| a16z Capital Management, L.L.C. | 3,233,170 | $44,068 |
| Sofinnova Investments, Inc. | 2,293,788 | $30,347 |
| Cormorant Asset Management, LP | 2,040,605 | $26,997 |
| Octagon Capital Advisors LP | 1,598,000 | $21,142 |
| BlackRock, Inc. | 1,527,541 | $20,209 |
| VANGUARD GROUP INC | 1,414,770 | $18,717 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,050,000 | $13,892 |
| ORBIMED ADVISORS LLC | 790,901 | $10,464 |
| Sands Capital Ventures, LLC | 786,353 | $10,403 |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | $8,644 |
| GEODE CAPITAL MANAGEMENT, LLC | 591,377 | $7,826 |
| Cosmic Management, LLC | 501,833 | $6,639 |
| STATE STREET CORP | 422,846 | $5,594 |
| JANUS HENDERSON GROUP PLC | 409,207 | $5,406 |
| Redpoint Management, LLC | 383,254 | $5,070 |
| D. E. Shaw & Co., Inc. | 339,909 | $4,497 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 334,126 | $4,420 |
| MORGAN STANLEY | 311,659 | $4,123 |
| ACADIAN ASSET MANAGEMENT LLC | 277,957 | $4 |
| Comprehensive Financial Management LLC | 271,842 | $3,596 |
| DIADEMA PARTNERS LP | 271,164 | $3,588 |
| SPHERA FUNDS MANAGEMENT LTD. | 243,035 | $3,215 |
| CITADEL ADVISORS LLC | 230,543 | $3,050 |
| Invesco Ltd. | 228,673 | $3,025 |
| MILLENNIUM MANAGEMENT LLC | 228,414 | $3,022 |
| MARSHALL WACE, LLP | 222,948 | $2,950 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 219,842 | $2,909 |
| ALGERT GLOBAL LLC | 196,048 | $3 |
| BANK OF AMERICA CORP /DE/ | 188,683 | $2,496 |
| NORTHERN TRUST CORP | 167,452 | $2,215 |
| ADAR1 Capital Management, LLC | 135,560 | $1,793 |
| Walleye Capital LLC | 134,795 | $1,783 |
| GOLDMAN SACHS GROUP INC | 126,238 | $1,670 |
| FMR LLC | 117,703 | $1,557 |
| BNP PARIBAS ARBITRAGE, SA | 111,789 | $1,479 |
| AMERIPRISE FINANCIAL INC | 82,963 | $1,098 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 80,000 | $1,058 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 77,600 | $1,027 |
| Persistent Asset Partners Ltd | 72,774 | $963 |
| Bank of New York Mellon Corp | 61,560 | $814 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,439 | $694 |
| AQR CAPITAL MANAGEMENT LLC | 51,918 | $687 |
| Schonfeld Strategic Advisors LLC | 51,366 | $680 |
| Squarepoint Ops LLC | 51,273 | $678 |
| Stonepine Capital Management, LLC | 45,000 | $595 |
| Jump Financial, LLC | 42,800 | $566 |
| TWO SIGMA INVESTMENTS, LP | 42,151 | $558 |
| Russell Investments Group, Ltd. | 41,308 | $547 |
| Point72 Asset Management, L.P. | 41,180 | $545 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 40,388 | $312 |
| Militia Capital Partners, LP | 40,300 | $533 |
| Trexquant Investment LP | 39,334 | $520 |
| BARCLAYS PLC | 37,780 | $500 |
| XTX Topco Ltd | 36,727 | $486 |
| Woodline Partners LP | 31,565 | $418 |
| Nuveen, LLC | 30,794 | $407 |
| UBS Group AG | 29,879 | $395 |
| RHUMBLINE ADVISERS | 29,527 | $391 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,788 | $368 |
| WELLS FARGO & COMPANY/MN | 26,597 | $352 |
| STRS OHIO | 22,500 | $298 |
| JPMORGAN CHASE & CO | 22,029 | $291 |
| TWO SIGMA ADVISERS, LP | 19,500 | $258 |
| RENAISSANCE TECHNOLOGIES LLC | 18,400 | $243 |
| FOX RUN MANAGEMENT, L.L.C. | 18,034 | $239 |
| OCCUDO QUANTITATIVE STRATEGIES LP | 17,735 | $235 |
| Quadrature Capital Ltd | 16,769 | $222 |
| GREAT LAKES ADVISORS, LLC | 16,199 | $214 |
| DEUTSCHE BANK AG\ | 15,796 | $209 |
| R Squared Ltd | 15,006 | $199 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,808 | $0 |
| MetLife Investment Management, LLC | 14,437 | $191 |
| Valor Management LLC | 13,105 | $173 |
| INTECH INVESTMENT MANAGEMENT LLC | 12,192 | $161 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,009 | $146 |
| NISA INVESTMENT ADVISORS, LLC | 10,237 | $135 |
| Police & Firemen's Retirement System of New Jersey | 6,577 | $87 |
| CANADA PENSION PLAN INVESTMENT BOARD | 6,300 | $83 |
| China Universal Asset Management Co., Ltd. | 5,843 | $77 |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | $67 |
| CWM, LLC | 3,693 | $0 |
| SIMPLEX TRADING, LLC | 2,860 | $38 |
| PNC Financial Services Group, Inc. | 2,183 | $29 |
| Legal & General Group Plc | 2,152 | $28 |
| Mirae Asset Global Investments Co., Ltd. | 1,742 | $23 |
| CITIGROUP INC | 1,538 | $20 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,461 | $19 |
| Sterling Capital Management LLC | 1,367 | $18 |
| Ameritas Investment Partners, Inc. | 1,269 | $17 |
| Tower Research Capital LLC (TRC) | 1,124 | $15 |
| OSAIC HOLDINGS, INC. | 883 | $12 |
| Parallel Advisors, LLC | 867 | $11 |
| AMALGAMATED BANK | 745 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 704 | $9 |
| ROYAL BANK OF CANADA | 640 | $9 |
| TD Waterhouse Canada Inc. | 256 | $3 |
| Torren Management, LLC | 213 | $3 |
| EverSource Wealth Advisors, LLC | 145 | $2 |
| US BANCORP \DE\ | 122 | $2 |
| Fortitude Family Office, LLC | 120 | $2 |
| 12 other institutions | 707 | $8 |