Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q1 2017 (← Previous) (Next →)
Filing Date: May 15, 2017
Total Value: $12.22B (98.3% shares, 1.7% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 34,110,011 | $4.559B | 37.3% | $73.07 | +74.2% | COM | 45337C102 |
| — | Seattle Genetics, Inc. | 45,715,556 | $2.874B | 23.5% | $35.70 | — | COM | 812578102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 25,819,768 | $888M | 7.3% | $16.42 | +115.0% | COM | 004225108 |
| — | Alexion Pharmaceuticals, Inc. | 6,544,130 | $793M | 6.5% | $180.77 | — | COM | 015351109 |
| — | Genomic Health, Inc. | 13,770,982 | $434M | 3.5% | $31.71 | — | COM | 37244C101 |
| BMRN | BioMarin Pharmaceutical Inc. | 4,806,483 | $422M | 3.5% | $76.68 | +16.0% | COM | 09061G101 |
| — | DBV Technologies S.A. | 5,509,560 | $194M | 1.6% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,934,154 | $182M | 1.5% | $13.36 | — | COM | 03842B101 |
| ONC | BeiGene, Ltd. | 3,673,175 | $134M | 1.1% | $29.81 | — | SPONSORED ADR | 07725L102 |
| — | Achaogen, Inc. | 4,582,382 | $116M | 0.9% | $13.07 | — | COM | 004449104 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 11,716,784 | $98.42M | 0.8% | $7.34 | -5.2% | COM | 09058V103 |
| — | BioMarin Pharmaceutical Inc. | 22,379,000 | $95.97M | 0.8% | $2.76 | — | NOTE 1.875% 4/23/2017 | 09061GAD3 |
| — | Advanced Accelerator Applications S.A. | 2,221,706 | $88.56M | 0.7% | $29.75 | — | SPONSORED ADS | 00790T100 |
| — | Invitae Corporation | 7,288,300 | $80.61M | 0.7% | $15.87 | — | COM | 46185L103 |
| — | Amarin Corporation plc | 22,656,469 | $72.5M | 0.6% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| — | Spark Therapeutics, Inc. | 1,318,341 | $70.32M | 0.6% | $76.38 | — | COM | 84652J103 |
| — | Acorda Therapeutics, Inc. | 3,301,791 | $69.34M | 0.6% | $39.85 | — | COM | 00484M106 |
| — | Bellicum Pharmaceuticals, Inc. | 5,032,313 | $62.1M | 0.5% | $22.31 | — | COM | 079481107 |
| CERS | Cerus Corporation | 13,053,275 | $58.09M | 0.5% | $4.68 | -9.5% | COM | 157085101 |
| EXEL | Exelixis, Inc. | 2,603,569 | $56.42M | 0.5% | $7.37 | +176.0% | COM | 30161Q104 |
| — | Novavax, Inc. | 108,500,000 | $48.55M | 0.4% | $0.45 | — | Note 3.75% 2/1/2023 ADDED | 670002AB0 |
| HRTX | Heron Therapeutics, Inc. | 2,783,569 | $41.75M | 0.3% | $13.67 | +1.2% | COM | 427746102 |
| NBIX | Neurocrine Biosciences, Inc. | 895,422 | $38.77M | 0.3% | $28.92 | +48.1% | COM | 64125C109 |
| — | AveXis, Inc. | 500,000 | $38.02M | 0.3% | $58.18 | — | COM | 05366U100 |
| ASND | Ascendis Pharma A/S | 1,351,463 | $37.84M | 0.3% | $19.94 | — | SPONSORED ADR | 04351P101 |
| — | Versartis, Inc. | 1,660,593 | $35.45M | 0.3% | $22.68 | — | COM | 92529L102 |
| — | bluebird bio, Inc. | 351,441 | $31.95M | 0.3% | $41.25 | — | COM | 09609G100 |
| — | Progenics Pharmaceuticals, Inc. | 3,150,808 | $29.74M | 0.2% | $4.44 | — | COM | 743187106 |
| — | Acorda Therapeutics, Inc. | 35,083,000 | $29.7M | 0.2% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| — | Merus N.V. | 1,160,014 | $28.29M | 0.2% | $8.27 | — | COM | N5749R100 |
| — | Idera Pharmaceuticals, Inc. | 10,286,483 | $25.41M | 0.2% | $2.56 | — | COM NEW | 45168K306 |
| SGMO | Sangamo Therapeutics, Inc. | 4,530,901 | $23.56M | 0.2% | $11.28 | -64.4% | COM | 800677106 |
| GLPG | Galapagos NV | 259,894 | $22.4M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| XNCR | Xencor, Inc. | 872,072 | $20.86M | 0.2% | $11.07 | +117.8% | COM | 98401F105 |
| HALO | Halozyme Therapeutics, Inc. | 1,391,507 | $18.03M | 0.1% | $6.50 | +94.5% | COM | 40637H109 |
| — | NeuroDerm Ltd. | 571,667 | $15.18M | 0.1% | $18.48 | — | ORD SHS | M74231107 |
| NTLA | Intellia Therapeutics, Inc. | 1,062,120 | $14.96M | 0.1% | $26.61 | -49.6% | COM | 45826J105 |
