Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q3 2017 (← Previous) (Next →)
Filing Date: Nov 14, 2017
Total Value: $12.33B (99.0% shares, 1.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 34,230,323 | $3.996B | 32.4% | $73.07 | +73.1% | COM | 45337C102 |
| — | Seattle Genetics, Inc. | 45,725,556 | $2.488B | 20.2% | $35.70 | — | COM | 812578102 |
| — | Alexion Pharmaceuticals, Inc. | 8,553,864 | $1.2B | 9.7% | $166.88 | — | COM | 015351109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 25,819,768 | $973M | 7.9% | $16.42 | +98.1% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 5,905,673 | $550M | 4.5% | $79.34 | +11.4% | COM | 09061G101 |
| — | Genomic Health, Inc. | 13,780,480 | $442M | 3.6% | $31.71 | — | COM | 37244C101 |
| ONC | BeiGene, Ltd. | 3,898,431 | $403M | 3.3% | $34.07 | — | SPONSORED ADR | 07725L102 |
| — | DBV Technologies S.A. | 5,509,560 | $234M | 1.9% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,934,154 | $155M | 1.3% | $13.36 | — | COM | 03842B101 |
| — | Advanced Accelerator Applications S.A. | 2,243,262 | $152M | 1.2% | $29.75 | — | SPONSORED ADS | 00790T100 |
| — | Spark Therapeutics, Inc. | 1,384,130 | $123M | 1.0% | $76.99 | — | COM | 84652J103 |
| ASND | Ascendis Pharma A/S | 2,348,840 | $85.14M | 0.7% | $25.42 | — | SPONSORED ADR | 04351P101 |
| — | Amarin Corporation plc | 22,669,509 | $79.34M | 0.6% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| — | AveXis, Inc. | 775,000 | $74.97M | 0.6% | $69.51 | — | COM | 05366U100 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 13,997,172 | $73.35M | 0.6% | $6.98 | -26.6% | COM | 09058V103 |
| — | Invitae Corporation | 7,288,300 | $68.29M | 0.6% | $15.87 | — | COM | 46185L103 |
| — | Array BioPharma Inc. | 5,213,528 | $64.13M | 0.5% | $10.58 | — | COM | 04269X105 |
| — | Achaogen, Inc. | 3,886,878 | $62M | 0.5% | $13.47 | — | COM | 004449104 |
| — | Bellicum Pharmaceuticals, Inc. | 5,032,313 | $58.12M | 0.5% | $22.31 | — | COM | 079481107 |
| EXEL | Exelixis, Inc. | 2,082,012 | $50.45M | 0.4% | $7.37 | +261.2% | COM | 30161Q104 |
| HRTX | Heron Therapeutics, Inc. | 2,787,992 | $45.03M | 0.4% | $13.67 | +14.7% | COM | 427746102 |
| — | Novavax, Inc. | 88,500,000 | $39.54M | 0.3% | $0.45 | — | NOTE 3.75% 2/1/2023 | 670002AB0 |
| NBIX | Neurocrine Biosciences, Inc. | 616,682 | $37.79M | 0.3% | $28.92 | +82.5% | COM | 64125C109 |
| — | bluebird bio, Inc. | 241,441 | $33.16M | 0.3% | $41.25 | — | COM | 09609G100 |
| SGMO | Sangamo Therapeutics, Inc. | 2,113,376 | $31.7M | 0.3% | $11.28 | -2.0% | COM | 800677106 |
| — | Acorda Therapeutics, Inc. | 35,083,000 | $31.57M | 0.3% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| — | Abeona Therapeutics Inc. | 1,684,364 | $28.72M | 0.2% | $4.92 | — | COM | 00289Y107 |
| HALO | Halozyme Therapeutics, Inc. | 1,581,424 | $27.47M | 0.2% | $7.32 | +85.0% | COM | 40637H109 |
| CERS | Cerus Corporation | 9,745,209 | $26.6M | 0.2% | $4.68 | -47.7% | COM | 157085101 |
| — | Mirati Therapeutics, Inc. | 2,269,198 | $26.55M | 0.2% | $18.66 | — | COM | 60468T105 |
| GLPG | Galapagos NV | 259,894 | $26.44M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| NTLA | Intellia Therapeutics, Inc. | 1,062,120 | $26.39M | 0.2% | $26.61 | -29.2% | COM | 45826J105 |
| — | Sage Therapeutics, Inc. | 405,485 | $25.26M | 0.2% | $49.49 | — | COM | 78667J108 |
| — | CymaBay Therapeutics, Inc. | 2,991,775 | $24.11M | 0.2% | $6.19 | — | COM | 23257D103 |
| — | Progenics Pharmaceuticals, Inc. | 3,150,808 | $23.19M | 0.2% | $4.44 | — | COM | 743187106 |
| — | Merus N.V. | 1,160,014 | $23.05M | 0.2% | $8.27 | — | COM | N5749R100 |
| — | Idera Pharmaceuticals, Inc. | 10,306,757 | $22.98M | 0.2% | $2.56 | — | COM NEW | 45168K306 |
| — | NeuroDerm Ltd. | 571,667 | $22.24M | 0.2% | $18.48 | — | ORD SHS | M74231107 |
| INSM | Insmed Incorporated | 700,000 | $21.85M | 0.2% | $16.38 | +16.3% | COM PAR $.01 | 457669307 |
