PLIANT THERAPEUTICS INC

Institution	Shares	Value ($000)
BML Capital Management, LLC	1,546,137	$1,886
DIADEMA PARTNERS LP	144,914	$177
Persistent Asset Partners Ltd	38,831	$47
Centiva Capital, LP	1,000,000	$1,220
Laurion Capital Management LP	257,400	$314
ADAR1 Capital Management, LLC	73,819	$90
Bronte Capital Management Pty Ltd.	18,613	$23
CANADA PENSION PLAN INVESTMENT BOARD	61,400	$75
Bare Financial Services, Inc	413	$1
HRT FINANCIAL LP	32,205	$0

Increased Positions (28)

Prosight Management, LP

Value ($000) $1,898 (+6159.7%) Shares 1,555,744 (+7493.8%)

Monaco Asset Management SAM

Value ($000) $2,365 (+94.3%) Shares 1,938,747 (+135.7%)

Rangeley Capital, LLC

Value ($000) $275 (+208.0%) Shares 225,000 (+273.6%)

TORNO CAPITAL, LLC

Value ($000) $390 (+101.5%) Shares 320,000 (+144.4%)

GSA CAPITAL PARTNERS LLP

Value ($000) $1 (+219.7%) Shares 623,698 (+287.7%)

TANG CAPITAL MANAGEMENT LLC

Value ($000) $7,495 (-15.6%) Shares 6,143,132 (+2.3%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $392 (+222.0%) Shares 321,530 (+290.7%)

Redmile Group, LLC

Value ($000) $1,972 (-16.3%) Shares 1,616,228 (+1.5%)

MARSHALL WACE, LLP

Value ($000) $1,318 (+197.3%) Shares 1,080,128 (+260.7%)

XTX Topco Ltd

Value ($000) $665 (-3.8%) Shares 545,016 (+16.7%)

Connor, Clark & Lunn Investment Management Ltd.

Value ($000) $454 (+1159.7%) Shares 371,951 (+1428.1%)

JACOBS LEVY EQUITY MANAGEMENT, INC

Value ($000) $679 (+25.1%) Shares 556,938 (+51.7%)

JANE STREET GROUP, LLC

Value ($000) $798 (+41.7%) Shares 653,774 (+71.9%)

CITADEL ADVISORS LLC

Value ($000) $3,152 (-9.0%) Shares 2,583,332 (+10.4%)

TWO SIGMA ADVISERS, LP

Value ($000) $1,520 (-4.3%) Shares 1,245,600 (+16.1%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,163 (+0.3%) Shares 953,293 (+21.7%)

Eversept Partners, LP

Value ($000) $1,027 (-15.8%) Shares 842,023 (+2.1%)

Quadrature Capital Ltd

Value ($000) $119 (+115.4%) Shares 97,891 (+160.4%)

Squarepoint Ops LLC

Value ($000) $121 (+141.2%) Shares 99,018 (+192.6%)

VANGUARD GROUP INC

Value ($000) $3,438 (-16.3%) Shares 2,818,241 (+1.5%)

Institution	Prev Shares	Curr Shares	Change
Prosight Management, LP	20,487	1,555,744	+1,535,257 (+7493.8%)
Monaco Asset Management SAM	822,693	1,938,747	+1,116,054 (+135.7%)
Rangeley Capital, LLC	60,220	225,000	+164,780 (+273.6%)
TORNO CAPITAL, LLC	130,916	320,000	+189,084 (+144.4%)
GSA CAPITAL PARTNERS LLP	160,884	623,698	+462,814 (+287.7%)
TANG CAPITAL MANAGEMENT LLC	6,003,446	6,143,132	+139,686 (+2.3%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	82,300	321,530	+239,230 (+290.7%)
Redmile Group, LLC	1,591,695	1,616,228	+24,533 (+1.5%)
MARSHALL WACE, LLP	299,461	1,080,128	+780,667 (+260.7%)
XTX Topco Ltd	466,984	545,016	+78,032 (+16.7%)
Connor, Clark & Lunn Investment Management Ltd.	24,340	371,951	+347,611 (+1428.1%)
JACOBS LEVY EQUITY MANAGEMENT, INC	367,113	556,938	+189,825 (+51.7%)
JANE STREET GROUP, LLC	380,327	653,774	+273,447 (+71.9%)
CITADEL ADVISORS LLC	2,339,468	2,583,332	+243,864 (+10.4%)
TWO SIGMA ADVISERS, LP	1,072,500	1,245,600	+173,100 (+16.1%)
TWO SIGMA INVESTMENTS, LP	783,255	953,293	+170,038 (+21.7%)
Eversept Partners, LP	824,594	842,023	+17,429 (+2.1%)
Quadrature Capital Ltd	37,595	97,891	+60,296 (+160.4%)
Squarepoint Ops LLC	33,842	99,018	+65,176 (+192.6%)
VANGUARD GROUP INC	2,775,938	2,818,241	+42,303 (+1.5%)

Decreased Positions (30)

Peapod Lane Capital LLC

Value ($000) $1,081 (-33.4%) Shares 886,374 (-19.2%)

Stonepine Capital Management, LLC

Value ($000) $281 (-34.4%) Shares 230,050 (-20.5%)

HighMark Wealth Management LLC

Value ($000) $209 (-35.7%) Shares 170,924 (-22.0%)

Woodline Partners LP

Value ($000) $2,472 (-62.9%) Shares 2,026,191 (-55.0%)

Point72 Asset Management, L.P.

Value ($000) $57 (-99.1%) Shares 46,537 (-98.9%)

MORGAN STANLEY

Value ($000) $670 (-87.1%) Shares 548,962 (-84.3%)

BARCLAYS PLC

Value ($000) $13 (-99.7%) Shares 10,584 (-97.5%)

JPMORGAN CHASE & CO

Value ($000) $1,480 (-53.1%) Shares 1,212,875 (-43.1%)

BlackRock, Inc.

Value ($000) $1,309 (-37.7%) Shares 1,073,272 (-24.5%)

GOLDMAN SACHS GROUP INC

Value ($000) $338 (-58.9%) Shares 276,866 (-50.1%)

UBS Group AG

Value ($000) $1,296 (-33.7%) Shares 1,062,615 (-19.6%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $1 (-99.7%) Shares 657 (-99.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $499 (-37.3%) Shares 408,831 (-23.9%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $42 (-61.9%) Shares 34,201 (-53.8%)

Qube Research & Technologies Ltd

Value ($000) $19 (-74.3%) Shares 15,425 (-68.8%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $149 (-33.9%) Shares 121,756 (-19.7%)

ROYAL BANK OF CANADA

Value ($000) $2 (-91.7%) Shares 1,185 (-92.7%)

NORTHERN TRUST CORP

Value ($000) $150 (-25.6%) Shares 123,273 (-9.7%)

OSAIC HOLDINGS, INC.

Value ($000) $140 (-24.4%) Shares 114,971 (-8.3%)

Vanguard Personalized Indexing Management, LLC

Value ($000) $32 (-37.7%) Shares 26,237 (-24.5%)

Institution	Prev Shares	Curr Shares	Change
Peapod Lane Capital LLC	1,097,028	886,374	-210,654 (-19.2%)
Stonepine Capital Management, LLC	289,237	230,050	-59,187 (-20.5%)
HighMark Wealth Management LLC	219,000	170,924	-48,076 (-22.0%)
Woodline Partners LP	4,504,817	2,026,191	-2,478,626 (-55.0%)
Point72 Asset Management, L.P.	4,338,394	46,537	-4,291,857 (-98.9%)
MORGAN STANLEY	3,507,288	548,962	-2,958,326 (-84.3%)
BARCLAYS PLC	421,499	10,584	-410,915 (-97.5%)
JPMORGAN CHASE & CO	2,130,489	1,212,875	-917,614 (-43.1%)
BlackRock, Inc.	1,420,863	1,073,272	-347,591 (-24.5%)
GOLDMAN SACHS GROUP INC	555,076	276,866	-278,210 (-50.1%)
UBS Group AG	1,322,017	1,062,615	-259,402 (-19.6%)
BNP PARIBAS ARBITRAGE, SA	182,356	657	-181,699 (-99.6%)
MILLENNIUM MANAGEMENT LLC	537,337	408,831	-128,506 (-23.9%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	73,954	34,201	-39,753 (-53.8%)
Qube Research & Technologies Ltd	49,515	15,425	-34,090 (-68.8%)
DIMENSIONAL FUND ADVISORS LP	151,673	121,756	-29,917 (-19.7%)
ROYAL BANK OF CANADA	16,175	1,185	-14,990 (-92.7%)
NORTHERN TRUST CORP	136,500	123,273	-13,227 (-9.7%)
OSAIC HOLDINGS, INC.	125,376	114,971	-10,405 (-8.3%)
Vanguard Personalized Indexing Management, LLC	34,743	26,237	-8,506 (-24.5%)

Exited Positions (14)

Mass General Brigham, Inc

Value ($000) $3,236 Shares 288,690

GREAT POINT PARTNERS LLC

Value ($000) $1,258 Shares 850,000

Catalyst Funds Management Pty Ltd

Value ($000) $88 Shares 59,539

Voleon Capital Management LP

Value ($000) $221 Shares 149,041

Tower Research Capital LLC (TRC)

Value ($000) $31 Shares 20,749

Jain Global LLC

Value ($000) $37 Shares 25,037

China Universal Asset Management Co., Ltd.

Value ($000) $16 Shares 10,760

FNY Investment Advisers, LLC

Value ($000) $0 Shares 25,400

CITIGROUP INC

Value ($000) $6 Shares 4,319

Mirae Asset Global Investments Co., Ltd.

Value ($000) $4 Shares 2,373

GF FUND MANAGEMENT CO. LTD.

Value ($000) $2 Shares 1,264

Rise Advisors, LLC

Value ($000) $1 Shares 740

Bell Investment Advisors, Inc

Value ($000) $0 Shares 307

Daiwa Securities Group Inc.

Value ($000) $0 Shares 196

Institution	Prev Shares	Prev Value ($000)
Mass General Brigham, Inc	288,690	$3,236
GREAT POINT PARTNERS LLC	850,000	$1,258
Catalyst Funds Management Pty Ltd	59,539	$88
Voleon Capital Management LP	149,041	$221
Tower Research Capital LLC (TRC)	20,749	$31
Jain Global LLC	25,037	$37
China Universal Asset Management Co., Ltd.	10,760	$16
FNY Investment Advisers, LLC	25,400	$0
CITIGROUP INC	4,319	$6
Mirae Asset Global Investments Co., Ltd.	2,373	$4
GF FUND MANAGEMENT CO. LTD.	1,264	$2
Rise Advisors, LLC	740	$1
Bell Investment Advisors, Inc	307	$0
Daiwa Securities Group Inc.	196	$0