Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2016 (← Previous) (Next →)
Filing Date: Feb 14, 2017
Total Value: $10.2B (87.9% shares, 12.1% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seattle Genetics, Inc. | 45,711,856 | $2.412B | 23.6% | $35.70 | — | COM | 812578102 |
| INCY | Incyte Corporation | 23,499,087 | $2.356B | 23.1% | $48.57 | +100.9% | COM | 45337C102 |
| — | Alexion Pharmaceuticals, Inc. | 6,543,295 | $801M | 7.8% | $180.77 | — | COM | 015351109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 25,819,768 | $745M | 7.3% | $16.42 | +61.1% | COM | 004225108 |
| — | Incyte Corporation | 274,500,000 | $559M | 5.5% | $1.21 | — | NOTE 1.25% 11/15/2020 | 45337CAL6 |
| — | Incyte Corporation | 259,000,000 | $518M | 5.1% | $1.20 | — | NOTE 0.375% 11/15/2018 | 45337CAK8 |
| — | Genomic Health, Inc. | 13,770,302 | $405M | 4.0% | $31.71 | — | COM | 37244C101 |
| BMRN | BioMarin Pharmaceutical Inc. | 4,806,483 | $398M | 3.9% | $76.68 | +12.2% | COM | 09061G101 |
| — | DBV Technologies S.A. | 5,509,560 | $194M | 1.9% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,536,092 | $174M | 1.7% | $13.23 | — | COM | 03842B101 |
| ONC | BeiGene, Ltd. | 3,673,175 | $112M | 1.1% | $29.81 | — | SPONSORED ADR | 07725L102 |
| ABBV | AbbVie Inc. | 1,685,994 | $106M | 1.0% | $42.33 | -1.3% | COM | 00287Y109 |
| — | BioMarin Pharmaceutical Inc. | 22,379,000 | $90.53M | 0.9% | $2.76 | — | NOTE 1.875% 4/23/2017 | 09061GAD3 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 10,963,944 | $69.4M | 0.7% | $7.37 | -29.4% | COM | 09058V103 |
| — | Amarin Corporation plc | 22,169,509 | $68.28M | 0.7% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| — | Bellicum Pharmaceuticals, Inc. | 4,865,647 | $66.27M | 0.6% | $22.66 | — | COM | 079481107 |
| — | Spark Therapeutics, Inc. | 1,318,341 | $65.78M | 0.6% | $76.38 | — | COM | 84652J103 |
| — | Acorda Therapeutics, Inc. | 3,301,791 | $62.07M | 0.6% | $39.85 | — | COM | 00484M106 |
| — | Achaogen, Inc. | 4,582,382 | $59.66M | 0.6% | $13.07 | — | COM | 004449104 |
| — | Advanced Accelerator Applications S.A. | 2,167,137 | $57.99M | 0.6% | $29.50 | — | SPONSORED ADR | 00790T100 |
| — | Invitae Corporation | 7,288,300 | $57.87M | 0.6% | $15.87 | — | COM | 46185L103 |
| CERS | Cerus Corporation | 13,053,275 | $56.78M | 0.6% | $4.68 | +11.1% | COM | 157085101 |
| EXEL | Exelixis, Inc. | 3,003,569 | $44.78M | 0.4% | $7.37 | +95.8% | COM | 30161Q104 |
| NBIX | Neurocrine Biosciences, Inc. | 895,422 | $34.65M | 0.3% | $28.92 | +56.5% | COM | 64125C109 |
| HRTX | Heron Therapeutics, Inc. | 2,383,569 | $31.23M | 0.3% | $13.64 | +15.0% | COM | 427746102 |
| — | Versartis, Inc. | 1,920,845 | $28.62M | 0.3% | $22.68 | — | COM | 92529L102 |
| — | Foamix Pharmaceuticals Ltd. | 2,466,702 | $27.38M | 0.3% | $7.55 | — | SHS | M46135105 |
| — | Progenics Pharmaceuticals, Inc. | 3,150,808 | $27.22M | 0.3% | $4.44 | — | COM | 743187106 |
| — | Acorda Therapeutics, Inc. | 35,083,000 | $26.57M | 0.3% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| — | Merus N.V. | 1,160,014 | $24.49M | 0.2% | $8.27 | — | COM | N5749R100 |
| XNCR | Xencor, Inc. | 872,072 | $22.95M | 0.2% | $11.07 | +117.3% | COM | 98401F105 |
