Location: Luxembourg
CIK: 0001053906 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $2.343B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| XBI | SPDR SER TR | 5,000,000 | $397M | 16.9% | — | — | Call | 78464A870 |
| LXRX | LEXICON PHARMACEUTICALS INC | 89,778,234 | $215M | 9.2% | $5.82 | -52.5% | COM NEW | 528872302 |
| — | MIRATI THERAPEUTICS INC | 1,325,000 | $92.54M | 3.9% | $150.04 | — | COM | 60468T105 |
| ONC | BEIGENE LTD | 650,000 | $87.63M | 3.7% | $156.62 | — | SPONSORED ADR | 07725L102 |
| APLS | APELLIS PHARMACEUTICALS INC | 1,000,000 | $68.3M | 2.9% | $59.17 | 0.0% | COM | 03753U106 |
| — | BELLUS HEALTH INC NEW | 6,000,000 | $63.36M | 2.7% | $5.24 | — | COM NEW | 07987C204 |
| — | MORPHIC HLDG INC | 2,150,000 | $60.84M | 2.6% | $24.53 | — | COM | 61775R105 |
| SRRK | SCHOLAR ROCK HLDG CORP | 8,750,034 | $60.64M | 2.6% | $10.79 | -22.8% | COM | 80706P103 |
| — | SPRINGWORKS THERAPEUTICS INC | 2,053,403 | $58.58M | 2.5% | $39.37 | — | COM | 85205L107 |
| FATE | FATE THERAPEUTICS INC | 2,600,000 | $58.27M | 2.5% | $28.23 | +2.4% | COM | 31189P102 |
| — | WW INTL INC | 14,818,300 | $58.24M | 2.5% | $37.82 | — | COM | 98262P101 |
| — | CEREVEL THERAPEUTICS HLDNG I | 2,000,000 | $56.52M | 2.4% | $19.31 | — | COM | 15678U128 |
| — | IGM BIOSCIENCES INC | 2,450,000 | $55.71M | 2.4% | $54.05 | — | COM | 449585108 |
| ARGX | ARGENX SE | 150,000 | $52.96M | 2.3% | $216.30 | — | SPONSORED ADR | 04016X101 |
| CYTK | CYTOKINETICS INC | 1,000,000 | $48.45M | 2.1% | $29.98 | +60.6% | COM NEW | 23282W605 |
| — | SEAGEN INC | 350,000 | $47.89M | 2.0% | $160.93 | — | COM | 81181C104 |
| — | ALLOVIR INC | 5,577,167 | $44M | 1.9% | $16.06 | — | COM | 019818103 |
| FOLD | AMICUS THERAPEUTICS INC | 4,000,000 | $41.76M | 1.8% | $11.63 | -4.2% | COM | 03152W109 |
| GOSS | GOSSAMER BIO INC | 3,246,624 | $38.9M | 1.7% | $16.20 | -23.4% | COM | 38341P102 |
| SEER | SEER INC | 4,750,000 | $36.77M | 1.6% | $63.62 | -84.7% | COM CL A | 81578P106 |
| KRYS | KRYSTAL BIOTECH INC | 500,000 | $34.85M | 1.5% | $56.38 | +28.1% | COM | 501147102 |
| KYMR | KYMERA THERAPEUTICS INC | 1,500,000 | $32.66M | 1.4% | $42.97 | -38.7% | COM | 501575104 |
| RLAY | RELAY THERAPEUTICS INC | 1,454,716 | $32.54M | 1.4% | $28.27 | -22.4% | COM | 75943R102 |
| — | SAGE THERAPEUTICS INC | 750,000 | $29.37M | 1.3% | $56.59 | — | COM | 78667J108 |
| — | KARUNA THERAPEUTICS INC | 125,000 | $28.12M | 1.2% | $224.93 | — | COM | 48576A100 |
| ERAS | ERASCA INC | 3,172,221 | $24.74M | 1.1% | $20.63 | -61.0% | COM | 29479A108 |
| — | VIGIL NEUROSCIENCE INC | 2,285,574 | $20.8M | 0.9% | $8.08 | — | COM | 92673K108 |
| — | EQRX INC | 4,000,000 | $19.8M | 0.8% | $6.82 | — | COM | 26886C107 |
| DNLI | DENALI THERAPEUTICS INC | 600,000 | $18.41M | 0.8% | $31.47 | +3.3% | COM | 24823R105 |
| SDGR | SCHRODINGER INC | 700,000 | $17.49M | 0.7% | $37.76 | -22.2% | COM | 80810D103 |
| REPL | REPLIMUNE GROUP INC | 900,000 | $15.54M | 0.7% | $20.83 | -8.5% | COM | 76029N106 |
| NTLA | INTELLIA THERAPEUTICS INC | 275,000 | $15.39M | 0.7% | $33.42 | +85.6% | COM | 45826J105 |
| KURA | KURA ONCOLOGY INC | 1,100,000 | $15.03M | 0.6% | $18.02 | -14.4% | COM | 50127T109 |
| — | GENERATION BIO CO | 2,814,191 | $14.94M | 0.6% | $21.00 | — | COM | 37148K100 |
| — | MERSANA THERAPEUTICS INC | 2,200,000 | $14.87M | 0.6% | $14.43 | — | COM | 59045L106 |
| FHTX | FOGHORN THERAPEUTICS INC | 1,720,720 | $14.76M | 0.6% | $19.16 | -32.8% | COM | 344174107 |
| — | VERVE THERAPEUTICS INC | 400,000 | $13.74M | 0.6% | $60.25 | — | COM | 92539P101 |
| — | SEAGEN INC | 100,000 | $13.68M | 0.6% | $160.93 | — | Call | 81181C104 |
| — | IVERIC BIO INC | 750,000 | $13.46M | 0.6% | $17.94 | — | COM | 46583P102 |
| — | OMEGA THERAPEUTICS INC | 2,273,530 | $12.32M | 0.5% | $18.85 | — | COM | 68217N105 |
| WVE | WAVE LIFE SCIENCES LTD | 3,000,000 | $10.83M | 0.5% | $3.30 | +0.2% | SHS | Y95308105 |
| EVO | EVOTEC AG | 1,149,425 | $10.1M | 0.4% | $23.75 | — | SPONSORED ADS | 30050E105 |
| SE | SEA LTD | 172,500 | $9.669M | 0.4% | $77.30 | — | SPONSORED ADS | 81141R100 |
| SYRS | SYROS PHARMACEUTICALS INC | 1,463,829 | $9.427M | 0.4% | $8.12 | 0.0% | COM NEW | 87184Q206 |
| — | IVERIC BIO INC | 500,000 | $8.97M | 0.4% | $17.94 | — | Call | 46583P102 |
| — | ALPINE IMMUNE SCIENCES INC | 1,193,030 | $8.59M | 0.4% | $7.99 | — | COM | 02083G100 |
| — | REPARE THERAPEUTICS INC | 700,000 | $8.491M | 0.4% | $28.89 | — | COM | 760273102 |
| — | AGENUS INC | 4,000,000 | $8.2M | 0.3% | $3.50 | — | COM NEW | 00847G705 |
| — | SELECTA BIOSCIENCES INC | 4,883,200 | $8.008M | 0.3% | $3.12 | — | COM | 816212104 |
| — | ITEOS THERAPEUTICS INC | 400,000 | $7.62M | 0.3% | $24.67 | — | COM | 46565G104 |
| AUPH | AURINIA PHARMACEUTICALS INC | 1,000,000 | $7.52M | 0.3% | $17.08 | -49.3% | COM | 05156V102 |
| — | OMEGA ALPHA SPAC | 750,000 | $7.448M | 0.3% | $9.90 | — | CL A | G6749V107 |
| ONC | BEIGENE LTD | 50,000 | $6.741M | 0.3% | $156.62 | — | Call | 07725L102 |