| — | ImmunoGen, Inc. | 2,688,489 | $20.57M | 0.2% | $11.68 | — | COM | 45253H101 |
| XNCR | Xencor, Inc. | 872,072 | $19.99M | 0.2% | $11.07 | +100.6% | COM | 98401F105 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $16.71M | 0.1% | $16.20 | — | COM | 00900T107 |
| — | Ignyta, Inc. | 1,299,199 | $16.05M | 0.1% | $10.07 | — | COM | 451731103 |
| — | MyoKardia, Inc. | 355,264 | $15.22M | 0.1% | $35.39 | — | COM | 62857M105 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $15.19M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 ADDED | 09061GAH4 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $14.55M | 0.1% | $17.96 | — | COM | 00771V108 |
| — | Foamix Pharmaceuticals Ltd. | 2,466,702 | $13.69M | 0.1% | $7.55 | — | SHS | M46135105 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $13.63M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,102,153 | $12.86M | 0.1% | $2.61 | +5.0% | COM | 14888U101 |
| — | Acorda Therapeutics, Inc. | 519,500 | $12.29M | 0.1% | $23.65 | — | COM | 00484M106 |
| — | Newlink Genetics Corporation | 1,007,273 | $10.25M | 0.1% | $8.78 | — | COM | 651511107 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $9.992M | 0.1% | $41.68 | +90.0% | COM NEW | 53220K504 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $9.613M | 0.1% | $37.28 | — | COM | 46116X101 |
| — | Loxo Oncology, Inc. | 96,062 | $8.849M | 0.1% | $17.33 | — | COM | 548862101 |
| — | Assembly Biosciences, Inc. | 250,000 | $8.73M | 0.1% | $13.24 | — | COM | 045396108 |
| AGIO | Agios Pharmaceuticals, Inc. | 128,666 | $8.588M | 0.1% | $37.79 | +58.9% | COM | 00847X104 |
| — | Syros Pharmaceuticals, Inc. | 574,835 | $8.462M | 0.1% | $16.82 | — | COM | 87184Q107 |
| — | Achillion Pharmaceuticals, Inc. | 1,856,637 | $8.336M | 0.1% | $8.21 | — | COM | 00448Q201 |
| — | ContraFect Corporation | 7,153,076 | $7.94M | 0.1% | $1.88 | — | COM | 212326102 |
| — | GlycoMimetics, Inc. | 563,312 | $7.881M | 0.1% | $8.53 | — | COM | 38000Q102 |
| — | Nabriva Therapeutics plc | 938,235 | $7.684M | 0.1% | $9.04 | — | SHS | G63637105 |
| ALKS | Alkermes plc | 150,251 | $7.639M | 0.1% | $70.02 | -23.6% | SHS | G01767105 |
| — | GW Pharmaceuticals plc | 75,000 | $7.612M | 0.1% | $101.49 | — | ADS | 36197T103 |
| VNDA | Vanda Pharmaceuticals Inc. | 423,884 | $7.588M | 0.1% | $16.73 | 0.0% | COM | 921659108 |
| — | Aegerion Pharmaceuticals, Inc. | 9,517,000 | $7.576M | 0.1% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| — | Dimension Therapeutics, Inc. | 1,251,881 | $7.511M | 0.1% | $11.23 | — | COM | 25433V105 |
| — | Stemline Therapeutics, Inc. | 633,497 | $7.032M | 0.1% | $16.60 | — | COM | 85858C107 |
| MGNX | MacroGenics, Inc. | 363,676 | $6.721M | 0.1% | $23.98 | -27.8% | COM | 556099109 |
| — | Rigel Pharmaceuticals, Inc. | 2,518,882 | $6.398M | 0.1% | $2.56 | — | COM NEW | 766559603 |
| — | Tetraphase Pharmaceuticals, Inc. | 935,000 | $6.395M | 0.1% | $6.84 | — | COM | 88165N105 |
| — | Spring Bank Pharmaceuticals, Inc. | 373,144 | $6.284M | 0.1% | $10.28 | — | COM | 849431101 |
| — | Acceleron Pharma Inc. | 163,900 | $6.117M | 0.0% | $37.72 | — | COM | 00434H108 |
| — | Aevi Genomic Medicine, Inc. | 4,546,426 | $5.728M | 0.0% | $2.12 | — | COM | 00835P105 |
| — | Aeglea BioTherapeutics, Inc. | 1,137,872 | $5.609M | 0.0% | $4.02 | — | COM | 00773J103 |
| — | Array BioPharma Inc. | 3,000,000 | $5.41M | 0.0% | $1.25 | — | NOTE 3.0% 6/1/2020 | 04269XAA3 |
| — | La Jolla Pharmaceutical Company | 154,675 | $5.38M | 0.0% | $29.30 | — | COM PAR $.0001 2 | 503459604 |
| — | Selecta Biosciences, Inc. | 289,809 | $5.289M | 0.0% | $16.30 | — | COM | 816212104 |
| VYGR | Voyager Therapeutics, Inc. | 237,014 | $4.88M | 0.0% | $20.59 | — | COM | 92915B106 |
| — | Epizyme, Inc. | 232,481 | $4.429M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | Clementia Pharmaceuticals Inc. | 250,000 | $4.223M | 0.0% | $16.89 | — | COM ADDED | 185575107 |
| — | Albireo Pharma, Inc. | 200,000 | $4.19M | 0.0% | $20.60 | — | COM | 01345P106 |
| — | Inotek Pharmaceuticals Corporation | 5,000,000 | $3.904M | 0.0% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| ANAB | AnaptysBio, Inc. | 111,386 | $3.893M | 0.0% | $23.32 | +15.7% | COM | 032724106 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $3.655M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Versartis, Inc. | 1,437,214 | $3.521M | 0.0% | $22.68 | — | COM | 92529L102 |
| — | Tonix Pharmaceuticals Holdings Corp. | 699,500 | $3.19M | 0.0% | $4.61 | — | COM | 890260409 |
| — | Akari Therapeutics plc | 496,901 | $3.051M | 0.0% | $21.86 | — | SPONSORED ADR | 00972G108 |
| NTRA | Natera, Inc. | 228,676 | $2.948M | 0.0% | $13.15 | -15.6% | COM | 632307104 |
| OVID | Ovid Therapeutics Inc. | 333,333 | $2.857M | 0.0% | $13.06 | -36.2% | COM | 690469101 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 57,762 | $2.598M | 0.0% | $9.69 | +93.2% | COM | 558868105 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $2.598M | 0.0% | $15.19 | — | COM | 74933V108 |
| — | Protalix BioTherapeutics, Inc. | 3,423,000 | $2.576M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| — | Trevena, Inc. | 950,000 | $2.423M | 0.0% | $6.70 | — | COM | 89532E109 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $2.383M | 0.0% | $31.09 | — | COM | 48576U106 |
| — | Novavax, Inc. | 2,000,000 | $2.28M | 0.0% | $1.15 | — | COM | 670002104 |
| ARGX | argenx SE | 100,000 | $2.261M | 0.0% | $21.21 | — | SPONSORED ADR | 04016X101 |
| — | Trillium Therapeutics Inc. | 413,697 | $2.131M | 0.0% | $13.74 | — | COM NEW | 89620X506 |
| KRYS | Krystal Biotech, Inc. | 200,000 | $1.994M | 0.0% | $10.08 | 0.0% | COM ADDED | 501147102 |
| — | Dynavax Technologies Corporation | 75,000 | $1.613M | 0.0% | $24.55 | — | COM NEW | 268158201 |
| — | Jounce Therapeutics, Inc. | 100,000 | $1.558M | 0.0% | $21.99 | — | COM | 481116101 |
| — | Immune Design Corp. | 148,937 | $1.541M | 0.0% | $20.65 | — | COM | 45252L103 |
| — | Sunesis Pharmaceuticals, Inc. | 741,665 | $1.439M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| CLLS | Cellectis S.A. | 50,000 | $1.423M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | MediWound Ltd. | 226,000 | $1.209M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $1.12M | 0.0% | $8.87 | -51.8% | COM | 03879J100 |
| — | Ritter Pharmaceuticals, Inc. | 2,800,000 | $980K | 0.0% | $0.94 | — | COM | 767836109 |
| — | Affimed N.V. | 400,000 | $900K | 0.0% | $6.30 | — | COM | N01045108 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $819K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $787K | 0.0% | $16.80 | — | COM | 33830X104 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $772K | 0.0% | $1.54 | -19.2% | COM | 45665G303 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $620K | 0.0% | $5.21 | — | COM | 09060J106 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $599K | 0.0% | $9.20 | -37.5% | COM | 359664109 |
| — | Proteon Therapeutics, Inc. | 298,591 | $597K | 0.0% | $9.69 | — | COM | 74371L109 |
| — | InVivo Therapeutics Holdings Corp. | 400,000 | $580K | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| — | Molecular Templates, Inc. | 72,412 | $505K | 0.0% | $6.97 | — | COM ADDED | 608550109 |
| — | T2 Biosystems, Inc. | 100,000 | $420K | 0.0% | $4.20 | — | COM | 89853L104 |
| — | ChemoCentryx, Inc. | 49,064 | $364K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | BioPharmX Corporation | 598,758 | $171K | 0.0% | $0.50 | — | COM | 09072X101 |
| — | Tenax Therapeutics, Inc. | 348,374 | $126K | 0.0% | $0.50 | — | COM | 88032L100 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $98,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $4,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |