Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q2 2021 (← Previous) (Next →)
Filing Date: Aug 16, 2021
Total Value: $22.77B (99.3% shares, 0.7% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 47,288,259 | $7.466B | 32.8% | $195.69 | — | COM | 81181C104 |
| ONC | BeiGene, Ltd. | 11,668,897 | $4.005B | 17.6% | $136.93 | — | SPONSORED ADR | 07725L102 |
| INCY | Incyte Corporation | 32,021,732 | $2.694B | 11.8% | $73.07 | +14.1% | COM | 45337C102 |
| KOD | Kodiak Sciences Inc. | 14,137,881 | $1.315B | 5.8% | $29.42 | +226.2% | COM | 50015M109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,910,704 | $1.022B | 4.5% | $18.86 | +19.7% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,589,294 | $633M | 2.8% | $81.02 | -2.2% | COM | 09061G101 |
| ASND | Ascendis Pharma A/S | 3,540,270 | $466M | 2.0% | $48.88 | — | SPONSORED ADR | 04351P101 |
| — | Invitae Corporation | 10,248,575 | $346M | 1.5% | $25.40 | — | COM | 46185L103 |
| ARGX | argenx SE | 1,119,557 | $337M | 1.5% | $79.01 | — | SPONSORED ADR | 04016X101 |
| PRLD | Prelude Therapeutics Incorporated | 10,123,824 | $290M | 1.3% | $28.24 | +26.1% | COM | 74065P101 |
| — | IGM Biosciences, Inc. | 3,156,102 | $263M | 1.2% | $17.75 | — | COM | 449585108 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $230M | 1.0% | $45.73 | -39.7% | COM | 00288U106 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $228M | 1.0% | $22.85 | — | COM | 60468T105 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $201M | 0.9% | $6.35 | +113.9% | COM | 09058V103 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,499,213 | $146M | 0.6% | $104.81 | +12.9% | COM | 558868105 |
| APLS | Apellis Pharmaceuticals, Inc. | 2,271,917 | $144M | 0.6% | $41.05 | +25.7% | COM | 03753U106 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $126M | 0.6% | $17.29 | -8.0% | COM | 427746102 |
| — | Amarin Corporation plc | 26,453,422 | $116M | 0.5% | $8.93 | — | SPONSORED ADR | 023111206 |
| — | Global Blood Therapeutics, Inc. | 3,217,441 | $113M | 0.5% | $44.81 | — | COM | 37890U108 |
| PACB | Pacific Biosciences of California, Inc. | 3,201,972 | $112M | 0.5% | $5.76 | +405.2% | COM | 69404D108 |
| IMCR | Immunocore Holdings plc | 2,520,730 | $98.44M | 0.4% | $42.57 | — | ADS | 45258D105 |
| KYMR | Kymera Therapeutics, Inc. | 1,959,211 | $95.02M | 0.4% | $30.53 | +42.2% | COM | 501575104 |
| — | Verastem, Inc. | 21,491,630 | $87.47M | 0.4% | $2.64 | — | COM | 92337C104 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $85.35M | 0.4% | $60.25 | — | COM | 92539P101 |
| — | Talis Biomedical Corporation | 7,574,835 | $83.55M | 0.4% | $12.85 | — | COM | 87424L108 |
| CERS | Cerus Corporation | 13,713,195 | $81.05M | 0.4% | $4.64 | +26.3% | COM | 157085101 |
| — | DBV Technologies S.A. | 14,614,264 | $79.79M | 0.4% | $19.06 | — | SPONSORED ADR | 23306J101 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 3,863,239 | $75.64M | 0.3% | $26.76 | -22.4% | COM | 76243J105 |
| — | Instil Bio, Inc. | 3,893,700 | $75.23M | 0.3% | $25.08 | — | COM | 45783C101 |
| LEGN | Legend Biotech Corporation | 1,664,534 | $68.33M | 0.3% | $41.16 | — | SPONSORED ADS | 52490G102 |
| NBIX | Neurocrine Biosciences, Inc. | 676,975 | $65.88M | 0.3% | $62.87 | +52.4% | COM | 64125C109 |
| NRIX | Nurix Therapeutics, Inc. | 2,454,082 | $65.11M | 0.3% | $28.63 | +2.6% | COM | 67080M103 |
| INSM | Insmed Incorporated | 2,156,001 | $61.36M | 0.3% | $22.18 | +33.8% | COM PAR $.01 | 457669307 |
| — | Allakos Inc. | 703,050 | $60.02M | 0.3% | $62.02 | — | COM | 01671P100 |
| — | Zymeworks Inc. | 1,708,472 | $59.27M | 0.3% | $14.76 | — | COM | 98985W102 |
| — | Horizon Therapeutics Public Ltd Co | 599,110 | $56.1M | 0.2% | $63.26 | — | SHS | G46188101 |
| — | Forma Therapeutics Holdings, Inc. | 2,024,876 | $50.4M | 0.2% | $45.04 | — | SHS | 34633R104 |
| IMTX | Immatics N.V. | 4,282,938 | $49.73M | 0.2% | $11.03 | +6.4% | SHS | N44445109 |
| — | Insmed Incorporated | 40,000,000 | $44.06M | 0.2% | $1.10 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| — | Merus N.V. | 2,037,469 | $42.93M | 0.2% | $10.77 | — | COM | N5749R100 |
| RARE | Ultragenyx Pharmaceutical Inc. | 444,444 | $42.38M | 0.2% | $118.63 | -12.2% | COM | 90400D108 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $41.88M | 0.2% | $5.77 | — | SPONSORED ADR | 00653A107 |
| KRYS | Krystal Biotech, Inc. | 607,735 | $41.33M | 0.2% | $26.63 | +162.1% | COM | 501147102 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $39M | 0.2% | $17.35 | — | COM CL A | G5269C101 |
| — | Sarepta Therapeutics, Inc. | 29,174,000 | $38.48M | 0.2% | $1.31 | — | DBCV 1.5% 11/15/2024 | 803607AB6 |
| FLGT | Fulgent Genetics, Inc. | 401,016 | $36.99M | 0.2% | $11.30 | +606.8% | COM | 359664109 |
| AXSM | Axsome Therapeutics, Inc. | 539,057 | $36.37M | 0.2% | $23.39 | +156.6% | COM | 05464T104 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $35.27M | 0.2% | $3.87 | — | COM | 64049K104 |
| BCAB | BioAtla, Inc. | 825,000 | $34.96M | 0.2% | $33.43 | +35.2% | COM | 09077B104 |
| ADCT | ADC Therapeutics SA | 1,418,107 | $34.53M | 0.2% | $38.22 | -39.3% | SHS | H0036K147 |
| — | Aligos Therapeutics, Inc. | 1,610,000 | $32.82M | 0.1% | $27.65 | — | COM | 01626L105 |
| — | Aerovate Therapeutics, Inc. | 1,428,571 | $32.61M | 0.1% | $22.83 | — | COM | 008064107 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $31.7M | 0.1% | $138.99 | — | CL A | 75615P103 |
| NVAX | Novavax, Inc. | 143,756 | $30.52M | 0.1% | $38.25 | +379.0% | COM | 670002401 |
| ALKS | Alkermes plc | 1,228,170 | $30.11M | 0.1% | $23.07 | -3.6% | SHS | G01767105 |
| — | Atreca, Inc. | 3,532,760 | $30.1M | 0.1% | $18.84 | — | CL A COM | 04965G109 |
| DSGN | Design Therapeutics, Inc. | 1,436,636 | $28.57M | 0.1% | $31.14 | -19.0% | COM | 25056L103 |
| — | Apellis Pharmaceuticals, Inc. | 15,000,000 | $27.79M | 0.1% | $1.85 | — | Note 3.5% 9/15/2026 | 03753UAB2 |
