| Lynx1 Capital Management LP | 8,019,148 | $8,019 |
| BVF INC/IL | 5,226,074 | $5,226 |
| BAKER BROS. ADVISORS LP | 2,784,792 | $2,785 |
| VANGUARD GROUP INC | 2,475,733 | $2,476 |
| BlackRock, Inc. | 1,848,695 | $1,849 |
| abrdn plc | 1,785,241 | $1,785 |
| Deer Management Co. LLC | 1,245,504 | $1,246 |
| RENAISSANCE TECHNOLOGIES LLC | 1,141,069 | $1,141 |
| TWO SIGMA INVESTMENTS, LP | 651,179 | $651 |
| DC Funds, LP | 630,000 | $630 |
| GEODE CAPITAL MANAGEMENT, LLC | 562,153 | $562 |
| MILLENNIUM MANAGEMENT LLC | 403,618 | $404 |
| JANE STREET GROUP, LLC | 388,284 | $388 |
| TWO SIGMA ADVISERS, LP | 353,900 | $354 |
| MARSHALL WACE, LLP | 339,240 | $339 |
| GSA CAPITAL PARTNERS LLP | 226,164 | $0 |
| MORGAN STANLEY | 225,829 | $226 |
| XTX Topco Ltd | 219,001 | $219 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 216,133 | $216 |
| STATE STREET CORP | 207,313 | $207 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 188,152 | $188 |
| CITADEL ADVISORS LLC | 162,877 | $163 |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | $143 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,400 | $115 |
| NORTHERN TRUST CORP | 98,198 | $98 |
| LETKO, BROSSEAU & ASSOCIATES INC | 95,875 | $96 |
| NewEdge Wealth, LLC | 91,463 | $91 |
| GOLDMAN SACHS GROUP INC | 86,903 | $87 |
| DIMENSIONAL FUND ADVISORS LP | 74,467 | $75 |
| STIFEL FINANCIAL CORP | 72,400 | $72 |
| D. E. Shaw & Co., Inc. | 69,427 | $69 |
| UBS Group AG | 55,198 | $55 |
| TANG CAPITAL MANAGEMENT LLC | 46,131 | $46 |
| BANK OF AMERICA CORP /DE/ | 38,700 | $39 |
| DC Investments Management, LLC | 35,563 | $36 |
| JPMORGAN CHASE & CO | 33,349 | $33 |
| ACADIAN ASSET MANAGEMENT LLC | 29,538 | $0 |
| HRT FINANCIAL LP | 26,581 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 26,360 | $26 |
| PANAGORA ASSET MANAGEMENT INC | 25,256 | $25 |
| HSBC HOLDINGS PLC | 24,574 | $25 |
| PRUDENTIAL FINANCIAL INC | 24,400 | $24 |
| BARCLAYS PLC | 23,196 | $23 |
| LPL Financial LLC | 22,500 | $23 |
| NEUBERGER BERMAN GROUP LLC | 18,400 | $18 |
| R Squared Ltd | 16,033 | $16 |
| TWO SIGMA SECURITIES, LLC | 15,942 | $16 |
| Vanguard Personalized Indexing Management, LLC | 14,677 | $15 |
| Point72 Asset Management, L.P. | 14,512 | $15 |
| OSAIC HOLDINGS, INC. | 12,245 | $12 |
| MIZUHO SECURITIES USA LLC | 10,000 | $10 |
| Waldron Private Wealth LLC | 10,000 | $10 |
| Aries Wealth Management | 10,000 | $10 |
| Tower Research Capital LLC (TRC) | 6,766 | $7 |
| FEDERATED HERMES, INC. | 4,989 | $5 |
| FMR LLC | 500 | $1 |
| SBI Securities Co., Ltd. | 392 | $0 |
| ROYAL BANK OF CANADA | 374 | $0 |
| Rockefeller Capital Management L.P. | 200 | $0 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 8 | $0 |