Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $15.27B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 46,912,266 | $6.419B | 42.0% | $195.69 | — | COM | 81181C104 |
| INCY | Incyte Corporation | 36,154,574 | $2.409B | 15.8% | $72.80 | +1.5% | COM | 45337C102 |
| ONC | BeiGene, Ltd. | 11,668,897 | $1.573B | 10.3% | $136.93 | — | SPONSORED ADR | 07725L102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,923,486 | $686M | 4.5% | $18.86 | -14.1% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,620,494 | $646M | 4.2% | $81.02 | +9.9% | COM | 09061G101 |
| ASND | Ascendis Pharma A/S | 4,852,655 | $501M | 3.3% | $74.51 | — | SPONSORED ADR | 04351P101 |
| — | Global Blood Therapeutics, Inc. | 3,732,502 | $254M | 1.7% | $42.96 | — | COM | 37890U108 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $160M | 1.0% | $6.35 | +102.6% | COM | 09058V103 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 6,062,702 | $149M | 1.0% | $23.38 | -20.5% | COM | 76243J105 |
| KOD | Kodiak Sciences Inc. | 17,310,490 | $134M | 0.9% | $30.30 | -67.9% | COM | 50015M109 |
| IMCR | Immunocore Holdings plc | 2,520,731 | $118M | 0.8% | $42.57 | — | ADS | 45258D105 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $103M | 0.7% | $45.73 | -76.0% | COM | 00288U106 |
| ARGX | argenx SE | 280,159 | $98.91M | 0.6% | $79.01 | — | SPONSORED ADR | 04016X101 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $98.46M | 0.6% | $22.85 | — | COM | 60468T105 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,499,213 | $97.43M | 0.6% | $104.81 | -33.7% | COM | 558868105 |
| — | ChemoCentryx, Inc. | 1,792,657 | $92.61M | 0.6% | $28.90 | — | COM | 16383L106 |
| TVTX | Travere Therapeutics, Inc. | 3,300,009 | $81.31M | 0.5% | $22.33 | +15.7% | COM | 89422G107 |
| — | Akero Therapeutics, Inc. | 2,368,378 | $80.64M | 0.5% | $33.89 | — | COM | 00973Y108 |
| TRDA | Entrada Therapeutics, Inc. | 4,865,819 | $76.69M | 0.5% | $16.96 | — | COM | 29384C108 |
| — | IGM Biosciences, Inc. | 3,156,102 | $71.77M | 0.5% | $17.75 | — | COM | 449585108 |
| REPL | Replimune Group, Inc. | 3,893,843 | $67.25M | 0.4% | $19.04 | +0.1% | COM | 76029N106 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $66.92M | 0.4% | $28.24 | -76.1% | COM | 74065P101 |
| KYMR | Kymera Therapeutics, Inc. | 2,879,825 | $62.69M | 0.4% | $33.35 | -21.0% | COM | 501575104 |
| — | Horizon Therapeutics Public Ltd Co | 969,727 | $60.02M | 0.4% | $77.79 | — | SHS | G46188101 |
| CERS | Cerus Corporation | 16,067,558 | $57.84M | 0.4% | $4.69 | +2.0% | COM | 157085101 |
| NRIX | Nurix Therapeutics, Inc. | 3,882,125 | $50.58M | 0.3% | $22.27 | -28.9% | COM | 67080M103 |
| — | Chinook Therapeutics, Inc. | 2,534,102 | $49.82M | 0.3% | $14.83 | — | COM | 16961L106 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $48.66M | 0.3% | $60.25 | — | COM | 92539P101 |
| IMTX | Immatics N.V. | 4,423,731 | $44.24M | 0.3% | $11.08 | -2.7% | SHS | N44445109 |
| — | Forma Therapeutics Holdings, Inc. | 1,886,760 | $37.64M | 0.2% | $45.04 | — | SHS | 34633R104 |
| — | Insmed Incorporated | 40,000,000 | $36.3M | 0.2% | $1.10 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $35.95M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $34.32M | 0.2% | $17.29 | -77.4% | COM | 427746102 |
| — | Aerovate Therapeutics, Inc. | 1,979,568 | $32.82M | 0.2% | $21.15 | — | COM | 008064107 |
| — | 2seventy bio, Inc. | 2,062,744 | $30.01M | 0.2% | $20.52 | — | COM | 901384107 |
| KRYS | Krystal Biotech, Inc. | 422,185 | $29.43M | 0.2% | $34.45 | +109.7% | COM | 501147102 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $27.13M | 0.2% | $13.09 | +174.7% | COM | 98420N105 |
