MONTE ROSA THERAPEUTICS INC

Institution	Shares	Value ($000)
TCG Crossover Management, LLC	4,622,151	$72,475
MPM BioImpact LLC	1,173,376	$18,399
BRAIDWELL LP	948,316	$14,870
Nextech Invest, Ltd.	279,237	$4,378
DIADEMA PARTNERS LP	62,281	$977
Atom Investors LP	137,261	$2,152
STEMPOINT CAPITAL LP	61,577	$966
Persistent Asset Partners Ltd	22,211	$348
ADVISORY RESEARCH INC	63,220	$991
EAM Investors, LLC	70,037	$1,098
AXQ CAPITAL, LP	13,742	$215
Brookwood Investment Group LLC	19,535	$306
Nantahala Capital Management, LLC	57,991	$909
TEMA ETFS LLC	24,767	$388
Trexquant Investment LP	149,712	$2,347
Mayflower Financial Advisors, LLC	10,000	$157
J. Goldman & Co LP	32,291	$506
WINTON GROUP Ltd	22,930	$360
PROFUND ADVISORS LLC	25,219	$395
Aquatic Capital Management LLC	30,940	$485

Increased Positions (53)

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $16,136 (+213.3%) Shares 1,029,066 (+48.1%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $8,207 (+208.6%) Shares 523,377 (+45.8%)

Empowered Funds, LLC

Value ($000) $4,360 (+572.9%) Shares 278,077 (+218.0%)

Campbell & CO Investment Adviser LLC

Value ($000) $1,423 (+275.6%) Shares 90,752 (+77.5%)

AMERICAN CENTURY COMPANIES INC

Value ($000) $20,848 (+374.1%) Shares 1,329,619 (+124.1%)

STATE STREET CORP

Value ($000) $33,045 (+426.7%) Shares 2,107,480 (+148.9%)

BlackRock, Inc.

Value ($000) $65,561 (+131.9%) Shares 4,181,161 (+9.6%)

Invesco Ltd.

Value ($000) $5,680 (+682.9%) Shares 362,213 (+270.0%)

Nuveen, LLC

Value ($000) $4,482 (+487.5%) Shares 285,859 (+177.6%)

VANGUARD GROUP INC

Value ($000) $50,905 (+129.8%) Shares 3,246,500 (+8.6%)

GOLDMAN SACHS GROUP INC

Value ($000) $4,639 (+519.0%) Shares 295,878 (+192.5%)

MORGAN STANLEY

Value ($000) $12,631 (+164.2%) Shares 805,530 (+24.9%)

AQR CAPITAL MANAGEMENT LLC

Value ($000) $12,310 (+131.6%) Shares 785,057 (+9.5%)

BARCLAYS PLC

Value ($000) $2,132 (+638.1%) Shares 135,984 (+149.5%)

CHARLES SCHWAB INVESTMENT MANAGEMENT INC

Value ($000) $7,036 (+147.7%) Shares 448,714 (+17.1%)

IEQ CAPITAL, LLC

Value ($000) $1,400 (+219.8%) Shares 89,268 (+51.1%)

SEI INVESTMENTS CO

Value ($000) $936 (+669.7%) Shares 59,668 (+263.7%)

TD Asset Management Inc

Value ($000) $3,347 (+162.5%) Shares 213,464 (+24.1%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $18,896 (+121.4%) Shares 1,204,844 (+4.6%)

UBS Group AG

Value ($000) $1,929 (+261.0%) Shares 123,000 (+70.6%)

Institution	Prev Shares	Curr Shares	Change
SILVERARC CAPITAL MANAGEMENT, LLC	694,942	1,029,066	+334,124 (+48.1%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	358,850	523,377	+164,527 (+45.8%)
Empowered Funds, LLC	87,450	278,077	+190,627 (+218.0%)
Campbell & CO Investment Adviser LLC	51,133	90,752	+39,619 (+77.5%)
AMERICAN CENTURY COMPANIES INC	593,394	1,329,619	+736,225 (+124.1%)
STATE STREET CORP	846,773	2,107,480	+1,260,707 (+148.9%)
BlackRock, Inc.	3,815,133	4,181,161	+366,028 (+9.6%)
Invesco Ltd.	97,898	362,213	+264,315 (+270.0%)
Nuveen, LLC	102,968	285,859	+182,891 (+177.6%)
VANGUARD GROUP INC	2,988,953	3,246,500	+257,547 (+8.6%)
GOLDMAN SACHS GROUP INC	101,144	295,878	+194,734 (+192.5%)
MORGAN STANLEY	645,196	805,530	+160,334 (+24.9%)
AQR CAPITAL MANAGEMENT LLC	717,262	785,057	+67,795 (+9.5%)
BARCLAYS PLC	54,508	135,984	+81,476 (+149.5%)
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	383,268	448,714	+65,446 (+17.1%)
IEQ CAPITAL, LLC	59,066	89,268	+30,202 (+51.1%)
SEI INVESTMENTS CO	16,406	59,668	+43,262 (+263.7%)
TD Asset Management Inc	172,078	213,464	+41,386 (+24.1%)
GEODE CAPITAL MANAGEMENT, LLC	1,151,566	1,204,844	+53,278 (+4.6%)
UBS Group AG	72,095	123,000	+50,905 (+70.6%)

Decreased Positions (39)

Versant Venture Management, LLC

Value ($000) $68,721 (+64.1%) Shares 4,382,687 (-22.5%)

BVF INC/IL

Value ($000) $60,147 (+43.4%) Shares 3,835,886 (-32.2%)

Rangeley Capital, LLC

Value ($000) $1,058 (+26.4%) Shares 67,500 (-40.3%)

Alphabet Inc.

Value ($000) $11,681 (+7.7%) Shares 744,948 (-49.1%)

BAKER BROS. ADVISORS LP

Value ($000) $68,141 (+87.1%) Shares 4,345,736 (-11.6%)

GSA CAPITAL PARTNERS LLP

Value ($000) $0 (-79.4%) Shares 12,981 (-90.3%)

Vestal Point Capital, LP

Value ($000) $12,152 (+105.0%) Shares 775,000 (-3.1%)

Virtus Investment Advisers, LLC

Value ($000) $256 (+49.2%) Shares 16,310 (-29.5%)

MARSHALL WACE, LLP

Value ($000) $6,255 (-6.5%) Shares 398,890 (-55.8%)

China Universal Asset Management Co., Ltd.

Value ($000) $292 (+27.8%) Shares 18,611 (-39.6%)

FMR LLC

Value ($000) $20,386 (-2.2%) Shares 1,300,096 (-53.8%)

SRS Capital Advisors, Inc.

Value ($000) $7 (-97.0%) Shares 460 (-98.6%)

XTX Topco Ltd

Value ($000) $488 (+31.4%) Shares 31,125 (-37.9%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $1,630 (-50.6%) Shares 103,972 (-76.6%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $220 (-81.7%) Shares 14,000 (-91.3%)

ROYAL BANK OF CANADA

Value ($000) $44 (-98.6%) Shares 2,818 (-99.4%)

JANE STREET GROUP, LLC

Value ($000) $2,149 (-5.6%) Shares 137,049 (-55.4%)

Brevan Howard Capital Management LP

Value ($000) $209 (-39.9%) Shares 13,323 (-71.6%)

Squarepoint Ops LLC

Value ($000) $157 (-77.6%) Shares 10,029 (-89.4%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $8,914 (+90.3%) Shares 568,367 (-10.1%)

