Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	Seagen Inc.	47,270,759	$6.564B	28.5%	$195.69	—	COM	81181C104
ONC	BeiGene, Ltd.	11,668,897	$4.062B	17.6%	$136.93	—	SPONSORED ADR	07725L102
INCY	Incyte Corporation	32,001,387	$2.601B	11.3%	$73.07	+16.8%	COM	45337C102
KOD	Kodiak Sciences Inc.	13,879,952	$1.574B	6.8%	$28.18	+384.6%	COM	50015M109
ACAD	ACADIA Pharmaceuticals Inc.	41,910,704	$1.081B	4.7%	$18.86	+133.5%	COM	004225108
—	Alexion Pharmaceuticals, Inc.	3,993,312	$611M	2.6%	$162.46	—	COM	015351109
—	Invitae Corporation	15,749,182	$602M	2.6%	$25.40	—	COM	46185L103
BMRN	BioMarin Pharmaceutical Inc.	7,589,294	$573M	2.5%	$81.02	+0.8%	COM	09061G101
ASND	Ascendis Pharma A/S	3,540,270	$456M	2.0%	$48.88	—	SPONSORED ADR	04351P101
PRLD	Prelude Therapeutics Incorporated	10,123,824	$439M	1.9%	$28.24	+134.9%	COM	74065P101
ABCL	AbCellera Biologics Inc.	10,450,180	$355M	1.5%	$45.73	-12.9%	COM	00288U106
ARGX	argenx SE	1,119,557	$308M	1.3%	$79.01	—	SPONSORED ADR	04016X101
—	IGM Biosciences, Inc.	3,156,102	$242M	1.0%	$17.75	—	COM	449585108
—	Mirati Therapeutics, Inc.	1,409,784	$241M	1.0%	$22.85	—	COM	60468T105
MDGL	Madrigal Pharmaceuticals, Inc.	1,499,213	$175M	0.8%	$104.81	+11.2%	COM	558868105
—	Amarin Corporation plc	26,453,422	$164M	0.7%	$8.93	—	SPONSORED ADR	023111206
—	Global Blood Therapeutics, Inc.	3,217,441	$131M	0.6%	$44.81	—	COM	37890U108
BCRX	BioCryst Pharmaceuticals, Inc.	12,710,818	$129M	0.6%	$6.35	+62.3%	COM	09058V103
IMCR	Immunocore Holdings plc	2,520,730	$107M	0.5%	$42.57	—	ADS	45258D105
PACB	Pacific Biosciences of California, Inc.	3,201,972	$107M	0.5%	$5.76	+508.0%	COM	69404D108
—	Instil Bio, Inc.	3,893,700	$97.65M	0.4%	$25.08	—	COM	45783C101
—	Talis Biomedical Corporation	7,574,835	$97.34M	0.4%	$12.85	—	COM	87424L108
HRTX	Heron Therapeutics, Inc.	5,994,704	$97.17M	0.4%	$17.78	+0.3%	COM	427746102
CERS	Cerus Corporation	13,713,195	$82.42M	0.4%	$4.64	+46.6%	COM	157085101
—	Allakos Inc.	703,050	$80.7M	0.3%	$62.02	—	COM	01671P100
—	DBV Technologies S.A.	14,614,264	$77.89M	0.3%	$19.06	—	SPONSORED ADR	23306J101
NRIX	Nurix Therapeutics, Inc.	2,454,082	$76.3M	0.3%	$28.63	+32.2%	COM	67080M103
KYMR	Kymera Therapeutics, Inc.	1,959,211	$76.14M	0.3%	$30.53	+97.2%	COM	501575104
RYTM	Rhythm Pharmaceuticals, Inc.	3,479,873	$74.02M	0.3%	$27.43	+5.8%	COM	76243J105
INSM	Insmed Incorporated	2,156,001	$73.43M	0.3%	$22.18	+72.3%	COM PAR $.01	457669307