| — | CinCor Pharma, Inc. | 807,212 | $26.49M | 0.2% | $32.82 | — | COM | 17240Y109 |
| — | DBV Technologies S.A. | 14,614,264 | $25.87M | 0.2% | $19.06 | — | SPONSORED ADR | 23306J101 |
| IDYA | IDEAYA Biosciences, Inc. | 1,668,355 | $24.89M | 0.2% | $12.99 | 0.0% | COM | 45166A102 |
| DSGN | Design Therapeutics, Inc. | 1,436,636 | $24.02M | 0.2% | $31.14 | -36.1% | COM | 25056L103 |
| — | Verastem, Inc. | 26,988,898 | $22.94M | 0.2% | $2.39 | — | COM | 92337C104 |
| ALT | Altimmune, Inc. | 1,769,681 | $22.6M | 0.1% | $7.80 | +89.4% | COM | 02155H200 |
| — | Invitae Corporation | 8,402,035 | $20.67M | 0.1% | $25.40 | — | COM | 46185L103 |
| BMEA | Biomea Fusion, Inc. | 2,104,559 | $20.58M | 0.1% | $8.56 | +34.1% | COM | 09077A106 |
| BCYC | Bicycle Therapeutics plc | 843,814 | $19.63M | 0.1% | $23.26 | — | SPONSORED ADS | 088786108 |
| RARE | Ultragenyx Pharmaceutical Inc. | 470,974 | $19.5M | 0.1% | $115.41 | -55.5% | COM | 90400D108 |
| — | Instil Bio, Inc. | 3,893,700 | $18.85M | 0.1% | $25.08 | — | COM | 45783C101 |
| — | Veru Inc. | 1,609,579 | $18.54M | 0.1% | $11.52 | — | COM | 92536C103 |
| RLMD | Relmada Therapeutics, Inc. | 495,113 | $18.33M | 0.1% | $25.31 | +9.5% | COM | 75955J402 |
| ALKS | Alkermes plc | 815,016 | $18.2M | 0.1% | $23.65 | +10.0% | SHS | G01767105 |
| DNLI | Denali Therapeutics Inc. | 588,738 | $18.07M | 0.1% | $25.39 | +28.0% | COM | 24823R105 |
| OPTEY | Opthea Limited | 2,691,391 | $16.69M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| — | bluebird bio, Inc. | 2,499,715 | $15.82M | 0.1% | $22.65 | — | COM | 09609G100 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 735,716 | $14.45M | 0.1% | $17.99 | +13.4% | COM | 22663K107 |
| WHWK | Aadi Bioscience, Inc. | 989,928 | $13.99M | 0.1% | $13.14 | 0.0% | COM | 00032Q104 |
| — | Tricida, Inc. | 1,320,290 | $13.84M | 0.1% | $7.18 | — | COM | 89610F101 |
| — | Affimed N.V. | 6,596,830 | $13.59M | 0.1% | $4.50 | — | COM | N01045108 |
| — | DICE Therapeutics, Inc. | 588,235 | $11.93M | 0.1% | $32.75 | — | COM | 23345J104 |
| ANAB | AnaptysBio, Inc. | 427,179 | $10.9M | 0.1% | $26.06 | -10.0% | COM | 032724106 |
| — | FibroGen, Inc. | 815,718 | $10.61M | 0.1% | $13.08 | — | COM | 31572Q808 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $10.57M | 0.1% | $5.77 | — | SPONSORED ADR | 00653A107 |
| — | Zymeworks Inc. | 1,708,472 | $10.51M | 0.1% | $14.76 | — | COM | 98985W102 |
| — | POINT Biopharma Global Inc. | 1,169,103 | $9.037M | 0.1% | $7.73 | — | COM | 730541109 |
| TCRX | TScan Therapeutics, Inc. | 2,784,792 | $8.494M | 0.1% | $6.08 | -46.1% | COM | 89854M101 |
| — | Invitae Corporation | 10,300,000 | $8.148M | 0.1% | $1.64 | — | Note 2.0% 9/1/2024 | 46185LAB9 |
| — | CymaBay Therapeutics, Inc. | 2,170,464 | $7.597M | 0.0% | $5.48 | — | COM | 23257D103 |
| VERA | Vera Therapeutics, Inc. | 333,333 | $7.103M | 0.0% | $21.52 | -13.0% | CL A | 92337R101 |
| PACB | Pacific Biosciences of California, Inc. | 1,127,782 | $6.547M | 0.0% | $15.59 | -63.2% | COM | 69404D108 |
| FLGT | Fulgent Genetics, Inc. | 166,619 | $6.352M | 0.0% | $11.30 | +343.8% | COM | 359664109 |
| — | Amarin Corporation plc | 5,377,113 | $5.861M | 0.0% | $8.93 | — | SPONSORED ADR | 023111206 |
| — | Achilles Therapeutics plc | 2,591,366 | $5.856M | 0.0% | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | Vor Biopharma Inc. | 1,465,925 | $5.834M | 0.0% | $4.75 | — | COM | 929033108 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $5.629M | 0.0% | $138.99 | — | CL A | 75615P103 |
| — | Atreca, Inc. | 3,532,760 | $5.546M | 0.0% | $18.84 | — | CL A COM | 04965G109 |
| NKTX | Nkarta, Inc. | 400,000 | $5.264M | 0.0% | $13.12 | +9.0% | COM | 65487U108 |
| — | Talis Biomedical Corporation | 7,624,835 | $5.197M | 0.0% | $12.85 | — | COM | 87424L108 |
| — | Kronos Bio, Inc. | 1,539,616 | $5.158M | 0.0% | $3.35 | — | COM | 50107A104 |
| — | Cyteir Therapeutics, Inc. | 2,643,640 | $5.076M | 0.0% | $8.65 | — | COM | 23284P103 |
| — | Surrozen, Inc. | 2,500,000 | $5.05M | 0.0% | $7.08 | — | COM | 86889P109 |
| EWTX | Edgewise Therapeutics, Inc. | 500,000 | $4.92M | 0.0% | $32.43 | -68.8% | COM | 28036F105 |
| FATE | Fate Therapeutics, Inc. | 215,695 | $4.834M | 0.0% | $28.89 | 0.0% | COM | 31189P102 |
| STOK | Stoke Therapeutics, Inc. | 369,327 | $4.742M | 0.0% | $15.94 | 0.0% | COM | 86150R107 |
| NTRA | Natera, Inc. | 100,000 | $4.382M | 0.0% | $37.02 | +28.6% | COM | 632307104 |
| RVMD | Revolution Medicines, Inc. | 222,222 | $4.382M | 0.0% | $44.84 | -51.0% | COM | 76155X100 |
| — | Allakos Inc. | 703,050 | $4.303M | 0.0% | $62.02 | — | COM | 01671P100 |
| — | Eiger BioPharmaceuticals, Inc. | 539,851 | $4.065M | 0.0% | $7.53 | — | COM | 28249U105 |
| PMVP | PMV Pharmaceuticals, Inc. | 322,024 | $3.832M | 0.0% | $14.45 | 0.0% | COM | 69353Y103 |
| IPSC | Century Therapeutics, Inc. | 370,587 | $3.665M | 0.0% | $10.53 | 0.0% | COM | 15673T100 |
| — | HOOKIPA Pharma Inc. | 2,400,481 | $3.217M | 0.0% | $3.58 | — | COM | 43906K100 |
| — | Athira Pharma, Inc. | 1,040,834 | $3.091M | 0.0% | $14.99 | — | COM | 04746L104 |
| MGNX | MacroGenics, Inc. | 892,579 | $3.088M | 0.0% | $14.35 | -73.4% | COM | 556099109 |
| — | iTeos Therapeutics, Inc. | 150,346 | $2.864M | 0.0% | $24.67 | — | COM | 46565G104 |
| — | Atara Biotherapeutics, Inc. | 744,186 | $2.813M | 0.0% | $7.79 | — | COM | 046513107 |
| TNGX | Tango Therapeutics, Inc. | 750,000 | $2.715M | 0.0% | $11.99 | -64.4% | COM | 87583X109 |
| SNDX | Syndax Pharmaceuticals, Inc. | 110,729 | $2.661M | 0.0% | $16.66 | +34.6% | COM | 87164F105 |
| — | Otonomy, Inc. | 8,443,134 | $2.491M | 0.0% | $2.47 | — | COM | 68906L105 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $2.446M | 0.0% | $3.87 | — | COM | 64049K104 |
| — | Aligos Therapeutics, Inc. | 2,076,400 | $2.284M | 0.0% | $24.92 | — | COM | 01626L105 |
| ALEC | Alector, Inc. | 239,228 | $2.263M | 0.0% | $25.49 | -57.6% | COM | 014442107 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $1.794M | 0.0% | $7.84 | — | COM | 00773J103 |
| — | TCR2 Therapeutics Inc. | 753,064 | $1.356M | 0.0% | $8.48 | — | COM | 87808K106 |
| ATYR | aTyr Pharma, Inc. | 201,361 | $604K | 0.0% | $5.98 | -44.0% | COM | 002120202 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $591K | 0.0% | $30.96 | -89.1% | COM STK | 74365U107 |
| — | Kezar Life Sciences, Inc. | 61,946 | $533K | 0.0% | $5.18 | — | COM | 49372L100 |
| — | Leap Therapeutics, Inc. | 559,705 | $493K | 0.0% | $1.17 | — | COM | 52187K101 |
| INSM | Insmed Incorporated | 19,950 | $430K | 0.0% | $22.18 | +8.1% | COM PAR $.01 | 457669307 |
| CABA | Cabaletta Bio, Inc. | 662,063 | $430K | 0.0% | $11.75 | -89.8% | COM | 12674W109 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $386K | 0.0% | $14.37 | -10.5% | COM | 344174107 |
| — | Genetron Holdings Limited | 455,306 | $356K | 0.0% | $13.55 | — | ADS | 37186H100 |
| — | Vincerx Pharma, Inc. | 241,379 | $333K | 0.0% | $16.17 | — | COM | 92731L106 |
| SERA | Sera Prognostics, Inc. | 201,562 | $322K | 0.0% | $10.38 | -80.6% | CLASS A COM | 81749D107 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $299K | 0.0% | $4.71 | — | COM | 079481404 |
| SRZNW | Surrozen, Inc. | 833,333 | $154K | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |
| — | LogicBio Therapeutics, Inc. | 139,105 | $38,000 | 0.0% | $7.63 | — | COM | 54142F102 |