| BlackRock, Inc. | 16,330,103 | $98,471 |
| SB INVESTMENT ADVISERS (UK) LTD | 13,116,977 | $79,095 |
| ARCH Venture Management, LLC | 12,916,663 | $77,887 |
| VANGUARD GROUP INC | 12,548,944 | $75,670 |
| GSK plc | 8,550,954 | $51,562 |
| STATE STREET CORP | 6,229,555 | $37,564 |
| FMR LLC | 3,158,416 | $19,045 |
| MORGAN STANLEY | 2,679,145 | $16,155 |
| DIMENSIONAL FUND ADVISORS LP | 2,536,277 | $15,292 |
| ORBIMED ADVISORS LLC | 2,380,715 | $14,356 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,328,207 | $14,041 |
| GOLDMAN SACHS GROUP INC | 1,568,904 | $9,460 |
| abrdn plc | 1,390,577 | $8,385 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,368,474 | $8,252 |
| Hudson Bay Capital Management LP | 1,325,000 | $7,990 |
| Candriam S.C.A. | 1,031,663 | $6,221 |
| MILLENNIUM MANAGEMENT LLC | 1,002,606 | $6,046 |
| BANK OF AMERICA CORP /DE/ | 930,908 | $5,613 |
| GordonMD Global Investments LP | 930,317 | $5,610 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 904,480 | $5,454 |
| NORTHERN TRUST CORP | 848,469 | $5,116 |
| AMERIPRISE FINANCIAL INC | 731,307 | $4,410 |
| Boxer Capital Management, LLC | 625,000 | $3,769 |
| RENAISSANCE TECHNOLOGIES LLC | 614,464 | $3,705 |
| NORDEA INVESTMENT MANAGEMENT AB | 609,726 | $3,546 |
| Clarius Group, LLC | 608,200 | $3,667 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 598,673 | $3,496 |
| HRT FINANCIAL LP | 591,648 | $4 |
| TWO SIGMA INVESTMENTS, LP | 589,561 | $3,555 |
| TWO SIGMA ADVISERS, LP | 577,700 | $3,484 |
| Ikarian Capital, LLC | 575,712 | $3,472 |
| Nuveen, LLC | 565,544 | $3,410 |
| Bank of New York Mellon Corp | 545,557 | $3,290 |
| BAKER BROS. ADVISORS LP | 542,539 | $3,272 |
| Ensign Peak Advisors, Inc | 531,431 | $3,205 |
| Alta Partners Management Company, L.P. | 509,917 | $3,075 |
| CITADEL ADVISORS LLC | 489,226 | $2,950 |
| Sio Capital Management, LLC | 478,343 | $2,884 |
| PRINCIPAL FINANCIAL GROUP INC | 450,595 | $2,717 |
| JPMORGAN CHASE & CO | 418,603 | $2,524 |
| UBS Group AG | 417,965 | $2,520 |
| Invesco Ltd. | 405,698 | $2,446 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 390,058 | $2,352 |
| PANAGORA ASSET MANAGEMENT INC | 371,291 | $2,239 |
| BARCLAYS PLC | 365,826 | $2,206 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 327,393 | $1,974 |
| Public Sector Pension Investment Board | 326,172 | $1,967 |
| CITIGROUP INC | 311,287 | $1,877 |
| AMERICAN CENTURY COMPANIES INC | 295,391 | $1,781 |
| PRUDENTIAL FINANCIAL INC | 281,542 | $1,698 |
| BNP PARIBAS ARBITRAGE, SA | 279,676 | $1,686 |
| JANE STREET GROUP, LLC | 264,006 | $1,592 |
| Corient Private Wealth LLC | 262,211 | $1,572 |
| Walleye Capital LLC | 256,125 | $1,544 |
| Legal & General Group Plc | 240,643 | $1,451 |
| Eagle Health Investments LP | 240,500 | $1,450 |
| Tejara Capital Ltd | 231,246 | $1,394 |
| RHUMBLINE ADVISERS | 208,359 | $1,256 |
| DEUTSCHE BANK AG\ | 206,222 | $1,244 |
| Allianz Asset Management GmbH | 205,125 | $1,237 |
| Point72 Asset Management, L.P. | 195,718 | $1,180 |
| WINTON GROUP Ltd | 189,306 | $1,142 |
| AQR CAPITAL MANAGEMENT LLC | 186,324 | $1,124 |
| Swiss National Bank | 178,000 | $1,073 |
| ExodusPoint Capital Management, LP | 177,103 | $1,068 |
| BOOTHBAY FUND MANAGEMENT, LLC | 135,701 | $818 |
| Rafferty Asset Management, LLC | 133,766 | $807 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 126,058 | $1 |
| UBS ASSET MANAGEMENT AMERICAS INC | 121,080 | $730 |
| ALLIANCEBERNSTEIN L.P. | 109,620 | $661 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 106,977 | $644 |
| WELLS FARGO & COMPANY/MN | 105,412 | $636 |
| DIADEMA PARTNERS LP | 100,000 | $603 |
| ACADIAN ASSET MANAGEMENT LLC | 97,891 | $1 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,773 | $529 |
| Qube Research & Technologies Ltd | 83,059 | $501 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,611 | $0 |
| Creative Planning | 79,696 | $481 |
| Jain Global LLC | 72,991 | $440 |
| TUDOR INVESTMENT CORP ET AL | 68,574 | $414 |
| LMR Partners LLP | 67,800 | $409 |
| COMMONWEALTH EQUITY SERVICES, LLC | 65,741 | $396 |
| Thrivent Financial for Lutherans | 65,006 | $0 |
| Persistent Asset Partners Ltd | 63,550 | $383 |
| XTX Topco Ltd | 60,078 | $362 |
| Campbell & CO Investment Adviser LLC | 59,784 | $360 |
| SG Americas Securities, LLC | 59,396 | $0 |
| PROFUND ADVISORS LLC | 56,693 | $342 |
| Quinn Opportunity Partners LLC | 50,976 | $307 |
| Quadrature Capital Ltd | 49,800 | $300 |
| D. E. Shaw & Co., Inc. | 49,792 | $300 |
| Brevan Howard Capital Management LP | 49,623 | $299 |
| Susquehanna Portfolio Strategies, LLC | 47,432 | $286 |
| State of Alaska, Department of Revenue | 47,323 | $0 |
| MARTINGALE ASSET MANAGEMENT L P | 44,802 | $270 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 43,745 | $260 |
| Louisiana State Employees Retirement System | 43,300 | $261 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,124 | $242 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 40,118 | $242 |
| Virtus Investment Advisers, LLC | 39,764 | $240 |
| 117 other institutions | 1,447,736 | $8,057 |