Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $4.688B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 7,567,900 | $781M | 16.7% | $103.26 | $73.22 | — | SPONSORED ADR | 04351P101 |
| BIIB | BIOGEN INC | 937,549 | $250M | 5.3% | $267.00 * | $216.32 | -1.8% | COM | 09062X103 |
| CTKB | CYTEK BIOSCIENCES INC | 13,381,054 | $197M | 4.2% | $14.72 * | $20.70 | -37.2% | COM | 23285D109 |
| — | FORMA THERAPEUTICS HLDGS INC | 9,011,651 | $180M | 3.8% | $19.95 | $46.49 | — | SHS | 34633R104 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,040,622 | $141M | 3.0% | $20.03 * | $18.13 | +17.3% | COM | 23954D109 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $137M | 2.9% | $16.58 | $22.83 | — | COM | 008064107 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,471,067 | $134M | 2.9% | $24.50 * | $24.11 | -22.9% | COM | 76243J105 |
| TVTX | TRAVERE THERAPEUTICS INC | 4,922,941 | $121M | 2.6% | $24.64 * | $24.15 | +7.0% | COM | 89422G107 |
| — | BELLUS HEALTH INC NEW | 11,385,574 | $120M | 2.6% | $10.56 | $8.30 | — | COM NEW | 07987C204 |
| JANX | JANUX THERAPEUTICS INC | 8,670,644 | $117M | 2.5% | $13.54 | $22.27 | -40.0% | COM | 47103J105 |
| PCVX | VAXCYTE INC | 4,581,203 | $110M | 2.3% | $24.00 * | $30.49 | -16.8% | COM | 92243G108 |
| — | DICE THERAPEUTICS INC | 5,208,911 | $106M | 2.3% | $20.28 | $32.75 | — | COM | 23345J104 |
| — | IMMUNOGEN INC | 21,741,458 | $104M | 2.2% | $4.78 | $5.49 | — | COM | 45253H101 |
| NKTX | NKARTA INC | 7,805,129 | $103M | 2.2% | $13.16 * | $24.86 | -42.5% | COM | 65487U108 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 9,770,773 | $98M | 2.1% | $10.03 * | $16.64 | -65.5% | COM | 00509G209 |
| LEGN | LEGEND BIOTECH CORP | 2,338,610 | $95.42M | 2.0% | $40.80 | $40.80 | — | SPONSORED ADS | 52490G102 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $84.15M | 1.8% | $19.05 | $24.67 | — | COM | 46565G104 |
| RLMD | RELMADA THERAPEUTICS INC | 2,000,000 | $74.04M | 1.6% | $37.02 * | $22.24 | +24.6% | COM | 75955J402 |
| PEPG | PEPGEN INC | 8,131,952 | $73.84M | 1.6% | $9.08 * | $11.15 | -11.8% | COM | 713317105 |
| GERN | GERON CORP | 30,126,299 | $70.5M | 1.5% | $2.34 * | $1.49 | +49.8% | COM | 374163103 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,398,453 | $69.23M | 1.5% | $15.74 | $13.86 | +13.7% | COM | 00461U105 |
| — | THIRD HARMONIC BIO INC | 3,475,687 | $65.93M | 1.4% | $18.97 | $18.97 | — | COM | 88427A107 |
| ANTX | AN2 THERAPEUTICS INC | 3,773,517 | $65.58M | 1.4% | $17.38 * | $15.13 | -23.0% | COM | 037326105 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $63.61M | 1.4% | $8.79 * | $19.11 | -52.1% | COM | 90240B106 |
| WVE | WAVE LIFE SCIENCES LTD | 17,202,009 | $62.1M | 1.3% | $3.61 * | $8.85 | -62.6% | SHS | Y95308105 |
| — | VERONA PHARMA PLC | 6,050,000 | $61.83M | 1.3% | $10.22 | $6.86 | — | SPONSORED ADS | 925050106 |
