Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $707,321 (99.3% shares, 0.7% debt)

Holdings (43)

HROW HARROW HEALTH INC 26.6%

Value ($000) $188,143 Shares 3,905,000 Est. Cost $6.33 Unrealized +494.8%

ETON ETON PHARMACEUTICALS INC 8.8%

Value ($000) $62,148 Shares 2,860,000 Est. Cost $5.71 Unrealized +190.6%

LQDA LIQUIDIA CORPORATION 8.4%

Value ($000) $59,465 Shares 2,615,000 Est. Cost $11.93 Unrealized +81.8%

RYTM RHYTHM PHARMACEUTICALS INC 6.6%

Value ($000) $46,627 Shares 461,700 Est. Cost $12.73 Unrealized +629.2%

IMNM IMMUNOME INC 5.3%

Value ($000) $37,296 Shares 3,185,000 Est. Cost $12.21 Unrealized -18.5%

SNWV SANUWAVE HEALTH INC 5.2%

Value ($000) $36,730 Shares 980,000 Est. Cost $28.49 Unrealized +30.0%

CDXS CODEXIS INC 4.4%

Value ($000) $31,220 Shares 12,795,000 Est. Cost $2.81 Unrealized -2.9%

TGTX TG THERAPEUTICS INC 2.7%

Value ($000) $19,327 Shares 535,000 Est. Cost $13.67 Unrealized +141.0%

OCUL OCULAR THERAPEUTIX INC 2.6%

Value ($000) $18,646 Shares 1,595,000 Est. Cost $5.10 Unrealized +134.7%

CGON CG ONCOLOGY INC 2.3%

Value ($000) $16,515 Shares 410,000 Est. Cost $27.46 Unrealized +5.9%

STOK STOKE THERAPEUTICS INC 2.3%

Value ($000) $16,027 Shares 682,017 Est. Cost $10.87 Unrealized +57.6%

APGE APOGEE THERAPEUTICS INC 2.0%

Value ($000) $14,432 Shares 363,257 Est. Cost $38.18 Unrealized 0.0%

ALKS ALKERMES PLC 1.9%

Value ($000) $13,500 Shares 450,000 Est. Cost $28.20 Unrealized 0.0%

IRON DISC MEDICINE INC 1.8%

Value ($000) $12,805 Shares 193,773 Est. Cost $51.23 Unrealized +16.1%

SRPT SAREPTA THERAPEUTICS INC 1.6%

Value ($000) $11,273 Shares 585,000 Est. Cost $39.05 Unrealized -54.4%

LRMR LARIMAR THERAPEUTICS INC 1.5%

Value ($000) $10,565 Shares 3,720,867 Est. Cost $2.71 Unrealized +38.4%

XOMA XOMA CORP DEL 1.4%

Value ($000) $9,831 Shares 255,087 Est. Cost $11.42 Unrealized +172.0%

RZLT REZOLUTE INC 1.2%

Value ($000) $8,492 Shares 903,442 Est. Cost $4.16 Unrealized +59.9%

ARVN ARVINAS INC 1.2%

Value ($000) $8,416 Shares 987,818 Est. Cost $24.80 Unrealized -69.4%

EWTX EDGEWISE THERAPEUTICS INC 1.1%

Value ($000) $8,110 Shares 500,000 Est. Cost $11.02 Unrealized +28.7%

ANNX ANNEXON INC 1.1%

Value ($000) $7,930 Shares 2,600,000 Est. Cost $2.48 Unrealized 0.0%

GOSS GOSSAMER BIO INC 1.0%

Value ($000) $7,167 Shares 2,725,000 Est. Cost $1.01 Unrealized +118.8%

PTGX PROTAGONIST THERAPEUTICS INC 1.0%

Value ($000) $6,975 Shares 105,000 Est. Cost $17.50 Unrealized +224.8%

DERM JOURNEY MEDICAL CORP 1.0%

Value ($000) $6,914 Shares 971,064 Est. Cost $7.08 Unrealized +2.5%

SLGL SOL GEL TECHNOLOGIES 0.8%

Value ($000) $5,971 Shares 204,835 Est. Cost $17.69 Unrealized 0.0%

PLX PROTALIX BIOTHERAPEUTICS INC 0.8%

Value ($000) $5,729 Shares 2,580,556 Est. Cost $1.63 Unrealized 0.0%

TMCI TREACE MEDICAL CONCEPTS INC 0.7%

Value ($000) $4,712 Shares 702,245 Est. Cost $6.53 Unrealized 0.0%

RVMD REVOLUTION MEDICINES INC 0.7%

Value ($000) $4,670 Shares 100,000 Est. Cost $38.42 Unrealized +1.9%

— KARYOPHARM THERAPEUTICS INC 0.7%

Value ($000) $4,631 Shares 6,000,000 Est. Cost $0.62 Unrealized —

MBX MBX BIOSCIENCES INC 0.6%

Value ($000) $4,428 Shares 253,000 Est. Cost $10.72 Unrealized +24.7%

TRVI TREVI THERAPEUTICS INC 0.5%

Value ($000) $3,569 Shares 390,000 Est. Cost $2.06 Unrealized +264.5%

ADCT ADC Therapeutics SA 0.4%

Value ($000) $2,730 Shares 682,529 Est. Cost $3.15 Unrealized 0.0%

ALMS ALUMIS INC 0.4%

Value ($000) $2,653 Shares 665,000 Est. Cost $4.72 Unrealized -12.8%

CABA CABALETTA BIO INC 0.3%

Value ($000) $1,893 Shares 808,882 Est. Cost $1.72 Unrealized 0.0%

IRD OPUS GENETICS INC 0.3%

Value ($000) $1,815 Shares 1,100,000 Est. Cost $1.11 Unrealized +11.9%

ZYME ZYMEWORKS INC 0.2%

Value ($000) $1,708 Shares 100,000 Est. Cost $13.35 Unrealized +7.2%

SYRE SPYRE THERAPEUTICS INC 0.2%

Value ($000) $1,089 Shares 65,000 Est. Cost $16.31 Unrealized 0.0%

RIGL RIGEL PHARMACEUTICALS 0.2%

Value ($000) $1,071 Shares 37,787 Est. Cost $29.91 Unrealized 0.0%

ACOG ALPHA COGNITION INC 0.1%

Value ($000) $750 Shares 115,142 Est. Cost $9.11 Unrealized 0.0%

ZNTL ZENTALIS PHARMACEUTICALS INC 0.1%

Value ($000) $478 Shares 316,550 Est. Cost $3.33 Unrealized -55.0%

PEPG PEPGEN INC 0.0%

Value ($000) $347 Shares 75,000 Est. Cost $4.62 Unrealized -65.1%

IBIO IBIO INC 0.0%

Value ($000) $310 Shares 375,000 Est. Cost $1.26 Unrealized -38.9%

ADGM ADAGIO MED HLDGS INC 0.0%

Value ($000) $215 Shares 110,571 Est. Cost $4.76 Unrealized -67.4%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,905,000	$188,143	26.6%	$6.33	+494.8%	COM	415858109
ETON	ETON PHARMACEUTICALS INC	2,860,000	$62,148	8.8%	$5.71	+190.6%	COM	29772L108
LQDA	LIQUIDIA CORPORATION	2,615,000	$59,465	8.4%	$11.93	+81.8%	COM NEW	53635D202
RYTM	RHYTHM PHARMACEUTICALS INC	461,700	$46,627	6.6%	$12.73	+629.2%	COM	76243J105
IMNM	IMMUNOME INC	3,185,000	$37,296	5.3%	$12.21	-18.5%	COM	45257U108
SNWV	SANUWAVE HEALTH INC	980,000	$36,730	5.2%	$28.49	+30.0%	COM	80303D305
CDXS	CODEXIS INC	12,795,000	$31,220	4.4%	$2.81	-2.9%	COM	192005106
TGTX	TG THERAPEUTICS INC	535,000	$19,327	2.7%	$13.67	+141.0%	COM	88322Q108