| — | Tricida, Inc. | 75,000,000 | $27.33M | 0.1% | $0.36 | — | Note 3.5% 5/15/2027 | 89610FAB7 |
| OPTEY | Opthea Limited | 3,412,062 | $27.09M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| — | Achilles Therapeutics plc | 2,591,366 | $25.37M | 0.1% | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $23.73M | 0.1% | $7.84 | — | COM | 00773J103 |
| PTGX | Protagonist Therapeutics, Inc. | 455,276 | $20.43M | 0.1% | $9.97 | +231.1% | COM | 74366E102 |
| — | Cyteir Therapeutics, Inc. | 812,640 | $17.39M | 0.1% | $21.40 | — | COM | 23284P103 |
| CRNX | Crinetics Pharmaceuticals, Inc. | 920,656 | $17.35M | 0.1% | $17.99 | -2.3% | COM | 22663K107 |
| — | Otonomy, Inc. | 7,222,474 | $16.11M | 0.1% | $2.55 | — | COM | 68906L105 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $15.57M | 0.1% | $1.01 | — | Note 0.599% 8/1/2024 | 09061GAH4 |
| — | Chinook Therapeutics, Inc. | 1,080,393 | $15.26M | 0.1% | $15.33 | — | COM | 16961L106 |
| AUPH | Aurinia Pharmaceuticals Inc. | 1,119,962 | $14.52M | 0.1% | $9.21 | +38.3% | COM | 05156V102 |
| — | Albireo Pharma, Inc. | 412,466 | $14.51M | 0.1% | $24.96 | — | COM | 01345P106 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $14M | 0.1% | $13.09 | +40.8% | COM | 98420N105 |
| — | Invitae Corporation | 10,300,000 | $13.89M | 0.1% | $1.64 | — | Note 2.0% 9/1/2024 | 46185LAB9 |
| MIRM | Mirum Pharmaceuticals, Inc. | 647,313 | $11.19M | 0.0% | $14.86 | +20.6% | COM | 604749101 |
| ANAB | AnaptysBio, Inc. | 427,179 | $11.08M | 0.0% | $26.06 | -8.0% | COM | 032724106 |
| EWTX | Edgewise Therapeutics, Inc. | 500,000 | $10.66M | 0.0% | $32.43 | -15.7% | COM | 28036F105 |
| ALT | Altimmune, Inc. | 1,072,038 | $10.56M | 0.0% | $9.32 | +46.7% | COM | 02155H200 |
| — | Cymabay Therapeutics, Inc. | 2,170,464 | $9.463M | 0.0% | $5.48 | — | COM | 23257D103 |
| — | Genetron Holdings Limited | 455,306 | $9.17M | 0.0% | $13.55 | — | ADS | 37186H100 |
| CNTA | Centessa Pharmaceuticals plc | 400,000 | $8.884M | 0.0% | $22.21 | — | SPONSORED ADS | 152309100 |
| — | IVERIC bio, Inc. | 1,406,037 | $8.872M | 0.0% | $3.89 | — | COM | 46583P102 |
| — | Athira Pharma, Inc. | 806,367 | $8.257M | 0.0% | $18.46 | — | COM | 04746L104 |
| — | Assembly Biosciences, Inc. | 2,108,621 | $8.181M | 0.0% | $13.84 | — | COM | 045396108 |
| — | Karuna Therapeutics, Inc. | 69,966 | $7.975M | 0.0% | $91.25 | — | COM | 48576A100 |
| MREO | Mereo BioPharma Group plc | 2,459,399 | $7.796M | 0.0% | $3.56 | — | ADS | 589492107 |
| SPRY | Silverback Therapeutics, Inc. | 238,095 | $7.355M | 0.0% | $33.40 | -4.0% | COM | 82835W108 |
| — | bluebird bio, Inc. | 226,988 | $7.259M | 0.0% | $58.05 | — | COM | 09609G100 |
| RVMD | Revolution Medicines, Inc. | 222,222 | $7.053M | 0.0% | $44.84 | -22.2% | COM | 76155X100 |
| DNLI | Denali Therapeutics Inc. | 88,738 | $6.961M | 0.0% | $20.86 | +196.6% | COM | 24823R105 |
| — | Chiasma, Inc. | 1,420,740 | $6.72M | 0.0% | $5.07 | — | COM | 16706W102 |
| — | HOOKIPA Pharma Inc. | 700,481 | $6.416M | 0.0% | $6.73 | — | COM | 43906K100 |
| — | Burning Rock Biotech Limited | 209,131 | $6.161M | 0.0% | $27.01 | — | SPONSORED ADS | 12233L107 |
| REPL | Replimune Group, Inc. | 153,512 | $5.898M | 0.0% | $22.66 | +50.9% | COM | 76029N106 |
| — | NGM Biopharmaceuticals, Inc. | 291,801 | $5.754M | 0.0% | $23.80 | — | COM | 62921N105 |
| CABA | Cabaletta Bio, Inc. | 636,363 | $5.473M | 0.0% | $11.85 | -17.1% | COM | 12674W109 |
| MGNX | MacroGenics, Inc. | 200,679 | $5.39M | 0.0% | $23.02 | +27.2% | COM | 556099109 |
| — | Orchard Therapeutics plc | 1,192,003 | $5.233M | 0.0% | $8.19 | — | ADS | 68570P101 |
| ALEC | Alector, Inc. | 239,228 | $4.983M | 0.0% | $25.49 | -26.0% | COM | 014442107 |
| — | NexImmune, Inc. | 294,117 | $4.8M | 0.0% | $19.08 | — | COM | 65344D109 |
| BMEA | Biomea Fusion, Inc. | 294,117 | $4.591M | 0.0% | $17.65 | 0.0% | COM | 09077A106 |
| — | Gamida Cell Ltd. | 610,626 | $3.914M | 0.0% | $6.83 | — | SHS | M47364100 |
| — | Iteos Therapeutics, Inc. | 150,346 | $3.856M | 0.0% | $24.67 | — | COM | 46565G104 |
| HRMY | Harmony Biosciences Holdings, Inc. | 123,600 | $3.489M | 0.0% | $36.46 | -17.7% | COM | 413197104 |
| — | Tricida, Inc. | 729,300 | $3.151M | 0.0% | $6.81 | — | COM | 89610F101 |
| — | Evofem Biosciences, Inc. | 2,697,110 | $3.048M | 0.0% | $2.13 | — | COM | 30048L104 |
| — | Akero Therapeutics, Inc. | 118,378 | $2.937M | 0.0% | $30.79 | — | COM | 00973Y108 |
| — | TCR2 Therapeutics Inc. | 176,461 | $2.896M | 0.0% | $20.97 | — | COM | 87808K106 |
| — | Acceleron Pharma Inc. | 22,430 | $2.815M | 0.0% | $89.85 | — | COM | 00434H108 |
| TVTX | Travere Therapeutics, Inc. | 186,915 | $2.727M | 0.0% | $27.63 | -28.6% | COM | 89422G107 |
| RLMD | Relmada Therapeutics, Inc. | 76,600 | $2.452M | 0.0% | $34.73 | 0.0% | COM | 75955J402 |
| — | LogicBio Therapeutics, Inc. | 451,478 | $2.005M | 0.0% | $7.63 | — | COM | 54142F102 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $1.945M | 0.0% | $30.96 | -63.4% | COM STK | 74365U107 |
| — | Inozyme Pharma, Inc. | 106,999 | $1.823M | 0.0% | $26.29 | — | COM | 45790W108 |
| — | Passage Bio, Inc. | 117,161 | $1.551M | 0.0% | $15.75 | — | COM | 702712100 |
| — | Affimed N.V. | 164,605 | $1.399M | 0.0% | $6.30 | — | COM | N01045108 |
| — | Oyster Point Pharma, Inc. | 61,424 | $1.056M | 0.0% | $28.88 | — | COM | 69242L106 |
| — | Leap Therapeutics, Inc. | 559,705 | $918K | 0.0% | $1.17 | — | COM | 52187K101 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $822K | 0.0% | $4.71 | — | COM | 079481404 |
| — | Kezar Life Sciences, Inc. | 139,676 | $758K | 0.0% | $5.18 | — | COM | 49372L100 |
| — | Frequency Therapeutics, Inc. | 55,555 | $553K | 0.0% | $17.53 | — | COM | 35803L108 |
| — | Syros Pharmaceuticals, Inc. | 65,497 | $357K | 0.0% | $13.72 | — | COM | 87184Q107 |