Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $470M (100.0% shares, 0.0% debt)

Holdings (45)

INSM INSMED INC 18.5%
Value $87.06M Shares 865,113 Est. Cost $17.79 Unrealized +329.8%
ACAD ACADIA PHARMACEUTICALS INC 11.8%
Value $55.29M Shares 2,563,209 Est. Cost $26.96 Unrealized -31.1%
BMRN BIOMARIN PHARMACEUTICAL INC 9.8%
Value $46.2M Shares 840,470 Est. Cost $83.16 Unrealized -29.2%
FOLD AMICUS THERAPEUTICS INC 6.8%
Value $32.15M Shares 5,610,513 Est. Cost $9.63 Unrealized -33.0%
UTHR UNITED THERAPEUTICS CORP 5.8%
Value $27.44M Shares 95,482 Est. Cost $89.23 Unrealized +234.9%
BIIB BIOGEN INC 5.5%
Value $25.84M Shares 205,759 Est. Cost $256.18 Unrealized -51.4%
ALNY ALNYLAM PHARMACEUTICALS INC 5.2%
Value $24.63M Shares 75,535 Est. Cost $260.36 Unrealized +6.3%
PTCT PTC THERAPEUTICS INC 4.2%
Value $19.85M Shares 406,469 Est. Cost $37.01 Unrealized +28.3%
ANAB ANAPTYSBIO INC 3.8%
Value $18.04M Shares 812,821 Est. Cost $19.30 Unrealized +8.4%
NVCR NOVOCURE LTD 3.6%
Value $17.13M Shares 962,396 Est. Cost $42.49 Unrealized -59.0%
STAA STAAR SURGICAL CO 2.8%
Value $13.29M Shares 791,879 Est. Cost $21.88 Unrealized -19.4%
AGIO AGIOS PHARMACEUTICALS INC 1.9%
Value $8.94M Shares 268,783 Est. Cost $33.17 Unrealized -8.6%
PRTA PROTHENA CORP PLC 1.6%
Value $7.738M Shares 1,274,753 Est. Cost $21.46 Unrealized -65.0%
IRON DISC MEDICINE INC 1.6%
Value $7.716M Shares 145,691 Est. Cost $46.97 Unrealized 0.0%
ALGN ALIGN TECHNOLOGY INC 1.5%
Value $7.151M Shares 37,772 Est. Cost $149.18 Unrealized +18.4%
GOSS GOSSAMER BIO INC 1.5%
Value $7.059M Shares 5,739,013 Est. Cost $1.58 Unrealized -30.9%
EHTH EHEALTH INC 1.5%
Value $6.864M Shares 1,577,850 Est. Cost $38.13 Unrealized -86.8%
ALKS ALKERMES PLC 1.3%
Value $6.323M Shares 221,021 Est. Cost $22.36 Unrealized +33.1%
IOVA IOVANCE BIOTHERAPEUTICS INC 1.3%
Value $5.898M Shares 3,429,329 Est. Cost $6.20 Unrealized -59.9%
SNDX SYNDAX PHARMACEUTICALS INC 0.9%
Value $4.161M Shares 444,367 Est. Cost $16.60 Unrealized -33.7%
RNAM AVIDITY BIOSCIENCES INC 0.7%
Value $3.376M Shares 118,886 Est. Cost $29.81 Unrealized 0.0%
DNLI DENALI THERAPEUTICS INC 0.7%
Value $3.355M Shares 239,809 Est. Cost $14.07 Unrealized 0.0%
MIRM MIRUM PHARMACEUTICALS INC 0.7%
Value $3.293M Shares 64,700 Est. Cost $15.56 Unrealized +186.2%
EW EDWARDS LIFESCIENCES CORP 0.7%
Value $3.087M Shares 39,473 Est. Cost $72.66 Unrealized +2.6%
TSHA TAYSHA GENE THERAPIES INC 0.6%
Value $2.878M Shares 1,246,033 Est. Cost $1.87 Unrealized +15.9%
BNTX BIONTECH SE-ADR 0.6%
Value $2.684M Shares 25,206 Est. Cost $118.77 Unrealized
DYN DYNE THERAPEUTICS INC 0.5%
Value $2.523M Shares 264,976 Est. Cost $14.30 Unrealized -23.0%
CRSP CRISPR THERAPEUTICS AG 0.5%
Value $2.171M Shares 44,625 Est. Cost $38.70 Unrealized 0.0%
ACRS ACLARIS THERAPEUTICS INC 0.4%
Value $1.974M Shares 1,390,028 Est. Cost $1.40 Unrealized -3.5%
RARE ULTRAGENYX PHARMACEUTICAL IN 0.4%
Value $1.773M Shares 48,750 Est. Cost $36.05 Unrealized 0.0%
BCYC BICYCLE THERAPEUTICS PLC-ADR 0.4%
Value $1.73M Shares 248,934 Est. Cost $16.07 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 0.4%
Value $1.676M Shares 13,334 Est. Cost $126.68 Unrealized -9.5%
TVTX TRAVERE THERAPEUTICS INC 0.3%
Value $1.639M Shares 110,719 Est. Cost $23.56 Unrealized -29.6%
NUVB NUVATION BIO INC 0.3%
Value $1.507M Shares 772,652 Est. Cost $1.92 Unrealized +8.5%
STOK STOKE THERAPEUTICS INC 0.3%
Value $1.429M Shares 125,861 Est. Cost $6.06 Unrealized +56.7%
PYXS PYXIS ONCOLOGY INC 0.2%
Value $1.141M Shares 1,037,421 Est. Cost $2.98 Unrealized -62.3%
HUM HUMANA INC 0.2%
Value $974K Shares 3,985 Est. Cost $369.63 Unrealized -33.3%
ALDX ALDEYRA THERAPEUTICS INC 0.2%
Value $864K Shares 225,465 Est. Cost $5.95 Unrealized -56.5%
KPTI KARYOPHARM THERAPEUTICS INC 0.2%
Value $810K Shares 187,911 Est. Cost $4.91 Unrealized 0.0%
VYNE VYNE THERAPEUTICS INC PIPE 0.2%
Value $735K Shares 445,434 Est. Cost $3.12 Unrealized -58.3%
ABEO ABEONA THERAPEUTICS INC 0.1%
Value $618K Shares 108,865 Est. Cost $6.04 Unrealized -5.8%
ALMS ALUMIS INC 0.1%
Value $430K Shares 143,437 Est. Cost $4.72 Unrealized 0.0%
URGN UROGEN PHARMA LTD 0.1%
Value $336K Shares 24,500 Est. Cost $27.01 Unrealized -64.5%
AKTX AKARI THERAPEUTICS PLC-ADR 0.0%
Value $171K Shares 146,024 Est. Cost $1.22 Unrealized
GENERATION BIO CO 0.0%
Value $48,167 Shares 150,475 Est. Cost $2.82 Unrealized