OCUL	OCULAR THERAPEUTIX INC	1,595,000	$18,646	2.6%	$5.10	+134.7%	COM	67576A100
CGON	CG ONCOLOGY INC	410,000	$16,515	2.3%	$27.46	+5.9%	COM	156944100
STOK	STOKE THERAPEUTICS INC	682,017	$16,027	2.3%	$10.87	+57.6%	COM	86150R107
APGE	APOGEE THERAPEUTICS INC	363,257	$14,432	2.0%	$38.18	0.0%	COM	03770N101
ALKS	ALKERMES PLC	450,000	$13,500	1.9%	$28.20	0.0%	SHS	G01767105
IRON	DISC MEDICINE INC	193,773	$12,805	1.8%	$51.23	+16.1%	COM	254604101
SRPT	SAREPTA THERAPEUTICS INC	585,000	$11,273	1.6%	$39.05	-54.4%	COM	803607100
LRMR	LARIMAR THERAPEUTICS INC	3,720,867	$10,565	1.5%	$2.71	+38.4%	COM	517125100
XOMA	XOMA CORP DEL	255,087	$9,831	1.4%	$11.42	+172.0%	COM NEW	98419J206
RZLT	REZOLUTE INC	903,442	$8,492	1.2%	$4.16	+59.9%	COM NEW	76200L309
ARVN	ARVINAS INC	987,818	$8,416	1.2%	$24.80	-69.4%	COM	04335A105
EWTX	EDGEWISE THERAPEUTICS INC	500,000	$8,110	1.1%	$11.02	+28.7%	COM	28036F105
ANNX	ANNEXON INC	2,600,000	$7,930	1.1%	$2.48	0.0%	COM	03589W102
GOSS	GOSSAMER BIO INC	2,725,000	$7,167	1.0%	$1.01	+118.8%	COM	38341P102
PTGX	PROTAGONIST THERAPEUTICS INC	105,000	$6,975	1.0%	$17.50	+224.8%	COM	74366E102
DERM	JOURNEY MEDICAL CORP	971,064	$6,914	1.0%	$7.08	+2.5%	COM	48115J109
SLGL	SOL GEL TECHNOLOGIES	204,835	$5,971	0.8%	$17.69	0.0%	SHS NEW	M8694L137
PLX	PROTALIX BIOTHERAPEUTICS INC	2,580,556	$5,729	0.8%	$1.63	0.0%	COM	74365A309
TMCI	TREACE MEDICAL CONCEPTS INC	702,245	$4,712	0.7%	$6.53	0.0%	COM	89455T109
RVMD	REVOLUTION MEDICINES INC	100,000	$4,670	0.7%	$38.42	+1.9%	COM	76155X100
—	KARYOPHARM THERAPEUTICS INC	6,000,000	$4,631	0.7%	$0.62	—	NOTE 3.000%10/1	48576UAA4
MBX	MBX BIOSCIENCES INC	253,000	$4,428	0.6%	$10.72	+24.7%	COM	55287L101
TRVI	TREVI THERAPEUTICS INC	390,000	$3,569	0.5%	$2.06	+264.5%	COM	89532M101
ADCT	ADC Therapeutics SA	682,529	$2,730	0.4%	$3.15	0.0%	SHS	H0036K147
ALMS	ALUMIS INC	665,000	$2,653	0.4%	$4.72	-12.8%	COM	022307102
CABA	CABALETTA BIO INC	808,882	$1,893	0.3%	$1.72	0.0%	COM	12674W109
IRD	OPUS GENETICS INC	1,100,000	$1,815	0.3%	$1.11	+11.9%	COM	67577R102
ZYME	ZYMEWORKS INC	100,000	$1,708	0.2%	$13.35	+7.2%	COM	98985Y108
SYRE	SPYRE THERAPEUTICS INC	65,000	$1,089	0.2%	$16.31	0.0%	COM NEW	00773J202
RIGL	RIGEL PHARMACEUTICALS	37,787	$1,071	0.2%	$29.91	0.0%	COM	766559702
ACOG	ALPHA COGNITION INC	115,142	$750	0.1%	$9.11	0.0%	COM NEW	02074J501
ZNTL	ZENTALIS PHARMACEUTICALS INC	316,550	$478	0.1%	$3.33	-55.0%	COM	98943L107
PEPG	PEPGEN INC	75,000	$347	0.0%	$4.62	-65.1%	COM	713317105
IBIO	IBIO INC	375,000	$310	0.0%	$1.26	-38.9%	COM NEW	451033708
ADGM	ADAGIO MED HLDGS INC	110,571	$215	0.0%	$4.76	-67.4%	COM	00534B100