Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q1 2018 (← Previous) (Next →)
Filing Date: May 15, 2018
Total Value: $11.8B (99.1% shares, 0.9% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | 34,230,751 | $2.852B | 24.2% | $73.07 | +23.4% | COM | 45337C102 |
| — | Seattle Genetics, Inc. | 49,575,409 | $2.595B | 22.0% | $36.99 | — | COM | 812578102 |
| ONC | BeiGene, Ltd. | 5,829,429 | $979M | 8.3% | $79.56 | — | SPONSORED ADR | 07725L102 |
| — | Alexion Pharmaceuticals, Inc. | 8,555,894 | $954M | 8.1% | $166.88 | — | COM | 015351109 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,583,084 | $615M | 5.2% | $81.02 | +5.9% | COM | 09061G101 |
| ACAD | ACADIA Pharmaceuticals Inc. | 27,228,338 | $612M | 5.2% | $17.23 | +60.7% | COM | 004225108 |
| — | Genomic Health, Inc. | 13,789,936 | $431M | 3.7% | $31.71 | — | COM | 37244C101 |
| ASND | Ascendis Pharma A/S | 2,837,352 | $186M | 1.6% | $29.89 | — | SPONSORED ADR | 04351P101 |
| — | Aquinox Pharmaceuticals, Inc. | 10,934,154 | $154M | 1.3% | $13.36 | — | COM | 03842B101 |
| — | AveXis, Inc. | 1,167,157 | $144M | 1.2% | $87.68 | — | COM | 05366U100 |
| HRTX | Heron Therapeutics, Inc. | 5,025,298 | $139M | 1.2% | $17.34 | +30.8% | COM | 427746102 |
| — | DBV Technologies S.A. | 5,509,560 | $127M | 1.1% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Ablynx NV | 2,176,802 | $119M | 1.0% | $24.99 | — | SPONSORED ADR | 00372Y105 |
| — | Sage Therapeutics, Inc. | 646,828 | $104M | 0.9% | $92.31 | — | COM | 78667J108 |
| — | Array BioPharma Inc. | 5,656,196 | $92.31M | 0.8% | $10.76 | — | COM | 04269X105 |
| — | Spark Therapeutics, Inc. | 1,384,130 | $92.17M | 0.8% | $76.99 | — | COM | 84652J103 |
| NBIX | Neurocrine Biosciences, Inc. | 944,624 | $78.34M | 0.7% | $44.09 | +91.5% | COM | 64125C109 |
| — | Mirati Therapeutics, Inc. | 2,549,461 | $78.27M | 0.7% | $18.61 | — | COM | 60468T105 |
| ARGX | argenx SE | 961,754 | $77.36M | 0.7% | $58.78 | — | SPONSORED ADR | 04016X101 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 615,684 | $71.91M | 0.6% | $52.67 | +134.4% | COM | 558868105 |
| — | Idera Pharmaceuticals, Inc. | 38,641,462 | $71.1M | 0.6% | $2.09 | — | COM NEW | 45168K306 |
| — | Amarin Corporation plc | 22,669,509 | $68.23M | 0.6% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 14,012,172 | $66.84M | 0.6% | $6.98 | -26.4% | COM | 09058V103 |
| — | ERYTECH Pharma S.A. | 3,090,069 | $64.89M | 0.6% | $22.02 | — | SPONSORED ADR | 29604W108 |
| — | Novavax, Inc. | 88,500,000 | $61.86M | 0.5% | $0.45 | — | Note 3.75% 2/1/2023 | 670002AB0 |
| CERS | Cerus Corporation | 10,749,937 | $58.91M | 0.5% | $4.67 | -2.7% | COM | 157085101 |
| — | CymaBay Therapeutics, Inc. | 3,917,700 | $50.89M | 0.4% | $7.80 | — | COM | 23257D103 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 2,049,020 | $40.77M | 0.3% | $26.40 | +0.6% | COM NEW | 76243J105 |
| — | Invitae Corporation | 8,399,411 | $39.39M | 0.3% | $14.39 | — | COM | 46185L103 |
| — | bluebird bio, Inc. | 200,000 | $34.15M | 0.3% | $41.25 | — | COM | 09609G100 |
| — | Abeona Therapeutics Inc. | 2,184,364 | $31.35M | 0.3% | $7.28 | — | COM | 00289Y107 |
| HALO | Halozyme Therapeutics, Inc. | 1,581,424 | $30.98M | 0.3% | $7.32 | +164.5% | COM | 40637H109 |
| SGMO | Sangamo Therapeutics, Inc. | 1,607,579 | $30.54M | 0.3% | $11.28 | +89.5% | COM | 800677106 |
| — | Nektar Therapeutics | 275,396 | $29.26M | 0.2% | $77.21 | — | COM | 640268108 |
| — | Bellicum Pharmaceuticals, Inc. | 4,151,578 | $27.23M | 0.2% | $22.31 | — | COM | 079481107 |
| — | Menlo Therapeutics Inc. | 700,000 | $26.31M | 0.2% | $37.58 | — | COM | 586858102 |
| XNCR | Xencor, Inc. | 872,072 | $26.14M | 0.2% | $11.07 | +136.3% | COM | 98401F105 |
| GLPG | Galapagos NV | 259,894 | $25.93M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| EXEL | Exelixis, Inc. | 1,162,644 | $25.75M | 0.2% | $7.37 | +275.1% | COM | 30161Q104 |
| — | GW Pharmaceuticals plc | 221,800 | $24.99M | 0.2% | $121.69 | — | ADS | 36197T103 |
| — | Merus N.V. | 1,160,014 | $21.5M | 0.2% | $8.27 | — | COM | N5749R100 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $21.45M | 0.2% | $16.20 | — | COM | 00900T107 |
| — | Endocyte, Inc. | 2,277,799 | $20.7M | 0.2% | $6.79 | — | COM | 29269A102 |
| NTLA | Intellia Therapeutics, Inc. | 833,795 | $17.59M | 0.1% | $26.35 | -6.7% | COM | 45826J105 |
| — | Progenics Pharmaceuticals, Inc. | 2,306,184 | $17.2M | 0.1% | $4.44 | — | COM | 743187106 |
| INSM | Insmed Incorporated | 700,000 | $15.76M | 0.1% | $16.38 | +60.7% | COM PAR $.01 | 457669307 |
| — | MyoKardia, Inc. | 290,264 | $14.16M | 0.1% | $35.39 | — | COM | 62857M105 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $14.1M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 | 09061GAH4 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $12.54M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| — | Audentes Therapeutics, Inc. | 393,222 | $11.82M | 0.1% | $30.05 | — | COM | 05070R104 |
| QURE | uniQure N.V. | 500,000 | $11.75M | 0.1% | $15.45 | +41.1% | SHS | N90064101 |
| — | Aerie Pharmaceuticals, Inc. | 215,655 | $11.7M | 0.1% | $17.96 | — | COM | 00771V108 |
| — | ContraFect Corporation | 7,153,076 | $11.63M | 0.1% | $1.88 | — | COM | 212326102 |
| — | Aeglea BioTherapeutics, Inc. | 1,137,872 | $11.29M | 0.1% | $4.02 | — | COM | 00773J103 |
| — | Corsicanto II Designated Activity Company | 10,000,000 | $11.03M | 0.1% | $1.10 | — | Note 3.5% 1/5/2047 | 220485AB2 |
| — | Achillion Pharmaceuticals, Inc. | 2,856,637 | $10.6M | 0.1% | $6.34 | — | COM | 00448Q201 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 4,381,072 | $10.47M | 0.1% | $2.70 | +23.0% | COM | 14888U101 |
| VNDA | Vanda Pharmaceuticals Inc. | 600,354 | $10.12M | 0.1% | $16.74 | +0.0% | COM | 921659108 |
| — | Assembly Biosciences, Inc. | 193,787 | $9.523M | 0.1% | $20.45 | — | COM | 045396108 |
| ANAB | AnaptysBio, Inc. | 91,086 | $9.48M | 0.1% | $42.73 | +163.8% | COM | 032724106 |
| MGNX | MacroGenics, Inc. | 363,676 | $9.15M | 0.1% | $23.98 | +1.3% | COM | 556099109 |
| — | GlycoMimetics, Inc. | 563,312 | $9.143M | 0.1% | $8.53 | — | COM | 38000Q102 |
| — | Rigel Pharmaceuticals, Inc. | 2,518,882 | $8.917M | 0.1% | $2.56 | — | COM NEW | 766559603 |
| — | Foamix Pharmaceuticals Ltd. | 1,598,991 | $8.203M | 0.1% | $7.55 | — | SHS | M46135105 |
| — | Aevi Genomic Medicine, Inc. | 4,055,142 | $8.151M | 0.1% | $2.12 | — | COM | 00835P105 |
| — | Albireo Pharma, Inc. | 250,000 | $8.143M | 0.1% | $22.99 | — | COM | 01345P106 |
| — | Syros Pharmaceuticals, Inc. | 574,835 | $7.461M | 0.1% | $16.82 | — | COM | 87184Q107 |
| — | Aegerion Pharmaceuticals, Inc. | 9,517,000 | $7.273M | 0.1% | $0.75 | — | NOTE 2.0% 8/15/2019 | 00767EAB8 |
| — | Acceleron Pharma Inc. | 163,900 | $6.408M | 0.1% | $37.72 | — | COM | 00434H108 |
| — | G1 Therapeutics, Inc. | 169,492 | $6.28M | 0.1% | $37.05 | — | COM | 3621LQ109 |
| ALKS | Alkermes plc | 100,251 | $5.811M | 0.0% | $70.02 | -16.5% | SHS | G01767105 |
| IFRX | InflaRx N.V. | 200,000 | $5.768M | 0.0% | $17.97 | +46.7% | COM | N44821101 |
| — | Spring Bank Pharmaceuticals, Inc. | 373,144 | $5.739M | 0.0% | $10.28 | — | COM | 849431101 |
| — | ChemoCentryx, Inc. | 414,029 | $5.631M | 0.0% | $13.66 | — | COM | 16383L106 |
| — | Momenta Pharmaceuticals, Inc. | 308,500 | $5.599M | 0.0% | $18.15 | — | COM | 60877T100 |
| — | Inotek Pharmaceuticals Corp. | 5,000,000 | $4.795M | 0.0% | $1.34 | — | NOTE 5.75% 8/1/2021 | 45780VAB8 |
| — | Nabriva Therapeutics plc | 938,235 | $4.719M | 0.0% | $9.04 | — | SHS | G63637105 |
| — | La Jolla Pharmaceutical Company | 154,675 | $4.606M | 0.0% | $29.30 | — | COM PAR $.0001 2 | 503459604 |
| — | Solid Biosciences Inc. | 587,884 | $4.409M | 0.0% | $7.50 | — | COM | 83422E105 |
| — | Stemline Therapeutics, Inc. | 287,827 | $4.404M | 0.0% | $16.60 | — | COM | 85858C107 |
| — | Novavax, Inc. | 2,000,000 | $4.2M | 0.0% | $1.15 | — | COM | 670002104 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $4.126M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Corbus Pharmaceuticals Holdings, Inc. | 660,714 | $4.03M | 0.0% | $7.10 | — | COM | 21833P103 |
| — | Clementia Pharmaceuticals Inc. | 250,000 | $3.788M | 0.0% | $16.89 | — | COM ADDED | 185575107 |
| — | NewLink Genetics Corporation | 507,273 | $3.678M | 0.0% | $8.78 | — | COM | 651511107 |
| — | Trillium Therapeutics Inc. | 409,323 | $2.947M | 0.0% | $13.74 | — | COM NEW | 89620X506 |
| — | Tetraphase Pharmaceuticals, Inc. | 935,000 | $2.87M | 0.0% | $6.84 | — | COM | 88165N105 |
| — | Versartis, Inc. | 1,426,310 | $2.353M | 0.0% | $22.68 | — | COM | 92529L102 |
| — | Jounce Therapeutics, Inc. | 100,000 | $2.235M | 0.0% | $21.99 | — | COM | 481116101 |
| NTRA | Natera, Inc. | 228,676 | $2.12M | 0.0% | $13.15 | -25.4% | COM | 632307104 |
| — | Tonix Pharmaceuticals Holdings Corp. | 699,500 | $2.098M | 0.0% | $4.61 | — | COM | 890260409 |
| KRYS | Krystal Biotech, Inc. | 200,000 | $2.018M | 0.0% | $10.08 | -2.2% | COM | 501147102 |
| OVID | Ovid Therapeutics Inc. | 247,733 | $1.751M | 0.0% | $13.06 | -38.0% | COM | 690469101 |
| CLLS | Cellectis S.A. | 50,000 | $1.576M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | Trevena, Inc. | 950,000 | $1.558M | 0.0% | $6.70 | — | COM | 89532E109 |
| — | Sunesis Pharmaceuticals, Inc. | 556,665 | $1.514M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Dynavax Technologies Corporation | 75,000 | $1.489M | 0.0% | $24.55 | — | COM NEW | 268158201 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $1.219M | 0.0% | $1.54 | +39.5% | COM | 45665G303 |
| — | MediWound Ltd. | 226,000 | $1.175M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $1.123M | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Selecta Biosciences, Inc. | 93,750 | $955K | 0.0% | $16.30 | — | COM | 816212104 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $945K | 0.0% | $15.19 | — | COM | 74933V108 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $903K | 0.0% | $8.87 | -40.3% | COM | 03879J100 |
| — | Ritter Pharmaceuticals, Inc. | 279,999 | $762K | 0.0% | $2.72 | — | COM | 767836307 |
| — | Proteon Therapeutics, Inc. | 298,591 | $746K | 0.0% | $9.69 | — | COM | 74371L109 |
| — | Affimed N.V. | 400,000 | $740K | 0.0% | $6.30 | — | COM | N01045108 |
| — | T2 Biosystems, Inc. | 100,000 | $649K | 0.0% | $4.20 | — | COM | 89853L104 |
| — | Akari Therapeutics, Plc | 339,833 | $618K | 0.0% | $16.83 | — | SPONSORED ADR | 00972G108 |
| — | Molecular Templates, Inc. | 72,412 | $579K | 0.0% | $6.97 | — | COM | 608550109 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $500K | 0.0% | $9.20 | -52.1% | COM | 359664109 |
| — | Immune Design Corp. | 148,937 | $491K | 0.0% | $20.65 | — | COM | 45252L103 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $473K | 0.0% | $5.21 | — | COM | 09060J106 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $77,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $2,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |