BAKER BROS. ADVISORS LP Diversified Active

CIK: 0001263508 · Show all filings

Period: Q4 2016 (← Previous) (Next →)

Filing Date: Feb 14, 2017

Total Value ($000): $10,200,965 (87.9% shares, 12.1% debt)

Holdings (133)

Seattle Genetics, Inc. 23.6%
Value ($000) $2,412,215 Shares 45,711,856 Est. Cost $35.70 Unrealized
INCY Incyte Corporation 23.1%
Value ($000) $2,356,253 Shares 23,499,087 Est. Cost $48.57 Unrealized +100.9%
Alexion Pharmaceuticals, Inc. 7.8%
Value ($000) $800,572 Shares 6,543,295 Est. Cost $180.77 Unrealized
ACAD ACADIA Pharmaceuticals Inc. 7.3%
Value ($000) $744,642 Shares 25,819,768 Est. Cost $16.42 Unrealized +61.1%
Incyte Corporation 5.5%
Value ($000) $558,650 Shares 274,500,000 Est. Cost $1.21 Unrealized
Incyte Corporation 5.1%
Value ($000) $518,139 Shares 259,000,000 Est. Cost $1.20 Unrealized
Genomic Health, Inc. 4.0%
Value ($000) $404,709 Shares 13,770,302 Est. Cost $31.71 Unrealized
BMRN BioMarin Pharmaceutical Inc. 3.9%
Value ($000) $398,169 Shares 4,806,483 Est. Cost $76.68 Unrealized +12.2%
DBV Technologies S.A. 1.9%
Value ($000) $193,551 Shares 5,509,560 Est. Cost $32.87 Unrealized
Aquinox Pharmaceuticals, Inc. 1.7%
Value ($000) $173,951 Shares 10,536,092 Est. Cost $13.23 Unrealized
ONC BeiGene, Ltd. 1.1%
Value ($000) $111,518 Shares 3,673,175 Est. Cost $29.81 Unrealized
ABBV AbbVie Inc. 1.0%
Value ($000) $105,577 Shares 1,685,994 Est. Cost $42.33 Unrealized -1.3%
BioMarin Pharmaceutical Inc. 0.9%
Value ($000) $90,531 Shares 22,379,000 Est. Cost $2.76 Unrealized
BCRX BioCryst Pharmaceuticals, Inc. 0.7%
Value ($000) $69,402 Shares 10,963,944 Est. Cost $7.37 Unrealized -29.4%
Amarin Corporation plc 0.7%
Value ($000) $68,282 Shares 22,169,509 Est. Cost $3.15 Unrealized
Bellicum Pharmaceuticals, Inc. 0.6%
Value ($000) $66,270 Shares 4,865,647 Est. Cost $22.66 Unrealized
Spark Therapeutics, Inc. 0.6%
Value ($000) $65,785 Shares 1,318,341 Est. Cost $76.38 Unrealized
Acorda Therapeutics, Inc. 0.6%
Value ($000) $62,074 Shares 3,301,791 Est. Cost $39.85 Unrealized
Achaogen, Inc. 0.6%
Value ($000) $59,663 Shares 4,582,382 Est. Cost $13.07 Unrealized
Advanced Accelerator Applications S.A. 0.6%
Value ($000) $57,993 Shares 2,167,137 Est. Cost $29.50 Unrealized
Invitae Corporation 0.6%
Value ($000) $57,869 Shares 7,288,300 Est. Cost $15.87 Unrealized
CERS Cerus Corporation 0.6%
Value ($000) $56,782 Shares 13,053,275 Est. Cost $4.68 Unrealized +11.1%
EXEL Exelixis, Inc. 0.4%
Value ($000) $44,783 Shares 3,003,569 Est. Cost $7.37 Unrealized +95.8%
NBIX Neurocrine Biosciences, Inc. 0.3%
Value ($000) $34,653 Shares 895,422 Est. Cost $28.92 Unrealized +56.5%
