SKYE BIOSCIENCE INC

Ticker: SKYE CUSIP: 83086J200 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (13)

R Squared Ltd
Value ($000) $11 Shares 14,782
XTX Topco Ltd
Value ($000) $40 Shares 53,040
TWO SIGMA ADVISERS, LP
Value ($000) $31 Shares 40,982
Engineers Gate Manager LP
Value ($000) $17 Shares 23,138
SIMPLEX TRADING, LLC
Value ($000) $5 Shares 6,331
FEDERATED HERMES, INC.
Value ($000) $1 Shares 1,158
NATIONAL BANK OF CANADA /FI/
Value ($000) $0 Shares 400
GSA CAPITAL PARTNERS LLP
Value ($000) $0 Shares 22,877
JPMORGAN CHASE & CO
Value ($000) $0 Shares 66
HRT FINANCIAL LP
Value ($000) $0 Shares 27,348
Dynamic Wealth Strategies, LLC
Value ($000) $0 Shares 8
CoreCap Advisors, LLC
Value ($000) $0 Shares 8
TUCKER ASSET MANAGEMENT LLC
Value ($000) $0 Shares 1

Increased Positions (4)

GROUP ONE TRADING, L.P.
Value ($000) $13 (+40.1%) Shares 17,697 (+634.3%)
JANE STREET GROUP, LLC
Value ($000) $18 (-63.1%) Shares 24,615 (+93.3%)
BANK OF AMERICA CORP /DE/
Value ($000) $0 (-20.9%) Shares 586 (+315.6%)
Fortitude Family Office, LLC
Value ($000) $0 (-35.5%) Shares 385 (+237.7%)

Decreased Positions (11)

Schonfeld Strategic Advisors LLC
Value ($000) $70 (-98.5%) Shares 93,407 (-92.1%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $39 (-89.3%) Shares 51,706 (-44.0%)
BARCLAYS PLC
Value ($000) $16 (-93.0%) Shares 21,251 (-63.3%)
Zurcher Kantonalbank (Zurich Cantonalbank)
Value ($000) $0 (-100.0%) Shares 52 (-99.8%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $285 (-82.0%) Shares 380,478 (-5.4%)
UBS Group AG
Value ($000) $10 (-91.5%) Shares 13,286 (-55.7%)
FMR LLC
Value ($000) $1 (-98.8%) Shares 748 (-93.7%)
NORTHERN TRUST CORP
Value ($000) $15 (-86.8%) Shares 20,142 (-30.6%)
MORGAN STANLEY
Value ($000) $3 (-83.6%) Shares 4,269 (-13.8%)
ROYAL BANK OF CANADA
Value ($000) $0 (-100.0%) Shares 124 (-69.1%)
OSAIC HOLDINGS, INC.
Value ($000) $0 (-98.4%) Shares 2 (-88.9%)

Exited Positions (23)

DRIEHAUS CAPITAL MANAGEMENT LLC
Value ($000) $2,438 Shares 620,395
Capital Advisors Wealth Management, LLC
Value ($000) $175 Shares 44,517
Ensign Peak Advisors, Inc
Value ($000) $3,015 Shares 767,287
Alyeska Investment Group, L.P.
Value ($000) $1,793 Shares 456,163
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $418 Shares 106,270
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.
Value ($000) $1,060 Shares 269,734
MARSHALL WACE, LLP
Value ($000) $989 Shares 251,645
BRIDGEWAY CAPITAL MANAGEMENT, LLC
Value ($000) $165 Shares 42,000
GOLDMAN SACHS GROUP INC
Value ($000) $287 Shares 73,126
CITADEL ADVISORS LLC
Value ($000) $113 Shares 28,852
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $113 Shares 28,735
Quadrature Capital Ltd
Value ($000) $65 Shares 16,408
LPL Financial LLC
Value ($000) $100 Shares 25,512
Qube Research & Technologies Ltd
Value ($000) $65 Shares 16,658
DIMENSIONAL FUND ADVISORS LP
Value ($000) $53 Shares 13,397
Tower Research Capital LLC (TRC)
Value ($000) $17 Shares 4,418
DEUTSCHE BANK AG\
Value ($000) $23 Shares 5,922
MAI Capital Management
Value ($000) $0 Shares 32
Groupe la Francaise
Value ($000) $0 Shares 14
SRS Capital Advisors, Inc.
Value ($000) $0 Shares 9