| NEA Management Company, LLC | 7,692,298 | $120,615 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,118,904 | $80 |
| TCG Crossover Management, LLC | 4,622,151 | $72,475 |
| Versant Venture Management, LLC | 4,382,687 | $68,721 |
| BAKER BROS. ADVISORS LP | 4,345,736 | $68,141 |
| BlackRock, Inc. | 4,181,161 | $65,561 |
| BVF INC/IL | 3,835,886 | $60,147 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,360,000 | $52,685 |
| VANGUARD GROUP INC | 3,246,500 | $50,905 |
| STATE STREET CORP | 2,107,480 | $33,045 |
| Aisling Capital Management LP | 1,472,331 | $23,086 |
| AMERICAN CENTURY COMPANIES INC | 1,329,619 | $20,848 |
| FMR LLC | 1,300,096 | $20,386 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,204,844 | $18,896 |
| MPM BioImpact LLC | 1,173,376 | $18,399 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,029,066 | $16,136 |
| BRAIDWELL LP | 948,316 | $14,870 |
| MORGAN STANLEY | 805,530 | $12,631 |
| AQR CAPITAL MANAGEMENT LLC | 785,057 | $12,310 |
| Vestal Point Capital, LP | 775,000 | $12,152 |
| Alphabet Inc. | 744,948 | $11,681 |
| Parkwood LLC | 708,000 | $11 |
| NORTHERN TRUST CORP | 697,034 | $10,929 |
| DIMENSIONAL FUND ADVISORS LP | 568,367 | $8,914 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 523,377 | $8,207 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 448,714 | $7,036 |
| MARSHALL WACE, LLP | 398,890 | $6,255 |
| Invesco Ltd. | 362,213 | $5,680 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 307,651 | $4,824 |
| GOLDMAN SACHS GROUP INC | 295,878 | $4,639 |
| Nuveen, LLC | 285,859 | $4,482 |
| Nextech Invest, Ltd. | 279,237 | $4,378 |
| Empowered Funds, LLC | 278,077 | $4,360 |
| ACADIAN ASSET MANAGEMENT LLC | 247,855 | $4 |
| BANK OF AMERICA CORP /DE/ | 223,571 | $3,506 |
| ADAR1 Capital Management, LLC | 215,752 | $3,383 |
| TD Asset Management Inc | 213,464 | $3,347 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200,000 | $3,136 |
| Bank of New York Mellon Corp | 173,304 | $2,717 |
| Trexquant Investment LP | 149,712 | $2,347 |
| WELLINGTON MANAGEMENT GROUP LLP | 148,057 | $2,322 |
| Atom Investors LP | 137,261 | $2,152 |
| JANE STREET GROUP, LLC | 137,049 | $2,149 |
| BARCLAYS PLC | 135,984 | $2,132 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,674 | $2,147 |
| UBS Group AG | 123,000 | $1,929 |
| AMERIPRISE FINANCIAL INC | 122,164 | $1,916 |
| MILLENNIUM MANAGEMENT LLC | 103,972 | $1,630 |
| Campbell & CO Investment Adviser LLC | 90,752 | $1,423 |
| IEQ CAPITAL, LLC | 89,268 | $1,400 |
| Casdin Capital, LLC | 86,014 | $1,349 |
| D. E. Shaw & Co., Inc. | 85,488 | $1,340 |
| FRANKLIN RESOURCES INC | 85,231 | $1,336 |
| EAM Investors, LLC | 70,037 | $1,098 |
| CANADA PENSION PLAN INVESTMENT BOARD | 68,100 | $1,068 |
| Rangeley Capital, LLC | 67,500 | $1,058 |
| Rafferty Asset Management, LLC | 67,438 | $1,057 |
| ALLIANCEBERNSTEIN L.P. | 63,480 | $995 |
| ADVISORY RESEARCH INC | 63,220 | $991 |
| DIADEMA PARTNERS LP | 62,281 | $977 |
| RHUMBLINE ADVISERS | 61,859 | $970 |
| STEMPOINT CAPITAL LP | 61,577 | $966 |
| SEI INVESTMENTS CO | 59,668 | $936 |
| Nantahala Capital Management, LLC | 57,991 | $909 |
| WELLS FARGO & COMPANY/MN | 52,588 | $825 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 49,630 | $778 |
| CITADEL ADVISORS LLC | 46,263 | $725 |
| STRS OHIO | 36,100 | $566 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 35,783 | $561 |
| SIMPLEX TRADING, LLC | 35,124 | $551 |
| Quantinno Capital Management LP | 33,580 | $527 |
| DEUTSCHE BANK AG\ | 33,108 | $519 |
| J. Goldman & Co LP | 32,291 | $506 |
| XTX Topco Ltd | 31,125 | $488 |
| Aquatic Capital Management LLC | 30,940 | $485 |
| CWM, LLC | 29,444 | $0 |
| AlphaQuest LLC | 28,322 | $444 |
| Allspring Global Investments Holdings, LLC | 26,955 | $423 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 26,806 | $349 |
| Voya Investment Management LLC | 26,382 | $414 |
| MetLife Investment Management, LLC | 26,187 | $411 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,552 | $402 |
| PROFUND ADVISORS LLC | 25,219 | $395 |
| NEOS Investment Management LLC | 25,137 | $394 |
| TEMA ETFS LLC | 24,767 | $388 |
| JPMORGAN CHASE & CO | 24,120 | $378 |
| Creative Planning | 23,403 | $367 |
| WINTON GROUP Ltd | 22,930 | $360 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,289 | $357 |
| Persistent Asset Partners Ltd | 22,211 | $348 |
| Mariner, LLC | 21,600 | $340 |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,628 | $308 |
| Brookwood Investment Group LLC | 19,535 | $306 |
| INTECH INVESTMENT MANAGEMENT LLC | 19,392 | $304 |
| Virtu Financial LLC | 18,717 | $0 |
| China Universal Asset Management Co., Ltd. | 18,611 | $292 |
| SG Americas Securities, LLC | 17,279 | $0 |
| Man Group plc | 16,312 | $256 |
| Virtus Investment Advisers, LLC | 16,310 | $256 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,950 | $234 |
| 59 other institutions | 267,803 | $3,963 |