APLS	Apellis Pharmaceuticals, Inc.	1,674,004	$71.83M	0.3%	$37.28	+26.9%	COM	03753U106
NBIX	Neurocrine Biosciences, Inc.	676,975	$65.84M	0.3%	$62.87	+66.8%	COM	64125C109
KRYS	Krystal Biotech, Inc.	760,412	$58.58M	0.3%	$26.63	+173.0%	COM	501147102
—	Forma Therapeutics Holdings, Inc.	2,024,876	$56.74M	0.2%	$45.04	—	SHS	34633R104
—	Horizon Therapeutics Public Ltd Co	599,110	$55.14M	0.2%	$63.26	—	SHS	G46188101
—	Atreca, Inc.	3,532,760	$54.16M	0.2%	$18.84	—	CL A COM	04965G109
—	Zymeworks Inc.	1,708,472	$53.95M	0.2%	$14.76	—	COM	98985W102
ADAPY	Adaptimmune Therapeutics plc	9,830,877	$52.2M	0.2%	$5.77	—	SPONSORED ADR	00653A107
—	Kiniksa Pharmaceuticals, Ltd.	2,799,577	$51.82M	0.2%	$17.35	—	COM CL A	G5269C101
RARE	Ultragenyx Pharmaceutical Inc.	444,444	$50.6M	0.2%	$118.63	+14.8%	COM	90400D108
—	Neoleukin Therapeutics, Inc.	3,821,740	$47.05M	0.2%	$3.87	—	COM	64049K104
IMTX	Immatics N.V.	3,992,756	$44.76M	0.2%	$10.98	+3.3%	SHS	N44445109
DSGN	Design Therapeutics, Inc.	1,436,636	$42.95M	0.2%	$31.14	0.0%	COM	25056L103
—	Achilles Therapeutics plc	2,591,366	$42.89M	0.2%	$16.55	—	SPONSORED ADS	00449L102
—	Merus N.V.	2,037,469	$42.56M	0.2%	$10.77	—	COM	N5749R100
—	Verastem, Inc.	17,019,294	$42.04M	0.2%	$2.27	—	COM	92337C104
BCAB	BioAtla, Inc.	825,000	$41.94M	0.2%	$33.43	+53.3%	COM	09077B104
ALT	Altimmune, Inc.	2,758,518	$38.98M	0.2%	$9.32	+73.4%	COM	02155H200
FLGT	Fulgent Genetics, Inc.	401,016	$38.75M	0.2%	$11.30	+813.9%	COM	359664109
PTGX	Protagonist Therapeutics, Inc.	1,436,192	$37.2M	0.2%	$9.97	+153.8%	COM	74366E102
—	Aligos Therapeutics, Inc.	1,610,000	$36.61M	0.2%	$27.65	—	COM	01626L105
AXSM	Axsome Therapeutics, Inc.	628,414	$35.58M	0.2%	$23.39	+200.8%	COM	05464T104
ADCT	ADC Therapeutics SA	1,418,107	$34.62M	0.2%	$38.22	-24.2%	SHS	H0036K147
—	ChemoCentryx, Inc.	656,710	$33.65M	0.1%	$35.60	—	COM	16383L106
OPTEY	Opthea Limited	3,308,705	$31.66M	0.1%	$11.21	—	SPONSORED ADS	68386J208
—	Aeglea BioTherapeutics, Inc.	3,410,106	$27.01M	0.1%	$7.84	—	COM	00773J103
NVAX	Novavax, Inc.	143,756	$26.06M	0.1%	$38.25	+421.0%	COM	670002401
ALKS	Alkermes plc	1,228,170	$22.94M	0.1%	$23.07	-11.3%	SHS	G01767105
MREO	Mereo BioPharma Group plc	6,719,948	$22.65M	0.1%	$3.56	—	ADS	589492107
—	Reata Pharmaceuticals, Inc.	223,976	$22.33M	0.1%	$138.99	—	CL A	75615P103
—	Otonomy, Inc.	7,220,074	$18.41M	0.1%	$2.55	—	COM	68906L105
AUPH	Aurinia Pharmaceuticals Inc.	1,410,064	$18.31M	0.1%	$9.21	+57.5%	COM	05156V102
EWTX	Edgewise Therapeutics, Inc.	500,000	$16.25M	0.1%	$32.43	0.0%	COM	28036F105
XNCR	Xencor, Inc.	369,370	$15.9M	0.1%	$11.07	+328.2%	COM	98401F105
—	Invitae Corporation	10,300,000	$15.56M	0.1%	$1.64	—	NOTE 2.0% 9/1/2024	46185LAB9
—	BioMarin Pharmaceutical Inc.	15,000,000	$15.3M	0.1%	$1.01	—	NOTE 0.599% 8/1/2024	09061GAH4
—	Athira Pharma, Inc.	806,367	$14.84M	0.1%	$18.46	—	COM	04746L104
—	Albireo Pharma, Inc.	412,466	$14.54M	0.1%	$24.96	—	COM	01345P106
XENE	Xenon Pharmaceuticals Inc.	751,639	$13.45M	0.1%	$13.09	+29.5%	COM	98420N105
MIRM	Mirum Pharmaceuticals, Inc.	647,313	$12.83M	0.1%	$14.86	+28.8%	COM	604749101
—	Sarepta Therapeutics, Inc.	9,174,000	$11.97M	0.1%	$1.30	—	DBCV 1.5% 11/15/2024	803607AB6
—	Chinook Therapeutics, Inc.	748,693	$11.63M	0.1%	$15.86	—	COM	16961L106
SPRY	Silverback Therapeutics, Inc.	238,095	$10.39M	0.0%	$33.40	+41.7%	COM	82835W108
RVMD	Revolution Medicines, Inc.	222,222	$10.2M	0.0%	$44.84	0.0%	COM	76155X100
—	Cymabay Therapeutics, Inc.	2,170,464	$9.854M	0.0%	$5.48	—	COM	23257D103
—	Genetron Holdings Limited	455,306	$9.771M	0.0%	$13.55	—	ADS	37186H100
—	HOOKIPA Pharma Inc.	700,481	$9.421M	0.0%	$6.73	—	COM	43906K100
CRNX	Crinetics Pharmaceuticals, Inc.	616,520	$9.42M	0.0%	$18.19	-14.8%	COM	22663K107
ANAB	AnaptysBio, Inc.	427,179	$9.206M	0.0%	$26.06	-3.1%	COM	032724106
—	IVERIC bio, Inc.	1,406,037	$8.689M	0.0%	$3.89	—	COM	46583P102
—	NGM Biopharmaceuticals, Inc.	291,801	$8.483M	0.0%	$23.80	—	COM	62921N105
—	Karuna Therapeutics, Inc.	69,966	$8.412M	0.0%	$91.25	—	COM	48576A100
—	Gamida Cell Ltd.	1,037,226	$8.391M	0.0%	$6.83	—	SHS	M47364100
—	Assembly Biosciences, Inc.	1,541,418	$7.091M	0.0%	$17.50	—	COM	045396108
CABA	Cabaletta Bio, Inc.	636,363	$7.064M	0.0%	$11.85	+3.1%	COM	12674W109
—	bluebird bio, Inc.	226,988	$6.844M	0.0%	$58.05	—	COM	09609G100
MGNX	MacroGenics, Inc.	200,679	$6.392M	0.0%	$23.02	+5.5%	COM	556099109
—	Burning Rock Biotech Limited	209,131	$5.63M	0.0%	$27.01	—	SPONSORED ADS	12233L107
—	NexImmune, Inc.	294,117	$5.612M	0.0%	$19.08	—	COM	65344D109
SGMO	Sangamo Therapeutics, Inc.	429,063	$5.376M	0.0%	$11.28	+19.4%	COM	800677106
—	Orchard Therapeutics plc	734,431	$5.332M	0.0%	$10.55	—	ADS	68570P101
—	Syros Pharmaceuticals, Inc.	690,167	$5.162M	0.0%	$13.72	—	COM	87184Q107
—	Iteos Therapeutics, Inc.	150,346	$5.139M	0.0%	$24.67	—	COM	46565G104