| — | Sage Therapeutics, Inc. | 208,328 | $14.81M | 0.1% | $37.36 | — | COM | 78667J108 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $14.64M | 0.1% | $16.20 | — | COM | 00900T107 |
| — | Array BioPharma Inc. | 1,585,913 | $14.18M | 0.1% | $6.65 | — | COM | 04269X105 |
| — | Dermira, Inc. | 415,448 | $14.17M | 0.1% | $25.12 | — | COM | 24983L104 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $13.83M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $13.58M | 0.1% | $17.96 | — | COM | 00771V108 |
| — | Aegerion Pharmaceuticals, Inc. | 16,517,000 | $13.24M | 0.1% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| — | Foamix Pharmaceuticals Ltd. | 2,466,702 | $12.21M | 0.1% | $7.55 | — | SHS | M46135105 |
| — | Mirati Therapeutics, Inc. | 2,269,198 | $11.8M | 0.1% | $18.66 | — | COM | 60468T105 |
| — | ImmunoGen, Inc. | 3,015,353 | $11.67M | 0.1% | $11.68 | — | COM | 45253H101 |
| — | La Jolla Pharmaceutical Company | 379,134 | $11.32M | 0.1% | $29.14 | — | COM PAR $.0001 2 | 503459604 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,102,153 | $9.949M | 0.1% | $2.61 | -51.3% | COM | 14888U101 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $9.899M | 0.1% | $37.28 | — | COM | 46116X101 |
| ALKS | Alkermes plc | 150,251 | $8.79M | 0.1% | $70.02 | -19.0% | SHS | G01767105 |
| — | Abeona Therapeutics Inc. | 1,684,364 | $8.422M | 0.1% | $4.92 | — | COM | 00289Y107 |
| — | Rigel Pharmaceuticals, Inc. | 2,518,882 | $8.337M | 0.1% | $2.56 | — | COM NEW | 766559603 |
| — | Achillion Pharmaceuticals, Inc. | 1,856,637 | $7.816M | 0.1% | $8.21 | — | COM | 00448Q201 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $7.767M | 0.1% | $41.68 | +57.8% | COM NEW | 53220K504 |
| AGIO | Agios Pharmaceuticals, Inc. | 128,666 | $7.514M | 0.1% | $37.79 | +26.8% | COM | 00847X104 |
| — | ContraFect Corporation | 4,045,876 | $7.283M | 0.1% | $2.48 | — | COM | 212326102 |
| INSM | Insmed Incorporated | 400,000 | $7.004M | 0.1% | $14.37 | +7.3% | COM PAR $.01 | 457669307 |
| MGNX | MacroGenics, Inc. | 363,676 | $6.764M | 0.1% | $23.98 | -19.5% | COM | 556099109 |
| — | Assembly Biosciences, Inc. | 250,000 | $6.373M | 0.1% | $13.24 | — | COM | 045396108 |
| — | CymaBay Therapeutics, Inc. | 1,413,499 | $6.078M | 0.0% | $3.74 | — | COM | 23257D103 |
| — | Loxo Oncology, Inc. | 137,735 | $5.796M | 0.0% | $17.33 | — | COM | 548862101 |
| — | Akari Therapeutics plc | 496,901 | $5.501M | 0.0% | $21.86 | — | SPONSORED ADR | 00972G108 |
| — | Stemline Therapeutics, Inc. | 633,497 | $5.416M | 0.0% | $16.60 | — | COM | 85858C107 |
| — | Ignyta, Inc. | 571,000 | $4.911M | 0.0% | $8.30 | — | COM | 451731103 |
| — | Alder BioPharmaceuticals, Inc. | 217,328 | $4.52M | 0.0% | $24.97 | — | COM | 014339105 |
| BIIB | Biogen Inc. | 16,500 | $4.511M | 0.0% | $296.43 | -4.6% | COM | 09062X103 |
| — | Array BioPharma Inc. | 3,000,000 | $4.258M | 0.0% | $1.25 | — | NOTE 3.0% 6/1/2020 | 04269XAA3 |
| — | Nabriva Therapeutics AG | 350,000 | $4.2M | 0.0% | $9.50 | — | SPONSORED ADR | 62957M104 |
| ANAB | AnaptysBio, Inc. | 150,000 | $4.163M | 0.0% | $23.32 | 0.0% | COM ADDED | 032724106 |
| — | Zogenix, Inc. | 381,939 | $4.144M | 0.0% | $13.50 | — | COM NEW | 98978L204 |
| — | Epizyme, Inc. | 232,481 | $3.987M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $3.789M | 0.0% | $15.19 | — | COM | 74933V108 |
| RARE | Ultragenyx Pharmaceutical Inc. | 50,000 | $3.389M | 0.0% | $51.09 | +49.2% | COM | 90400D108 |
| — | Syros Pharmaceuticals, Inc. | 204,465 | $3.257M | 0.0% | $18.15 | — | COM | 87184Q107 |
| — | Trevena, Inc. | 857,206 | $3.146M | 0.0% | $7.18 | — | COM | 89532E109 |
| — | Sunesis Pharmaceuticals, Inc. | 741,665 | $3.041M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $3.021M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Aevi Genomic Medicine, Inc. | 1,618,089 | $3.01M | 0.0% | $3.67 | — | COM | 00835P105 |
| — | Inotek Pharmaceuticals Corporation | 5,000,000 | $3.008M | 0.0% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $2.786M | 0.0% | $31.09 | — | COM | 48576U106 |
| — | Trillium Therapeutics Inc. | 413,697 | $2.544M | 0.0% | $13.74 | — | COM NEW | 89620X506 |
| — | Protalix BioTherapeutics, Inc. | 3,423,000 | $2.543M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| — | Selecta Biosciences, Inc. | 175,712 | $2.516M | 0.0% | $13.99 | — | COM | 816212104 |
| — | Jounce Therapeutics, Inc. | 100,000 | $2.199M | 0.0% | $21.99 | — | COM ADDED | 481116101 |
| — | Dimension Therapeutics, Inc. | 1,251,881 | $2.191M | 0.0% | $11.23 | — | COM | 25433V105 |
| — | Tonix Pharmaceuticals Holdings Corp. | 449,500 | $2.099M | 0.0% | $4.67 | — | COM ADDED | 890260409 |
| — | GlycoMimetics, Inc. | 381,235 | $2.07M | 0.0% | $7.27 | — | COM | 38000Q102 |
| NTRA | Natera, Inc. | 228,676 | $2.028M | 0.0% | $13.15 | -27.6% | COM | 632307104 |
| — | Spring Bank Pharmaceuticals, Inc. | 219,298 | $1.952M | 0.0% | $7.99 | — | COM | 849431101 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $1.875M | 0.0% | $1.54 | +60.2% | COM | 45665G303 |
| — | InVivo Therapeutics Holdings Corp. | 400,000 | $1.62M | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| — | MediWound Ltd. | 226,000 | $1.492M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | Aeglea BioTherapeutics, Inc. | 189,987 | $1.415M | 0.0% | $4.86 | — | COM | 00773J103 |
| — | Seres Therapeutics, Inc. | 125,000 | $1.409M | 0.0% | $41.50 | — | COM | 81750R102 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $1.365M | 0.0% | $9.20 | +28.5% | COM | 359664109 |
| — | MyoKardia, Inc. | 100,000 | $1.315M | 0.0% | $16.34 | — | COM | 62857M105 |
| CLLS | Cellectis S.A. | 50,000 | $1.2M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | Juno Therapeutics, Inc. | 50,000 | $1.11M | 0.0% | $52.22 | — | COM | 48205A109 |
| — | Corbus Pharmaceuticals Holdings, Inc. | 130,129 | $1.074M | 0.0% | $8.45 | — | COM | 21833P103 |
| — | Immune Design Corp. | 148,937 | $1.013M | 0.0% | $20.65 | — | COM | 45252L103 |
| — | Affimed N.V. | 400,000 | $920K | 0.0% | $6.30 | — | COM | N01045108 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 57,762 | $890K | 0.0% | $9.69 | +62.3% | COM | 558868105 |
| — | Acceleron Pharma Inc. | 28,765 | $761K | 0.0% | $39.60 | — | COM | 00434H108 |
| — | Chimerix, Inc. | 115,216 | $735K | 0.0% | $40.26 | — | COM | 16934W106 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $696K | 0.0% | $16.80 | — | COM | 33830X104 |
| — | Palatin Technologies, Inc. | 2,050,000 | $671K | 0.0% | $0.73 | — | COM PAR $.01 | 696077403 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $587K | 0.0% | $8.87 | -68.7% | COM | 03879J100 |
| — | Ritter Pharmaceuticals, Inc. | 400,000 | $568K | 0.0% | $4.45 | — | COM | 767836109 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $551K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Proteon Therapeutics, Inc. | 298,591 | $523K | 0.0% | $9.69 | — | COM | 74371L109 |
| — | Bioverativ Inc. | 8,249 | $449K | 0.0% | $54.43 | — | COM ADDED | 09075E100 |
| — | Dynavax Technologies Corporation | 75,000 | $446K | 0.0% | $24.55 | — | COM NEW | 268158201 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $399K | 0.0% | $5.21 | — | COM | 09060J106 |
| — | ChemoCentryx, Inc. | 49,064 | $357K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | Windtree Therapeutics, Inc. | 254,973 | $291K | 0.0% | $1.93 | — | COM | 97382D105 |
| — | BioPharmX Corporation | 377,295 | $191K | 0.0% | $0.51 | — | COM | 09072X101 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $83,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $12,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |