Location: Palo Alto, CA
CIK: 0001306923 · Show all filings
Period: Q2 2025 (← Previous) (Next →)
Filing Date: Aug 14, 2025
Total Value: $470M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| INSM | INSMED INC | 865,113 | $87.06M | 18.5% | $100.64 * | $17.79 | +329.8% | COM | 457669307 |
| ACAD | ACADIA PHARMACEUTICALS INC | 2,563,209 | $55.29M | 11.8% | $21.57 * | $26.96 | -31.1% | COM | 004225108 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 840,470 | $46.2M | 9.8% | $54.97 * | $83.16 | -29.2% | COM | 09061G101 |
| FOLD | AMICUS THERAPEUTICS INC | 5,610,513 | $32.15M | 6.8% | $5.73 * | $9.63 | -33.0% | COM | 03152W109 |
| UTHR | UNITED THERAPEUTICS CORP | 95,482 | $27.44M | 5.8% | $287.35 * | $89.23 | +234.9% | COM | 91307C102 |
| BIIB | BIOGEN INC | 205,759 | $25.84M | 5.5% | $125.59 | $256.18 | -51.4% | SPONSORED ADS | 09062X103 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 75,535 | $24.63M | 5.2% | $326.09 * | $260.36 | +6.3% | SHS | 02043Q107 |
| PTCT | PTC THERAPEUTICS INC | 406,469 | $19.85M | 4.2% | $48.84 * | $37.01 | +28.3% | SHS | 69366J200 |
| ANAB | ANAPTYSBIO INC | 812,821 | $18.04M | 3.8% | $22.20 * | $19.30 | +8.4% | COM | 032724106 |
| NVCR | NOVOCURE LTD | 962,396 | $17.13M | 3.6% | $17.80 * | $42.49 | -59.0% | COM | G6674U108 |
| STAA | STAAR SURGICAL CO | 791,879 | $13.29M | 2.8% | $16.78 * | $21.88 | -19.4% | COM | 852312305 |
| AGIO | AGIOS PHARMACEUTICALS INC | 268,783 | $8.94M | 1.9% | $33.26 * | $33.17 | -8.6% | COM | 00847X104 |
| PRTA | PROTHENA CORP PLC | 1,274,753 | $7.738M | 1.6% | $6.07 * | $21.46 | -65.0% | COM CL A | G72800108 |
| IRON | DISC MEDICINE INC | 145,691 | $7.716M | 1.6% | $52.96 * | $46.97 | 0.0% | COM | 254604101 |
| ALGN | ALIGN TECHNOLOGY INC | 37,772 | $7.151M | 1.5% | $189.33 * | $149.18 | +18.4% | COM | 016255101 |
| GOSS | GOSSAMER BIO INC | 5,739,013 | $7.059M | 1.5% | $1.23 * | $1.58 | -30.9% | COM | 38341P102 |
| EHTH | EHEALTH INC | 1,577,850 | $6.864M | 1.5% | $4.35 * | $38.13 | -86.8% | COM | 28238P109 |
| ALKS | ALKERMES PLC | 221,021 | $6.323M | 1.3% | $28.61 * | $22.36 | +33.1% | COM | G01767105 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 3,429,329 | $5.898M | 1.3% | $1.72 * | $6.20 | -59.9% | COM NEW | 462260100 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 444,367 | $4.161M | 0.9% | $9.37 * | $16.60 | -33.7% | COM | 87164F105 |
| RNAM | AVIDITY BIOSCIENCES INC | 118,886 | $3.376M | 0.7% | $28.40 * | $29.81 | 0.0% | COM | 05370A108 |
| DNLI | DENALI THERAPEUTICS INC | 239,809 | $3.355M | 0.7% | $13.99 | $14.07 | 0.0% | COM | 24823R105 |
| MIRM | MIRUM PHARMACEUTICALS INC | 64,700 | $3.293M | 0.7% | $50.89 * | $15.56 | +186.2% | COM | 604749101 |
| EW | EDWARDS LIFESCIENCES CORP | 39,473 | $3.087M | 0.7% | $78.21 * | $72.66 | +2.6% | COM | 28176E108 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,246,033 | $2.878M | 0.6% | $2.31 * | $1.87 | +15.9% | COM | 877619106 |
| BNTX | BIONTECH SE-ADR | 25,206 | $2.684M | 0.6% | $106.47 | $118.77 | — | COM | 09075V102 |
| DYN | DYNE THERAPEUTICS INC | 264,976 | $2.523M | 0.5% | $9.52 * | $14.30 | -23.0% | SPONSORED ADS | 26818M108 |
| CRSP | CRISPR THERAPEUTICS AG | 44,625 | $2.171M | 0.5% | $48.64 * | $38.70 | 0.0% | NAMEN AKT | H17182108 |
| ACRS | ACLARIS THERAPEUTICS INC | 1,390,028 | $1.974M | 0.4% | $1.42 * | $1.40 | -3.5% | COM | 00461U105 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 48,750 | $1.773M | 0.4% | $36.36 | $36.05 | 0.0% | COM | 90400D108 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 248,934 | $1.73M | 0.4% | $6.95 | $16.07 | — | COM | 088786108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 13,334 | $1.676M | 0.4% | $125.69 * | $126.68 | -9.5% | COM | 64125C109 |
| TVTX | TRAVERE THERAPEUTICS INC | 110,719 | $1.639M | 0.3% | $14.80 * | $23.56 | -29.6% | COM SHS | 89422G107 |
| NUVB | NUVATION BIO INC | 772,652 | $1.507M | 0.3% | $1.95 * | $1.92 | +8.5% | ORD SHS | 67080N101 |
| STOK | STOKE THERAPEUTICS INC | 125,861 | $1.429M | 0.3% | $11.35 * | $6.06 | +56.7% | COM PAR $0.01 | 86150R107 |
| PYXS | PYXIS ONCOLOGY INC | 1,037,421 | $1.141M | 0.2% | $1.10 | $2.98 | -62.3% | COM | 747324101 |
| HUM | HUMANA INC | 3,985 | $974K | 0.2% | $244.48 | $369.63 | -33.3% | COM | 444859102 |
| ALDX | ALDEYRA THERAPEUTICS INC | 225,465 | $864K | 0.2% | $3.83 * | $5.95 | -56.5% | SPONSORED ADR | 01438T106 |
| KPTI | KARYOPHARM THERAPEUTICS INC | 187,911 | $810K | 0.2% | $4.31 * | $4.91 | 0.0% | COM | 48576U205 |
| VYNE | VYNE THERAPEUTICS INC PIPE | 445,434 | $735K | 0.2% | $1.65 * | $3.12 | -58.3% | COM | 92941V308 |
| ABEO | ABEONA THERAPEUTICS INC | 108,865 | $618K | 0.1% | $5.68 | $6.04 | -5.8% | COM NEW | 00289Y206 |
| ALMS | ALUMIS INC | 143,437 | $430K | 0.1% | $3.00 * | $4.72 | 0.0% | COM | 022307102 |
| URGN | UROGEN PHARMA LTD | 24,500 | $336K | 0.1% | $13.70 * | $27.01 | -64.5% | COM | M96088105 |
| AKTX | AKARI THERAPEUTICS PLC-ADR | 146,024 | $171K | 0.0% | $1.17 | $1.22 | — | COM | 00972G207 |
| — | GENERATION BIO CO | 150,475 | $48,167 | 0.0% | $0.32 | $2.82 | — | COM | 37148K100 |