Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $540,390 (100.0% shares, 0.0% debt)

Holdings (44)

INSM INSMED INC 13.1%
Value ($000) $70,825 Shares 491,805 Est. Cost $17.79 Unrealized +588.6%
PTCT PTC THERAPEUTICS INC 9.8%
Value ($000) $52,939 Shares 862,613 Est. Cost $44.98 Unrealized +15.8%
ACAD ACADIA PHARMACEUTICALS INC 9.7%
Value ($000) $52,639 Shares 2,466,684 Est. Cost $26.96 Unrealized -12.3%
FOLD AMICUS THERAPEUTICS INC 7.8%
Value ($000) $42,298 Shares 5,367,798 Est. Cost $9.63 Unrealized -26.1%
BMRN BIOMARIN PHARMACEUTICAL INC 7.6%
Value ($000) $40,837 Shares 754,007 Est. Cost $83.16 Unrealized -31.2%
BIIB BIOGEN INC 4.8%
Value ($000) $26,007 Shares 185,661 Est. Cost $256.18 Unrealized -47.2%
UTHR UNITED THERAPEUTICS CORP 4.5%
Value ($000) $24,392 Shares 58,186 Est. Cost $89.23 Unrealized +276.9%
ANAB ANAPTYSBIO INC 3.8%
Value ($000) $20,623 Shares 673,520 Est. Cost $19.30 Unrealized +18.9%
IOVA IOVANCE BIOTHERAPEUTICS INC 3.1%
Value ($000) $16,531 Shares 7,618,132 Est. Cost $4.09 Unrealized -42.2%
NVCR NOVOCURE LTD 3.0%
Value ($000) $16,230 Shares 1,256,159 Est. Cost $35.67 Unrealized -62.5%
DYN DYNE THERAPEUTICS INC 3.0%
Value ($000) $15,973 Shares 1,262,674 Est. Cost $12.01 Unrealized -5.1%
IRON DISC MEDICINE INC 2.7%
Value ($000) $14,822 Shares 224,300 Est. Cost $51.36 Unrealized +15.8%
ALNY ALNYLAM PHARMACEUTICALS INC 2.7%
Value ($000) $14,738 Shares 32,320 Est. Cost $260.36 Unrealized +56.4%
GOSS GOSSAMER BIO INC 2.7%
Value ($000) $14,371 Shares 5,464,349 Est. Cost $1.58 Unrealized +39.6%
PRTA PROTHENA CORP PLC 2.4%
Value ($000) $12,923 Shares 1,324,028 Est. Cost $20.95 Unrealized -63.3%
RARE ULTRAGENYX PHARMACEUTICAL IN 2.1%
Value ($000) $11,115 Shares 369,531 Est. Cost $30.79 Unrealized -2.6%
AGIO AGIOS PHARMACEUTICALS INC 2.0%
Value ($000) $10,657 Shares 265,497 Est. Cost $33.17 Unrealized +13.4%
SNDX SYNDAX PHARMACEUTICALS INC 1.9%
Value ($000) $10,076 Shares 654,930 Est. Cost $15.47 Unrealized -15.4%
EHTH EHEALTH INC 1.2%
Value ($000) $6,657 Shares 1,544,619 Est. Cost $38.13 Unrealized -89.9%
DNLI DENALI THERAPEUTICS INC 1.1%
Value ($000) $5,924 Shares 408,006 Est. Cost $14.20 Unrealized +1.2%
ALGN ALIGN TECHNOLOGY INC 1.1%
Value ($000) $5,727 Shares 45,735 Est. Cost $150.48 Unrealized +4.1%
ALKS ALKERMES PLC 1.0%
Value ($000) $5,518 Shares 183,938 Est. Cost $22.36 Unrealized +26.1%
RNAM AVIDITY BIOSCIENCES INC 0.9%
Value ($000) $4,785 Shares 109,831 Est. Cost $29.81 Unrealized +35.6%
MIRM MIRUM PHARMACEUTICALS INC 0.9%
Value ($000) $4,743 Shares 64,700 Est. Cost $15.56 Unrealized +308.6%
CDNA CAREDX INC 0.9%
Value ($000) $4,598 Shares 316,204 Est. Cost $14.26 Unrealized 0.0%
TSHA TAYSHA GENE THERAPIES INC 0.8%
Value ($000) $4,075 Shares 1,246,033 Est. Cost $1.87 Unrealized +51.1%
NUVB NUVATION BIO INC 0.7%
Value ($000) $3,776 Shares 1,020,547 Est. Cost $2.12 Unrealized +28.8%
ACRS ACLARIS THERAPEUTICS INC 0.6%
Value ($000) $2,977 Shares 1,566,840 Est. Cost $1.44 Unrealized +21.0%
CRSP CRISPR THERAPEUTICS AG 0.5%
Value ($000) $2,672 Shares 41,226 Est. Cost $38.70 Unrealized +48.4%
TVTX TRAVERE THERAPEUTICS INC 0.5%
Value ($000) $2,646 Shares 110,719 Est. Cost $23.56 Unrealized -20.2%
EW EDWARDS LIFESCIENCES CORP 0.5%
Value ($000) $2,616 Shares 33,640 Est. Cost $72.66 Unrealized +7.5%
NBIX NEUROCRINE BIOSCIENCES INC 0.5%
Value ($000) $2,543 Shares 18,117 Est. Cost $129.01 Unrealized +5.0%
STOK STOKE THERAPEUTICS INC 0.5%
Value ($000) $2,478 Shares 105,427 Est. Cost $6.06 Unrealized +182.8%
PYXS PYXIS ONCOLOGY INC 0.4%
Value ($000) $2,303 Shares 1,037,421 Est. Cost $2.98 Unrealized -51.8%
BNTX BIONTECH SE-ADR 0.4%
Value ($000) $1,934 Shares 19,614 Est. Cost $118.77 Unrealized
BCYC BICYCLE THERAPEUTICS PLC-ADR 0.3%
Value ($000) $1,711 Shares 221,071 Est. Cost $16.07 Unrealized
ALDX ALDEYRA THERAPEUTICS INC 0.2%
Value ($000) $1,177 Shares 225,465 Est. Cost $5.95 Unrealized -12.3%
HUM HUMANA INC 0.2%
Value ($000) $1,037 Shares 3,985 Est. Cost $369.63 Unrealized -29.3%
ORKA ORUKA THERAPEUTICS INC 0.1%
Value ($000) $791 Shares 59,985 Est. Cost $14.82 Unrealized 0.0%
ABEO ABEONA THERAPEUTICS INC 0.1%
Value ($000) $575 Shares 108,865 Est. Cost $6.04 Unrealized +4.9%
URGN UROGEN PHARMA LTD 0.1%
Value ($000) $489 Shares 24,500 Est. Cost $27.01 Unrealized -33.5%
PRQR PROQR THERAPEUTICS NV 0.1%
Value ($000) $402 Shares 188,807 Est. Cost $2.18 Unrealized 0.0%
AKTX AKARI THERAPEUTICS PLC-ADR 0.0%
Value ($000) $147 Shares 146,024 Est. Cost $1.22 Unrealized
GENERATION BIO CO 0.0%
Value ($000) $92 Shares 15,047 Est. Cost $2.82 Unrealized