| DYN | DYNE THERAPEUTICS INC | 525,000 | $6.668M | 0.3% | $20.85 | -45.0% | COM | 26818M108 |
| — | Y-MABS THERAPEUTICS INC | 400,000 | $5.768M | 0.2% | $24.99 | — | COM | 984241109 |
| — | IKENA ONCOLOGY INC | 1,549,513 | $5.501M | 0.2% | $28.25 | — | COM | 45175G108 |
| — | TALARIS THERAPEUTICS INC | 2,064,262 | $5.429M | 0.2% | $14.69 | — | COM | 87410C104 |
| — | KRONOS BIO INC | 1,542,954 | $5.169M | 0.2% | $27.50 | — | COM | 50107A104 |
| — | LYELL IMMUNOPHARMA INC | 700,000 | $5.131M | 0.2% | $16.24 | — | COM | 55083R104 |
| — | ACHILLES THERAPEUTICS PLC | 2,255,375 | $5.097M | 0.2% | $16.55 | — | SPONSORED ADS | 00449L102 |
| RXRX | RECURSION PHARMACEUTICALS IN | 450,000 | $4.788M | 0.2% | $19.06 | -46.9% | CL A | 75629V104 |
| ALXO | ALX ONCOLOGY HLDGS INC | 500,000 | $4.785M | 0.2% | $64.13 | -81.8% | COM | 00166B105 |
| OVID | OVID THERAPEUTICS INC | 2,500,000 | $4.6M | 0.2% | $6.69 | -68.7% | COM | 690469101 |
| — | EXSCIENTIA PLC | 550,000 | $4.516M | 0.2% | $19.76 | — | ADS | 30223G102 |
| NTRA | NATERA INC | 100,000 | $4.382M | 0.2% | $47.60 | 0.0% | COM | 632307104 |
| RNAM | AVIDITY BIOSCIENCES INC | 250,000 | $4.083M | 0.2% | $26.70 | -28.4% | COM | 05370A108 |
| — | OATLY GROUP AB | 1,500,000 | $3.945M | 0.2% | $24.46 | — | SPONSORED ADS | 67421J108 |
| — | CONCERT PHARMACEUTICALS INC | 573,062 | $3.84M | 0.2% | $6.70 | — | COM | 206022105 |
| — | THIRD HARMONIC BIO INC | 200,000 | $3.794M | 0.2% | $18.97 | — | COM | 88427A107 |
| MIR | MIRION TECHNOLOGIES INC | 500,000 | $3.735M | 0.2% | $10.74 | -34.4% | COM CL A | 60471A101 |
| PFTA | PORTAGE FINTECH ACQUISITN CO | 380,000 | $3.713M | 0.2% | $10.00 | — | CLASS A ORD SHS | G7185D106 |
| SQZB | SQZ BIOTECHNOLOGIES CO | 1,606,309 | $3.662M | 0.2% | $28.98 | — | COM | 78472W104 |
| NBTX | NANOBIOTIX | 1,000,000 | $3.54M | 0.2% | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | LEAP THERAPEUTICS INC | 4,000,000 | $3.52M | 0.2% | $2.55 | — | COM | 52187K101 |
| NBP | I MAB | 850,000 | $3.409M | 0.1% | $36.36 | — | SPONSORED ADS | 44975P103 |
| STOK | STOKE THERAPEUTICS INC | 250,000 | $3.21M | 0.1% | $24.59 | -35.2% | COM | 86150R107 |
| CGEM | CULLINAN ONCOLOGY INC | 250,000 | $3.205M | 0.1% | $28.21 | -52.2% | COM | 230031106 |
| ACIU | AC IMMUNE SA | 1,000,000 | $3.16M | 0.1% | $11.29 | -72.1% | SHS | H00263105 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 1,646,517 | $2.783M | 0.1% | $30.42 | -89.9% | COM | 09203E105 |
| — | ZYMEWORKS INC | 450,000 | $2.768M | 0.1% | $43.78 | — | COM | 98985W102 |
| — | PRAXIS PRECISION MEDICINES I | 1,200,000 | $2.724M | 0.1% | $41.24 | — | COM | 74006W108 |
| BBIO | BRIDGEBIO PHARMA INC | 250,000 | $2.485M | 0.1% | $32.20 | -67.7% | COM | 10806X102 |
| — | HOOKIPA PHARMA INC | 1,849,616 | $2.478M | 0.1% | $4.24 | — | COM | 43906K100 |
| SANA | SANA BIOTECHNOLOGY INC | 400,000 | $2.4M | 0.1% | $32.56 | -77.8% | COM | 799566104 |
| — | CYCLERION THERAPEUTICS INC | 2,779,122 | $2.391M | 0.1% | $7.29 | — | COM | 23255M105 |
| — | AMBRX BIOPHARMA INC | 2,152,291 | $2.324M | 0.1% | $13.20 | — | SPONSORED ADS | 02290A102 |
| NERV | MINERVA NEUROSCIENCES INC | 250,000 | $2.308M | 0.1% | $5.92 | 0.0% | COM NEW | 603380205 |
| — | SENTI BIOSCIENCES INC | 1,055,555 | $2.291M | 0.1% | $1.96 | — | COM | 81726A100 |
| — | FUSION PHARMACEUTICALS INC | 750,000 | $2.258M | 0.1% | $9.98 | — | COM | 36118A100 |
| — | APTINYX INC | 6,116,493 | $2.251M | 0.1% | $2.87 | — | COM | 03836N103 |
| — | GRAPHITE BIO INC | 700,000 | $2.219M | 0.1% | $30.73 | — | COM | 38870X104 |
| IMUX | IMMUNIC INC | 700,000 | $2.212M | 0.1% | $10.33 | -59.5% | COM | 4525EP101 |
| — | VOR BIOPHARMA INC | 550,000 | $2.189M | 0.1% | $43.10 | — | COM | 929033108 |
| — | INSTIL BIO INC | 450,000 | $2.178M | 0.1% | $25.08 | — | COM | 45783C101 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,040,882 | $2.009M | 0.1% | $23.52 | -84.6% | COM SHS | 877619106 |
| — | GRITSTONE BIO INC | 750,000 | $1.928M | 0.1% | $12.86 | — | COM | 39868T105 |
| — | 23ANDME HOLDING CO | 661,009 | $1.89M | 0.1% | $6.66 | — | CLASS A COM | 90138Q108 |
| — | 111 INC | 686,431 | $1.84M | 0.1% | $9.49 | — | ADS | 68247Q102 |
| IMMP | IMMUTEP LTD | 1,000,000 | $1.56M | 0.1% | $3.87 | — | SPONSORED ADS | 45257L108 |
| — | KINNATE BIOPHARMA INC | 125,000 | $1.494M | 0.1% | $39.78 | — | COM | 49705R105 |
| — | SOLID BIOSCIENCES INC | 3,000,000 | $1.4M | 0.1% | $4.75 | — | COM | 83422E105 |
| — | TCR2 THERAPEUTICS INC | 750,000 | $1.35M | 0.1% | $19.56 | — | COM | 87808K106 |
| XLO | XILIO THERAPEUTICS INC | 450,000 | $1.31M | 0.1% | $17.03 | -83.7% | COM | 98422T100 |
| MREO | MEREO BIOPHARMA GROUP PLC | 1,500,000 | $1.292M | 0.1% | $3.37 | — | SPON ADS | 589492107 |
| ORIC | ORIC PHARMACEUTICALS INC | 400,000 | $1.28M | 0.1% | $24.42 | -83.6% | COM | 68622P109 |
| ADAG | ADAGENE INC | 1,000,000 | $1.28M | 0.1% | $17.07 | — | ADS | 005329107 |
| — | AXCELLA HEALTH INC | 712,500 | $1.218M | 0.1% | $6.82 | — | COM | 05454B105 |
| CRDF | CARDIFF ONCOLOGY INC | 750,000 | $1.155M | 0.0% | $6.60 | -63.6% | COM | 14147L108 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 110,532 | $1.145M | 0.0% | $13.01 | -12.9% | COM CL A | 46333X108 |
| — | IGM BIOSCIENCES INC | 50,000 | $1.137M | 0.0% | $54.05 | — | Call | 449585108 |
| CRBU | CARIBOU BIOSCIENCES INC | 105,347 | $1.111M | 0.0% | $24.45 | -61.9% | COM | 142038108 |
| — | ARAVIVE INC | 1,311,291 | $1.072M | 0.0% | $11.29 | — | COM | 03890D108 |
| — | MARINUS PHARMACEUTICALS INC | 157,000 | $1.044M | 0.0% | $14.99 | — | COM NEW | 56854Q200 |
| SPRO | SPERO THERAPEUTICS INC | 500,000 | $1M | 0.0% | $11.60 | -91.4% | COM | 84833T103 |
| — | HARPOON THERAPEUTICS INC | 1,000,000 | $970K | 0.0% | $15.27 | — | COM | 41358P106 |
| — | LAVA THERAPEUTICS NV | 200,000 | $914K | 0.0% | $15.19 | — | SHS | N51517105 |
| — | CURIS INC | 1,300,000 | $910K | 0.0% | $3.14 | — | COM NEW | 231269200 |
| — | ORCHARD THERAPEUTICS PLC | 1,803,858 | $902K | 0.0% | $8.41 | — | SPON ADS | 68570P101 |
| — | RUBIUS THERAPEUTICS INC | 2,042,666 | $886K | 0.0% | $20.48 | — | COM | 78116T103 |
| AVTR | AVANTOR INC | 45,000 | $882K | 0.0% | $26.79 | 0.0% | COM | 05352A100 |
| OLMA | OLEMA PHARMACEUTICALS INC | 260,500 | $719K | 0.0% | $46.89 | -91.0% | COM | 68062P106 |
| — | NEXIMMUNE INC | 1,200,000 | $666K | 0.0% | $19.08 | — | COM | 65344D109 |
| — | MINK THERAPEUTICS INC | 289,588 | $611K | 0.0% | $4.46 | — | COM | 603693102 |
| — | METACRINE INC | 924,898 | $449K | 0.0% | $10.21 | — | COM | 59101E103 |
| HIPO | HIPPO HLDGS INC | 24,000 | $445K | 0.0% | $22.11 | 0.0% | COM NEW | 433539202 |
| CRVS | CORVUS PHARMACEUTICALS INC | 500,000 | $409K | 0.0% | $2.96 | -67.8% | COM | 221015100 |
| — | MEI PHARMA INC | 1,000,000 | $387K | 0.0% | $3.78 | — | COM NEW | 55279B202 |
| — | APPLIED THERAPEUTICS INC | 400,000 | $372K | 0.0% | $20.66 | — | COM | 03828A101 |
| ADBE | ADOBE SYSTEMS INCORPORATED | 1,300 | $358K | 0.0% | $378.38 | 0.0% | COM | 00724F101 |
| — | YUMANITY THERAPEUTICS INC | 217,391 | $341K | 0.0% | $17.00 | — | COM | 98872L102 |
| — | ASTRIA THERAPEUTICS INC | 33,333 | $301K | 0.0% | $8.85 | — | COM | 04635X102 |
| — | CONTRAFECT CORP | 1,500,000 | $252K | 0.0% | $4.97 | — | COM NEW | 212326300 |
| — | CODIAK BIOSCIENCES INC | 200,000 | $156K | 0.0% | $15.08 | — | COM | 192010106 |
| — | CIDARA THERAPEUTICS INC | 224,675 | $141K | 0.0% | $3.69 | — | COM | 171757107 |
| — | SIGILON THERAPEUTICS INC | 276,000 | $139K | 0.0% | $48.03 | — | COM | 82657L107 |