Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2017 (← Previous) (Next →)
Filing Date: Feb 14, 2018
Total Value: $11.54B (99.0% shares, 1.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 34,230,523 | $3.242B | 28.1% | $73.07 | +43.0% | COM | 45337C102 |
| — | Seattle Genetics, Inc. | 45,725,556 | $2.446B | 21.2% | $35.70 | — | COM | 812578102 |
| — | Alexion Pharmaceuticals, Inc. | 8,553,864 | $1.023B | 8.9% | $166.88 | — | COM | 015351109 |
| ACAD | ACADIA Pharmaceuticals Inc. | 27,228,338 | $820M | 7.1% | $17.23 | +85.6% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,583,084 | $676M | 5.9% | $81.02 | +7.3% | COM | 09061G101 |
| — | Genomic Health, Inc. | 13,781,102 | $471M | 4.1% | $31.71 | — | COM | 37244C101 |
| ONC | BeiGene, Ltd. | 3,849,231 | $376M | 3.3% | $34.07 | — | SPONSORED ADR | 07725L102 |
| — | DBV Technologies S.A. | 5,509,560 | $136M | 1.2% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,934,154 | $129M | 1.1% | $13.36 | — | COM | 03842B101 |
| ASND | Ascendis Pharma A/S | 2,618,818 | $105M | 0.9% | $26.93 | — | SPONSORED ADR | 04351P101 |
| — | Ablynx NV | 4,161,118 | $104M | 0.9% | $24.99 | — | SPONSORED ADR | 00372Y105 |
| — | Sage Therapeutics, Inc. | 616,514 | $102M | 0.9% | $88.93 | — | COM | 78667J108 |
| — | Amarin Corporation plc | 22,669,509 | $90.91M | 0.8% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| — | AveXis, Inc. | 775,000 | $85.77M | 0.7% | $69.51 | — | COM | 05366U100 |
| NBIX | Neurocrine Biosciences, Inc. | 1,004,624 | $77.95M | 0.7% | $44.09 | +54.7% | COM | 64125C109 |
| — | Array BioPharma Inc. | 5,656,196 | $72.4M | 0.6% | $10.76 | — | COM | 04269X105 |
| — | Spark Therapeutics, Inc. | 1,384,130 | $71.17M | 0.6% | $76.99 | — | COM | 84652J103 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 13,997,172 | $68.73M | 0.6% | $6.98 | -30.6% | COM | 09058V103 |
| — | Erytech Pharma S.A. | 3,090,069 | $68.04M | 0.6% | $22.02 | — | SPONSORED ADR | 29604W108 |
| — | Invitae Corporation | 7,288,300 | $66.18M | 0.6% | $15.87 | — | COM | 46185L103 |
| ARGX | argenx SE | 961,754 | $60.73M | 0.5% | $58.78 | — | SPONSORED ADR | 04016X101 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 2,049,020 | $59.55M | 0.5% | $26.40 | 0.0% | COM | 76243J105 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 615,684 | $56.51M | 0.5% | $52.67 | +8.4% | COM | 558868105 |
| HRTX | Heron Therapeutics, Inc. | 3,060,641 | $55.4M | 0.5% | $13.91 | +17.2% | COM | 427746102 |
| — | Mirati Therapeutics, Inc. | 2,549,461 | $46.53M | 0.4% | $18.61 | — | COM | 60468T105 |
| EXEL | Exelixis, Inc. | 1,506,499 | $45.8M | 0.4% | $7.37 | +261.0% | COM | 30161Q104 |
| — | Bellicum Pharmaceuticals, Inc. | 5,032,313 | $42.32M | 0.4% | $22.31 | — | COM | 079481107 |
| — | Novavax, Inc. | 88,500,000 | $40.86M | 0.4% | $0.45 | — | Note 3.75% 2/1/2023 | 670002AB0 |
| — | Idera Pharmaceuticals, Inc. | 18,315,802 | $38.65M | 0.3% | $2.36 | — | COM NEW | 45168K306 |
