Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
CLDX	CELLDEX THERAPEUTICS INC	296,408	$9.402M	1.4%	$25.41	0.0%	COM NEW	15117B202
CYTK	CYTOKINETICS INC	32,195	$2.122M	0.3%	$64.44	0.0%	COM NEW	23282W605
VSTM	VERASTEM INC	246,093	$1.304M	0.2%	$6.48	0.0%	COM NEW	92337C203
MDGL	MADRIGAL PHARMACEUTICALS INC	1,787	$935K	0.1%	$492.48	0.0%	COM	558868105
XERS	XERIS BIOPHARMA HOLDINGS INC	104,410	$606K	0.1%	$7.21	0.0%	COM	98422E103

Increased Positions (16)

MIRM MIRUM PHARMACEUTICALS INC 4.6%

Value $30.04M (+143.1%) Shares 325,175 (+107.9%) Est. Cost $73.46 Unrealized +31.5%

UTHR UNITED THERAPEUTICS CORP 5.7%

Value $37.24M (+31.4%) Shares 62,809 (+7.9%) Est. Cost $118.03 Unrealized +307.1%

BCAX BICARA THERAPEUTICS INC 1.7%

Value $10.95M (+117.9%) Shares 550,408 (+84.3%) Est. Cost $16.72 Unrealized -2.6%

PTCT PTC THERAPEUTICS INC 9.6%

Value $62.79M (-8.6%) Shares 921,607 (+2.0%) Est. Cost $46.78 Unrealized +57.6%

ANNX ANNEXON INC 2.5%

Value $16.33M (+36.5%) Shares 2,948,090 (+23.7%) Est. Cost $4.19 Unrealized +37.1%

SNDX SYNDAX PHARMACEUTICALS INC 3.1%

Value $20.21M (+21.0%) Shares 864,986 (+8.9%) Est. Cost $16.22 Unrealized +28.0%

TVTX TRAVERE THERAPEUTICS INC 1.0%

Value $6.847M (+61.8%) Shares 230,453 (+108.1%) Est. Cost $27.44 Unrealized +13.1%

ACAD ACADIA PHARMACEUTICALS INC 9.8%

Value $63.95M (-3.6%) Shares 2,872,695 (+15.6%) Est. Cost $26.72 Unrealized -5.7%

RARE ULTRAGENYX PHARMACEUTICAL IN 1.9%

Value $12.5M (+17.8%) Shares 596,495 (+29.3%) Est. Cost $29.43 Unrealized -20.6%

ACRS ACLARIS THERAPEUTICS INC 0.9%

Value $6.05M (+28.3%) Shares 1,613,430 (+3.0%) Est. Cost $1.50 Unrealized +122.7%

DYN DYNE THERAPEUTICS INC 4.6%

Value $29.97M (+4.1%) Shares 1,652,972 (+12.3%) Est. Cost $13.45 Unrealized +27.3%

IRON DISC MEDICINE INC 3.9%

Value $25.69M (+1.9%) Shares 401,719 (+26.5%) Est. Cost $63.80 Unrealized +16.1%

STOK STOKE THERAPEUTICS INC 0.4%

Value $2.756M (+20.5%) Shares 84,631 (+17.5%) Est. Cost $9.90 Unrealized +221.6%

CAPR CAPRICOR THERAPEUTICS INC 1.1%

Value $6.985M (+6.9%) Shares 229,763 (+1.5%) Est. Cost $13.24 Unrealized +88.0%

TSHA TAYSHA GENE THERAPIES INC 1.0%

Value $6.219M (-4.4%) Shares 1,391,382 (+17.6%) Est. Cost $2.31 Unrealized +106.4%

CDNA CAREDX INC 1.4%

Value $9.233M (+2.5%) Shares 531,870 (+11.2%) Est. Cost $15.56 Unrealized +26.5%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
MIRM	MIRUM PHARMACEUTICALS INC	325,175 (+107.9%)	$30.04M (+143.1%)	4.6%	$73.46	+31.5%	COM	604749101
UTHR	UNITED THERAPEUTICS CORP	62,809 (+7.9%)	$37.24M (+31.4%)	5.7%	$118.03	+307.1%	COM	91307C102
BCAX	BICARA THERAPEUTICS INC	550,408 (+84.3%)	$10.95M (+117.9%)	1.7%	$16.72	-2.6%	COM	055477103
PTCT	PTC THERAPEUTICS INC	921,607 (+2.0%)	$62.79M (-8.6%)	9.6%	$46.78	+57.6%	COM	69366J200
ANNX	ANNEXON INC	2,948,090 (+23.7%)	$16.33M (+36.5%)	2.5%	$4.19	+37.1%	COM	03589W102
SNDX	SYNDAX PHARMACEUTICALS INC	864,986 (+8.9%)	$20.21M (+21.0%)	3.1%	$16.22	+28.0%	COM	87164F105
TVTX	TRAVERE THERAPEUTICS INC	230,453 (+108.1%)	$6.847M (+61.8%)	1.0%	$27.44	+13.1%	COM	89422G107
ACAD	ACADIA PHARMACEUTICALS INC	2,872,695 (+15.6%)	$63.95M (-3.6%)	9.8%	$26.72	-5.7%	COM	004225108
RARE	ULTRAGENYX PHARMACEUTICAL IN	596,495 (+29.3%)	$12.5M (+17.8%)	1.9%	$29.43	-20.6%	COM	90400D108
ACRS	ACLARIS THERAPEUTICS INC	1,613,430 (+3.0%)	$6.05M (+28.3%)	0.9%	$1.50	+122.7%	COM	00461U105
DYN	DYNE THERAPEUTICS INC	1,652,972 (+12.3%)	$29.97M (+4.1%)	4.6%	$13.45	+27.3%	COM	26818M108
IRON	DISC MEDICINE INC	401,719 (+26.5%)	$25.69M (+1.9%)	3.9%	$63.80	+16.1%	COM	254604101
STOK	STOKE THERAPEUTICS INC	84,631 (+17.5%)	$2.756M (+20.5%)	0.4%	$9.90	+221.6%	COM	86150R107
CAPR	CAPRICOR THERAPEUTICS INC	229,763 (+1.5%)	$6.985M (+6.9%)	1.1%	$13.24	+88.0%	COM NEW	14070B309
TSHA	TAYSHA GENE THERAPIES INC	1,391,382 (+17.6%)	$6.219M (-4.4%)	1.0%	$2.31	+106.4%	COM SHS	877619106
CDNA	CAREDX INC	531,870 (+11.2%)	$9.233M (+2.5%)	1.4%	$15.56	+26.5%	COM	14167L103

Exited Positions (3)

GOSS GOSSAMER BIO INC 2.1%

Value $13.86M Shares 4,471,592 Est. Cost $1.58 Unrealized +42.9%

— GENERATION BIO CO 0.0%

Value $85,467 Shares 15,047 Est. Cost $5.68 Unrealized —

AKTX AKARI THERAPEUTICS PLC-ADR 0.0%

Value $42,201 Shares 146,024 Est. Cost $1.22 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
GOSS	GOSSAMER BIO INC	4,471,592	$13.86M	2.1%	$1.58	+42.9%	—	38341P102
—	GENERATION BIO CO	15,047	$85,467	0.0%	$5.68	—	—	37148K209
AKTX	AKARI THERAPEUTICS PLC-ADR	146,024	$42,201	0.0%	$1.22	—	—	00972G207

Decreased Positions (17)

FOLD AMICUS THERAPEUTICS INC 2.5%

Value $16.09M (-78.3%) Shares 1,113,045 (-78.6%) Est. Cost $9.63 Unrealized +48.6%

INSM INSMED INC 10.4%

Value $67.9M (-20.3%) Shares 415,269 (-15.2%) Est. Cost $17.79 Unrealized +793.9%

BIIB BIOGEN INC 3.9%

Value $25.8M (-20.1%) Shares 140,719 (-23.3%) Est. Cost $256.18 Unrealized -28.5%

DNLI DENALI THERAPEUTICS INC 0.7%

Value $4.504M (-57.5%) Shares 234,582 (-63.4%) Est. Cost $15.17 Unrealized +29.4%

BMRN BIOMARIN PHARMACEUTICAL INC 5.9%

Value $38.71M (-12.7%) Shares 685,182 (-8.2%) Est. Cost $83.16 Unrealized -29.4%

CMPX COMPASS THERAPEUTICS INC 1.2%

Value $8.012M (-41.1%) Shares 1,514,504 (-40.2%) Est. Cost $4.62 Unrealized +29.9%

EHTH EHEALTH INC 0.3%

Value $1.913M (-72.8%) Shares 1,482,797 (-3.2%) Est. Cost $38.13 Unrealized -92.6%

IOVA IOVANCE BIOTHERAPEUTICS INC 3.4%

Value $22.29M (+14.7%) Shares 6,349,563 (-10.8%) Est. Cost $4.09 Unrealized -34.4%

NVCR NOVOCURE LTD 2.1%

Value $13.96M (-16.9%) Shares 1,280,439 (-1.4%) Est. Cost $34.92 Unrealized -64.0%

NUVB NUVATION BIO INC 0.3%

Value $2.183M (-54.7%) Shares 508,846 (-5.4%) Est. Cost $2.12 Unrealized +192.4%

ANAB ANAPTYSBIO INC 5.4%

Value $35.39M (+5.8%) Shares 638,161 (-7.5%) Est. Cost $19.77 Unrealized +149.7%

XENE XENON PHARMACEUTICALS INC 0.5%

Value $2.986M (-31.0%) Shares 51,345 (-46.8%) Est. Cost $42.00 Unrealized -0.0%

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $263K (-77.5%) Shares 155,709 (-30.9%) Est. Cost $5.95 Unrealized -16.6%

PRTA PROTHENA CORP PLC 1.8%

Value $11.75M (-6.8%) Shares 1,208,568 (-8.5%) Est. Cost $20.95 Unrealized -56.5%

BCYC BICYCLE THERAPEUTICS PLC-ADR 0.1%

Value $937K (-40.1%) Shares 201,890 (-8.7%) Est. Cost $16.07 Unrealized —

PYXS PYXIS ONCOLOGY INC 0.2%

Value $1.475M (+23.7%) Shares 1,010,510 (-2.6%) Est. Cost $2.98 Unrealized -48.7%

CRSP CRISPR THERAPEUTICS AG 0.3%

Value $1.884M (-12.9%) Shares 39,605 (-3.9%) Est. Cost $38.70 Unrealized +38.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
FOLD	AMICUS THERAPEUTICS INC	1,113,045 (-78.6%)	$16.09M (-78.3%)	2.5%	$9.63	+48.6%	COM	03152W109
INSM	INSMED INC	415,269 (-15.2%)	$67.9M (-20.3%)	10.4%	$17.79	+793.9%	COM PAR $.01	457669307
BIIB	BIOGEN INC	140,719 (-23.3%)	$25.8M (-20.1%)	3.9%	$256.18	-28.5%	COM	09062X103
DNLI	DENALI THERAPEUTICS INC	234,582 (-63.4%)	$4.504M (-57.5%)	0.7%	$15.17	+29.4%	COM	24823R105
BMRN	BIOMARIN PHARMACEUTICAL INC	685,182 (-8.2%)	$38.71M (-12.7%)	5.9%	$83.16	-29.4%	COM	09061G101
CMPX	COMPASS THERAPEUTICS INC	1,514,504 (-40.2%)	$8.012M (-41.1%)	1.2%	$4.62	+29.9%	COM	20454B104
EHTH	EHEALTH INC	1,482,797 (-3.2%)	$1.913M (-72.8%)	0.3%	$38.13	-92.6%	COM	28238P109
IOVA	IOVANCE BIOTHERAPEUTICS INC	6,349,563 (-10.8%)	$22.29M (+14.7%)	3.4%	$4.09	-34.4%	COM	462260100
NVCR	NOVOCURE LTD	1,280,439 (-1.4%)	$13.96M (-16.9%)	2.1%	$34.92	-64.0%	ORD SHS	G6674U108
NUVB	NUVATION BIO INC	508,846 (-5.4%)	$2.183M (-54.7%)	0.3%	$2.12	+192.4%	COM CL A	67080N101
ANAB	ANAPTYSBIO INC	638,161 (-7.5%)	$35.39M (+5.8%)	5.4%	$19.77	+149.7%	COM	032724106
XENE	XENON PHARMACEUTICALS INC	51,345 (-46.8%)	$2.986M (-31.0%)	0.5%	$42.00	-0.0%	COM	98420N105
ALDX	ALDEYRA THERAPEUTICS INC	155,709 (-30.9%)	$263K (-77.5%)	0.0%	$5.95	-16.6%	COM	01438T106
PRTA	PROTHENA CORP PLC	1,208,568 (-8.5%)	$11.75M (-6.8%)	1.8%	$20.95	-56.5%	SHS	G72800108
BCYC	BICYCLE THERAPEUTICS PLC-ADR	201,890 (-8.7%)	$937K (-40.1%)	0.1%	$16.07	—	SPONSORED ADS	088786108
PYXS	PYXIS ONCOLOGY INC	1,010,510 (-2.6%)	$1.475M (+23.7%)	0.2%	$2.98	-48.7%	COMMON STOCK	747324101
CRSP	CRISPR THERAPEUTICS AG	39,605 (-3.9%)	$1.884M (-12.9%)	0.3%	$38.70	+38.2%	NAMEN AKT	H17182108

