Location: New York, NY
CIK: 0001493215 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $4.899B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| ALNY | ALNYLAM PHARMACEUTICALS INC | 1,683,362 | $400M | 8.2% | $95.85 | +122.5% | COM | 02043Q107 |
| — | PROMETHEUS BIOSCIENCES INC | 3,354,303 | $369M | 7.5% | $22.06 | — | COM | 74349U108 |
| RCKT | ROCKET PHARMACEUTICALS INC | 17,687,772 | $346M | 7.1% | $17.75 | +3.7% | COM | 77313F106 |
| IMCR | IMMUNOCORE HLDGS PLC | 5,559,322 | $317M | 6.5% | $41.88 | — | ADS | 45258D105 |
| TMO | THERMO FISHER SCIENTIFIC INC | 435,500 | $240M | 4.9% | $545.57 | -3.8% | COM | 883556102 |
| AXSM | AXSOME THERAPEUTICS INC | 2,980,482 | $230M | 4.7% | $48.24 | +23.9% | COM | 05464T104 |
| MASI | MASIMO CORP | 1,501,493 | $222M | 4.5% | $166.52 | -17.4% | COM | 574795100 |
| PTCT | PTC THERAPEUTICS INC | 5,615,387 | $214M | 4.4% | $36.25 | +14.7% | COM | 69366J200 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 3,966,915 | $184M | 3.8% | $56.88 | -30.9% | COM | 90400D108 |
| ARGX | ARGENX SE | 482,195 | $183M | 3.7% | $324.68 | — | SPONSORED ADR | 04016X101 |
| — | MIRATI THERAPEUTICS INC | 3,643,114 | $165M | 3.4% | $74.50 | — | COM | 60468T105 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 2,374,138 | $156M | 3.2% | $25.47 | +137.2% | COM | G31249108 |
| PEN | PENUMBRA INC | 698,371 | $155M | 3.2% | $259.17 | -24.6% | COM | 70975L107 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 3,084,215 | $137M | 2.8% | $8.74 | +308.6% | COM NEW | 15117B202 |
| RNAM | AVIDITY BIOSCIENCES INC | 5,605,566 | $124M | 2.5% | $26.09 | -42.8% | COM | 05370A108 |
| CYTK | CYTOKINETICS INC | 2,574,198 | $118M | 2.4% | $26.72 | +60.8% | COM NEW | 23282W605 |
| ILMN | ILLUMINA INC | 564,375 | $114M | 2.3% | $341.04 | -39.2% | COM | 452327109 |
| NTRA | NATERA INC | 2,609,283 | $105M | 2.1% | $42.64 | -3.4% | COM | 632307104 |
| VCEL | VERICEL CORP | 3,099,904 | $81.65M | 1.7% | $12.98 | +83.5% | COM | 92346J108 |
| — | CUTERA INC | 1,798,675 | $79.54M | 1.6% | $47.50 | — | COM | 232109108 |
| ACAD | ACADIA PHARMACEUTICALS INC | 3,670,938 | $58.44M | 1.2% | $18.68 | -16.3% | COM | 004225108 |
| GMED | GLOBUS MED INC | 747,685 | $55.53M | 1.1% | $57.59 | +18.2% | CL A | 379577208 |
| — | AXONICS INC | 884,974 | $55.34M | 1.1% | $21.35 | — | COM | 05465P101 |
| VTYX | VENTYX BIOSCIENCES INC | 1,551,778 | $50.88M | 1.0% | $18.95 | +56.3% | COM | 92332V107 |
| RGNX | REGENXBIO INC | 1,845,366 | $41.85M | 0.9% | $34.74 | -34.9% | COM | 75901B107 |
| — | AVADEL PHARMACEUTICALS PLC | 5,741,939 | $41.11M | 0.8% | $7.74 | — | SPONSORED ADR | 05337M104 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 3,591,986 | $39.19M | 0.8% | $22.73 | -62.9% | COM | 74366E102 |
| — | ADICET BIO INC | 4,241,472 | $37.92M | 0.8% | $16.61 | — | COM | 007002108 |
| PMVP | PMV PHARMACEUTICALS INC | 4,356,920 | $37.91M | 0.8% | $23.66 | -55.0% | COM | 69353Y103 |
| TARS | TARSUS PHARMACEUTICALS INC | 2,548,125 | $37.36M | 0.8% | $26.03 | -36.4% | COM | 87650L103 |
| BCYC | BICYCLE THERAPEUTICS PLC | 1,258,587 | $37.25M | 0.8% | $55.45 | — | SPONSORED ADS | 088786108 |
| FULC | FULCRUM THERAPEUTICS INC | 4,993,279 | $36.35M | 0.7% | $11.56 | -43.6% | COM | 359616109 |
| STOK | STOKE THERAPEUTICS INC | 3,870,981 | $35.73M | 0.7% | $26.62 | -60.9% | COM | 86150R107 |
| TXG | 10X GENOMICS INC | 872,592 | $31.8M | 0.6% | $67.28 | -51.4% | CL A COM | 88025U109 |
| — | OYSTER PT PHARMA INC | 2,304,977 | $25.75M | 0.5% | $28.47 | — | COM | 69242L106 |
| — | OLINK HLDG AB | 981,918 | $24.92M | 0.5% | $27.52 | — | SPONSORED ADS | 680710100 |
| — | OUTSET MED INC | 909,652 | $23.49M | 0.5% | $51.37 | — | COM | 690145107 |
| GHRS | GH RESEARCH PLC | 2,168,957 | $21.08M | 0.4% | $20.43 | -47.1% | ORDINARY SHARES | G3855L106 |
| — | IVERIC BIO INC | 821,288 | $17.58M | 0.4% | $17.94 | — | COM | 46583P102 |
| MIST | MILESTONE PHARMACEUTICALS IN | 4,315,102 | $17.09M | 0.3% | $20.06 | -73.8% | COM | 59935V107 |
| — | CINCOR PHARMA INC | 1,389,705 | $17.08M | 0.3% | $17.54 | — | COM | 17240Y109 |
| CCCC | C4 THERAPEUTICS INC | 2,819,472 | $16.63M | 0.3% | $27.93 | -70.3% | COM STK | 12529R107 |
| — | ALLAKOS INC | 1,643,500 | $13.84M | 0.3% | $6.12 | — | COM | 01671P100 |
| CSTL | CASTLE BIOSCIENCES INC | 516,995 | $12.17M | 0.2% | $25.00 | -7.3% | COM | 14843C105 |
| GH | GUARDANT HEALTH INC | 430,887 | $11.72M | 0.2% | $95.11 | -51.9% | COM | 40131M109 |
| TERN | TERNS PHARMACEUTICALS INC | 1,000,000 | $10.18M | 0.2% | $6.66 | 0.0% | COM | 880881107 |
| — | HEALTH SCIENCES ACQ CORP 2 | 1,000,000 | $9.98M | 0.2% | $9.90 | — | ORD SHS | G4411D109 |
| WHWK | AADI BIOSCIENCE INC | 764,701 | $9.811M | 0.2% | $30.48 | -57.2% | COM | 00032Q104 |
| GLUE | MONTE ROSA THERAPEUTICS INC | 1,214,572 | $9.243M | 0.2% | $20.37 | -59.1% | COM | 61225M102 |
| SGHT | SIGHT SCIENCES INC | 665,323 | $8.124M | 0.2% | $32.87 | -71.1% | COM | 82657M105 |
| APYX | APYX MEDICAL CORPORATION | 3,398,279 | $7.952M | 0.2% | $7.55 | -59.6% | COM | 03837C106 |
| URGN | UROGEN PHARMA LTD | 857,464 | $7.606M | 0.2% | $15.85 | -40.3% | COM | M96088105 |
| IMTX | IMMATICS N.V | 845,000 | $7.36M | 0.2% | $10.42 | -0.7% | SHS | N44445109 |
| RLMD | RELMADA THERAPEUTICS INC | 2,067,824 | $7.217M | 0.1% | $29.80 | -70.5% | COM | 75955J402 |
| ROIV | ROIVANT SCIENCES LTD | 802,717 | $6.414M | 0.1% | $8.32 | -33.1% | SHS | G76279101 |
| — | JOUNCE THERAPEUTICS INC | 5,106,341 | $5.668M | 0.1% | $6.72 | — | COM | 481116101 |
| IMUX | IMMUNIC INC | 3,861,290 | $5.406M | 0.1% | $9.69 | -71.9% | COM | 4525EP101 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 500,000 | $5.25M | 0.1% | $6.29 | +41.5% | CLASS A ORD | 61559X104 |
| — | SUMMIT HEALTHCRE ACQUISTN CO | 500,000 | $5.06M | 0.1% | $10.01 | — | UNIT 06/03/2026 | G8566R128 |
| — | ARYA SCIENCES ACQU CORP IV | 500,000 | $5.05M | 0.1% | $10.47 | — | CL A | G31659108 |
| — | ARYA SCIENCES ACQUISITN CORP | 500,000 | $5.045M | 0.1% | $9.88 | — | CLASS A ORD SHS | G31658100 |
| TNYA | TENAYA THERAPEUTICS INC | 2,458,750 | $4.942M | 0.1% | $21.49 | -88.6% | COM | 87990A106 |
| DMTKQ | DERMTECH INC | 2,718,356 | $4.811M | 0.1% | $9.75 | — | COM | 24984K105 |
| — | AKOYA BIOSCIENCES INC | 483,815 | $4.63M | 0.1% | $13.32 | — | COM | 00974H104 |
| TELA | TELA BIO INC | 390,364 | $4.489M | 0.1% | $12.40 | -27.7% | COM | 872381108 |
| BWAY | BRAINSWAY LTD | 1,602,381 | $3.958M | 0.1% | $9.54 | — | SPONSORED ADS | 10501L106 |
| XGN | EXAGEN INC | 1,364,336 | $3.274M | 0.1% | $12.68 | -79.8% | COM | 30068X103 |
| JNJ | JOHNSON & JOHNSON | 18,127 | $3.202M | 0.1% | $119.09 | +31.9% | COM | 478160104 |
| — | MEDICUS SCIENCES ACQUISITION | 300,000 | $3.021M | 0.1% | $9.65 | — | CL A SHS | G5960S108 |
| — | THIRD HARMONIC BIO INC | 609,687 | $2.622M | 0.1% | $18.97 | — | COM | 88427A107 |
| MASS | 908 DEVICES INC | 312,000 | $2.377M | 0.0% | $20.05 | -39.6% | COM | 65443P102 |
| LUNG | PULMONX CORP | 275,000 | $2.318M | 0.0% | $48.68 | -80.5% | COM | 745848101 |
| NYXH | NYXOAH S A | 269,993 | $1.347M | 0.0% | $31.50 | -81.9% | SHS | B6S7WD106 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 600,000 | $1.08M | 0.0% | $10.83 | -82.2% | COM | 63909J108 |
| — | SCIENCE 37 HOLDINGS INC | 2,586,108 | $1.074M | 0.0% | $11.76 | — | COM | 808644108 |
| — | MIROMATRIX MED INC | 280,000 | $837K | 0.0% | $11.65 | — | COM | 60471P108 |
| — | MEDICUS SCIENCES ACQUISITION | 33,331 | $3,000 | 0.0% | $1.02 | — | *W EXP 02/12/202 | G5960S124 |