| — | Ignyta, Inc. | 1,384,266 | $36.96M | 0.3% | $11.09 | — | COM | 451731103 |
| — | bluebird bio, Inc. | 200,000 | $35.62M | 0.3% | $41.25 | — | COM | 09609G100 |
| SGMO | Sangamo Therapeutics, Inc. | 2,113,376 | $34.66M | 0.3% | $11.28 | +31.9% | COM | 800677106 |
| CERS | Cerus Corporation | 9,745,209 | $32.94M | 0.3% | $4.68 | -27.7% | COM | 157085101 |
| HALO | Halozyme Therapeutics, Inc. | 1,581,424 | $32.04M | 0.3% | $7.32 | +151.1% | COM | 40637H109 |
| — | Abeona Therapeutics Inc. | 1,984,364 | $31.45M | 0.3% | $6.57 | — | COM | 00289Y107 |
| — | Acorda Therapeutics, Inc. | 35,083,000 | $29.75M | 0.3% | $0.99 | — | NOTE 1.75% 6/15/2021 | 00484MAA4 |
| — | GW Pharmaceuticals plc | 221,800 | $29.28M | 0.3% | $121.69 | — | ADS | 36197T103 |
| — | CymaBay Therapeutics, Inc. | 2,991,775 | $27.52M | 0.2% | $6.19 | — | COM | 23257D103 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $25.49M | 0.2% | $16.20 | — | COM | 00900T107 |
| GLPG | Galapagos NV | 259,894 | $24.37M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 5,852,153 | $22.88M | 0.2% | $2.70 | +22.3% | COM | 14888U101 |
| — | Merus N.V. | 1,160,014 | $22.5M | 0.2% | $8.27 | — | COM | N5749R100 |
| NTLA | Intellia Therapeutics, Inc. | 1,145,453 | $22.02M | 0.2% | $26.35 | -12.4% | COM | 45826J105 |
| INSM | Insmed Incorporated | 700,000 | $21.83M | 0.2% | $16.38 | +80.4% | COM PAR $.01 | 457669307 |
| XNCR | Xencor, Inc. | 872,072 | $19.12M | 0.2% | $11.07 | +96.0% | COM | 98401F105 |
| — | Progenics Pharmaceuticals, Inc. | 3,150,808 | $18.75M | 0.2% | $4.44 | — | COM | 743187106 |
| ANAB | AnaptysBio, Inc. | 181,386 | $18.27M | 0.2% | $42.73 | +72.3% | COM | 032724106 |
| — | Aerie Pharmaceuticals, Inc. | 299,356 | $17.89M | 0.2% | $17.96 | — | COM | 00771V108 |
| — | ImmunoGen, Inc. | 2,563,489 | $16.43M | 0.1% | $11.68 | — | COM | 45253H101 |
| — | MyoKardia, Inc. | 355,264 | $14.96M | 0.1% | $35.39 | — | COM | 62857M105 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $14.93M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 | 09061GAH4 |
| — | Foamix Pharmaceuticals Ltd. | 2,466,702 | $14.82M | 0.1% | $7.55 | — | SHS | M46135105 |
| — | Assembly Biosciences, Inc. | 322,727 | $14.6M | 0.1% | $20.45 | — | COM | 045396108 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $13.22M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| — | Nektar Therapeutics | 171,934 | $10.27M | 0.1% | $59.72 | — | COM | 640268108 |
| LGND | Ligand Pharmaceuticals Incorporated | 73,386 | $10.05M | 0.1% | $41.68 | +107.9% | COM NEW | 53220K504 |
| — | Stemline Therapeutics, Inc. | 633,497 | $9.883M | 0.1% | $16.60 | — | COM | 85858C107 |
| — | Rigel Pharmaceuticals, Inc. | 2,518,882 | $9.773M | 0.1% | $2.56 | — | COM NEW | 766559603 |
| — | GlycoMimetics, Inc. | 563,312 | $9.458M | 0.1% | $8.53 | — | COM | 38000Q102 |
| QURE | uniQure N.V. | 482,557 | $9.453M | 0.1% | $15.23 | 0.0% | SHS | N90064101 |
| — | Intra-Cellular Therapies, Inc. | 609,166 | $8.821M | 0.1% | $37.28 | — | COM | 46116X101 |
| — | Achillion Pharmaceuticals, Inc. | 2,856,637 | $8.227M | 0.1% | $6.34 | — | COM | 00448Q201 |
| ALKS | Alkermes plc | 150,251 | $8.223M | 0.1% | $70.02 | -27.1% | SHS | G01767105 |
| — | NewLink Genetics Corporation | 1,007,273 | $8.169M | 0.1% | $8.78 | — | COM | 651511107 |
| — | Aegerion Pharmaceuticals, Inc. | 9,517,000 | $7.566M | 0.1% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| AGIO | Agios Pharmaceuticals, Inc. | 128,666 | $7.356M | 0.1% | $37.79 | +66.5% | COM | 00847X104 |
| — | ContraFect Corporation | 7,153,076 | $7.225M | 0.1% | $1.88 | — | COM | 212326102 |
| — | Acceleron Pharma Inc. | 163,900 | $6.956M | 0.1% | $37.72 | — | COM | 00434H108 |
| MGNX | MacroGenics, Inc. | 363,676 | $6.91M | 0.1% | $23.98 | -22.1% | COM | 556099109 |
| VNDA | Vanda Pharmaceuticals Inc. | 423,884 | $6.443M | 0.1% | $16.73 | -11.3% | COM | 921659108 |
| — | Aeglea BioTherapeutics, Inc. | 1,137,872 | $6.156M | 0.1% | $4.02 | — | COM | 00773J103 |
| — | Tetraphase Pharmaceuticals, Inc. | 935,000 | $5.891M | 0.1% | $6.84 | — | COM | 88165N105 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $5.85M | 0.1% | $14.46 | — | COM | 00548A106 |
| — | Nabriva Therapeutics plc | 938,235 | $5.611M | 0.0% | $9.04 | — | SHS | G63637105 |
| — | Syros Pharmaceuticals, Inc. | 574,835 | $5.593M | 0.0% | $16.82 | — | COM | 87184Q107 |
| — | Albireo Pharma, Inc. | 200,000 | $5.12M | 0.0% | $20.60 | — | COM | 01345P106 |
| — | Spring Bank Pharmaceuticals, Inc. | 373,144 | $5.015M | 0.0% | $10.28 | — | COM | 849431101 |
| — | La Jolla Pharmaceutical Company | 154,675 | $4.977M | 0.0% | $29.30 | — | COM PAR $.0001 2 | 503459604 |
| — | Aevi Genomic Medicine, Inc. | 4,055,142 | $4.866M | 0.0% | $2.12 | — | COM | 00835P105 |
| — | Clementia Pharmaceuticals Inc. | 250,000 | $4.745M | 0.0% | $16.89 | — | COM | 185575107 |
| — | Corbus Pharmaceuticals Holdings, Inc. | 660,714 | $4.691M | 0.0% | $7.10 | — | COM | 21833P103 |
| — | Endocyte, Inc. | 1,087,323 | $4.654M | 0.0% | $4.28 | — | COM | 29269A102 |
| — | Advanced Accelerator Applications S.A. | 55,125 | $4.499M | 0.0% | $29.75 | — | SPONSORED ADS | 00790T100 |
| — | Acorda Therapeutics, Inc. | 205,966 | $4.418M | 0.0% | $23.65 | — | COM | 00484M106 |
| IFRX | InflaRx N.V. | 200,000 | $4.19M | 0.0% | $17.97 | 0.0% | COM | N44821101 |
| — | INOTEK Technologies Corp. | 5,000,000 | $4.009M | 0.0% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| OVID | Ovid Therapeutics Inc. | 333,333 | $3.29M | 0.0% | $13.06 | -29.7% | COM | 690469101 |
| — | Versartis, Inc. | 1,426,310 | $3.138M | 0.0% | $22.68 | — | COM | 92529L102 |
| — | Akari Therapeutics Plc | 696,901 | $3.018M | 0.0% | $16.83 | — | SPONSORED ADR | 00972G108 |
| — | Trillium Therapeutics Inc. | 409,323 | $2.968M | 0.0% | $13.74 | — | COM NEW | 89620X506 |
| — | Epizyme, Inc. | 232,481 | $2.918M | 0.0% | $21.12 | — | COM | 29428V104 |
| — | Selecta Biosciences, Inc. | 283,716 | $2.783M | 0.0% | $16.30 | — | COM | 816212104 |
| — | Sunesis Pharmaceuticals, Inc. | 741,665 | $2.737M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Protalix BioTherapeutics, Inc. | 3,423,000 | $2.576M | 0.0% | $0.76 | — | NOTE 4.5% 9/15/2018 | 74365AAB7 |
| — | Novavax, Inc. | 2,000,000 | $2.48M | 0.0% | $1.15 | — | COM | 670002104 |
| — | Tonix Pharmaceuticals Holdings Corp. | 699,500 | $2.413M | 0.0% | $4.61 | — | COM | 890260409 |
| KRYS | Krystal Biotech, Inc. | 200,000 | $2.104M | 0.0% | $10.08 | -0.6% | COM | 501147102 |
| — | Karyopharm Therapeutics Inc. | 216,990 | $2.083M | 0.0% | $31.09 | — | COM | 48576U106 |
| NTRA | Natera, Inc. | 228,676 | $2.056M | 0.0% | $13.15 | -17.8% | COM | 632307104 |
| — | Trevena, Inc. | 950,000 | $1.52M | 0.0% | $6.70 | — | COM | 89532E109 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $1.513M | 0.0% | $15.19 | — | COM | 74933V108 |
| CLLS | Cellectis S.A. | 50,000 | $1.458M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | Dynavax Technologies Corporation | 75,000 | $1.403M | 0.0% | $24.55 | — | COM NEW | 268158201 |
| — | Achaogen, Inc. | 122,482 | $1.315M | 0.0% | $13.47 | — | COM | 004449104 |
| — | Jounce Therapeutics, Inc. | 100,000 | $1.275M | 0.0% | $21.99 | — | COM | 481116101 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $1.178M | 0.0% | $1.54 | +35.0% | COM | 45665G303 |
| — | MediWound Ltd. | 226,000 | $1.006M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| — | Ritter Pharmaceuticals, Inc. | 2,800,000 | $922K | 0.0% | $0.94 | — | COM | 767836109 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $912K | 0.0% | $8.87 | -33.9% | COM | 03879J100 |
| — | Molecular Templates, Inc. | 72,412 | $726K | 0.0% | $6.97 | — | COM | 608550109 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $668K | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $620K | 0.0% | $5.21 | — | COM | 09060J106 |
| — | Immune Design Corp. | 148,937 | $581K | 0.0% | $20.65 | — | COM | 45252L103 |
| — | Proteon Therapeutics, Inc. | 298,591 | $567K | 0.0% | $9.69 | — | COM | 74371L109 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $548K | 0.0% | $9.20 | -58.4% | COM | 359664109 |
| — | Affimed N.V. | 400,000 | $520K | 0.0% | $6.30 | — | COM | N01045108 |
| — | Five Prime Therapeutics, Inc. | 19,247 | $422K | 0.0% | $16.80 | — | COM | 33830X104 |
| — | T2 Biosystems, Inc. | 100,000 | $412K | 0.0% | $4.20 | — | COM | 89853L104 |
| — | ChemoCentryx, Inc. | 49,064 | $292K | 0.0% | $14.14 | — | COM | 16383L106 |
| — | InVivo Therapeutics Holdings Corp. | 331,393 | $255K | 0.0% | $6.98 | — | COM NEW | 46186M209 |
| — | Tenax Therapeutics, Inc. | 348,374 | $171K | 0.0% | $0.50 | — | COM | 88032L100 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $92,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $2,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |