Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 15, 2025

Total Value ($000): $494,141 (97.9% shares, 2.1% debt)

Holdings (41)

HROW HARROW HEALTH INC 24.1%

Value ($000) $119,259 Shares 3,905,000 Est. Cost $6.33 Unrealized +324.3%

ETON ETON PHARMACEUTICALS INC 8.2%

Value ($000) $40,755 Shares 2,860,000 Est. Cost $5.71 Unrealized +176.8%

IMNM IMMUNOME INC 6.6%

Value ($000) $32,825 Shares 3,529,581 Est. Cost $12.21 Unrealized -32.9%

SNWV SANUWAVE HEALTH INC 6.5%

Value ($000) $32,203 Shares 980,000 Est. Cost $28.49 Unrealized +6.1%

LQDA LIQUIDIA CORPORATION 6.2%

Value ($000) $30,839 Shares 2,475,000 Est. Cost $11.38 Unrealized +30.1%

CDXS CODEXIS INC 6.2%

Value ($000) $30,744 Shares 12,600,000 Est. Cost $2.81 Unrealized -16.5%

RYTM RHYTHM PHARMACEUTICALS INC 6.1%

Value ($000) $30,015 Shares 475,000 Est. Cost $12.73 Unrealized +380.9%

TGTX TG THERAPEUTICS INC 3.9%

Value ($000) $19,255 Shares 535,000 Est. Cost $13.67 Unrealized +172.4%

OCUL OCULAR THERAPEUTIX INC 3.0%

Value ($000) $14,802 Shares 1,595,000 Est. Cost $5.10 Unrealized +53.6%

ARVN ARVINAS INC 2.5%

Value ($000) $12,365 Shares 1,680,000 Est. Cost $24.80 Unrealized -70.3%

LRMR LARIMAR THERAPEUTICS INC 2.4%

Value ($000) $11,878 Shares 4,110,000 Est. Cost $2.71 Unrealized -14.5%

IRON DISC MEDICINE INC 2.0%

Value ($000) $9,873 Shares 186,418 Est. Cost $50.91 Unrealized -7.7%

SRPT SAREPTA THERAPEUTICS INC 1.7%

Value ($000) $8,550 Shares 500,000 Est. Cost $42.66 Unrealized 0.0%

— VIGIL NEUROSCIENCES INC 1.6%

Value ($000) $7,950 Shares 1,000,000 Est. Cost $7.95 Unrealized —

CGON CG ONCOLOGY INC 1.4%

Value ($000) $6,916 Shares 266,000 Est. Cost $26.58 Unrealized -9.4%

XOMA XOMA CORP DEL 1.3%

Value ($000) $6,428 Shares 255,087 Est. Cost $11.42 Unrealized +109.8%

EWTX EDGEWISE THERAPEUTICS INC 1.3%

Value ($000) $6,424 Shares 490,000 Est. Cost $10.96 Unrealized +31.6%

STOK STOKE THERAPEUTICS INC 1.3%

Value ($000) $6,380 Shares 562,120 Est. Cost $9.54 Unrealized -0.4%

ANIK ANIKA THERAPEUTICS INC 1.3%

Value ($000) $6,229 Shares 588,797 Est. Cost $15.31 Unrealized -17.6%

— GOSSAMER BIO INC 1.2%

Value ($000) $5,949 Shares 11,500,000 Est. Cost $0.43 Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 1.2%

Value ($000) $5,803 Shares 105,000 Est. Cost $17.50 Unrealized +174.3%

DNA GINKGO BIOWORKS HOLDINGS 1.1%

Value ($000) $5,625 Shares 500,000 Est. Cost $9.56 Unrealized -19.0%

— KARYOPHARM THERAPEUTICS INC 0.9%

Value ($000) $4,556 Shares 6,000,000 Est. Cost $0.62 Unrealized —

GOSS GOSSAMER BIO INC 0.9%

Value ($000) $4,360 Shares 3,545,000 Est. Cost $1.01 Unrealized +8.2%

RZLT REZOLUTE INC 0.8%

Value ($000) $4,029 Shares 903,442 Est. Cost $4.16 Unrealized -10.9%

RVMD REVOLUTION MEDICINES INC 0.8%

Value ($000) $3,863 Shares 105,000 Est. Cost $38.42 Unrealized 0.0%

— ESSA PHARMA INC 0.8%

Value ($000) $3,757 Shares 2,209,998 Est. Cost $1.79 Unrealized —

— CARGO THERAPEUTICS INC 0.6%

Value ($000) $2,746 Shares 666,503 Est. Cost $15.86 Unrealized —

MBX MBX BIOSCIENCES INC 0.6%

Value ($000) $2,731 Shares 239,319 Est. Cost $10.57 Unrealized -3.6%

ZYME ZYMEWORKS INC 0.5%

Value ($000) $2,636 Shares 210,000 Est. Cost $13.35 Unrealized -10.8%

TARA PROTARA THERAPEUTICS INC 0.5%

Value ($000) $2,591 Shares 855,000 Est. Cost $27.06 Unrealized -87.3%

ALMS ALUMIS INC 0.5%

Value ($000) $2,325 Shares 775,000 Est. Cost $4.72 Unrealized 0.0%

ZNTL ZENTALIS PHARMACEUTICALS INC 0.5%

Value ($000) $2,232 Shares 1,924,300 Est. Cost $3.33 Unrealized -60.4%

TRVI TREVI THERAPEUTICS INC 0.4%

Value ($000) $2,133 Shares 390,000 Est. Cost $2.06 Unrealized +202.4%

RCEL AVITA MEDICAL INC 0.4%

Value ($000) $2,061 Shares 389,519 Est. Cost $9.34 Unrealized -22.1%

IRD OPUS GENETICS INC 0.2%

Value ($000) $1,149 Shares 1,220,000 Est. Cost $1.11 Unrealized -16.6%

DERM JOURNEY MEDICAL CORP 0.1%

Value ($000) $682 Shares 95,000 Est. Cost $5.46 Unrealized +26.7%

— ELEVATION ONCOLOGY INC 0.1%

Value ($000) $529 Shares 1,442,061 Est. Cost $0.37 Unrealized —

IBIO IBIO INC 0.1%

Value ($000) $285 Shares 375,000 Est. Cost $1.26 Unrealized -13.7%

PEPG PEPGEN INC 0.1%

Value ($000) $266 Shares 240,000 Est. Cost $4.62 Unrealized -69.4%

ADGM ADAGIO MED HLDGS INC 0.0%

Value ($000) $144 Shares 110,571 Est. Cost $4.76 Unrealized -76.1%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,905,000	$119,259	24.1%	$6.33	+324.3%	COM	415858109
ETON	ETON PHARMACEUTICALS INC	2,860,000	$40,755	8.2%	$5.71	+176.8%	COM	29772L108
IMNM	IMMUNOME INC	3,529,581	$32,825	6.6%	$12.21	-32.9%	COM	45257U108
SNWV	SANUWAVE HEALTH INC	980,000	$32,203	6.5%	$28.49	+6.1%	COM	80303D305
LQDA	LIQUIDIA CORPORATION	2,475,000	$30,839	6.2%	$11.38	+30.1%	COM NEW	53635D202
CDXS	CODEXIS INC	12,600,000	$30,744	6.2%	$2.81	-16.5%	COM	192005106
RYTM	RHYTHM PHARMACEUTICALS INC	475,000	$30,015	6.1%	$12.73	+380.9%	COM	76243J105
TGTX	TG THERAPEUTICS INC	535,000	$19,255	3.9%	$13.67	+172.4%	COM	88322Q108
OCUL	OCULAR THERAPEUTIX INC	1,595,000	$14,802	3.0%	$5.10	+53.6%	COM	67576A100
ARVN	ARVINAS INC	1,680,000	$12,365	2.5%	$24.80	-70.3%	COM	04335A105
LRMR	LARIMAR THERAPEUTICS INC	4,110,000	$11,878	2.4%	$2.71	-14.5%	COM	517125100
IRON	DISC MEDICINE INC	186,418	$9,873	2.0%	$50.91	-7.7%	COM	254604101
SRPT	SAREPTA THERAPEUTICS INC	500,000	$8,550	1.7%	$42.66	0.0%	COM	803607100
—	VIGIL NEUROSCIENCES INC	1,000,000	$7,950	1.6%	$7.95	—	COM	92673K108
CGON	CG ONCOLOGY INC	266,000	$6,916	1.4%	$26.58	-9.4%	COM	156944100
XOMA	XOMA CORP DEL	255,087	$6,428	1.3%	$11.42	+109.8%	COM NEW	98419J206
EWTX	EDGEWISE THERAPEUTICS INC	490,000	$6,424	1.3%	$10.96	+31.6%	COM	28036F105
STOK	STOKE THERAPEUTICS INC	562,120	$6,380	1.3%	$9.54	-0.4%	COM	86150R107
ANIK	ANIKA THERAPEUTICS INC	588,797	$6,229	1.3%	$15.31	-17.6%	COM	035255108
—	GOSSAMER BIO INC	11,500,000	$5,949	1.2%	$0.43	—	NOTE 5.000% 6/0	38341PAA0
PTGX	PROTAGONIST THERAPEUTICS INC	105,000	$5,803	1.2%	$17.50	+174.3%	COM	74366E102
DNA	GINKGO BIOWORKS HOLDINGS	500,000	$5,625	1.1%	$9.56	-19.0%	Class A New	37611X209
—	KARYOPHARM THERAPEUTICS INC	6,000,000	$4,556	0.9%	$0.62	—	NOTE 3.000%10/1	48576UAA4
GOSS	GOSSAMER BIO INC	3,545,000	$4,360	0.9%	$1.01	+8.2%	COM	38341P102
RZLT	REZOLUTE INC	903,442	$4,029	0.8%	$4.16	-10.9%	COM NEW	76200L309
RVMD	REVOLUTION MEDICINES INC	105,000	$3,863	0.8%	$38.42	0.0%	COM	76155X100
—	ESSA PHARMA INC	2,209,998	$3,757	0.8%	$1.79	—	COM NEW	29668H708
—	CARGO THERAPEUTICS INC	666,503	$2,746	0.6%	$15.86	—	COM	14179K101
MBX	MBX BIOSCIENCES INC	239,319	$2,731	0.6%	$10.57	-3.6%	COM	55287L101
ZYME	ZYMEWORKS INC	210,000	$2,636	0.5%	$13.35	-10.8%	COM	98985Y108
TARA	PROTARA THERAPEUTICS INC	855,000	$2,591	0.5%	$27.06	-87.3%	COM STK	74365U107
ALMS	ALUMIS INC	775,000	$2,325	0.5%	$4.72	0.0%	COM	022307102
ZNTL	ZENTALIS PHARMACEUTICALS INC	1,924,300	$2,232	0.5%	$3.33	-60.4%	COM	98943L107
TRVI	TREVI THERAPEUTICS INC	390,000	$2,133	0.4%	$2.06	+202.4%	COM	89532M101
RCEL	AVITA MEDICAL INC	389,519	$2,061	0.4%	$9.34	-22.1%	COM	05380C102
IRD	OPUS GENETICS INC	1,220,000	$1,149	0.2%	$1.11	-16.6%	COM	67577R102
DERM	JOURNEY MEDICAL CORP	95,000	$682	0.1%	$5.46	+26.7%	COM	48115J109
—	ELEVATION ONCOLOGY INC	1,442,061	$529	0.1%	$0.37	—	COM	28623U101
IBIO	IBIO INC	375,000	$285	0.1%	$1.26	-13.7%	COM NEW	451033708
PEPG	PEPGEN INC	240,000	$266	0.1%	$4.62	-69.4%	COM	713317105
ADGM	ADAGIO MED HLDGS INC	110,571	$144	0.0%	$4.76	-76.1%	COM	00534B100