| COGT | COGENT COMMUNICATIONS HLDGS | 4,013,453 | $59.88M | 1.3% | $14.92 * | $13.71 | 0.0% | COM NEW | 19240Q201 |
| — | NANOSTRING TECHNOLOGIES | 4,602,478 | $58.77M | 1.3% | $12.77 | $12.72 | — | COM | 63009R109 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 2,075,000 | $58.33M | 1.2% | $28.11 * | $44.65 | -31.3% | COM NEW | 15117B202 |
| GHRS | GH RESEARCH PLC | 4,898,373 | $56.92M | 1.2% | $11.62 * | $19.20 | -34.3% | ORDINARY SHARES | G3855L106 |
| FULC | FULCRUM THERAPEUTICS INC | 7,000,000 | $56.63M | 1.2% | $8.09 * | $7.16 | 0.0% | COM | 359616109 |
| — | KINNATE BIOPHARMA INC | 4,264,144 | $50.96M | 1.1% | $11.95 | $35.29 | — | COM | 49705R105 |
| ENTA | ENANTA PHARMACEUTICALS INC | 896,724 | $46.51M | 1.0% | $51.87 * | $65.07 | -10.2% | COM | 29251M106 |
| DSGN | DESIGN THERAPEUTICS INC | 2,773,231 | $46.37M | 1.0% | $16.72 * | $28.77 | -30.8% | COM | 25056L103 |
| — | 89BIO INC | 7,782,669 | $45.06M | 1.0% | $5.79 | $17.59 | — | COM | 282559103 |
| — | VOR BIOPHARMA INC | 11,120,973 | $44.26M | 0.9% | $3.98 | $43.10 | — | COM | 929033108 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $42.48M | 0.9% | $3.23 | $20.66 | -84.6% | COM | 28658R106 |
| — | INSTIL BIO INC | 7,670,793 | $37.13M | 0.8% | $4.84 | $17.61 | — | COM | 45783C101 |
| RXST | RXSIGHT INC | 3,052,796 | $36.63M | 0.8% | $12.00 * | $13.76 | -0.2% | COM | 78349D107 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $35.49M | 0.8% | $6.00 | $13.11 | — | COM | 80405P107 |
| RNAM | AVIDITY BIOSCIENCES INC | 2,167,391 | $35.39M | 0.8% | $16.33 * | $17.92 | +6.8% | COM | 05370A108 |
| VERA | VERA THERAPEUTICS INC | 1,578,820 | $33.65M | 0.7% | $21.31 * | $21.52 | -13.0% | CL A | 92337R101 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,107,149 | $33.63M | 0.7% | $15.96 * | $36.45 | -57.2% | COM | 77313F106 |
| — | AKERO THERAPEUTICS INC | 958,980 | $32.65M | 0.7% | $34.05 | $34.05 | — | COM | 00973Y108 |
| — | ALPINE IMMUNE SCIENCES INC | 4,356,632 | $31.37M | 0.7% | $7.20 | $7.20 | — | COM | 02083G100 |
| — | HILLEVAX INC | 1,760,019 | $30.08M | 0.6% | $17.09 | $10.93 | — | COM | 43157M102 |
| — | ADICET BIO INC | 2,059,372 | $29.28M | 0.6% | $14.22 | $14.22 | — | COM | 007002108 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,370,506 | $26.66M | 0.6% | $7.91 * | $11.52 | -19.4% | COM NEW | 30233G209 |
| MIST | MILESTONE PHARMACEUTICALS IN | 2,246,503 | $20.64M | 0.4% | $9.19 * | $7.17 | +5.8% | COM | 59935V107 |
| PMVP | PMV PHARMACEUTICALS INC | 1,710,265 | $20.35M | 0.4% | $11.90 * | $36.80 | -60.7% | COM | 69353Y103 |
| HOWL | WEREWOLF THERAPEUTICS INC | 4,291,881 | $19.36M | 0.4% | $4.51 * | $13.70 | -60.4% | COM | 95075A107 |
| — | ICOSAVAX INC | 5,963,565 | $18.84M | 0.4% | $3.16 | $28.89 | — | COM | 45114M109 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 880,000 | $18.05M | 0.4% | $20.51 * | $17.98 | 0.0% | SPONSORED ADS | 92790C104 |
| RLAY | RELAY THERAPEUTICS INC | 717,618 | $16.05M | 0.3% | $22.37 | $29.33 | -25.2% | COM | 75943R102 |
| — | DA32 LIFE SCNCE | 1,500,000 | $14.6M | 0.3% | $9.73 | $9.83 | — | CLASS A COM | 23312M106 |
| — | BCLS ACQUISITION CORP | 1,250,000 | $12.53M | 0.3% | $10.02 | $11.14 | — | COM CL A | G0904B105 |
| — | PARDES BIOSCIENCES INC | 6,175,038 | $11.42M | 0.2% | $1.85 | $11.85 | — | COM | 69945Q105 |
| — | ACHILLES THERAPEUTICS PLC | 5,014,687 | $11.33M | 0.2% | $2.26 | $11.66 | — | SPONSORED ADS | 00449L102 |
| — | FRAZIER LIFESCIENCES ACQU CO | 1,000,000 | $9.98M | 0.2% | $9.98 | $10.38 | — | CL A SHS | G3710A121 |
| — | ARYA SCIENCES ACQUISITN CORP | 1,000,000 | $9.8M | 0.2% | $9.80 | $9.88 | — | CLASS A ORD SHS | G31658100 |
| — | CONNECT BIOPHARMA HLDGS LTD | 6,991,003 | $9.018M | 0.2% | $1.29 | $19.09 | — | ADS | 207523101 |
| WHWK | AADI BIOSCIENCE INC | 590,218 | $8.34M | 0.2% | $14.13 * | $14.25 | -7.8% | COM | 00032Q104 |
| — | 5 01 ACQUISITION CORP | 750,000 | $7.5M | 0.2% | $10.00 | $10.17 | — | COM CL A | 33836P105 |
| — | CONCERT PHARMACEUTICALS INC | 1,088,296 | $7.292M | 0.2% | $6.70 | $7.05 | — | COM | 206022105 |
| — | DBV TECHNOLOGIES S A | 3,724,740 | $6.593M | 0.1% | $1.77 | $1.77 | — | SPONSORED ADR | 23306J101 |
| — | HEALTH SCIENCES ACQ CORP 2 | 610,283 | $6.042M | 0.1% | $9.90 | $11.00 | — | ORD SHS | G4411D109 |
| — | SOLID BIOSCIENCES INC | 12,367,873 | $5.771M | 0.1% | $0.47 | $7.59 | — | COM | 83422E105 |
| — | ATHIRA PHARMA INC | 1,878,000 | $5.578M | 0.1% | $2.97 | $3.05 | — | COM | 04746L104 |
| — | MAGENTA THERAPEUTICS INC | 3,588,081 | $5.059M | 0.1% | $1.41 | $1.41 | — | COM | 55910K108 |
| IOBT | IO BIOTECH INC | 1,857,755 | $5.035M | 0.1% | $2.71 * | $9.66 | -61.6% | COM | 449778109 |
| TNYA | TENAYA THERAPEUTICS INC | 1,602,009 | $4.646M | 0.1% | $2.90 * | $21.49 | -78.3% | COM | 87990A106 |
| — | SYNLOGIC INC | 4,618,415 | $4.387M | 0.1% | $0.95 | $3.05 | — | COM | 87166L100 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 2,589,904 | $4.377M | 0.1% | $1.69 * | $30.22 | -89.8% | COM | 09203E105 |
| CVRX | CVRX INC | 275,000 | $2.566M | 0.1% | $9.33 * | $28.00 | -71.7% | COM | 126638105 |
| ENTX | ENTERA BIO LTD | 2,082,372 | $2.166M | 0.0% | $1.04 * | $3.70 | -59.2% | SHS | M40527109 |
| — | FUSION PHARMACEUTICALS INC | 659,992 | $1.987M | 0.0% | $3.01 | $3.01 | — | COM | 36118A100 |
| PYXS | PYXIS ONCOLOGY INC | 764,653 | $1.506M | 0.0% | $1.97 * | $11.45 | -77.2% | COMMON STOCK | 747324101 |
| — | SENSEI BIOTHERAPEUTICS | 683,529 | $1.059M | 0.0% | $1.55 | $2.27 | — | COM | 81728A108 |
| — | BOLT BIOTHERAPEUTICS INC | 533,432 | $789K | 0.0% | $1.48 | $1.95 | — | COM | 097702104 |
| — | APTINYX INC | 1,954,698 | $720K | 0.0% | $0.37 | $0.37 | — | COM | 03836N103 |
| — | AEGLEA BIOTHERAPEUTICS INC | 10,439 | $5,000 | 0.0% | $0.48 | $0.48 | — | COM | 00773J103 |