BIOAGE LABS INC

Institution	Shares	Value ($000)
Octagon Capital Advisors LP	1,598,000	$21,142
DIADEMA PARTNERS LP	271,164	$3,588
SPHERA FUNDS MANAGEMENT LTD.	243,035	$3,215
Persistent Asset Partners Ltd	72,774	$963
ADAGE CAPITAL PARTNERS GP, L.L.C.	1,050,000	$13,892
FOX RUN MANAGEMENT, L.L.C.	18,034	$239
XTX Topco Ltd	36,727	$486
Jump Financial, LLC	42,800	$566
JANUS HENDERSON GROUP PLC	409,207	$5,406
Trexquant Investment LP	39,334	$520
Schonfeld Strategic Advisors LLC	51,366	$680
Invesco Ltd.	228,673	$3,025
China Universal Asset Management Co., Ltd.	5,843	$77
Squarepoint Ops LLC	51,273	$678
Point72 Asset Management, L.P.	41,180	$545
GREAT LAKES ADVISORS, LLC	16,199	$214
MetLife Investment Management, LLC	14,437	$191
CANADA PENSION PLAN INVESTMENT BOARD	6,300	$83
Mirae Asset Global Investments Co., Ltd.	1,742	$23
GF FUND MANAGEMENT CO. LTD.	704	$9

Increased Positions (40)

ALGERT GLOBAL LLC

Value ($000) $3 (+3830.3%) Shares 196,048 (+1658.0%)

JACOBS LEVY EQUITY MANAGEMENT, INC

Value ($000) $4,420 (+252.8%) Shares 334,126 (+56.8%)

Walleye Capital LLC

Value ($000) $1,783 (+2252.3%) Shares 134,795 (+945.5%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $1,027 (+231.9%) Shares 77,600 (+47.5%)

D. E. Shaw & Co., Inc.

Value ($000) $4,497 (+633.4%) Shares 339,909 (+226.0%)

BlackRock, Inc.

Value ($000) $20,209 (+168.6%) Shares 1,527,541 (+19.4%)

STATE STREET CORP

Value ($000) $5,594 (+380.2%) Shares 422,846 (+113.4%)

BANK OF AMERICA CORP /DE/

Value ($000) $2,496 (+3718.1%) Shares 188,683 (+1596.9%)

CITADEL ADVISORS LLC

Value ($000) $3,050 (+354.8%) Shares 230,543 (+102.1%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $1,479 (+877.4%) Shares 111,789 (+334.4%)

MORGAN STANLEY

Value ($000) $4,123 (+207.3%) Shares 311,659 (+36.6%)

MARSHALL WACE, LLP

Value ($000) $2,950 (+188.0%) Shares 222,948 (+28.0%)

AMERIPRISE FINANCIAL INC

Value ($000) $1,098 (+512.8%) Shares 82,963 (+172.3%)

BARCLAYS PLC

Value ($000) $500 (+101.9%) Shares 37,780 (+217.5%)

Russell Investments Group, Ltd.

Value ($000) $547 (+1952.2%) Shares 41,308 (+812.1%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $694 (+1066.8%) Shares 52,439 (+418.6%)

GOLDMAN SACHS GROUP INC

Value ($000) $1,670 (+216.7%) Shares 126,238 (+40.8%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $2,909 (+158.5%) Shares 219,842 (+14.9%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $7,826 (+136.4%) Shares 591,377 (+5.1%)

FMR LLC

Value ($000) $1,557 (+190.6%) Shares 117,703 (+29.2%)

Institution	Prev Shares	Curr Shares	Change
ALGERT GLOBAL LLC	11,152	196,048	+184,896 (+1658.0%)
JACOBS LEVY EQUITY MANAGEMENT, INC	213,088	334,126	+121,038 (+56.8%)
Walleye Capital LLC	12,893	134,795	+121,902 (+945.5%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	52,600	77,600	+25,000 (+47.5%)
D. E. Shaw & Co., Inc.	104,281	339,909	+235,628 (+226.0%)
BlackRock, Inc.	1,279,621	1,527,541	+247,920 (+19.4%)
STATE STREET CORP	198,111	422,846	+224,735 (+113.4%)
BANK OF AMERICA CORP /DE/	11,119	188,683	+177,564 (+1596.9%)
CITADEL ADVISORS LLC	114,063	230,543	+116,480 (+102.1%)
BNP PARIBAS ARBITRAGE, SA	25,735	111,789	+86,054 (+334.4%)
MORGAN STANLEY	228,158	311,659	+83,501 (+36.6%)
MARSHALL WACE, LLP	174,196	222,948	+48,752 (+28.0%)
AMERIPRISE FINANCIAL INC	30,463	82,963	+52,500 (+172.3%)
BARCLAYS PLC	11,900	37,780	+25,880 (+217.5%)
Russell Investments Group, Ltd.	4,529	41,308	+36,779 (+812.1%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	10,112	52,439	+42,327 (+418.6%)
GOLDMAN SACHS GROUP INC	89,678	126,238	+36,560 (+40.8%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	191,383	219,842	+28,459 (+14.9%)
GEODE CAPITAL MANAGEMENT, LLC	562,731	591,377	+28,646 (+5.1%)
FMR LLC	91,118	117,703	+26,585 (+29.2%)

Decreased Positions (22)

ADAR1 Capital Management, LLC

Value ($000) $1,793 (-83.8%) Shares 135,560 (-92.8%)

Stonepine Capital Management, LLC

Value ($000) $595 (-46.3%) Shares 45,000 (-76.1%)

Cormorant Asset Management, LP

Value ($000) $26,997 (+114.5%) Shares 2,040,605 (-4.7%)

R Squared Ltd

Value ($000) $199 (+29.1%) Shares 15,006 (-42.6%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $243 (-71.0%) Shares 18,400 (-87.1%)

VANGUARD GROUP INC

Value ($000) $18,717 (+92.8%) Shares 1,414,770 (-14.3%)

LOS ANGELES CAPITAL MANAGEMENT LLC

Value ($000) $312 (-56.1%) Shares 40,388 (-66.6%)

TWO SIGMA ADVISERS, LP

Value ($000) $258 (-50.0%) Shares 19,500 (-77.8%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $558 (-4.8%) Shares 42,151 (-57.7%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $3,022 (+67.6%) Shares 228,414 (-25.5%)

NORTHERN TRUST CORP

Value ($000) $2,215 (+101.9%) Shares 167,452 (-10.2%)

ROYAL BANK OF CANADA

Value ($000) $9 (-90.1%) Shares 640 (-95.8%)

JPMORGAN CHASE & CO

Value ($000) $291 (+34.5%) Shares 22,029 (-40.2%)

DEUTSCHE BANK AG\

Value ($000) $209 (+40.3%) Shares 15,796 (-37.6%)

UBS Group AG

Value ($000) $395 (+82.0%) Shares 29,879 (-19.1%)

OCCUDO QUANTITATIVE STRATEGIES LP

Value ($000) $235 (+106.8%) Shares 17,735 (-8.1%)

Tower Research Capital LLC (TRC)

Value ($000) $15 (-2.5%) Shares 1,124 (-56.7%)

SRS Capital Advisors, Inc.

Value ($000) $0 (-98.1%) Shares 4 (-99.2%)

Sterling Capital Management LLC

Value ($000) $18 (+87.9%) Shares 1,367 (-16.5%)

MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.

Value ($000) $146 (+122.4%) Shares 11,009 (-1.1%)

Institution	Prev Shares	Curr Shares	Change
ADAR1 Capital Management, LLC	1,880,073	135,560	-1,744,513 (-92.8%)
Stonepine Capital Management, LLC	188,571	45,000	-143,571 (-76.1%)
Cormorant Asset Management, LP	2,140,605	2,040,605	-100,000 (-4.7%)
R Squared Ltd	26,159	15,006	-11,153 (-42.6%)
RENAISSANCE TECHNOLOGIES LLC	143,000	18,400	-124,600 (-87.1%)
VANGUARD GROUP INC	1,651,247	1,414,770	-236,477 (-14.3%)
LOS ANGELES CAPITAL MANAGEMENT LLC	120,929	40,388	-80,541 (-66.6%)
TWO SIGMA ADVISERS, LP	87,700	19,500	-68,200 (-77.8%)
TWO SIGMA INVESTMENTS, LP	99,669	42,151	-57,518 (-57.7%)
MILLENNIUM MANAGEMENT LLC	306,552	228,414	-78,138 (-25.5%)
NORTHERN TRUST CORP	186,568	167,452	-19,116 (-10.2%)
ROYAL BANK OF CANADA	15,384	640	-14,744 (-95.8%)
JPMORGAN CHASE & CO	36,848	22,029	-14,819 (-40.2%)
DEUTSCHE BANK AG\	25,325	15,796	-9,529 (-37.6%)
UBS Group AG	36,934	29,879	-7,055 (-19.1%)
OCCUDO QUANTITATIVE STRATEGIES LP	19,295	17,735	-1,560 (-8.1%)
Tower Research Capital LLC (TRC)	2,595	1,124	-1,471 (-56.7%)
SRS Capital Advisors, Inc.	474	4	-470 (-99.2%)
Sterling Capital Management LLC	1,637	1,367	-270 (-16.5%)
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	11,136	11,009	-127 (-1.1%)

Exited Positions (9)

TANG CAPITAL MANAGEMENT LLC

Value ($000) $9,408 Shares 1,600,000

Siren, L.L.C.

Value ($000) $2,249 Shares 382,406

PRELUDE CAPITAL MANAGEMENT, LLC

Value ($000) $219 Shares 37,193

GSA CAPITAL PARTNERS LLP

Value ($000) $0 Shares 30,723

Vontobel Holding Ltd.

Value ($000) $88 Shares 15,000

FEDERATED HERMES, INC.

Value ($000) $1 Shares 184

PRINCIPAL SECURITIES, INC.

Value ($000) $0 Shares 41

Clearstead Advisors, LLC

Value ($000) $0 Shares 18

Advisory Services Network, LLC

Value ($000) $0 Shares 13

Institution	Prev Shares	Prev Value ($000)
TANG CAPITAL MANAGEMENT LLC	1,600,000	$9,408
Siren, L.L.C.	382,406	$2,249
PRELUDE CAPITAL MANAGEMENT, LLC	37,193	$219
GSA CAPITAL PARTNERS LLP	30,723	$0
Vontobel Holding Ltd.	15,000	$88
FEDERATED HERMES, INC.	184	$1
PRINCIPAL SECURITIES, INC.	41	$0
Clearstead Advisors, LLC	18	$0
Advisory Services Network, LLC	13	$0