Location: Boston, MA
CIK: 0001346824 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $4.931B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ASND | ASCENDIS PHARMA A/S | 6,957,179 | $850M | 17.2% | $122.13 | $73.22 | — | SPONSORED ADR | 04351P101 |
| PCVX | VAXCYTE INC | 5,857,459 | $281M | 5.7% | $47.95 * | $32.39 | +21.1% | COM | 92243G108 |
| — | AEROVATE THERAPEUTICS INC | 8,263,982 | $242M | 4.9% | $29.30 | $22.83 | — | COM | 008064107 |
| — | DICE THERAPEUTICS INC | 6,848,911 | $214M | 4.3% | $31.20 | $32.38 | — | COM | 23345J104 |
| — | VERONA PHARMA PLC | 6,317,990 | $165M | 3.3% | $26.13 | $7.68 | — | SPONSORED ADS | 925050106 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 5,516,067 | $161M | 3.3% | $29.12 * | $24.11 | +6.6% | COM | 76243J105 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 7,040,622 | $152M | 3.1% | $21.52 * | $18.13 | +13.1% | COM | 23954D109 |
| — | VOR BIOPHARMA INC | 22,748,880 | $151M | 3.1% | $6.65 | $24.47 | — | COM | 929033108 |
| BIIB | BIOGEN INC | 532,892 | $148M | 3.0% | $276.92 | $216.32 | +30.6% | COM | 09062X103 |
| CTKB | CYTEK BIOSCIENCES INC | 13,381,054 | $137M | 2.8% | $10.21 * | $20.70 | -35.1% | COM | 23285D109 |
| LEGN | LEGEND BIOTECH CORP | 2,436,223 | $122M | 2.5% | $49.92 | $41.17 | — | SPONSORED ADS | 52490G102 |
| RNAM | AVIDITY BIOSCIENCES INC | 5,454,533 | $121M | 2.5% | $22.19 * | $16.10 | -7.4% | COM | 05370A108 |
| WVE | WAVE LIFE SCIENCES LTD | 17,202,009 | $120M | 2.4% | $7.00 * | $8.85 | -48.0% | SHS | Y95308105 |
| JANX | JANUX THERAPEUTICS INC | 8,670,644 | $114M | 2.3% | $13.17 * | $22.27 | -34.3% | COM | 47103J105 |
| — | 89BIO INC | 8,955,410 | $114M | 2.3% | $12.73 | $16.95 | — | COM | 282559103 |
| PEPG | PEPGEN INC | 8,131,952 | $109M | 2.2% | $13.37 * | $11.15 | +15.8% | COM | 713317105 |
| — | IMMUNOGEN INC | 21,853,958 | $108M | 2.2% | $4.96 | $5.49 | — | COM | 45253H101 |
| — | BELLUS HEALTH INC NEW | 12,452,574 | $102M | 2.1% | $8.22 | $8.30 | — | COM NEW | 07987C204 |
| — | INHIBRX INC | 3,853,867 | $94.96M | 1.9% | $24.64 | $24.64 | — | COM | 45720L107 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 2,075,000 | $92.48M | 1.9% | $44.57 * | $44.65 | -20.0% | COM NEW | 15117B202 |
| — | ITEOS THERAPEUTICS INC | 4,417,259 | $86.27M | 1.7% | $19.53 | $24.67 | — | COM | 46565G104 |
| TVTX | TRAVERE THERAPEUTICS INC | 3,984,681 | $83.8M | 1.7% | $21.03 | $24.15 | -12.3% | COM | 89422G107 |
| COGT | COGENT COMMUNICATIONS HLDGS | 5,999,481 | $69.35M | 1.4% | $11.56 * | $13.27 | -6.6% | COM NEW | 19240Q201 |
| ACRS | ACLARIS THERAPEUTICS INC | 4,398,453 | $69.28M | 1.4% | $15.75 * | $13.86 | +16.1% | COM | 00461U105 |
| FULC | FULCRUM THERAPEUTICS INC | 9,505,925 | $69.2M | 1.4% | $7.28 * | $6.99 | -6.7% | COM | 359616109 |
| ACRV | ACRIVON THERAPEUTICS INC | 4,810,508 | $55.42M | 1.1% | $11.52 * | $12.69 | 0.0% | COMMON STOCK | 004890109 |
| TYRA | TYRA BIOSCIENCES INC | 7,236,454 | $55M | 1.1% | $7.60 * | $19.11 | -63.0% | COM | 90240B106 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 9,770,773 | $52.76M | 1.1% | $5.40 * | $16.64 | -59.6% | COM | 00509G209 |
| — | AKERO THERAPEUTICS INC | 958,980 | $52.55M | 1.1% | $54.80 | $34.05 | — | COM | 00973Y108 |
| CLYM | ELIEM THERAPEUTICS INC | 13,150,849 | $48.26M | 1.0% | $3.67 * | $20.66 | -85.7% | COM | 28658R106 |
| GHRS | GH RESEARCH PLC | 4,898,373 | $47.61M | 1.0% | $9.72 * | $19.20 | -43.7% | ORDINARY SHARES | G3855L106 |
| — | ICOSAVAX INC | 5,963,565 | $47.35M | 1.0% | $7.94 | $28.89 | — | COM | 45114M109 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,407,149 | $47.11M | 1.0% | $19.57 * | $34.21 | -46.2% | COM | 77313F106 |
| NKTX | NKARTA INC | 7,805,129 | $46.75M | 0.9% | $5.99 * | $24.86 | -59.4% | COM | 65487U108 |
| NAMS | NEWAMSTERDAM PHARMA COMPANY | 4,000,000 | $43.6M | 0.9% | $10.90 * | $9.95 | 0.0% | ORDINARY SHARES | N62509109 |
| RXST | RXSIGHT INC | 3,052,796 | $38.68M | 0.8% | $12.67 * | $13.76 | -11.6% | COM | 78349D107 |
| ANTX | AN2 THERAPEUTICS INC | 3,773,517 | $35.96M | 0.7% | $9.53 * | $15.13 | -11.5% | COM | 037326105 |
| — | ALPINE IMMUNE SCIENCES INC | 4,397,368 | $32.32M | 0.7% | $7.35 | $7.20 | — | COM | 02083G100 |
| GERN | GERON CORP | 12,930,711 | $31.29M | 0.6% | $2.42 * | $1.49 | +49.9% | COM | 374163103 |
| DSGN | DESIGN THERAPEUTICS INC | 2,971,231 | $30.48M | 0.6% | $10.26 * | $27.75 | -51.2% | COM | 25056L103 |
| — | HILLEVAX INC | 1,760,019 | $29.45M | 0.6% | $16.73 | $10.93 | — | COM | 43157M102 |
| — | KINNATE BIOPHARMA INC | 4,264,144 | $26.01M | 0.5% | $6.10 | $35.29 | — | COM | 49705R105 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 880,000 | $25.7M | 0.5% | $29.21 * | $17.98 | +28.2% | SPONSORED ADS | 92790C104 |
| SPRY | ARS PHARMACEUTICALS INC | 3,009,678 | $25.67M | 0.5% | $8.53 * | $6.49 | 0.0% | COM | 82835W108 |
| CELC | CELCUITY INC | 1,400,001 | $19.61M | 0.4% | $14.01 * | $10.24 | 0.0% | COM | 15102K100 |
| SLDB | SOLID BIOSCIENCES INC | 3,426,286 | $18.43M | 0.4% | $5.38 * | $6.55 | 0.0% | COM | 83422E204 |
| — | DA32 LIFE SCNCE | 1,500,000 | $14.99M | 0.3% | $9.99 | $9.83 | — | CLASS A COM | 23312M106 |
| — | SCPHARMACEUTICALS INC | 1,856,904 | $13.31M | 0.3% | $7.17 | $7.17 | — | COM | 810648105 |
| — | IMARA INC | 3,250,724 | $13.3M | 0.3% | $4.09 | $4.09 | — | COM | 45249V107 |
| TNYA | TENAYA THERAPEUTICS INC | 6,067,483 | $12.2M | 0.2% | $2.01 * | $7.47 | -67.3% | COM | 87990A106 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 3,370,506 | $11.8M | 0.2% | $3.50 * | $11.52 | -61.7% | COM NEW | 30233G209 |
| — | ARYA SCIENCES ACQUISITN CORP | 1,000,000 | $10.09M | 0.2% | $10.09 | $9.88 | — | CLASS A ORD SHS | G31658100 |
| HOWL | WEREWOLF THERAPEUTICS INC | 4,291,881 | $8.798M | 0.2% | $2.05 * | $13.70 | -80.9% | COM | 95075A107 |
| WHWK | AADI BIOSCIENCE INC | 590,218 | $7.572M | 0.2% | $12.83 | $14.25 | -8.4% | COM | 00032Q104 |
| — | CONCERT PHARMACEUTICALS INC | 1,088,296 | $6.356M | 0.1% | $5.84 | $7.05 | — | COM | 206022105 |
| — | HEALTH SCIENCES ACQ CORP 2 | 610,283 | $6.091M | 0.1% | $9.98 | $11.00 | — | ORD SHS | G4411D109 |
| — | CONNECT BIOPHARMA HLDGS LTD | 6,991,003 | $6.067M | 0.1% | $0.87 | $19.09 | — | ADS | 207523101 |
| — | ATHIRA PHARMA INC | 1,881,300 | $5.964M | 0.1% | $3.17 | $3.05 | — | COM | 04746L104 |
| — | SATSUMA PHARMACEUTICALS INC | 5,914,252 | $5.323M | 0.1% | $0.90 | $13.11 | — | COM | 80405P107 |
| CVRX | CVRX INC | 275,000 | $5.046M | 0.1% | $18.35 * | $28.00 | -55.9% | COM | 126638105 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 2,589,904 | $4.662M | 0.1% | $1.80 | $30.22 | -94.0% | COM | 09203E105 |
| — | DBV TECHNOLOGIES S A | 1,958,957 | $2.997M | 0.1% | $1.53 | $1.77 | — | SPONSORED ADR | 23306J101 |
| IOBT | IO BIOTECH INC | 1,127,260 | $2.593M | 0.1% | $2.30 * | $9.66 | -72.6% | COM | 449778109 |
| — | THIRD HARMONIC BIO INC | 534,687 | $2.299M | 0.0% | $4.30 | $18.97 | — | COM | 88427A107 |
| — | FUSION PHARMACEUTICALS INC | 659,992 | $2.079M | 0.0% | $3.15 | $3.01 | — | COM | 36118A100 |
| — | ACHILLES THERAPEUTICS PLC | 1,607,834 | $1.447M | 0.0% | $0.90 | $11.66 | — | SPONSORED ADS | 00449L102 |
| — | NANOSTRING TECHNOLOGIES | 143,900 | $1.147M | 0.0% | $7.97 | $12.72 | — | COM | 63009R109 |
| IMUX | IMMUNIC INC | 632,184 | $885K | 0.0% | $1.40 * | $2.73 | 0.0% | COM | 4525EP101 |
| NAMSW | NEWAMSTERDAM PHARMA COMPANY | 333,333 | $289K | 0.0% | $0.87 | $0.87 | — | *W EXP 11/22/202 | N62509117 |
| ENTX | ENTERA BIO LTD | 295,966 | $216K | 0.0% | $0.73 | $3.70 | -80.4% | SHS | M40527109 |