DNLI	Denali Therapeutics Inc.	88,738	$5.067M	0.0%	$20.86	+220.9%	COM	24823R105
ALEC	Alector, Inc.	239,228	$4.818M	0.0%	$25.49	-29.7%	COM	014442107
—	Evofem Biosciences, Inc.	2,697,110	$4.72M	0.0%	$2.13	—	COM	30048L104
REPL	Replimune Group, Inc.	153,512	$4.684M	0.0%	$22.66	+65.3%	COM	76029N106
TVTX	Travere Therapeutics, Inc.	186,915	$4.667M	0.0%	$27.63	0.0%	COM	89422G107
SRPT	Sarepta Therapeutics, Inc.	58,700	$4.375M	0.0%	$92.28	0.0%	COM	803607100
—	Passage Bio, Inc.	235,362	$4.114M	0.0%	$15.75	—	COM	702712100
HRMY	Harmony Biosciences Holdings, Inc.	123,600	$4.084M	0.0%	$36.46	-3.8%	COM	413197104
—	TCR2 Therapeutics Inc.	176,461	$3.896M	0.0%	$20.97	—	COM	87808K106
—	Tricida, Inc.	729,300	$3.858M	0.0%	$6.81	—	COM	89610F101
—	Akero Therapeutics, Inc.	118,378	$3.434M	0.0%	$30.79	—	COM	00973Y108
LEGN	Legend Biotech Corporation	115,626	$3.355M	0.0%	$42.56	—	SPONSORED ADS	52490G102
—	LogicBio Therapeutics, Inc.	451,478	$3.287M	0.0%	$7.63	—	COM	54142F102
TARA	Protara Therapeutics, Inc.	199,671	$3.143M	0.0%	$30.96	-40.1%	COM STK	74365U107
—	Acceleron Pharma Inc.	22,430	$3.042M	0.0%	$89.85	—	COM	00434H108
—	Constellation Pharmaceuticals, Inc.	114,735	$2.684M	0.0%	$6.73	—	COM	210373106
—	Idera Pharmaceuticals, Inc.	2,047,180	$2.661M	0.0%	$1.32	—	COM PAR	45168K405
AUTL	Autolus Therapeutics plc	461,726	$2.646M	0.0%	$15.17	—	SPONSORED ADS	05280R100
—	Chiasma, Inc.	742,133	$2.323M	0.0%	$5.38	—	COM	16706W102
VKTX	Viking Therapeutics, Inc.	363,980	$2.302M	0.0%	$11.90	-40.9%	COM	92686J106
—	Inozyme Pharma, Inc.	106,999	$2.119M	0.0%	$26.29	—	COM	45790W108
—	Molecular Templates, Inc.	133,833	$1.689M	0.0%	$7.45	—	COM	608550109
—	Affimed N.V.	164,605	$1.302M	0.0%	$6.30	—	COM	N01045108
—	Oyster Point Pharma, Inc.	61,424	$1.123M	0.0%	$28.88	—	COM	69242L106
—	Leap Therapeutics, Inc.	559,705	$1.063M	0.0%	$1.17	—	COM	52187K101
—	Bellicum Pharmaceuticals, Inc.	249,123	$937K	0.0%	$4.71	—	COM	079481404
GLPG	Galapagos NV	11,180	$862K	0.0%	$51.50	—	SPONSORED ADR	36315X101
—	Kezar Life Sciences, Inc.	139,676	$832K	0.0%	$5.18	—	COM	49372L100
—	Adamas Pharmaceuticals, Inc.	147,996	$710K	0.0%	$14.46	—	COM	00548A106
—	Galmed Pharmaceuticals Ltd.	184,927	$634K	0.0%	$11.90	—	SHS	M47238106
IFRX	Inflarx N.V.	138,040	$538K	0.0%	$2.91	+76.1%	COM	N44821101
—	Frequency Therapeutics, Inc.	55,555	$528K	0.0%	$17.53	—	COM	35803L108
GNFTY	Genfit SA	14,720	$68,000	0.0%	$14.24	—	ADS	372279109