BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q1 2021 (← Previous) (Next →)

Filing Date: May 17, 2021

Total Value ($000): $23,065,323 (99.8% shares, 0.2% debt)

Holdings (126)

Seagen Inc. 28.5%
Value ($000) $6,564,018 Shares 47,270,759 Est. Cost $195.69 Unrealized
ONC BeiGene, Ltd. 17.6%
Value ($000) $4,061,710 Shares 11,668,897 Est. Cost $136.93 Unrealized
INCY Incyte Corporation 11.3%
Value ($000) $2,600,753 Shares 32,001,387 Est. Cost $73.07 Unrealized +16.8%
KOD Kodiak Sciences Inc. 6.8%
Value ($000) $1,573,848 Shares 13,879,952 Est. Cost $28.18 Unrealized +384.6%
ACAD ACADIA Pharmaceuticals Inc. 4.7%
Value ($000) $1,081,296 Shares 41,910,704 Est. Cost $18.86 Unrealized +133.5%
Alexion Pharmaceuticals, Inc. 2.6%
Value ($000) $610,617 Shares 3,993,312 Est. Cost $162.46 Unrealized
Invitae Corporation 2.6%
Value ($000) $601,776 Shares 15,749,182 Est. Cost $25.40 Unrealized
BMRN BioMarin Pharmaceutical Inc. 2.5%
Value ($000) $573,068 Shares 7,589,294 Est. Cost $81.02 Unrealized +0.8%
ASND Ascendis Pharma A/S 2.0%
Value ($000) $456,270 Shares 3,540,270 Est. Cost $48.88 Unrealized
PRLD Prelude Therapeutics Incorporated 1.9%
Value ($000) $438,665 Shares 10,123,824 Est. Cost $28.24 Unrealized +134.9%
ABCL AbCellera Biologics Inc. 1.5%
Value ($000) $354,888 Shares 10,450,180 Est. Cost $45.73 Unrealized -12.9%
ARGX argenx SE 1.3%
Value ($000) $308,315 Shares 1,119,557 Est. Cost $79.01 Unrealized
IGM Biosciences, Inc. 1.0%
Value ($000) $242,041 Shares 3,156,102 Est. Cost $17.75 Unrealized
Mirati Therapeutics, Inc. 1.0%
Value ($000) $241,496 Shares 1,409,784 Est. Cost $22.85 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 0.8%
Value ($000) $175,363 Shares 1,499,213 Est. Cost $104.81 Unrealized +11.2%
Amarin Corporation plc 0.7%
Value ($000) $164,276 Shares 26,453,422 Est. Cost $8.93 Unrealized
Global Blood Therapeutics, Inc. 0.6%
Value ($000) $131,111 Shares 3,217,441 Est. Cost $44.81 Unrealized
BCRX BioCryst Pharmaceuticals, Inc. 0.6%
Value ($000) $129,269 Shares 12,710,818 Est. Cost $6.35 Unrealized +62.3%
IMCR Immunocore Holdings plc 0.5%
Value ($000) $107,307 Shares 2,520,730 Est. Cost $42.57 Unrealized
PACB Pacific Biosciences of California, Inc. 0.5%
Value ($000) $106,658 Shares 3,201,972 Est. Cost $5.76 Unrealized +508.0%
Instil Bio, Inc. 0.4%
Value ($000) $97,654 Shares 3,893,700 Est. Cost $25.08 Unrealized
Talis Biomedical Corporation 0.4%
Value ($000) $97,337 Shares 7,574,835 Est. Cost $12.85 Unrealized
HRTX Heron Therapeutics, Inc. 0.4%
Value ($000) $97,174 Shares 5,994,704 Est. Cost $17.78 Unrealized +0.3%
CERS Cerus Corporation 0.4%
Value ($000) $82,416 Shares 13,713,195 Est. Cost $4.64 Unrealized +46.6%
Allakos Inc. 0.3%
Value ($000) $80,696 Shares 703,050 Est. Cost $62.02 Unrealized
DBV Technologies S.A. 0.3%
Value ($000) $77,894 Shares 14,614,264 Est. Cost $19.06 Unrealized
NRIX Nurix Therapeutics, Inc. 0.3%
Value ($000) $76,297 Shares 2,454,082 Est. Cost $28.63 Unrealized +32.2%
KYMR Kymera Therapeutics, Inc. 0.3%
Value ($000) $76,135 Shares 1,959,211 Est. Cost $30.53 Unrealized +97.2%
RYTM Rhythm Pharmaceuticals, Inc. 0.3%
Value ($000) $74,017 Shares 3,479,873 Est. Cost $27.43 Unrealized +5.8%
INSM Insmed Incorporated 0.3%
Value ($000) $73,433 Shares 2,156,001 Est. Cost $22.18 Unrealized +72.3%
APLS Apellis Pharmaceuticals, Inc. 0.3%
Value ($000) $71,832 Shares 1,674,004 Est. Cost $37.28 Unrealized +26.9%
NBIX Neurocrine Biosciences, Inc. 0.3%
Value ($000) $65,836 Shares 676,975 Est. Cost $62.87 Unrealized +66.8%
KRYS Krystal Biotech, Inc. 0.3%
Value ($000) $58,582 Shares 760,412 Est. Cost $26.63 Unrealized +173.0%
Forma Therapeutics Holdings, Inc. 0.2%
Value ($000) $56,737 Shares 2,024,876 Est. Cost $45.04 Unrealized
Horizon Therapeutics Public Ltd Co 0.2%
Value ($000) $55,142 Shares 599,110 Est. Cost $63.26 Unrealized
Atreca, Inc. 0.2%
Value ($000) $54,157 Shares 3,532,760 Est. Cost $18.84 Unrealized
Zymeworks Inc. 0.2%
Value ($000) $53,954 Shares 1,708,472 Est. Cost $14.76 Unrealized
ADAPY Adaptimmune Therapeutics plc 0.2%
Value ($000) $52,202 Shares 9,830,877 Est. Cost $5.77 Unrealized
Kiniksa Pharmaceuticals, Ltd. 0.2%
Value ($000) $51,820 Shares 2,799,577 Est. Cost $17.35 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.2%
Value ($000) $50,604 Shares 444,444 Est. Cost $118.63 Unrealized +14.8%
Neoleukin Therapeutics, Inc. 0.2%
Value ($000) $47,046 Shares 3,821,740 Est. Cost $3.87 Unrealized
IMTX Immatics N.V. 0.2%
Value ($000) $44,759 Shares 3,992,756 Est. Cost $10.98 Unrealized +3.3%
DSGN Design Therapeutics, Inc. 0.2%
Value ($000) $42,955 Shares 1,436,636 Est. Cost $31.14 Unrealized 0.0%
Achilles Therapeutics plc 0.2%
Value ($000) $42,887 Shares 2,591,366 Est. Cost $16.55 Unrealized
Merus N.V. 0.2%
Value ($000) $42,563 Shares 2,037,469 Est. Cost $10.77 Unrealized
Verastem, Inc. 0.2%
Value ($000) $42,038 Shares 17,019,294 Est. Cost $2.27 Unrealized
BCAB BioAtla, Inc. 0.2%
Value ($000) $41,943 Shares 825,000 Est. Cost $33.43 Unrealized +53.3%
ALT Altimmune, Inc. 0.2%
Value ($000) $38,978 Shares 2,758,518 Est. Cost $9.32 Unrealized +73.4%
FLGT Fulgent Genetics, Inc. 0.2%
Value ($000) $38,746 Shares 401,016 Est. Cost $11.30 Unrealized +813.9%
PTGX Protagonist Therapeutics, Inc. 0.2%
Value ($000) $37,197 Shares 1,436,192 Est. Cost $9.97 Unrealized +153.8%
Aligos Therapeutics, Inc. 0.2%
Value ($000) $36,611 Shares 1,610,000 Est. Cost $27.65 Unrealized
AXSM Axsome Therapeutics, Inc. 0.2%
Value ($000) $35,581 Shares 628,414 Est. Cost $23.39 Unrealized +200.8%
ADCT ADC Therapeutics SA 0.2%
Value ($000) $34,616 Shares 1,418,107 Est. Cost $38.22 Unrealized -24.2%
ChemoCentryx, Inc. 0.1%
Value ($000) $33,650 Shares 656,710 Est. Cost $35.60 Unrealized
OPTEY Opthea Limited 0.1%
Value ($000) $31,664 Shares 3,308,705 Est. Cost $11.21 Unrealized
Aeglea BioTherapeutics, Inc. 0.1%
Value ($000) $27,008 Shares 3,410,106 Est. Cost $7.84 Unrealized
NVAX Novavax, Inc. 0.1%
Value ($000) $26,064 Shares 143,756 Est. Cost $38.25 Unrealized +421.0%
ALKS Alkermes plc 0.1%
Value ($000) $22,942 Shares 1,228,170 Est. Cost $23.07 Unrealized -11.3%
MREO Mereo BioPharma Group plc 0.1%
Value ($000) $22,646 Shares 6,719,948 Est. Cost $3.56 Unrealized
Reata Pharmaceuticals, Inc. 0.1%
Value ($000) $22,330 Shares 223,976 Est. Cost $138.99 Unrealized
Otonomy, Inc. 0.1%
Value ($000) $18,411 Shares 7,220,074 Est. Cost $2.55 Unrealized
AUPH Aurinia Pharmaceuticals Inc. 0.1%
Value ($000) $18,310 Shares 1,410,064 Est. Cost $9.21 Unrealized +57.5%
EWTX Edgewise Therapeutics, Inc. 0.1%
Value ($000) $16,250 Shares 500,000 Est. Cost $32.43 Unrealized 0.0%
XNCR Xencor, Inc. 0.1%
Value ($000) $15,905 Shares 369,370 Est. Cost $11.07 Unrealized +328.2%
Invitae Corporation 0.1%
Value ($000) $15,557 Shares 10,300,000 Est. Cost $1.64 Unrealized
BioMarin Pharmaceutical Inc. 0.1%
Value ($000) $15,299 Shares 15,000,000 Est. Cost $1.01 Unrealized
Athira Pharma, Inc. 0.1%
Value ($000) $14,837 Shares 806,367 Est. Cost $18.46 Unrealized
Albireo Pharma, Inc. 0.1%
Value ($000) $14,539 Shares 412,466 Est. Cost $24.96 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.1%
Value ($000) $13,454 Shares 751,639 Est. Cost $13.09 Unrealized +29.5%
MIRM Mirum Pharmaceuticals, Inc. 0.1%
Value ($000) $12,830 Shares 647,313 Est. Cost $14.86 Unrealized +28.8%
Sarepta Therapeutics, Inc. 0.1%
Value ($000) $11,970 Shares 9,174,000 Est. Cost $1.30 Unrealized
Chinook Therapeutics, Inc. 0.1%
Value ($000) $11,635 Shares 748,693 Est. Cost $15.86 Unrealized
SPRY Silverback Therapeutics, Inc. 0.0%
Value ($000) $10,388 Shares 238,095 Est. Cost $33.40 Unrealized +41.7%
RVMD Revolution Medicines, Inc. 0.0%
Value ($000) $10,196 Shares 222,222 Est. Cost $44.84 Unrealized 0.0%
Cymabay Therapeutics, Inc. 0.0%
Value ($000) $9,854 Shares 2,170,464 Est. Cost $5.48 Unrealized
Genetron Holdings Limited 0.0%
Value ($000) $9,771 Shares 455,306 Est. Cost $13.55 Unrealized
HOOKIPA Pharma Inc. 0.0%
Value ($000) $9,421 Shares 700,481 Est. Cost $6.73 Unrealized
CRNX Crinetics Pharmaceuticals, Inc. 0.0%
Value ($000) $9,420 Shares 616,520 Est. Cost $18.19 Unrealized -14.8%
ANAB AnaptysBio, Inc. 0.0%
Value ($000) $9,206 Shares 427,179 Est. Cost $26.06 Unrealized -3.1%
IVERIC bio, Inc. 0.0%
Value ($000) $8,689 Shares 1,406,037 Est. Cost $3.89 Unrealized
NGM Biopharmaceuticals, Inc. 0.0%
Value ($000) $8,483 Shares 291,801 Est. Cost $23.80 Unrealized
Karuna Therapeutics, Inc. 0.0%
Value ($000) $8,412 Shares 69,966 Est. Cost $91.25 Unrealized
Gamida Cell Ltd. 0.0%
Value ($000) $8,391 Shares 1,037,226 Est. Cost $6.83 Unrealized
Assembly Biosciences, Inc. 0.0%
Value ($000) $7,091 Shares 1,541,418 Est. Cost $17.50 Unrealized
CABA Cabaletta Bio, Inc. 0.0%
Value ($000) $7,064 Shares 636,363 Est. Cost $11.85 Unrealized +3.1%
bluebird bio, Inc. 0.0%
Value ($000) $6,844 Shares 226,988 Est. Cost $58.05 Unrealized
MGNX MacroGenics, Inc. 0.0%
Value ($000) $6,392 Shares 200,679 Est. Cost $23.02 Unrealized +5.5%
Burning Rock Biotech Limited 0.0%
Value ($000) $5,630 Shares 209,131 Est. Cost $27.01 Unrealized
NexImmune, Inc. 0.0%
Value ($000) $5,612 Shares 294,117 Est. Cost $19.08 Unrealized
SGMO Sangamo Therapeutics, Inc. 0.0%
Value ($000) $5,376 Shares 429,063 Est. Cost $11.28 Unrealized +19.4%
Orchard Therapeutics plc 0.0%
Value ($000) $5,332 Shares 734,431 Est. Cost $10.55 Unrealized
Syros Pharmaceuticals, Inc. 0.0%
Value ($000) $5,162 Shares 690,167 Est. Cost $13.72 Unrealized
Iteos Therapeutics, Inc. 0.0%