HRTX Heron Therapeutics, Inc. 0.3%
Value ($000) $31,225 Shares 2,383,569 Est. Cost $13.64 Unrealized +15.0%
Versartis, Inc. 0.3%
Value ($000) $28,621 Shares 1,920,845 Est. Cost $22.68 Unrealized
Foamix Pharmaceuticals Ltd. 0.3%
Value ($000) $27,380 Shares 2,466,702 Est. Cost $7.55 Unrealized
Progenics Pharmaceuticals, Inc. 0.3%
Value ($000) $27,223 Shares 3,150,808 Est. Cost $4.44 Unrealized
Acorda Therapeutics, Inc. 0.3%
Value ($000) $26,570 Shares 35,083,000 Est. Cost $0.99 Unrealized
Merus N.V. 0.2%
Value ($000) $24,488 Shares 1,160,014 Est. Cost $8.27 Unrealized
XNCR Xencor, Inc. 0.2%
Value ($000) $22,953 Shares 872,072 Est. Cost $11.07 Unrealized +117.3%
Array BioPharma Inc. 0.2%
Value ($000) $22,730 Shares 2,585,913 Est. Cost $6.65 Unrealized
bluebird bio, Inc. 0.2%
Value ($000) $21,684 Shares 351,441 Est. Cost $41.25 Unrealized
ASND Ascendis Pharma A/S 0.2%
Value ($000) $20,711 Shares 1,023,266 Est. Cost $17.36 Unrealized
Derma Sciences, Inc. 0.2%
Value ($000) $19,512 Shares 3,752,390 Est. Cost $12.19 Unrealized
Aegerion Pharmaceuticals, Inc. 0.2%
Value ($000) $19,103 Shares 26,517,000 Est. Cost $0.75 Unrealized
GLPG Galapagos NV 0.2%
Value ($000) $16,683 Shares 259,894 Est. Cost $51.50 Unrealized
Idera Pharmaceuticals, Inc. 0.2%
Value ($000) $15,408 Shares 10,272,314 Est. Cost $2.56 Unrealized
AveXis, Inc. 0.1%
Value ($000) $15,049 Shares 315,300 Est. Cost $47.73 Unrealized
NTLA Intellia Therapeutics, Inc. 0.1%
Value ($000) $13,924 Shares 1,062,120 Est. Cost $26.61 Unrealized -43.5%
Aimmune Therapeutics, Inc. 0.1%
Value ($000) $13,781 Shares 673,908 Est. Cost $16.20 Unrealized
HALO Halozyme Therapeutics, Inc. 0.1%
Value ($000) $13,748 Shares 1,391,507 Est. Cost $6.50 Unrealized +68.5%
BioMarin Pharmaceutical Inc. 0.1%
Value ($000) $13,733 Shares 12,228,000 Est. Cost $1.06 Unrealized
NeuroDerm Ltd. 0.1%
Value ($000) $12,691 Shares 571,667 Est. Cost $18.48 Unrealized
SGMO Sangamo Therapeutics, Inc. 0.1%
Value ($000) $12,370 Shares 4,055,876 Est. Cost $12.13 Unrealized -70.0%
Aerie Pharmaceuticals, Inc. 0.1%
Value ($000) $11,331 Shares 299,356 Est. Cost $17.96 Unrealized
Mirati Therapeutics, Inc. 0.1%
Value ($000) $10,779 Shares 2,269,198 Est. Cost $18.66 Unrealized
Sage Therapeutics, Inc. 0.1%
Value ($000) $10,637 Shares 208,328 Est. Cost $37.36 Unrealized
Zogenix, Inc. 0.1%
Value ($000) $10,192 Shares 838,809 Est. Cost $13.50 Unrealized
Dermira, Inc. 0.1%
Value ($000) $9,901 Shares 326,428 Est. Cost $22.67 Unrealized
Intra-Cellular Therapies, Inc. 0.1%
Value ($000) $9,192 Shares 609,166 Est. Cost $37.28 Unrealized
ALKS Alkermes plc 0.1%
Value ($000) $8,351 Shares 150,251 Est. Cost $70.02 Unrealized -23.7%
Abeona Therapeutics Inc. 0.1%
Value ($000) $8,169 Shares 1,684,364 Est. Cost $4.92 Unrealized
Achillion Pharmaceuticals, Inc. 0.1%
Value ($000) $7,668 Shares 1,856,637 Est. Cost $8.21 Unrealized
LGND Ligand Pharmaceuticals Incorporated 0.1%
Value ($000) $7,457 Shares 73,386 Est. Cost $41.68 Unrealized +51.4%
MGNX MacroGenics, Inc. 0.1%
Value ($000) $7,434 Shares 363,676 Est. Cost $23.98 Unrealized +5.0%
ContraFect Corporation 0.1%
Value ($000) $7,080 Shares 4,045,876 Est. Cost $2.48 Unrealized
ImmunoGen, Inc. 0.1%
Value ($000) $6,151 Shares 3,015,353 Est. Cost $11.68 Unrealized
Dimension Therapeutics, Inc. 0.1%
Value ($000) $5,446 Shares 1,251,881 Est. Cost $11.23 Unrealized
AGIO Agios Pharmaceuticals, Inc. 0.1%
Value ($000) $5,369 Shares 128,666 Est. Cost $37.79 Unrealized +38.9%
CPRX Catalyst Pharmaceuticals, Inc. 0.1%
Value ($000) $5,357 Shares 5,102,153 Est. Cost $2.61 Unrealized -56.3%
INSM Insmed Incorporated 0.1%
Value ($000) $5,292 Shares 400,000 Est. Cost $14.37 Unrealized -5.1%
Inotek Pharmaceuticals Corporation 0.1%
Value ($000) $5,167 Shares 5,000,000 Est. Cost $1.34 Unrealized
Alcobra Ltd. 0.0%
Value ($000) $4,906 Shares 2,336,359 Est. Cost $5.61 Unrealized
Rigel Pharmaceuticals, Inc. 0.0%
Value ($000) $4,805 Shares 2,018,882 Est. Cost $2.38 Unrealized
BIIB Biogen Inc. 0.0%
Value ($000) $4,679 Shares 16,500 Est. Cost $296.43 Unrealized 0.0%
Aevi Genomic Medicine, Inc. 0.0%
Value ($000) $4,561 Shares 880,539 Est. Cost $5.18 Unrealized
Alder BioPharmaceuticals, Inc. 0.0%
Value ($000) $4,520 Shares 217,328 Est. Cost $24.97 Unrealized
Loxo Oncology, Inc. 0.0%
Value ($000) $4,423 Shares 137,735 Est. Cost $17.33 Unrealized
Array BioPharma Inc. 0.0%
Value ($000) $4,195 Shares 3,000,000 Est. Cost $1.25 Unrealized
Stemline Therapeutics, Inc. 0.0%
Value ($000) $3,568 Shares 333,497 Est. Cost $23.84 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.0%
Value ($000) $3,516 Shares 50,000 Est. Cost $51.09 Unrealized +38.9%
Akari Therapeutics plc 0.0%
Value ($000) $3,498 Shares 496,901 Est. Cost $21.86 Unrealized
Minerva Neurosciences, Inc. 0.0%
Value ($000) $3,041 Shares 258,805 Est. Cost $10.21 Unrealized
Assembly Biosciences, Inc. 0.0%
Value ($000) $3,038 Shares 250,000 Est. Cost $13.24 Unrealized
Ignyta, Inc. 0.0%
Value ($000) $3,026 Shares 571,000 Est. Cost $8.30 Unrealized
Selecta Biosciences, Inc. 0.0%
Value ($000) $3,013 Shares 175,712 Est. Cost $13.99 Unrealized
NTRA Natera, Inc. 0.0%
Value ($000) $2,919 Shares 249,269 Est. Cost $13.15 Unrealized -16.3%
Adamas Pharmaceuticals, Inc. 0.0%
Value ($000) $2,917 Shares 172,630 Est. Cost $14.46 Unrealized
Epizyme, Inc. 0.0%
Value ($000) $2,813 Shares 232,481 Est. Cost $21.12 Unrealized
IONS Ionis Pharmaceuticals, Inc. 0.0%
Value ($000) $2,733 Shares 57,140 Est. Cost $53.96 Unrealized -26.7%
Ra Pharmaceuticals, Inc. 0.0%
Value ($000) $2,703 Shares 177,952 Est. Cost $15.19 Unrealized
Sunesis Pharmaceuticals, Inc. 0.0%
Value ($000) $2,685 Shares 741,665 Est. Cost $4.37 Unrealized
Trevena, Inc. 0.0%
Value ($000) $2,646 Shares 450,000 Est. Cost $10.35 Unrealized
ENTA Enanta Pharmaceuticals, Inc. 0.0%
Value ($000) $2,524 Shares 75,357 Est. Cost $19.50 Unrealized +47.0%
Syros Pharmaceuticals, Inc. 0.0%
Value ($000) $2,486 Shares 204,465 Est. Cost $18.15 Unrealized
Osiris Therapeutics, Inc. 0.0%
Value ($000) $2,451 Shares 499,193 Est. Cost $16.34 Unrealized
Trillium Therapeutics Inc. 0.0%
Value ($000) $2,337 Shares 413,697 Est. Cost $13.74 Unrealized
GlycoMimetics, Inc. 0.0%
Value ($000) $2,326 Shares 381,235 Est. Cost $7.27 Unrealized
Protalix BioTherapeutics, Inc. 0.0%
Value ($000) $2,293 Shares 3,423,000 Est. Cost $0.76 Unrealized
Corbus Pharmaceuticals Holdings, Inc. 0.0%
Value ($000) $2,198 Shares 260,129 Est. Cost $8.45 Unrealized
Nabriva Therapeutics AG 0.0%
Value ($000) $2,086 Shares 350,000 Est. Cost $9.50 Unrealized
Karyopharm Therapeutics Inc. 0.0%
Value ($000) $2,040 Shares 216,990 Est. Cost $31.09 Unrealized
Aeglea BioTherapeutics, Inc. 0.0%
Value ($000) $1,758 Shares 404,230 Est. Cost $4.86 Unrealized
Spring Bank Pharmaceuticals, Inc. 0.0%
Value ($000) $1,752 Shares 219,298 Est. Cost $7.99 Unrealized
InVivo Therapeutics Holdings Corp. 0.0%
Value ($000) $1,680 Shares 400,000 Est. Cost $6.98 Unrealized
Concert Pharmaceuticals, Inc. 0.0%
Value ($000) $1,574 Shares 152,964 Est. Cost $10.71 Unrealized
Juno Therapeutics, Inc. 0.0%
Value ($000) $1,508 Shares 80,000 Est. Cost $52.22 Unrealized
SCYNEXIS, Inc. 0.0%
Value ($000) $1,492 Shares 467,600 Est. Cost $2.17 Unrealized
FLGT Fulgent Genetics, Inc. 0.0%
Value ($000) $1,446 Shares 125,000 Est. Cost $9.20 Unrealized +2.6%
MyoKardia, Inc. 0.0%
Value ($000) $1,295 Shares 100,000 Est. Cost $16.34 Unrealized
QURE uniQure N.V. 0.0%
Value ($000) $1,288 Shares 230,000 Est. Cost $14.92 Unrealized -55.0%
Seres Therapeutics, Inc. 0.0%
Value ($000) $1,238 Shares 125,000 Est. Cost $41.50 Unrealized
Colucid Pharmaceuticals, Inc. 0.0%
Value ($000) $1,103 Shares 30,310 Est. Cost $38.14 Unrealized
Ritter Pharmaceuticals, Inc. 0.0%
Value ($000) $1,084 Shares 400,000 Est. Cost $4.45 Unrealized
PRQR ProQR Therapeutics N.V. 0.0%
Value ($000) $1,042 Shares 212,698 Est. Cost $14.32 Unrealized -64.0%
MediWound Ltd. 0.0%
Value ($000) $1,035 Shares 226,000 Est. Cost $11.38 Unrealized
Palatin Technologies, Inc. 0.0%
Value ($000) $1,035 Shares 2,050,000 Est. Cost $0.73 Unrealized
Five Prime Therapeutics, Inc. 0.0%
Value ($000) $964 Shares 19,247 Est. Cost $16.80 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 0.0%
Value ($000) $861 Shares 57,762 Est. Cost $9.69 Unrealized +65.8%
CLLS Cellectis S.A. 0.0%
Value ($000) $848 Shares 50,000 Est. Cost $34.58 Unrealized
Immune Design Corp. 0.0%
Value ($000) $819 Shares 148,937 Est. Cost $20.65 Unrealized
Tenax Therapeutics, Inc. 0.0%
Value ($000) $819 Shares 420,000 Est. Cost $3.58 Unrealized
INFIQ Infinity Pharmaceuticals, Inc. 0.0%
Value ($000) $784 Shares 580,400 Est. Cost $1.54 Unrealized -15.0%
ALDX Aldeyra Therapeutics, Inc. 0.0%
Value ($000) $760 Shares 142,000 Est. Cost $10.20 Unrealized -42.5%
Proteon Therapeutics, Inc. 0.0%
Value ($000) $740 Shares 389,394 Est. Cost $9.69 Unrealized
Acceleron Pharma Inc. 0.0%
Value ($000) $734 Shares 28,765 Est. Cost $39.60 Unrealized
Affimed N.V. 0.0%
Value ($000) $720 Shares 400,000 Est. Cost $6.30 Unrealized
CymaBay Therapeutics, Inc. 0.0%
Value ($000) $535 Shares 309,268 Est. Cost $1.73 Unrealized
Chimerix, Inc. 0.0%
Value ($000) $530 Shares 115,216 Est. Cost $40.26 Unrealized
ABUS Arbutus Biopharma Corporation 0.0%
Value ($000) $442 Shares 180,582 Est. Cost $8.87 Unrealized -67.2%
ALNY Alnylam Pharmaceuticals, Inc. 0.0%
Value ($000) $425 Shares 11,340 Est. Cost $77.42 Unrealized -45.9%
ADAPY Adaptimmune Therapeutics plc 0.0%
Value ($000) $405 Shares 100,000 Est. Cost $18.33 Unrealized
Foundation Medicine, Inc. 0.0%
Value ($000) $370 Shares 20,892 Est. Cost $25.16 Unrealized
BioDelivery Sciences International, Inc. 0.0%
Value ($000) $368 Shares 210,021 Est. Cost $5.21 Unrealized
ChemoCentryx, Inc. 0.0%
Value ($000) $363 Shares 49,064 Est. Cost $14.14 Unrealized
Aptose Biosciences Inc. 0.0%
Value ($000) $359 Shares 258,311 Est. Cost $2.25 Unrealized
Windtree Therapeutics, Inc. 0.0%
Value ($000) $319 Shares 254,973 Est. Cost $1.93 Unrealized
ProNAi Therapeutics, Inc. 0.0%
Value ($000) $298 Shares 200,000 Est. Cost $20.52 Unrealized
Dynavax Technologies Corporation 0.0%
Value ($000) $296 Shares 75,000 Est. Cost $24.55 Unrealized
La Jolla Pharmaceutical Company 0.0%
Value ($000) $241 Shares 13,746 Est. Cost $10.24 Unrealized
Cyclacel Pharmaceuticals, Inc. 0.0%
Value ($000) $82 Shares 13,253 Est. Cost $7.20 Unrealized
BioTime, Inc. 0.0%
Value ($000) $14 Shares 20,084 Est. Cost $1.07 Unrealized