| BlackRock, Inc. | 11,927,218 | $182,606 |
| PRIMECAP MANAGEMENT CO/CA/ | 10,218,322 | $156,443 |
| VANGUARD GROUP INC | 7,165,450 | $109,703 |
| BVF INC/IL | 7,133,720 | $109,217 |
| RTW INVESTMENTS, LP | 6,777,461 | $103,763 |
| STATE STREET CORP | 4,507,254 | $69,006 |
| EcoR1 Capital, LLC | 3,251,112 | $49,775 |
| TCG Crossover Management, LLC | 2,452,138 | $37,542 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,752,918 | $26,842 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,601,762 | $25 |
| MORGAN STANLEY | 1,508,727 | $23,099 |
| Defilade Capital Management, L.P. | 1,414,755 | $21,660 |
| Legal & General Group Plc | 1,308,088 | $20,027 |
| DIMENSIONAL FUND ADVISORS LP | 1,249,288 | $19,125 |
| BAKER BROS. ADVISORS LP | 1,102,106 | $16,873 |
| GOLDMAN SACHS GROUP INC | 753,258 | $11,532 |
| JOHNSON & JOHNSON | 748,062 | $11,453 |
| Jefferies Financial Group Inc. | 720,440 | $11,030 |
| Lynx1 Capital Management LP | 705,558 | $10,802 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 700,435 | $10,724 |
| NORTHERN TRUST CORP | 674,657 | $10,329 |
| UBS Group AG | 638,021 | $9,768 |
| BANK OF AMERICA CORP /DE/ | 629,408 | $9,636 |
| MILLENNIUM MANAGEMENT LLC | 594,435 | $9,101 |
| PANAGORA ASSET MANAGEMENT INC | 583,778 | $8,938 |
| TWO SIGMA ADVISERS, LP | 506,600 | $7,756 |
| TORONTO DOMINION BANK | 491,000 | $7,517 |
| Erste Asset Management GmbH | 480,200 | $7,347 |
| BRAIDWELL LP | 459,166 | $7,030 |
| Hudson Bay Capital Management LP | 425,000 | $6,507 |
| ACADIAN ASSET MANAGEMENT LLC | 411,725 | $6 |
| Bank of New York Mellon Corp | 410,650 | $6,287 |
| BARCLAYS PLC | 359,235 | $5,500 |
| PRINCIPAL FINANCIAL GROUP INC | 340,326 | $5,210 |
| CITADEL ADVISORS LLC | 321,808 | $4,927 |
| JPMORGAN CHASE & CO | 303,979 | $4,654 |
| TWO SIGMA INVESTMENTS, LP | 268,737 | $4,114 |
| Invesco Ltd. | 265,820 | $4,070 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 259,319 | $3,970 |
| Public Sector Pension Investment Board | 247,242 | $3,785 |
| DEUTSCHE BANK AG\ | 216,568 | $3,316 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200,000 | $3,062 |
| Woodline Partners LP | 193,117 | $2,957 |
| Susquehanna Portfolio Strategies, LLC | 191,463 | $2,931 |
| Trexquant Investment LP | 175,152 | $2,682 |
| AMERICAN CENTURY COMPANIES INC | 174,603 | $2,673 |
| RHUMBLINE ADVISERS | 165,797 | $2,538 |
| Rhenman & Partners Asset Management AB | 165,750 | $2,538 |
| Nantahala Capital Management, LLC | 164,639 | $2,521 |
| DCF Advisers, LLC | 154,736 | $2,369 |
| AMERIPRISE FINANCIAL INC | 135,806 | $2,079 |
| Nuveen, LLC | 134,051 | $2,052 |
| SG Americas Securities, LLC | 128,345 | $2 |
| ALGERT GLOBAL LLC | 124,400 | $2 |
| UBS ASSET MANAGEMENT AMERICAS INC | 119,789 | $1,834 |
| Swiss National Bank | 119,600 | $1,831 |
| CITIGROUP INC | 112,275 | $1,719 |
| AQR CAPITAL MANAGEMENT LLC | 112,271 | $1,719 |
| Seven Fleet Capital Management LP | 109,554 | $1,677 |
| Essex LLC | 98,661 | $1,511 |
| Rafferty Asset Management, LLC | 97,749 | $1,497 |
| FMR LLC | 92,883 | $1,422 |
| WINTON GROUP Ltd | 88,038 | $1,348 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 87,717 | $1,343 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,942 | $1,253 |
| Thrivent Financial for Lutherans | 82,828 | $1 |
| WELLS FARGO & COMPANY/MN | 79,667 | $1,220 |
| TD Asset Management Inc | 77,802 | $1,191 |
| ALLIANCEBERNSTEIN L.P. | 72,090 | $1,104 |
| INTECH INVESTMENT MANAGEMENT LLC | 70,612 | $1,081 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 70,526 | $1 |
| PRUDENTIAL FINANCIAL INC | 67,570 | $1,034 |
| NEOS Investment Management LLC | 61,362 | $939 |
| TEMA ETFS LLC | 60,457 | $926 |
| ALPS ADVISORS INC | 58,639 | $898 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,530 | $896 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 57,164 | $1 |
| ADAR1 Capital Management, LLC | 56,165 | $860 |
| Point72 Asset Management, L.P. | 55,339 | $847 |
| BNP PARIBAS ARBITRAGE, SA | 48,687 | $745 |
| Schonfeld Strategic Advisors LLC | 47,848 | $733 |
| Russell Investments Group, Ltd. | 47,189 | $722 |
| Quantinno Capital Management LP | 47,134 | $722 |
| PROFUND ADVISORS LLC | 43,960 | $673 |
| FRANKLIN RESOURCES INC | 41,225 | $631 |
| Linden Thomas Advisory Services, LLC | 40,963 | $627 |
| MetLife Investment Management, LLC | 40,212 | $616 |
| CIBC Private Wealth Group, LLC | 40,017 | $613 |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,825 | $594 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,448 | $587 |
| RAYMOND JAMES FINANCIAL INC | 38,037 | $582 |
| State of Alaska, Department of Revenue | 36,407 | $1 |
| TUDOR INVESTMENT CORP ET AL | 34,794 | $533 |
| RENAISSANCE TECHNOLOGIES LLC | 34,158 | $523 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 34,097 | $482 |
| Jump Financial, LLC | 33,198 | $508 |
| Louisiana State Employees Retirement System | 32,700 | $501 |
| XTX Topco Ltd | 32,009 | $490 |
| DekaBank Deutsche Girozentrale | 31,800 | $1 |
| Cerity Partners LLC | 31,302 | $479 |
| 105 other institutions | 999,107 | $13,724 |