Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q2 2019 (← Previous) (Next →)

Filing Date: Aug 14, 2019

Total Value ($000): $328,094 (100.0% shares, 0.0% debt)

Holdings (43)

CDXS CODEXIS INC 7.6%

Value ($000) $24,881 Shares 1,350,000 Est. Cost $3.21 Unrealized +500.5%

— HARROW HEALTH 5.9%

Value ($000) $19,227 Shares 2,210,000 Est. Cost $4.09 Unrealized —

AXGN AXOGEN INC 5.4%

Value ($000) $17,820 Shares 900,000 Est. Cost $3.33 Unrealized +543.4%

— EPIZYME INC 5.2%

Value ($000) $17,131 Shares 1,365,000 Est. Cost $8.49 Unrealized —

QURE UNIQURE NV 4.9%

Value ($000) $16,021 Shares 205,000 Est. Cost $44.67 Unrealized +42.6%

— ODONATE THERAPEUTICS INC 4.8%

Value ($000) $15,593 Shares 425,000 Est. Cost $24.62 Unrealized —

OCUL OCULAR THERAPEUTIX INC 4.0%

Value ($000) $12,980 Shares 2,950,000 Est. Cost $3.91 Unrealized -5.2%

— AMARIN CORP PLC 3.8%

Value ($000) $12,507 Shares 645,000 Est. Cost $3.50 Unrealized —

— BLUEPRINT MEDICINES CORP 3.6%

Value ($000) $11,791 Shares 125,000 Est. Cost $27.77 Unrealized —

— CERECOR INC 3.4%

Value ($000) $11,176 Shares 2,185,536 Est. Cost $2.99 Unrealized —

— AUDENTES THERAPEUTICS INC 3.2%

Value ($000) $10,601 Shares 280,000 Est. Cost $26.09 Unrealized —

PTCT PTC THERAPEUTICS INC 3.1%

Value ($000) $10,187 Shares 226,388 Est. Cost $28.36 Unrealized +39.2%

— CYTOKINETICS 3.1%

Value ($000) $10,125 Shares 900,000 Est. Cost $8.27 Unrealized —

TGTX TG THERAPEUTICS INC 3.0%

Value ($000) $9,948 Shares 1,150,000 Est. Cost $7.37 Unrealized +2.6%

— EIDOS THERAPEUTICS INC 2.9%

Value ($000) $9,496 Shares 305,550 Est. Cost $21.64 Unrealized —

LXRX LEXICON PHARMACEUTICALS INC 2.8%

Value ($000) $9,309 Shares 1,480,000 Est. Cost $5.99 Unrealized 0.0%

ETON ETON PHARMACEUTICALS INC 2.6%

Value ($000) $8,493 Shares 1,075,000 Est. Cost $6.79 Unrealized +14.4%

— MAGENTA THERAPEUTICS INC 2.4%

Value ($000) $7,891 Shares 535,000 Est. Cost $13.22 Unrealized —

— TRICIDA INC 2.3%

Value ($000) $7,695 Shares 195,000 Est. Cost $31.08 Unrealized —

— DECIPHERA PHARMACEUTICALS IN 2.1%

Value ($000) $6,991 Shares 310,000 Est. Cost $22.57 Unrealized —

— FIBROGEN INC 2.1%

Value ($000) $6,777 Shares 150,000 Est. Cost $26.18 Unrealized —

— BIOHAVEN PHARMACEUTICAL HLDG 2.0%

Value ($000) $6,569 Shares 150,000 Est. Cost $43.79 Unrealized —

— CHIMERIX INC 1.9%

Value ($000) $6,350 Shares 1,470,000 Est. Cost $4.07 Unrealized —

XOMA XOMA CORP DEL 1.8%

Value ($000) $5,944 Shares 400,000 Est. Cost $8.03 Unrealized +86.9%

— AVENUE THERAPEUTICS INC 1.8%

Value ($000) $5,859 Shares 930,000 Est. Cost $5.31 Unrealized —

IRWD IRONWOOD PHARMACEUTICAL INC 1.8%

Value ($000) $5,748 Shares 525,400 Est. Cost $11.20 Unrealized 0.0%

ACAD ACADIA PHARMACEUTICALS INC 1.6%

Value ($000) $5,346 Shares 200,000 Est. Cost $15.92 Unrealized +60.4%

ARVN ARVINAS INC 1.5%

Value ($000) $4,838 Shares 220,000 Est. Cost $21.02 Unrealized 0.0%

— VERMILLION INC 1.2%

Value ($000) $3,783 Shares 4,250,000 Est. Cost $0.89 Unrealized —

— ZYMEWORKS INC 1.1%

Value ($000) $3,744 Shares 170,000 Est. Cost $19.65 Unrealized —

— STRONGBRIDGE BIOPHARMA PLC 1.1%

Value ($000) $3,568 Shares 1,140,000 Est. Cost $4.28 Unrealized —

— FORTRESS BIOTECH INC 1.1%

Value ($000) $3,548 Shares 2,365,000 Est. Cost $1.74 Unrealized —

VKTX VIKING THERAPEUTICS INC 1.0%

Value ($000) $3,320 Shares 400,000 Est. Cost $4.57 Unrealized +86.9%

— AIMMUNE THERAPEUTICS INC 0.8%

Value ($000) $2,708 Shares 130,000 Est. Cost $23.78 Unrealized —

AQST AQUESTIVE THERAPEUTICS INC 0.8%

Value ($000) $2,478 Shares 590,000 Est. Cost $5.12 Unrealized 0.0%

— SYNTHORX INC 0.6%

Value ($000) $2,129 Shares 157,600 Est. Cost $15.25 Unrealized —

— RA PHARMACEUTICALS INC 0.5%

Value ($000) $1,534 Shares 51,000 Est. Cost $30.08 Unrealized —

FENC FENNEC PHARMACEUTICALS INC 0.4%

Value ($000) $1,180 Shares 295,000 Est. Cost $10.08 Unrealized -58.0%

— ARQULE INC 0.3%

Value ($000) $1,101 Shares 100,000 Est. Cost $11.01 Unrealized —

CRNX CRINETICS PHARMACEUTICALS INC 0.3%

Value ($000) $900 Shares 36,000 Est. Cost $24.58 Unrealized +0.8%

— PROTALIX BIOTHERAPEUTICS INC 0.1%

Value ($000) $469 Shares 1,000,000 Est. Cost $0.47 Unrealized —

— AZURRX BIOPHARMA INC 0.1%

Value ($000) $247 Shares 145,000 Est. Cost $1.70 Unrealized —

— BIOLINERX LTD (Does not reflect a reverse stock split effectuated after June 30, 2019) 0.0%

Value ($000) $91 Shares 250,000 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CDXS	CODEXIS INC	1,350,000	$24,881	7.6%	$3.21	+500.5%	COM	192005106
—	HARROW HEALTH	2,210,000	$19,227	5.9%	$4.09	—	COM	45323A201
AXGN	AXOGEN INC	900,000	$17,820	5.4%	$3.33	+543.4%	COM	05463X106
—	EPIZYME INC	1,365,000	$17,131	5.2%	$8.49	—	COM	29428V104
QURE	UNIQURE NV	205,000	$16,021	4.9%	$44.67	+42.6%	SHS	N90064101
—	ODONATE THERAPEUTICS INC	425,000	$15,593	4.8%	$24.62	—	COM	676079106
OCUL	OCULAR THERAPEUTIX INC	2,950,000	$12,980	4.0%	$3.91	-5.2%	COM	67576A100
—	AMARIN CORP PLC	645,000	$12,507	3.8%	$3.50	—	SPONSORED ADR	023111206
—	BLUEPRINT MEDICINES CORP	125,000	$11,791	3.6%	$27.77	—	COM	09627Y109
—	CERECOR INC	2,185,536	$11,176	3.4%	$2.99	—	COM	15671L109
—	AUDENTES THERAPEUTICS INC	280,000	$10,601	3.2%	$26.09	—	COM	05070R104
PTCT	PTC THERAPEUTICS INC	226,388	$10,187	3.1%	$28.36	+39.2%	COM	69366J200
—	CYTOKINETICS	900,000	$10,125	3.1%	$8.27	—	COM NEW	23282W905
TGTX	TG THERAPEUTICS INC	1,150,000	$9,948	3.0%	$7.37	+2.6%	COM	88322Q108
—	EIDOS THERAPEUTICS INC	305,550	$9,496	2.9%	$21.64	—	COM	28249H104
LXRX	LEXICON PHARMACEUTICALS INC	1,480,000	$9,309	2.8%	$5.99	0.0%	COM NEW	528872302
ETON	ETON PHARMACEUTICALS INC	1,075,000	$8,493	2.6%	$6.79	+14.4%	COM	29772L108
—	MAGENTA THERAPEUTICS INC	535,000	$7,891	2.4%	$13.22	—	COM	55910K108
—	TRICIDA INC	195,000	$7,695	2.3%	$31.08	—	COM	89610F101
—	DECIPHERA PHARMACEUTICALS IN	310,000	$6,991	2.1%	$22.57	—	COM	24344T101
—	FIBROGEN INC	150,000	$6,777	2.1%	$26.18	—	COM	31572Q808
—	BIOHAVEN PHARMACEUTICAL HLDG	150,000	$6,569	2.0%	$43.79	—	COM	G11196105
—	CHIMERIX INC	1,470,000	$6,350	1.9%	$4.07	—	COM	16934W106
XOMA	XOMA CORP DEL	400,000	$5,944	1.8%	$8.03	+86.9%	COM NEW	98419J206
—	AVENUE THERAPEUTICS INC	930,000	$5,859	1.8%	$5.31	—	COM NEW	05360L205
IRWD	IRONWOOD PHARMACEUTICAL INC	525,400	$5,748	1.8%	$11.20	0.0%	COM CLASS A	46333X108
ACAD	ACADIA PHARMACEUTICALS INC	200,000	$5,346	1.6%	$15.92	+60.4%	COM	004225108
ARVN	ARVINAS INC	220,000	$4,838	1.5%	$21.02	0.0%	COM	04335A105
—	VERMILLION INC	4,250,000	$3,783	1.2%	$0.89	—	COM NEW	92407M206
—	ZYMEWORKS INC	170,000	$3,744	1.1%	$19.65	—	COM	98985W102
—	STRONGBRIDGE BIOPHARMA PLC	1,140,000	$3,568	1.1%	$4.28	—	COM	G85347105
—	FORTRESS BIOTECH INC	2,365,000	$3,548	1.1%	$1.74	—	COM	034960Q19
VKTX	VIKING THERAPEUTICS INC	400,000	$3,320	1.0%	$4.57	+86.9%	COM	92686J106
—	AIMMUNE THERAPEUTICS INC	130,000	$2,708	0.8%	$23.78	—	COM	00900T107
AQST	AQUESTIVE THERAPEUTICS INC	590,000	$2,478	0.8%	$5.12	0.0%	COM	03843E104
—	SYNTHORX INC	157,600	$2,129	0.6%	$15.25	—	COM	87167A103
—	RA PHARMACEUTICALS INC	51,000	$1,534	0.5%	$30.08	—	COM	74933V108
FENC	FENNEC PHARMACEUTICALS INC	295,000	$1,180	0.4%	$10.08	-58.0%	COM	31447P100
—	ARQULE INC	100,000	$1,101	0.3%	$11.01	—	COM	04269E107
CRNX	CRINETICS PHARMACEUTICALS INC	36,000	$900	0.3%	$24.58	+0.8%	COM	22663K107
—	PROTALIX BIOTHERAPEUTICS INC	1,000,000	$469	0.1%	$0.47	—	COM	74365A101
—	AZURRX BIOPHARMA INC	145,000	$247	0.1%	$1.70	—	COM	05502L105
—	BIOLINERX LTD (Does not reflect a reverse stock split effectuated after June 30, 2019)	250,000	$91	0.0%	$1426.15	—	SPONSORED ADR	09071M106