RELMADA THERAPEUTICS INC

Ticker: RLMD CUSIP: 75955J402 Class: Common Stock

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (32)

Opaleye Management Inc.
Value ($000) $4,516 Shares 935,000
Persistent Asset Partners Ltd
Value ($000) $1,116 Shares 231,123
DIADEMA PARTNERS LP
Value ($000) $1,881 Shares 389,395
ORBIMED ADVISORS LLC
Value ($000) $12,609 Shares 2,610,600
BRAIDWELL LP
Value ($000) $7,642 Shares 1,582,257
EAM Investors, LLC
Value ($000) $785 Shares 162,552
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $20,624 Shares 4,270,000
JANUS HENDERSON GROUP PLC
Value ($000) $35,041 Shares 7,270,000
Pale Fire Capital SE
Value ($000) $215 Shares 44,550
ADAR1 Capital Management, LLC
Value ($000) $149 Shares 30,866
MILLENNIUM MANAGEMENT LLC
Value ($000) $8,081 Shares 1,673,017
AMERIPRISE FINANCIAL INC
Value ($000) $9,274 Shares 1,920,099
MANGROVE PARTNERS IM, LLC
Value ($000) $132 Shares 27,380
BALYASNY ASSET MANAGEMENT L.P.
Value ($000) $2,646 Shares 547,854
XTX Topco Ltd
Value ($000) $199 Shares 41,293
ExodusPoint Capital Management, LP
Value ($000) $333 Shares 68,883
Point72 Asset Management, L.P.
Value ($000) $905 Shares 187,377
Quadrature Capital Ltd
Value ($000) $258 Shares 53,444
OMERS ADMINISTRATION Corp
Value ($000) $318 Shares 65,900
Qube Research & Technologies Ltd
Value ($000) $751 Shares 155,529

Increased Positions (21)

Ikarian Capital, LLC
Value ($000) $14,820 (+300.1%) Shares 3,068,359 (+66.5%)
DRIEHAUS CAPITAL MANAGEMENT LLC
Value ($000) $9,080 (+510.5%) Shares 1,880,006 (+154.1%)
PARSONS CAPITAL MANAGEMENT INC/RI
Value ($000) $1,270 (+286.9%) Shares 263,000 (+61.0%)
MARSHALL WACE, LLP
Value ($000) $15,406 (+2717.4%) Shares 3,189,662 (+1072.4%)
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $4,034 (+189.5%) Shares 835,300 (+20.5%)
Corient Private Wealth LLC
Value ($000) $3,443 (+756.6%) Shares 719,582 (+248.2%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $2,767 (+692.9%) Shares 572,835 (+229.9%)
VANGUARD GROUP INC
Value ($000) $5,812 (+590.8%) Shares 1,203,307 (+187.5%)
BlackRock, Inc.
Value ($000) $6,122 (+499.6%) Shares 1,267,503 (+149.5%)
GEODE CAPITAL MANAGEMENT, LLC
Value ($000) $4,131 (+593.7%) Shares 854,932 (+188.6%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $1,864 (+570.0%) Shares 385,942 (+178.8%)
TWO SIGMA ADVISERS, LP
Value ($000) $783 (+904.5%) Shares 162,200 (+318.0%)
STATE STREET CORP
Value ($000) $1,550 (+657.1%) Shares 320,820 (+215.1%)
JANE STREET GROUP, LLC
Value ($000) $1,309 (+660.5%) Shares 271,109 (+216.5%)
NORTHERN TRUST CORP
Value ($000) $799 (+573.6%) Shares 165,453 (+180.3%)
MORGAN STANLEY
Value ($000) $301 (+14324.6%) Shares 62,357 (+5901.6%)
BANK OF AMERICA CORP /DE/
Value ($000) $122 (+23080.5%) Shares 25,340 (+9535.0%)
CITIGROUP INC
Value ($000) $109 (+2720875.0%) Shares 22,534 (+1126600.0%)
RENAISSANCE TECHNOLOGIES LLC
Value ($000) $894 (+162.0%) Shares 185,000 (+9.0%)
BNP PARIBAS ARBITRAGE, SA
Value ($000) $15 (+7751.9%) Shares 3,040 (+3168.8%)

Decreased Positions (9)

AdvisorShares Investments LLC
Value ($000) $1,543 (+90.3%) Shares 319,510 (-20.8%)
RBF Capital, LLC
Value ($000) $676 (+106.1%) Shares 140,000 (-14.2%)
BARCLAYS PLC
Value ($000) $290 (-38.7%) Shares 60,000 (-58.9%)
SIMPLEX TRADING, LLC
Value ($000) $90 (+84702.8%) Shares 18,611 (-64.9%)
UBS Group AG
Value ($000) $200 (+66.7%) Shares 41,468 (-30.6%)
World Investment Advisors
Value ($000) $50 (+135.8%) Shares 10,444 (-1.9%)
Farther Finance Advisors, LLC
Value ($000) $3 (+96.2%) Shares 684 (-18.4%)
ACADIAN ASSET MANAGEMENT LLC
Value ($000) $3 (+117.2%) Shares 526,718 (-9.6%)
SBI Securities Co., Ltd.
Value ($000) $0 (+34.1%) Shares 57 (-44.1%)

Exited Positions (1)

Tower Research Capital LLC (TRC)
Value ($000) $3 Shares 1,581