |
| — | Inozyme Pharma, Inc. | 106,999 | $510K | 0.0% | $26.29 | — | COM | 45790W108 |
| SERA | Sera Prognostics, Inc. | 201,562 | $331K | 0.0% | $10.38 | -81.5% | CLASS A COM | 81749D107 |
| — | Vincerx Pharma, Inc. | 241,379 | $319K | 0.0% | $16.17 | — | COM | 92731L106 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $296K | 0.0% | $4.71 | — | COM | 079481404 |
| — | Passage Bio, Inc. | 117,161 | $276K | 0.0% | $15.75 | — | COM | 702712100 |
| SRZNW | Surrozen, Inc. | 833,333 | $159K | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |
| — | LogicBio Therapeutics, Inc. | 451,478 | $158K | 0.0% | $7.63 | — | COM | 54142F102 |
| — | NexImmune, Inc. | 20,000 | $32,000 | 0.0% | $19.08 | — | COM | 65344D109 |