| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,567,001 | $29,171 |
| VR Adviser, LLC | 5,345,115 | $28,008 |
| JPMORGAN CHASE & CO | 4,472,756 | $23,437 |
| GREAT POINT PARTNERS LLC | 3,815,930 | $19,995 |
| BRAIDWELL LP | 3,180,389 | $16,665 |
| Pfizer Inc | 2,970,022 | $15,563 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,750,000 | $14,410 |
| Affinity Asset Advisors, LLC | 1,813,671 | $9,504 |
| ARMISTICE CAPITAL, LLC | 1,560,000 | $8,174 |
| MORGAN STANLEY | 1,509,411 | $7,909 |
| Siren, L.L.C. | 1,300,000 | $6,812 |
| MILLENNIUM MANAGEMENT LLC | 1,032,680 | $5,411 |
| MARSHALL WACE, LLP | 877,763 | $4,599 |
| Ikarian Capital, LLC | 802,322 | $4,204 |
| JANE STREET GROUP, LLC | 657,854 | $3,447 |
| VANGUARD GROUP INC | 568,118 | $2,977 |
| ADAR1 Capital Management, LLC | 562,065 | $2,945 |
| FMR LLC | 529,304 | $2,774 |
| UBS Group AG | 470,540 | $2,466 |
| TWO SIGMA INVESTMENTS, LP | 412,423 | $2,161 |
| GEODE CAPITAL MANAGEMENT, LLC | 404,479 | $2,120 |
| BlackRock, Inc. | 369,365 | $1,935 |
| CITADEL ADVISORS LLC | 309,157 | $1,620 |
| RENAISSANCE TECHNOLOGIES LLC | 303,100 | $1,588 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 284,097 | $1,489 |
| BOOTHBAY FUND MANAGEMENT, LLC | 262,283 | $1,374 |
| 683 Capital Management, LLC | 259,165 | $1,358 |
| Point72 Asset Management, L.P. | 226,833 | $1,189 |
| GOLDMAN SACHS GROUP INC | 216,810 | $1,136 |
| Seven Fleet Capital Management LP | 166,500 | $872 |
| STATE STREET CORP | 156,363 | $819 |
| Caption Management, LLC | 155,936 | $817 |
| Alberta Investment Management Corp | 133,200 | $698 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 117,995 | $618 |
| NORTHERN TRUST CORP | 100,836 | $528 |
| TWO SIGMA ADVISERS, LP | 80,400 | $421 |
| Jump Financial, LLC | 77,700 | $407 |
| RBF Capital, LLC | 68,193 | $357 |
| OMERS ADMINISTRATION Corp | 67,200 | $352 |
| XTX Topco Ltd | 66,453 | $348 |
| Hudson Bay Capital Management LP | 63,084 | $331 |
| Dauntless Investment Group, LLC | 61,010 | $320 |
| Qube Research & Technologies Ltd | 59,869 | $314 |
| INSIGNEO ADVISORY SERVICES, LLC | 55,650 | $292 |
| ALPS ADVISORS INC | 53,389 | $280 |
| ACADIAN ASSET MANAGEMENT LLC | 52,040 | $0 |
| Boxer Capital Management, LLC | 50,000 | $262 |
| BARCLAYS PLC | 48,661 | $255 |
| ExodusPoint Capital Management, LP | 46,921 | $246 |
| CITIGROUP INC | 39,759 | $208 |
| Mariner, LLC | 36,616 | $192 |
| Quadrature Capital Ltd | 36,572 | $192 |
| Squarepoint Ops LLC | 33,801 | $177 |
| SIMPLEX TRADING, LLC | 31,161 | $163 |
| RAYMOND JAMES FINANCIAL INC | 26,509 | $139 |
| DIMENSIONAL FUND ADVISORS LP | 23,532 | $123 |
| Lighthouse Investment Partners, LLC | 21,660 | $113 |
| AMERICAN CENTURY COMPANIES INC | 21,383 | $112 |
| Forefront Analytics, LLC | 19,577 | $103 |
| BNP PARIBAS ARBITRAGE, SA | 18,758 | $98 |
| Abel Hall, LLC | 13,190 | $69 |
| BANK OF MONTREAL /CAN/ | 10,000 | $52 |
| Tower Research Capital LLC (TRC) | 8,280 | $43 |
| Allworth Financial LP | 5,750 | $30 |
| BANK OF AMERICA CORP /DE/ | 4,393 | $23 |
| MAI Capital Management | 4,000 | $21 |
| ROYAL BANK OF CANADA | 2,158 | $11 |
| Steward Partners Investment Advisory, LLC | 1,000 | $5 |
| NISA INVESTMENT ADVISORS, LLC | 702 | $4 |
| GROUP ONE TRADING, L.P. | 200 | $1 |
| CWM, LLC | 142 | $0 |
| SBI Securities Co., Ltd. | 138 | $1 |
| SRS Capital Advisors, Inc. | 24 | $0 |
| Optiver Holding B.V. | 16 | $0 |