Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $707M (99.3% shares, 0.7% debt)

Holdings (43)

HROW HARROW HEALTH INC 26.6%
Value $188M Shares 3,905,000 Est. Cost $6.33 Unrealized +494.8%
ETON ETON PHARMACEUTICALS INC 8.8%
Value $62.15M Shares 2,860,000 Est. Cost $5.71 Unrealized +190.6%
LQDA LIQUIDIA CORPORATION 8.4%
Value $59.47M Shares 2,615,000 Est. Cost $11.93 Unrealized +81.8%
RYTM RHYTHM PHARMACEUTICALS INC 6.6%
Value $46.63M Shares 461,700 Est. Cost $12.73 Unrealized +629.2%
IMNM IMMUNOME INC 5.3%
Value $37.3M Shares 3,185,000 Est. Cost $12.21 Unrealized -18.5%
SNWV SANUWAVE HEALTH INC 5.2%
Value $36.73M Shares 980,000 Est. Cost $28.49 Unrealized +30.0%
CDXS CODEXIS INC 4.4%
Value $31.22M Shares 12,795,000 Est. Cost $2.81 Unrealized -2.9%
TGTX TG THERAPEUTICS INC 2.7%
Value $19.33M Shares 535,000 Est. Cost $13.67 Unrealized +141.0%
OCUL OCULAR THERAPEUTIX INC 2.6%
Value $18.65M Shares 1,595,000 Est. Cost $5.10 Unrealized +134.7%
CGON CG ONCOLOGY INC 2.3%
Value $16.51M Shares 410,000 Est. Cost $27.46 Unrealized +5.9%
STOK STOKE THERAPEUTICS INC 2.3%
Value $16.03M Shares 682,017 Est. Cost $10.87 Unrealized +57.6%
APGE APOGEE THERAPEUTICS INC 2.0%
Value $14.43M Shares 363,257 Est. Cost $38.18 Unrealized 0.0%
ALKS ALKERMES PLC 1.9%
Value $13.5M Shares 450,000 Est. Cost $28.20 Unrealized 0.0%
IRON DISC MEDICINE INC 1.8%
Value $12.8M Shares 193,773 Est. Cost $51.23 Unrealized +16.1%
SRPT SAREPTA THERAPEUTICS INC 1.6%
Value $11.27M Shares 585,000 Est. Cost $39.05 Unrealized -54.4%
LRMR LARIMAR THERAPEUTICS INC 1.5%
Value $10.56M Shares 3,720,867 Est. Cost $2.71 Unrealized +38.4%
XOMA XOMA CORP DEL 1.4%
Value $9.831M Shares 255,087 Est. Cost $11.42 Unrealized +172.0%
RZLT REZOLUTE INC 1.2%
Value $8.492M Shares 903,442 Est. Cost $4.16 Unrealized +59.9%
ARVN ARVINAS INC 1.2%
Value $8.416M Shares 987,818 Est. Cost $24.80 Unrealized -69.4%
EWTX EDGEWISE THERAPEUTICS INC 1.1%
Value $8.11M Shares 500,000 Est. Cost $11.02 Unrealized +28.7%
ANNX ANNEXON INC 1.1%
Value $7.93M Shares 2,600,000 Est. Cost $2.48 Unrealized 0.0%
GOSS GOSSAMER BIO INC 1.0%
Value $7.167M Shares 2,725,000 Est. Cost $1.01 Unrealized +118.8%
PTGX PROTAGONIST THERAPEUTICS INC 1.0%
Value $6.975M Shares 105,000 Est. Cost $17.50 Unrealized +224.8%
DERM JOURNEY MEDICAL CORP 1.0%
Value $6.914M Shares 971,064 Est. Cost $7.08 Unrealized +2.5%
SLGL SOL GEL TECHNOLOGIES 0.8%
Value $5.971M Shares 204,835 Est. Cost $17.69 Unrealized 0.0%
PLX PROTALIX BIOTHERAPEUTICS INC 0.8%
Value $5.729M Shares 2,580,556 Est. Cost $1.63 Unrealized 0.0%
TMCI TREACE MEDICAL CONCEPTS INC 0.7%
Value $4.712M Shares 702,245 Est. Cost $6.53 Unrealized 0.0%
RVMD REVOLUTION MEDICINES INC 0.7%
Value $4.67M Shares 100,000 Est. Cost $38.42 Unrealized +1.9%
KARYOPHARM THERAPEUTICS INC 0.7%
Value $4.631M Shares 6,000,000 Est. Cost $0.62 Unrealized
MBX MBX BIOSCIENCES INC 0.6%
Value $4.428M Shares 253,000 Est. Cost $10.72 Unrealized +24.7%
TRVI TREVI THERAPEUTICS INC 0.5%
Value $3.568M Shares 390,000 Est. Cost $2.06 Unrealized +264.5%
ADCT ADC Therapeutics SA 0.4%
Value $2.73M Shares 682,529 Est. Cost $3.15 Unrealized 0.0%
ALMS ALUMIS INC 0.4%
Value $2.653M Shares 665,000 Est. Cost $4.72 Unrealized -12.8%
CABA CABALETTA BIO INC 0.3%
Value $1.893M Shares 808,882 Est. Cost $1.72 Unrealized 0.0%
IRD OPUS GENETICS INC 0.3%
Value $1.815M Shares 1,100,000 Est. Cost $1.11 Unrealized +11.9%
ZYME ZYMEWORKS INC 0.2%
Value $1.708M Shares 100,000 Est. Cost $13.35 Unrealized +7.2%
SYRE SPYRE THERAPEUTICS INC 0.2%
Value $1.089M Shares 65,000 Est. Cost $16.31 Unrealized 0.0%
RIGL RIGEL PHARMACEUTICALS 0.2%
Value $1.071M Shares 37,787 Est. Cost $29.91 Unrealized 0.0%
ACOG ALPHA COGNITION INC 0.1%
Value $750K Shares 115,142 Est. Cost $9.11 Unrealized 0.0%
ZNTL ZENTALIS PHARMACEUTICALS INC 0.1%
Value $478K Shares 316,550 Est. Cost $3.33 Unrealized -55.0%
PEPG PEPGEN INC 0.0%
Value $347K Shares 75,000 Est. Cost $4.62 Unrealized -65.1%
IBIO IBIO INC 0.0%
Value $310K Shares 375,000 Est. Cost $1.26 Unrealized -38.9%
ADGM ADAGIO MED HLDGS INC 0.0%
Value $215K Shares 110,571 Est. Cost $4.76 Unrealized -67.4%