Value ($000) $5,139 Shares 150,346 Est. Cost $24.67 Unrealized
DNLI Denali Therapeutics Inc. 0.0%
Value ($000) $5,067 Shares 88,738 Est. Cost $20.86 Unrealized +220.9%
ALEC Alector, Inc. 0.0%
Value ($000) $4,818 Shares 239,228 Est. Cost $25.49 Unrealized -29.7%
Evofem Biosciences, Inc. 0.0%
Value ($000) $4,720 Shares 2,697,110 Est. Cost $2.13 Unrealized
REPL Replimune Group, Inc. 0.0%
Value ($000) $4,684 Shares 153,512 Est. Cost $22.66 Unrealized +65.3%
TVTX Travere Therapeutics, Inc. 0.0%
Value ($000) $4,667 Shares 186,915 Est. Cost $27.63 Unrealized 0.0%
SRPT Sarepta Therapeutics, Inc. 0.0%
Value ($000) $4,375 Shares 58,700 Est. Cost $92.28 Unrealized 0.0%
Passage Bio, Inc. 0.0%
Value ($000) $4,114 Shares 235,362 Est. Cost $15.75 Unrealized
HRMY Harmony Biosciences Holdings, Inc. 0.0%
Value ($000) $4,084 Shares 123,600 Est. Cost $36.46 Unrealized -3.8%
TCR2 Therapeutics Inc. 0.0%
Value ($000) $3,896 Shares 176,461 Est. Cost $20.97 Unrealized
Tricida, Inc. 0.0%
Value ($000) $3,858 Shares 729,300 Est. Cost $6.81 Unrealized
Akero Therapeutics, Inc. 0.0%
Value ($000) $3,434 Shares 118,378 Est. Cost $30.79 Unrealized
LEGN Legend Biotech Corporation 0.0%
Value ($000) $3,355 Shares 115,626 Est. Cost $42.56 Unrealized
LogicBio Therapeutics, Inc. 0.0%
Value ($000) $3,287 Shares 451,478 Est. Cost $7.63 Unrealized
TARA Protara Therapeutics, Inc. 0.0%
Value ($000) $3,143 Shares 199,671 Est. Cost $30.96 Unrealized -40.1%
Acceleron Pharma Inc. 0.0%
Value ($000) $3,042 Shares 22,430 Est. Cost $89.85 Unrealized
Constellation Pharmaceuticals, Inc. 0.0%
Value ($000) $2,684 Shares 114,735 Est. Cost $6.73 Unrealized
Idera Pharmaceuticals, Inc. 0.0%
Value ($000) $2,661 Shares 2,047,180 Est. Cost $1.32 Unrealized
AUTL Autolus Therapeutics plc 0.0%
Value ($000) $2,646 Shares 461,726 Est. Cost $15.17 Unrealized
Chiasma, Inc. 0.0%
Value ($000) $2,323 Shares 742,133 Est. Cost $5.38 Unrealized
VKTX Viking Therapeutics, Inc. 0.0%
Value ($000) $2,302 Shares 363,980 Est. Cost $11.90 Unrealized -40.9%
Inozyme Pharma, Inc. 0.0%
Value ($000) $2,119 Shares 106,999 Est. Cost $26.29 Unrealized
Molecular Templates, Inc. 0.0%
Value ($000) $1,689 Shares 133,833 Est. Cost $7.45 Unrealized
Affimed N.V. 0.0%
Value ($000) $1,302 Shares 164,605 Est. Cost $6.30 Unrealized
Oyster Point Pharma, Inc. 0.0%
Value ($000) $1,123 Shares 61,424 Est. Cost $28.88 Unrealized
Leap Therapeutics, Inc. 0.0%
Value ($000) $1,063 Shares 559,705 Est. Cost $1.17 Unrealized
Bellicum Pharmaceuticals, Inc. 0.0%
Value ($000) $937 Shares 249,123 Est. Cost $4.71 Unrealized
GLPG Galapagos NV 0.0%
Value ($000) $862 Shares 11,180 Est. Cost $51.50 Unrealized
Kezar Life Sciences, Inc. 0.0%
Value ($000) $832 Shares 139,676 Est. Cost $5.18 Unrealized
Adamas Pharmaceuticals, Inc. 0.0%
Value ($000) $710 Shares 147,996 Est. Cost $14.46 Unrealized
Galmed Pharmaceuticals Ltd. 0.0%
Value ($000) $634 Shares 184,927 Est. Cost $11.90 Unrealized
IFRX Inflarx N.V. 0.0%
Value ($000) $538 Shares 138,040 Est. Cost $2.91 Unrealized +76.1%
Frequency Therapeutics, Inc. 0.0%
Value ($000) $528 Shares 55,555 Est. Cost $17.53 Unrealized
GNFTY Genfit SA 0.0%
Value ($000) $68 Shares 14,720 Est. Cost $14.24 Unrealized