Institution	Prev Shares	Curr Shares	Change
Versant Venture Management, LLC	5,652,922	4,382,687	-1,270,235 (-22.5%)
BVF INC/IL	5,660,132	3,835,886	-1,824,246 (-32.2%)
Rangeley Capital, LLC	113,000	67,500	-45,500 (-40.3%)
Alphabet Inc.	1,464,015	744,948	-719,067 (-49.1%)
BAKER BROS. ADVISORS LP	4,916,095	4,345,736	-570,359 (-11.6%)
GSA CAPITAL PARTNERS LLP	133,455	12,981	-120,474 (-90.3%)
Vestal Point Capital, LP	800,000	775,000	-25,000 (-3.1%)
Virtus Investment Advisers, LLC	23,128	16,310	-6,818 (-29.5%)
MARSHALL WACE, LLP	902,834	398,890	-503,944 (-55.8%)
China Universal Asset Management Co., Ltd.	30,825	18,611	-12,214 (-39.6%)
FMR LLC	2,812,251	1,300,096	-1,512,155 (-53.8%)
SRS Capital Advisors, Inc.	32,445	460	-31,985 (-98.6%)
XTX Topco Ltd	50,128	31,125	-19,003 (-37.9%)
MILLENNIUM MANAGEMENT LLC	444,939	103,972	-340,967 (-76.6%)
TWO SIGMA INVESTMENTS, LP	161,481	14,000	-147,481 (-91.3%)
ROYAL BANK OF CANADA	435,767	2,818	-432,949 (-99.4%)
JANE STREET GROUP, LLC	307,049	137,049	-170,000 (-55.4%)
Brevan Howard Capital Management LP	46,912	13,323	-33,589 (-71.6%)
Squarepoint Ops LLC	94,707	10,029	-84,678 (-89.4%)
DIMENSIONAL FUND ADVISORS LP	632,182	568,367	-63,815 (-10.1%)

Exited Positions (16)

JBF Capital, Inc.

Value ($000) $1,101 Shares 148,566

Scientech Research LLC

Value ($000) $120 Shares 16,254

SUMMIT WEALTH GROUP LLC / CO

Value ($000) $311 Shares 2,002

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $2,932 Shares 395,733

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $3,027 Shares 408,540

MACQUARIE GROUP LTD

Value ($000) $1,482 Shares 200,000

PRELUDE CAPITAL MANAGEMENT, LLC

Value ($000) $76 Shares 10,202

Qube Research & Technologies Ltd

Value ($000) $1,095 Shares 147,726

BAILARD, INC.

Value ($000) $167 Shares 22,500

Point72 Asset Management, L.P.

Value ($000) $670 Shares 90,419

MACKENZIE FINANCIAL CORP

Value ($000) $575 Shares 77,635

OMERS ADMINISTRATION Corp

Value ($000) $210 Shares 28,300

Engineers Gate Manager LP

Value ($000) $81 Shares 10,871

ROYCE & ASSOCIATES LP

Value ($000) $82 Shares 11,024

PRUDENTIAL FINANCIAL INC

Value ($000) $89 Shares 12,054

TWO SIGMA ADVISERS, LP

Value ($000) $82 Shares 11,100

Institution	Prev Shares	Prev Value ($000)
JBF Capital, Inc.	148,566	$1,101
Scientech Research LLC	16,254	$120
SUMMIT WEALTH GROUP LLC / CO	2,002	$311
RENAISSANCE TECHNOLOGIES LLC	395,733	$2,932
BALYASNY ASSET MANAGEMENT L.P.	408,540	$3,027
MACQUARIE GROUP LTD	200,000	$1,482
PRELUDE CAPITAL MANAGEMENT, LLC	10,202	$76
Qube Research & Technologies Ltd	147,726	$1,095
BAILARD, INC.	22,500	$167
Point72 Asset Management, L.P.	90,419	$670
MACKENZIE FINANCIAL CORP	77,635	$575
OMERS ADMINISTRATION Corp	28,300	$210
Engineers Gate Manager LP	10,871	$81
ROYCE & ASSOCIATES LP	11,024	$82
PRUDENTIAL FINANCIAL INC	12,054	$89
TWO SIGMA ADVISERS, LP	11,100	$82