| — | Array BioPharma Inc. | 2,585,913 | $22.73M | 0.2% | $6.65 | — | COM | 04269X105 |
| — | bluebird bio, Inc. | 351,441 | $21.68M | 0.2% | $41.25 | — | COM | 09609G100 |
| ASND | Ascendis Pharma A/S | 1,023,266 | $20.71M | 0.2% | $17.36 | — | SPONSORED ADR | 04351P101 |
| — | Derma Sciences, Inc. | 3,752,390 | $19.51M | 0.2% | $12.19 | — | COM PAR $.01 | 249827502 |
| — | Aegerion Pharmaceuticals, Inc. | 26,517,000 | $19.1M | 0.2% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| GLPG | Galapagos NV | 259,894 | $16.68M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| — | Idera Pharmaceuticals, Inc. | 10,272,314 | $15.41M | 0.2% | $2.56 | — | COM NEW | 45168K306 |
| — | AveXis, Inc. | 315,300 | $15.05M | 0.1% | $47.73 | — | COM | 05366U100 |
| NTLA | Intellia Therapeutics, Inc. | 1,062,120 | $13.92M | 0.1% | $26.61 | -43.5% | COM | 45826J105 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $13.78M | 0.1% | $16.20 | — | COM | 00900T107 |
| HALO | Halozyme Therapeutics, Inc. | 1,391,507 | $13.75M | 0.1% | $6.50 | +68.5% | COM | 40637H109 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $13.73M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| — | NeuroDerm Ltd. | 571,667 | $12.69M | 0.1% | $18.48 | — | ORD SHS | M74231107 |
| SGMO | Sangamo Therapeutics, Inc. | 4,055,876 | $12.37M | 0.1% | $12.13 | -70.0% | COM | 800677106 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $11.33M | 0.1% | $17.96 | — | COM | 00771V108 |
| — | Mirati Therapeutics, Inc. | 2,269,198 | $10.78M | 0.1% | $18.66 | — | COM | 60468T105 |
| — | Sage Therapeutics, Inc. | 208,328 | $10.64M | 0.1% | $37.36 | — | COM | 78667J108 |
| — | Zogenix, Inc. | 838,809 | $10.19M | 0.1% | $13.50 | — | COM NEW | 98978L204 |
| — | Dermira, Inc. | 326,428 | $9.901M | 0.1% | $22.67 | — | COM | 24983L104 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $9.192M | 0.1% | $37.28 | — | COM | 46116X101 |
| ALKS | Alkermes plc | 150,251 | $8.351M | 0.1% | $70.02 | -23.7% | SHS | G01767105 |
| — | Abeona Therapeutics Inc. | 1,684,364 | $8.169M | 0.1% | $4.92 | — | COM | 00289Y107 |
| — | Achillion Pharmaceuticals, Inc. | 1,856,637 | $7.668M | 0.1% | $8.21 | — | COM | 00448Q201 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $7.457M | 0.1% | $41.68 | +51.4% | COM NEW | 53220K504 |
| MGNX | MacroGenics, Inc. | 363,676 | $7.434M | 0.1% | $23.98 | +5.0% | COM | 556099109 |
| — | ContraFect Corporation | 4,045,876 | $7.08M | 0.1% | $2.48 | — | COM | 212326102 |
| — | ImmunoGen, Inc. | 3,015,353 | $6.151M | 0.1% | $11.68 | — | COM | 45253H101 |
| — | Dimension Therapeutics, Inc. | 1,251,881 | $5.446M | 0.1% | $11.23 | — | COM | 25433V105 |
| AGIO | Agios Pharmaceuticals, Inc. | 128,666 | $5.369M | 0.1% | $37.79 | +38.9% | COM | 00847X104 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,102,153 | $5.357M | 0.1% | $2.61 | -56.3% | COM | 14888U101 |
| INSM | Insmed Incorporated | 400,000 | $5.292M | 0.1% | $14.37 | -5.1% | COM PAR $.01 | 457669307 |
| — | Inotek Pharmaceuticals Corporation | 5,000,000 | $5.167M | 0.1% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| — | Alcobra Ltd. | 2,336,359 | $4.906M | 0.0% | $5.61 | — | SHS | M2239P109 |
| — | Rigel Pharmaceuticals, Inc. | 2,018,882 | $4.805M | 0.0% | $2.38 | — | COM NEW | 766559603 |
| BIIB | Biogen Inc. | 16,500 | $4.679M | 0.0% | $296.43 | 0.0% | COM | 09062X103 |
| — | Aevi Genomic Medicine, Inc. | 880,539 | $4.561M | 0.0% | $5.18 | — | COM ADDED | 00835P105 |
| — | Alder BioPharmaceuticals, Inc. | 217,328 | $4.52M | 0.0% | $24.97 | — | COM | 014339105 |
| — | Loxo Oncology, Inc. | 137,735 | $4.423M | 0.0% | $17.33 | — | COM | 548862101 |
| — | Array BioPharma Inc. | 3,000,000 | $4.195M | 0.0% | $1.25 | — | NOTE 3.0% 6/1/2020 | 04269XAA3 |
| — | Stemline Therapeutics, Inc. | 333,497 | $3.568M | 0.0% | $23.84 | — | COM | 85858C107 |
| RARE | Ultragenyx Pharmaceutical Inc. | 50,000 | $3.516M | 0.0% | $51.09 | +38.9% | COM | 90400D108 |
| — | Akari Therapeutics plc | 496,901 | $3.498M | 0.0% | $21.86 | — | SPONSORED ADR | 00972G108 |
| — | Minerva Neurosciences, Inc. | 258,805 | $3.041M | 0.0% | $10.21 | — | COM | 603380106 |
| — | Assembly Biosciences, Inc. | 250,000 | $3.038M | 0.0% | $13.24 | — | COM | 045396108 |
| — | Ignyta, Inc. | 571,000 | $3.026M | 0.0% | $8.30 | — | COM | 451731103 |
| — | Selecta Biosciences, Inc. | 175,712 | $3.013M | 0.0% | $13.99 | — | COM | 816212104 |
| NTRA | Natera, Inc. | 249,269 | $2.919M | 0.0% | $13.15 | -16.3% | COM | 632307104 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $2.917M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Epizyme, Inc. | 232,481 | $2.813M | 0.0% | $21.12 | — | COM | 29428V104 |
| IONS | Ionis Pharmaceuticals, Inc. | 57,140 | $2.733M | 0.0% | $53.96 | -26.7% | COM | 462222100 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $2.703M | 0.0% | $15.19 | — | COM ADDED | 74933V108 |
| — | Sunesis Pharmaceuticals, Inc. | 741,665 | $2.685M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Trevena, Inc. | 450,000 | $2.646M | 0.0% | $10.35 | — | COM | 89532E109 |
| ENTA | Enanta Pharmaceuticals, Inc. | 75,357 | $2.524M | 0.0% | $19.50 | +47.0% | COM | 29251M106 |
| — | Syros Pharmaceuticals, Inc. | 204,465 | $2.486M | 0.0% | $18.15 | — | COM | 87184Q107 |
| — | Osiris Therapeutics, Inc. | 499,193 | $2.451M | 0.0% | $16.34 | — | COM | 68827R108 |
| — | Trillium Therapeutics Inc. | 413,697 | $2.337M | 0.0% | $13.74 | — | COM NEW | 89620X506 |
| — | GlycoMimetics, Inc. | 381,235 | $2.326M | 0.0% | $7.27 | — | COM | 38000Q102 |
| — | Protalix BioTherapeutics, Inc. | 3,423,000 | $2.293M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| — | Corbus Pharmaceuticals Holdings, Inc. | 260,129 | $2.198M | 0.0% | $8.45 | — | COM | 21833P103 |
| — | Nabriva Therapeutics AG | 350,000 | $2.086M | 0.0% | $9.50 | — | SPONSORED ADR | 62957M104 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $2.04M | 0.0% | $31.09 | — | COM | 48576U106 |
| — | Aeglea BioTherapeutics, Inc. | 404,230 | $1.758M | 0.0% | $4.86 | — | COM | 00773J103 |
| — | Spring Bank Pharmaceuticals, Inc. | 219,298 | $1.752M | 0.0% | $7.99 | — | COM | 849431101 |
| — | InVivo Therapeutics Holdings Corp. | 400,000 | $1.68M | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| — | Concert Pharmaceuticals, Inc. | 152,964 | $1.574M | 0.0% | $10.71 | — | COM | 206022105 |
| — | Juno Therapeutics, Inc. | 80,000 | $1.508M | 0.0% | $52.22 | — | COM | 48205A109 |
| — | SCYNEXIS, Inc. | 467,600 | $1.492M | 0.0% | $2.17 | — | COM | 811292101 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $1.446M | 0.0% | $9.20 | +2.6% | COM | 359664109 |
| — | MyoKardia, Inc. | 100,000 | $1.295M | 0.0% | $16.34 | — | COM | 62857M105 |
| QURE | uniQure N.V. | 230,000 | $1.288M | 0.0% | $14.92 | -55.0% | SHS | N90064101 |
| — | Seres Therapeutics, Inc. | 125,000 | $1.238M | 0.0% | $41.50 | — | COM | 81750R102 |
| — | Colucid Pharmaceuticals, Inc. | 30,310 | $1.103M | 0.0% | $38.14 | — | COM | 19716T101 |
| — | Ritter Pharmaceuticals, Inc. | 400,000 | $1.084M | 0.0% | $4.45 | — | COM | 767836109 |
| PRQR | ProQR Therapeutics N.V. | 212,698 | $1.042M | 0.0% | $14.32 | -64.0% | SHS EURO | N71542109 |
| — | MediWound Ltd. | 226,000 | $1.035M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | Palatin Technologies, Inc. | 2,050,000 | $1.035M | 0.0% | $0.73 | — | COM PAR $.01 | 696077403 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $964K | 0.0% | $16.80 | — | COM | 33830X104 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 57,762 | $861K | 0.0% | $9.69 | +65.8% | COM | 558868105 |
| CLLS | Cellectis S.A. | 50,000 | $848K | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | Immune Design Corp. | 148,937 | $819K | 0.0% | $20.65 | — | COM | 45252L103 |
| — | Tenax Therapeutics, Inc. | 420,000 | $819K | 0.0% | $3.58 | — | COM | 88032L100 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $784K | 0.0% | $1.54 | -15.0% | COM | 45665G303 |
| ALDX | Aldeyra Therapeutics, Inc. | 142,000 | $760K | 0.0% | $10.20 | -42.5% | COM | 01438T106 |
| — | Proteon Therapeutics, Inc. | 389,394 | $740K | 0.0% | $9.69 | — | COM | 74371L109 |
| — | Acceleron Pharma Inc. | 28,765 | $734K | 0.0% | $39.60 | — | COM | 00434H108 |
| — | Affimed N.V. | 400,000 | $720K | 0.0% | $6.30 | — | COM | N01045108 |
| — | CymaBay Therapeutics, Inc. | 309,268 | $535K | 0.0% | $1.73 | — | COM | 23257D103 |
| — | Chimerix, Inc. | 115,216 | $530K | 0.0% | $40.26 | — | COM | 16934W106 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $442K | 0.0% | $8.87 | -67.2% | COM | 03879J100 |
| ALNY | Alnylam Pharmaceuticals, Inc. | 11,340 | $425K | 0.0% | $77.42 | -45.9% | COM | 02043Q107 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $405K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Foundation Medicine, Inc. | 20,892 | $370K | 0.0% | $25.16 | — | COM | 350465100 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $368K | 0.0% | $5.21 | — | COM | 09060J106 |
| — | ChemoCentryx, Inc. | 49,064 | $363K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | Aptose Biosciences Inc. | 258,311 | $359K | 0.0% | $2.25 | — | COM NEW | 03835T200 |
| — | Windtree Therapeutics, Inc. | 254,973 | $319K | 0.0% | $1.93 | — | COM | 97382D105 |
| — | ProNAi Therapeutics, Inc. | 200,000 | $298K | 0.0% | $20.52 | — | COM | 74346L101 |
| — | Dynavax Technologies Corporation | 75,000 | $296K | 0.0% | $24.55 | — | COM NEW | 268158201 |
| — | La Jolla Pharmaceutical Company | 13,746 | $241K | 0.0% | $10.24 | — | COM PAR $.0001 2 | 503459604 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $82,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $14,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |