Location: Palo Alto, CA
CIK: 0001306923 · Show all filings
Period: Q4 2025 (← Previous) (Next →)
Filing Date: Feb 17, 2026
Total Value: $718M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| INSM | INSMED INC | 489,482 | $85.19M | 11.9% | $174.04 * | $17.79 | +925.7% | COM | 457669307 |
| FOLD | AMICUS THERAPEUTICS INC | 5,205,767 | $74.13M | 10.3% | $14.24 * | $9.63 | +2.1% | COM | 03152W109 |
| PTCT | PTC THERAPEUTICS INC | 903,916 | $68.66M | 9.6% | $75.96 * | $46.25 | +57.1% | COM | 69366J200 |
| ACAD | ACADIA PHARMACEUTICALS INC | 2,484,031 | $66.35M | 9.2% | $26.71 * | $26.96 | -11.4% | COM | 004225108 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 746,256 | $44.35M | 6.2% | $59.43 * | $83.16 | -34.5% | COM | 09061G101 |
| ANAB | ANAPTYSBIO INC | 690,032 | $33.45M | 4.7% | $48.48 * | $19.77 | +97.2% | COM | 032724106 |
| BIIB | BIOGEN INC | 183,571 | $32.31M | 4.5% | $175.99 * | $256.18 | -36.2% | SPONSORED ADS | 09062X103 |
| DYN | DYNE THERAPEUTICS INC | 1,472,197 | $28.8M | 4.0% | $19.56 * | $13.00 | +45.7% | SPONSORED ADS | 26818M108 |
| UTHR | UNITED THERAPEUTICS CORP | 58,186 | $28.35M | 3.9% | $487.25 * | $89.23 | +421.9% | COM | 91307C102 |
| IRON | DISC MEDICINE INC | 317,456 | $25.21M | 3.5% | $79.41 * | $61.08 | +38.3% | COM | 254604101 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 7,116,676 | $19.43M | 2.7% | $2.73 * | $4.09 | -43.4% | COM NEW | 462260100 |
| NVCR | NOVOCURE LTD | 1,298,964 | $16.8M | 2.3% | $12.93 | $34.92 | -63.2% | COM | G6674U108 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 794,507 | $16.69M | 2.3% | $21.01 * | $15.82 | +10.3% | COM | 87164F105 |
| GOSS | GOSSAMER BIO INC | 4,471,592 | $13.86M | 1.9% | $3.10 * | $1.58 | +80.7% | COM | 38341P102 |
| CMPX | COMPASS THERAPEUTICS INC | 2,532,419 | $13.6M | 1.9% | $5.37 * | $4.62 | 0.0% | COM | 20454B104 |
| PRTA | PROTHENA CORP PLC | 1,320,510 | $12.61M | 1.8% | $9.55 * | $20.95 | -51.4% | COM CL A | G72800108 |
| MIRM | MIRUM PHARMACEUTICALS INC | 156,421 | $12.36M | 1.7% | $78.99 * | $48.52 | +47.9% | COM | 604749101 |
| ANNX | ANNEXON INC | 2,384,192 | $11.97M | 1.7% | $5.02 * | $3.82 | 0.0% | COM | 03589W102 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 461,294 | $10.61M | 1.5% | $23.00 * | $31.21 | +5.4% | COM | 90400D108 |
| DNLI | DENALI THERAPEUTICS INC | 641,239 | $10.59M | 1.5% | $16.51 * | $15.17 | +11.3% | COM | 24823R105 |
| CDNA | CAREDX INC | 478,220 | $9.01M | 1.3% | $18.84 * | $15.10 | +10.9% | COM | 14167L103 |
| EHTH | EHEALTH INC | 1,531,429 | $7.045M | 1.0% | $4.60 * | $38.13 | -88.4% | COM | 28238P109 |
| ALKS | ALKERMES PLC | 242,560 | $6.787M | 0.9% | $27.98 * | $24.20 | +23.8% | COM | G01767105 |
| CAPR | CAPRICOR THERAPEUTICS INC | 226,304 | $6.531M | 0.9% | $28.86 * | $13.06 | 0.0% | COM NEW | 14070B309 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,183,195 | $6.508M | 0.9% | $5.50 * | $1.87 | +159.1% | COM | 877619106 |
| ALGN | ALIGN TECHNOLOGY INC | 41,520 | $6.483M | 0.9% | $156.15 * | $150.48 | -4.8% | COM | 016255101 |
| AGIO | AGIOS PHARMACEUTICALS INC | 212,499 | $5.784M | 0.8% | $27.22 * | $33.17 | +5.8% | COM | 00847X104 |
| BCAX | BICARA THERAPEUTICS INC | 298,575 | $5.025M | 0.7% | $16.83 | $17.08 | 0.0% | COM | 055477103 |
| NUVB | NUVATION BIO INC | 538,079 | $4.821M | 0.7% | $8.96 * | $2.12 | +192.8% | COM CL A | 67080N101 |
| ACRS | ACLARIS THERAPEUTICS INC | 1,566,840 | $4.716M | 0.7% | $3.01 * | $1.44 | +75.3% | COM | 00461U105 |
| XENE | XENON PHARMACEUTICALS INC | 96,519 | $4.326M | 0.6% | $44.82 * | $42.00 | 0.0% | COM | 98420N105 |
| TVTX | TRAVERE THERAPEUTICS INC | 110,719 | $4.231M | 0.6% | $38.21 * | $23.56 | +38.0% | COM SHS | 89422G107 |
| EW | EDWARDS LIFESCIENCES CORP | 33,640 | $2.868M | 0.4% | $85.25 * | $72.66 | +13.0% | COM | 28176E108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 18,117 | $2.57M | 0.4% | $141.83 * | $129.01 | +12.3% | COM | 64125C109 |
| STOK | STOKE THERAPEUTICS INC | 72,022 | $2.286M | 0.3% | $31.74 * | $6.06 | +396.2% | COM | 86150R107 |
| CRSP | CRISPR THERAPEUTICS AG | 41,226 | $2.162M | 0.3% | $52.44 * | $38.70 | +54.8% | NAMEN AKT | H17182108 |
| BNTX | BIONTECH SE-ADR | 19,614 | $1.867M | 0.3% | $95.20 | $118.77 | — | COM | 09075V102 |
| ORKA | ORUKA THERAPEUTICS INC | 59,985 | $1.818M | 0.3% | $30.31 * | $14.82 | +88.0% | COM | 687604108 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 221,071 | $1.565M | 0.2% | $7.08 | $16.07 | — | COM | 088786108 |
| PYXS | PYXIS ONCOLOGY INC | 1,037,421 | $1.193M | 0.2% | $1.15 * | $2.98 | +18.2% | COM | 747324101 |
| ALDX | ALDEYRA THERAPEUTICS INC | 225,465 | $1.168M | 0.2% | $5.18 | $5.95 | -13.6% | SPONSORED ADR | 01438T106 |
| HUM | HUMANA INC | 3,985 | $1.021M | 0.1% | $256.13 * | $369.63 | -29.3% | COM | 444859102 |
| INSP | INSPIRE MEDICAL SYSTEMS INC | 8,772 | $809K | 0.1% | $92.23 * | $95.68 | 0.0% | COM | 457730109 |
| CMPS | COMPASS PATHWAYS PLC ADR | 115,616 | $798K | 0.1% | $6.90 | $6.90 | — | SPONSORED ADS | 20451W101 |
| URGN | UROGEN PHARMA LTD | 24,500 | $574K | 0.1% | $23.42 * | $27.01 | -19.7% | COM | M96088105 |
| ABEO | ABEONA THERAPEUTICS INC | 108,865 | $574K | 0.1% | $5.27 * | $6.04 | -16.7% | COM NEW | 00289Y206 |
| PRQR | PROQR THERAPEUTICS NV | 188,807 | $381K | 0.1% | $2.02 * | $2.18 | +7.0% | SHS EURO | N71542109 |
| — | GENERATION BIO CO | 15,047 | $85,467 | 0.0% | $5.68 | $5.68 | — | COM | 37148K209 |
| AKTX | AKARI THERAPEUTICS PLC-ADR | 146,024 | $42,201 | 0.0% | $0.29 | $1.22 | — | COM | 00972G207 |