Unchanged Positions (13)

ALKS ALKERMES PLC 1.3%

Value $8.577M Shares 242,560 Est. Cost $24.20 Unrealized +33.7%

AGIO AGIOS PHARMACEUTICALS INC 1.1%

Value $7.226M Shares 213,601 Est. Cost $33.17 Unrealized -15.5%

ORKA ORUKA THERAPEUTICS INC 0.4%

Value $2.942M Shares 59,985 Est. Cost $14.82 Unrealized +118.9%

ALGN ALIGN TECHNOLOGY INC 1.1%

Value $7.118M Shares 41,520 Est. Cost $150.48 Unrealized +16.1%

INSP INSPIRE MEDICAL SYSTEMS INC 0.1%

Value $452K Shares 8,772 Est. Cost $95.68 Unrealized -19.1%

HUM HUMANA INC 0.1%

Value $691K Shares 3,985 Est. Cost $369.63 Unrealized -39.5%

NBIX NEUROCRINE BIOSCIENCES INC 0.4%

Value $2.387M Shares 18,117 Est. Cost $129.01 Unrealized +4.1%

EW EDWARDS LIFESCIENCES CORP 0.4%

Value $2.694M Shares 33,640 Est. Cost $72.66 Unrealized +12.8%

CMPS COMPASS PATHWAYS PLC ADR 0.1%

Value $639K Shares 115,616 Est. Cost $6.90 Unrealized —

URGN UROGEN PHARMA LTD 0.1%

Value $441K Shares 24,500 Est. Cost $27.01 Unrealized -22.9%

BNTX BIONTECH SE-ADR 0.3%

Value $1.743M Shares 19,614 Est. Cost $118.77 Unrealized —

ABEO ABEONA THERAPEUTICS INC 0.1%

Value $488K Shares 108,865 Est. Cost $6.04 Unrealized -14.5%

PRQR PROQR THERAPEUTICS NV 0.0%

Value $306K Shares 188,807 Est. Cost $2.18 Unrealized -25.2%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ALKS	ALKERMES PLC	242,560	$8.577M	1.3%	$24.20	+33.7%	SHS	G01767105
AGIO	AGIOS PHARMACEUTICALS INC	213,601	$7.226M	1.1%	$33.17	-15.5%	COM	00847X104
ORKA	ORUKA THERAPEUTICS INC	59,985	$2.942M	0.4%	$14.82	+118.9%	COM	687604108
ALGN	ALIGN TECHNOLOGY INC	41,520	$7.118M	1.1%	$150.48	+16.1%	COM	016255101
INSP	INSPIRE MEDICAL SYSTEMS INC	8,772	$452K	0.1%	$95.68	-19.1%	COM	457730109
HUM	HUMANA INC	3,985	$691K	0.1%	$369.63	-39.5%	COM	444859102
NBIX	NEUROCRINE BIOSCIENCES INC	18,117	$2.387M	0.4%	$129.01	+4.1%	COM	64125C109
EW	EDWARDS LIFESCIENCES CORP	33,640	$2.694M	0.4%	$72.66	+12.8%	COM	28176E108
CMPS	COMPASS PATHWAYS PLC ADR	115,616	$639K	0.1%	$6.90	—	SPONSORED ADS	20451W101
URGN	UROGEN PHARMA LTD	24,500	$441K	0.1%	$27.01	-22.9%	COM	M96088105
BNTX	BIONTECH SE-ADR	19,614	$1.743M	0.3%	$118.77	—	SPONSORED ADS	09075V102
ABEO	ABEONA THERAPEUTICS INC	108,865	$488K	0.1%	$6.04	-14.5%	COM NEW	00289Y206
PRQR	PROQR THERAPEUTICS NV	188,807	$306K	0.0%	$2.18	-25.2%	SHS EURO	N71542109