Location: Palo Alto, CA
CIK: 0001306923 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $540M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| INSM | INSMED INC | 491,805 | $70.82M | 13.1% | $144.01 * | $17.79 | +588.6% | COM | 457669307 |
| PTCT | PTC THERAPEUTICS INC | 862,613 | $52.94M | 9.8% | $61.37 * | $44.98 | +15.8% | COM | 69366J200 |
| ACAD | ACADIA PHARMACEUTICALS INC | 2,466,684 | $52.64M | 9.7% | $21.34 * | $26.96 | -12.3% | COM | 004225108 |
| FOLD | AMICUS THERAPEUTICS INC | 5,367,798 | $42.3M | 7.8% | $7.88 * | $9.63 | -26.1% | COM | 03152W109 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 754,007 | $40.84M | 7.6% | $54.16 * | $83.16 | -31.2% | COM | 09061G101 |
| BIIB | BIOGEN INC | 185,661 | $26.01M | 4.8% | $140.08 * | $256.18 | -47.2% | SPONSORED ADS | 09062X103 |
| UTHR | UNITED THERAPEUTICS CORP | 58,186 | $24.39M | 4.5% | $419.21 * | $89.23 | +276.9% | COM | 91307C102 |
| ANAB | ANAPTYSBIO INC | 673,520 | $20.62M | 3.8% | $30.62 * | $19.30 | +18.9% | COM | 032724106 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 7,618,132 | $16.53M | 3.1% | $2.17 * | $4.09 | -42.2% | COM NEW | 462260100 |
| NVCR | NOVOCURE LTD | 1,256,159 | $16.23M | 3.0% | $12.92 * | $35.67 | -62.5% | COM | G6674U108 |
| DYN | DYNE THERAPEUTICS INC | 1,262,674 | $15.97M | 3.0% | $12.65 * | $12.01 | -5.1% | SPONSORED ADS | 26818M108 |
| IRON | DISC MEDICINE INC | 224,300 | $14.82M | 2.7% | $66.08 * | $51.36 | +15.8% | COM | 254604101 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 32,320 | $14.74M | 2.7% | $456.00 * | $260.36 | +56.4% | COM | 02043Q107 |
| GOSS | GOSSAMER BIO INC | 5,464,349 | $14.37M | 2.7% | $2.63 * | $1.58 | +39.6% | COM | 38341P102 |
| PRTA | PROTHENA CORP PLC | 1,324,028 | $12.92M | 2.4% | $9.76 * | $20.95 | -63.3% | COM CL A | G72800108 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 369,531 | $11.12M | 2.1% | $30.08 | $30.79 | -2.6% | COM | 90400D108 |
| AGIO | AGIOS PHARMACEUTICALS INC | 265,497 | $10.66M | 2.0% | $40.14 * | $33.17 | +13.4% | COM | 00847X104 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 654,930 | $10.08M | 1.9% | $15.38 * | $15.47 | -15.4% | COM | 87164F105 |
| EHTH | EHEALTH INC | 1,544,619 | $6.657M | 1.2% | $4.31 * | $38.13 | -89.9% | COM | 28238P109 |
| DNLI | DENALI THERAPEUTICS INC | 408,006 | $5.924M | 1.1% | $14.52 | $14.20 | +1.2% | COM | 24823R105 |
| ALGN | ALIGN TECHNOLOGY INC | 45,735 | $5.727M | 1.1% | $125.22 * | $150.48 | +4.1% | COM | 016255101 |
| ALKS | ALKERMES PLC | 183,938 | $5.518M | 1.0% | $30.00 * | $22.36 | +26.1% | COM | G01767105 |
| RNAM | AVIDITY BIOSCIENCES INC | 109,831 | $4.785M | 0.9% | $43.57 * | $29.81 | +35.6% | COM | 05370A108 |
| MIRM | MIRUM PHARMACEUTICALS INC | 64,700 | $4.743M | 0.9% | $73.31 * | $15.56 | +308.6% | COM | 604749101 |
| CDNA | CAREDX INC | 316,204 | $4.598M | 0.9% | $14.54 | $14.26 | 0.0% | COM | 14167L103 |
| TSHA | TAYSHA GENE THERAPIES INC | 1,246,033 | $4.075M | 0.8% | $3.27 * | $1.87 | +51.1% | COM | 877619106 |
| NUVB | NUVATION BIO INC | 1,020,547 | $3.776M | 0.7% | $3.70 * | $2.12 | +28.8% | COM CL A | 67080N101 |
| ACRS | ACLARIS THERAPEUTICS INC | 1,566,840 | $2.977M | 0.6% | $1.90 * | $1.44 | +21.0% | COM | 00461U105 |
| CRSP | CRISPR THERAPEUTICS AG | 41,226 | $2.672M | 0.5% | $64.81 * | $38.70 | +48.4% | NAMEN AKT | H17182108 |
| TVTX | TRAVERE THERAPEUTICS INC | 110,719 | $2.646M | 0.5% | $23.90 * | $23.56 | -20.2% | COM SHS | 89422G107 |
| EW | EDWARDS LIFESCIENCES CORP | 33,640 | $2.616M | 0.5% | $77.77 | $72.66 | +7.5% | COM | 28176E108 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 18,117 | $2.543M | 0.5% | $140.38 * | $129.01 | +5.0% | COM | 64125C109 |
| STOK | STOKE THERAPEUTICS INC | 105,427 | $2.478M | 0.5% | $23.50 * | $6.06 | +182.8% | COM | 86150R107 |
| PYXS | PYXIS ONCOLOGY INC | 1,037,421 | $2.303M | 0.4% | $2.22 * | $2.98 | -51.8% | COM | 747324101 |
| BNTX | BIONTECH SE-ADR | 19,614 | $1.934M | 0.4% | $98.62 | $118.77 | — | COM | 09075V102 |
| BCYC | BICYCLE THERAPEUTICS PLC-ADR | 221,071 | $1.711M | 0.3% | $7.74 | $16.07 | — | COM | 088786108 |
| ALDX | ALDEYRA THERAPEUTICS INC | 225,465 | $1.177M | 0.2% | $5.22 | $5.95 | -12.3% | SPONSORED ADR | 01438T106 |
| HUM | HUMANA INC | 3,985 | $1.037M | 0.2% | $260.17 | $369.63 | -29.3% | COM | 444859102 |
| ORKA | ORUKA THERAPEUTICS INC | 59,985 | $791K | 0.1% | $13.19 * | $14.82 | 0.0% | COM | 687604108 |
| ABEO | ABEONA THERAPEUTICS INC | 108,865 | $575K | 0.1% | $5.28 * | $6.04 | +4.9% | COM NEW | 00289Y206 |
| URGN | UROGEN PHARMA LTD | 24,500 | $489K | 0.1% | $19.95 * | $27.01 | -33.5% | COM | M96088105 |
| PRQR | PROQR THERAPEUTICS NV | 188,807 | $402K | 0.1% | $2.13 * | $2.18 | 0.0% | SHS EURO | N71542109 |
| AKTX | AKARI THERAPEUTICS PLC-ADR | 146,024 | $147K | 0.0% | $1.01 | $1.22 | — | COM | 00972G207 |
| — | GENERATION BIO CO | 15,047 | $92,088 | 0.0% | $6.12 | $2.82 | — | COM | 37148K100 |