| TCG Crossover Management, LLC | 10,000,000 | $15,600 |
| BlackRock, Inc. | 7,147,766 | $11,151 |
| VANGUARD GROUP INC | 6,908,054 | $10,777 |
| Foresite Capital Management IV, LLC | 3,887,200 | $6,064 |
| Merck & Co., Inc. | 3,545,719 | $5,531 |
| ACADIAN ASSET MANAGEMENT LLC | 3,442,449 | $5 |
| 683 Capital Management, LLC | 3,350,000 | $5,226 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,265,575 | $5,094 |
| D. E. Shaw & Co., Inc. | 2,365,151 | $3,690 |
| FMR LLC | 2,231,171 | $3,481 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,173,202 | $3,390 |
| Ikarian Capital, LLC | 2,082,606 | $3,249 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,075,220 | $3,238 |
| Kynam Capital Management, LP | 2,000,000 | $3,120 |
| STATE STREET CORP | 1,814,298 | $2,830 |
| RENAISSANCE TECHNOLOGIES LLC | 1,543,650 | $2,408 |
| MEDICI CAPITAL LLC | 1,500,520 | $2,341 |
| MILLENNIUM MANAGEMENT LLC | 1,332,914 | $2,079 |
| Euclidean Capital LLC | 1,307,858 | $2,040 |
| MARSHALL WACE, LLP | 1,166,817 | $1,820 |
| Spruce Street Capital LP | 1,117,986 | $1,744 |
| ADAR1 Capital Management, LLC | 1,108,000 | $1,728 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,055,192 | $1,646 |
| TWO SIGMA INVESTMENTS, LP | 1,039,656 | $1,622 |
| DEUTSCHE BANK AG\ | 1,035,154 | $1,615 |
| Eversept Partners, LP | 1,006,163 | $1,570 |
| JANE STREET GROUP, LLC | 993,913 | $1,551 |
| DAFNA Capital Management LLC | 908,351 | $1,417 |
| Elmind Capital, LP | 900,000 | $1,404 |
| PANAGORA ASSET MANAGEMENT INC | 850,298 | $1,326 |
| Vestal Point Capital, LP | 755,000 | $1,178 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 665,491 | $1,038 |
| MACKENZIE FINANCIAL CORP | 660,168 | $1,001 |
| TWO SIGMA ADVISERS, LP | 651,800 | $1,017 |
| AQR CAPITAL MANAGEMENT LLC | 599,569 | $935 |
| XTX Topco Ltd | 592,839 | $925 |
| NORTHERN TRUST CORP | 587,653 | $917 |
| BOOTHBAY FUND MANAGEMENT, LLC | 559,726 | $873 |
| GOLDMAN SACHS GROUP INC | 437,959 | $683 |
| BARCLAYS PLC | 398,687 | $622 |
| AMERIPRISE FINANCIAL INC | 354,299 | $553 |
| MORGAN STANLEY | 319,072 | $498 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 291,180 | $454 |
| Invesco Ltd. | 279,468 | $436 |
| GSA CAPITAL PARTNERS LLP | 225,566 | $0 |
| Bank of New York Mellon Corp | 217,862 | $340 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 200,000 | $312 |
| DIMENSIONAL FUND ADVISORS LP | 199,126 | $310 |
| CANADA PENSION PLAN INVESTMENT BOARD | 172,300 | $269 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 136,000 | $212 |
| BANK OF AMERICA CORP /DE/ | 134,506 | $210 |
| Utah Retirement Systems | 133,718 | $209 |
| Nuveen, LLC | 133,248 | $208 |
| UBS Group AG | 119,411 | $186 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,000 | $179 |
| STRS OHIO | 110,400 | $172 |
| Graham Capital Management, L.P. | 104,851 | $164 |
| RHUMBLINE ADVISERS | 101,926 | $159 |
| DekaBank Deutsche Girozentrale | 100,000 | $1 |
| Jasper Ridge Partners, L.P. | 95,068 | $148 |
| CITADEL ADVISORS LLC | 93,547 | $146 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 93,052 | $141 |
| ALLIANCEBERNSTEIN L.P. | 92,940 | $145 |
| WELLS FARGO & COMPANY/MN | 90,108 | $141 |
| Man Group plc | 86,162 | $134 |
| SIMPLEX TRADING, LLC | 82,017 | $128 |
| Squarepoint Ops LLC | 77,618 | $121 |
| Russell Investments Group, Ltd. | 71,887 | $112 |
| Blackstone Inc. | 66,859 | $104 |
| Quadrature Capital Ltd | 62,273 | $97 |
| HRT FINANCIAL LP | 57,341 | $0 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 56,203 | $0 |
| Cannell & Spears LLC | 54,642 | $85 |
| Lexington Partners L.P. | 53,488 | $83 |
| Vanguard Personalized Indexing Management, LLC | 53,056 | $83 |
| HSBC HOLDINGS PLC | 48,521 | $76 |
| OXFORD ASSET MANAGEMENT LLP | 42,905 | $67 |
| TUDOR INVESTMENT CORP ET AL | 41,282 | $64 |
| Tower Research Capital LLC (TRC) | 39,520 | $62 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,271 | $58 |
| INTECH INVESTMENT MANAGEMENT LLC | 34,510 | $54 |
| JPMORGAN CHASE & CO | 32,623 | $51 |
| PRUDENTIAL FINANCIAL INC | 32,225 | $50 |
| Vontobel Holding Ltd. | 30,000 | $47 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,829 | $45 |
| SG Americas Securities, LLC | 27,002 | $0 |
| Dynamic Technology Lab Private Ltd | 25,881 | $40 |
| Police & Firemen's Retirement System of New Jersey | 23,426 | $37 |
| Point72 Asset Management, L.P. | 23,102 | $36 |
| BNP PARIBAS ARBITRAGE, SA | 22,385 | $35 |
| Virtu Financial LLC | 21,886 | $0 |
| HERSHEY TRUST CO | 20,572 | $32 |
| Bronte Capital Management Pty Ltd. | 19,282 | $30 |
| SEI INVESTMENTS CO | 16,884 | $26 |
| ProShare Advisors LLC | 14,672 | $23 |
| NEUBERGER BERMAN GROUP LLC | 14,173 | $22 |
| Diversified Trust Co | 14,102 | $22 |
| Voya Investment Management LLC | 13,929 | $22 |
| Cerity Partners LLC | 13,682 | $21 |
| R Squared Ltd | 12,474 | $19 |
| 29 other institutions | 96,802 | $128 |