Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q2 2018 (← Previous) (Next →)
Filing Date: Aug 14, 2018
Total Value: $13.31B (99.2% shares, 0.8% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seattle Genetics, Inc. | 51,046,060 | $3.389B | 25.5% | $37.84 | — | COM | 812578102 |
| INCY | Incyte Corporation | 34,251,034 | $2.295B | 17.2% | $73.07 | -6.4% | COM | 45337C102 |
| ONC | BeiGene, Ltd. | 11,959,824 | $1.839B | 13.8% | $117.58 | — | SPONSORED ADR | 07725L102 |
| — | Alexion Pharmaceuticals, Inc. | 8,555,894 | $1.062B | 8.0% | $166.88 | — | COM | 015351109 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,583,084 | $714M | 5.4% | $81.02 | +8.1% | COM | 09061G101 |
| — | Genomic Health, Inc. | 13,790,574 | $695M | 5.2% | $31.71 | — | COM | 37244C101 |
| ACAD | ACADIA Pharmaceuticals Inc. | 27,228,338 | $416M | 3.1% | $17.23 | +3.5% | COM | 004225108 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,169,278 | $327M | 2.5% | $110.87 | +58.4% | COM | 558868105 |
| HRTX | Heron Therapeutics, Inc. | 5,025,298 | $195M | 1.5% | $17.34 | +83.6% | COM | 427746102 |
| ASND | Ascendis Pharma A/S | 2,837,352 | $189M | 1.4% | $29.89 | — | SPONSORED ADR | 04351P101 |
| — | Mirati Therapeutics, Inc. | 2,513,462 | $124M | 0.9% | $18.61 | — | COM | 60468T105 |
| — | Spark Therapeutics, Inc. | 1,384,130 | $115M | 0.9% | $76.99 | — | COM | 84652J103 |
| — | DBV Technologies S.A. | 5,509,560 | $106M | 0.8% | $32.87 | — | SPONSORED ADR | 23306J101 |
| — | Sage Therapeutics, Inc. | 613,300 | $96M | 0.7% | $92.31 | — | COM | 78667J108 |
| — | Array BioPharma Inc. | 5,656,196 | $94.91M | 0.7% | $10.76 | — | COM | 04269X105 |
| NBIX | Neurocrine Biosciences, Inc. | 944,624 | $92.8M | 0.7% | $44.09 | +103.0% | COM | 64125C109 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 2,708,200 | $84.66M | 0.6% | $26.63 | +2.7% | COM | 76243J105 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 14,012,172 | $80.29M | 0.6% | $6.98 | -21.1% | COM | 09058V103 |
| ARGX | argenx SE | 961,754 | $79.69M | 0.6% | $58.78 | — | SPONSORED ADR | 04016X101 |
| CERS | Cerus Corporation | 10,749,937 | $71.7M | 0.5% | $4.67 | +31.3% | COM | 157085101 |
| — | Amarin Corporation plc | 22,669,509 | $70.05M | 0.5% | $3.15 | — | SPONSORED ADR NEW | 023111206 |
| — | CymaBay Therapeutics, Inc. | 4,917,700 | $66M | 0.5% | $8.94 | — | COM | 23257D103 |
| — | Invitae Corporation | 8,399,411 | $61.74M | 0.5% | $14.39 | — | COM | 46185L103 |
| — | Kiniksa Pharmaceuticals, Ltd. | 3,000,000 | $52.05M | 0.4% | $17.35 | — | COM CL A | G5269C101 |
| — | Idera Pharmaceuticals, Inc. | 38,654,811 | $51.02M | 0.4% | $1.32 | — | COM NEW | 45168K405 |
| — | Tricida, Inc. | 1,600,000 | $47.84M | 0.4% | $29.90 | — | COM | 89610F101 |
| — | GW Pharmaceuticals plc | 321,800 | $44.9M | 0.3% | $127.24 | — | ADS | 36197T103 |
| — | Novavax, Inc. | 73,500,000 | $42.67M | 0.3% | $0.45 | — | NOTE 3.75% 2/1/23 | 670002AB0 |
| — | Abeona Therapeutics Inc. | 2,184,364 | $34.95M | 0.3% | $7.28 | — | COM | 00289Y107 |
| — | ERYTECH Pharma S.A. | 3,085,969 | $34.47M | 0.3% | $22.02 | — | SPONSORED ADR | 29604W108 |
| XNCR | Xencor, Inc. | 872,072 | $32.27M | 0.2% | $11.07 | +211.4% | COM | 98401F105 |
| — | Endocyte, Inc. | 2,277,799 | $31.43M | 0.2% | $6.79 | — | COM | 29269A102 |
| — | bluebird bio, Inc. | 200,000 | $31.39M | 0.2% | $41.25 | — | COM | 09609G100 |
| — | Bellicum Pharmaceuticals, Inc. | 4,093,447 | $30.21M | 0.2% | $22.31 | — | COM | 079481107 |
| — | Aquinox Pharmaceuticals, Inc. | 10,934,154 | $28.98M | 0.2% | $13.36 | — | COM | 03842B101 |
| — | Merus N.V. | 1,160,014 | $26.4M | 0.2% | $8.27 | — | COM | N5749R100 |
| GLPG | Galapagos NV | 259,894 | $23.96M | 0.2% | $51.50 | — | SPONSORED ADR | 36315X101 |
| QURE | uniQure N.V. | 605,000 | $22.87M | 0.2% | $18.33 | +74.7% | SHS | N90064101 |
| HALO | Halozyme Therapeutics, Inc. | 1,283,929 | $21.66M | 0.2% | $7.32 | +158.2% | COM | 40637H109 |
| — | MyoKardia, Inc. | 433,121 | $21.5M | 0.2% | $40.09 | — | COM | 62857M105 |
| — | Solid Biosciences Inc. | 587,884 | $20.95M | 0.2% | $7.50 | — | COM | 83422E105 |
| — | Zymeworks Inc. | 1,311,085 | $19.38M | 0.1% | $14.78 | — | COM | 98985W102 |
| SGMO | Sangamo Therapeutics, Inc. | 1,283,923 | $18.23M | 0.1% | $11.28 | +47.2% | COM | 800677106 |
| — | Aimmune Therapeutics, Inc. | 673,908 | $18.12M | 0.1% | $16.20 | — | COM | 00900T107 |
| INSM | Insmed Incorporated | 700,000 | $16.55M | 0.1% | $16.38 | +57.2% | COM PAR $.01 | 457669307 |
| — | ContraFect Corporation | 7,153,076 | $15.81M | 0.1% | $1.88 | — | COM | 212326102 |
| — | Clementia Pharmaceuticals Inc. | 1,192,595 | $15.7M | 0.1% | $13.94 | — | COM | 185575107 |
| — | BioMarin Pharmaceutical Inc. | 15,000,000 | $15.2M | 0.1% | $1.01 | — | NOTE 0.599% 8/1/2024 | 09061GAH4 |
| — | Audentes Therapeutics, Inc. | 393,222 | $15.03M | 0.1% | $30.05 | — | COM | 05070R104 |
| NTLA | Intellia Therapeutics, Inc. | 546,922 | $14.96M | 0.1% | $26.35 | -8.1% | COM | 45826J105 |
| — | Aeglea BioTherapeutics, Inc. | 1,387,872 | $14.68M | 0.1% | $5.20 | — | COM | 00773J103 |
| — | Neurocrine Biosciences, Inc. | 10,000,000 | $14.47M | 0.1% | $1.45 | — | NOTE 2.25% 5/15/2024 | 64125CAD1 |
| — | BioMarin Pharmaceutical Inc. | 12,228,000 | $13M | 0.1% | $1.06 | — | NOTE 0.75% 10/15/2018 | 09061GAE1 |
| CPRX | Catalyst Pharmaceuticals, Inc. | 3,621,962 | $11.3M | 0.1% | $2.70 | +12.3% | COM | 14888U101 |
| EXEL | Exelixis, Inc. | 513,410 | $11.05M | 0.1% | $7.37 | +180.6% | COM | 30161Q104 |
| — | Corsicanto II Designated Activity Company | 10,000,000 | $10.91M | 0.1% | $1.10 | — | NOTE 3.5% 1/5/2047 | 220485AB2 |
| — | Albireo Pharma, Inc. | 250,000 | $8.875M | 0.1% | $22.99 | — | COM | 01345P106 |
| IFRX | InflaRx N.V. | 258,824 | $8.347M | 0.1% | $21.73 | +58.9% | COM | N44821101 |
| — | Acceleron Pharma Inc. | 163,900 | $7.952M | 0.1% | $37.72 | — | COM | 00434H108 |
| — | Progenics Pharmaceuticals, Inc. | 979,016 | $7.871M | 0.1% | $4.44 | — | COM | 743187106 |
| — | Galmed Pharmaceuticals Ltd. | 636,140 | $7.57M | 0.1% | $11.90 | — | SHS | M47238106 |
| — | Foamix Pharmaceuticals Ltd. | 1,490,201 | $7.466M | 0.1% | $7.55 | — | SHS | M46135105 |
| — | G1 Therapeutics, Inc. | 169,492 | $7.366M | 0.1% | $37.05 | — | COM | 3621LQ109 |
| — | Momenta Pharmaceuticals, Inc. | 308,500 | $6.309M | 0.0% | $18.15 | — | COM | 60877T100 |
| AUTL | Autolus Therapeutics plc | 235,294 | $6.304M | 0.0% | $26.79 | — | SPON ADS | 05280R100 |
| — | Aegerion Pharmaceuticals, Inc. | 9,517,000 | $6.027M | 0.0% | $0.75 | — | NOTE 2% 8/15/2019 | 00767EAB8 |
| VNDA | Vanda Pharmaceuticals Inc. | 310,354 | $5.912M | 0.0% | $16.74 | -0.1% | COM | 921659108 |
| — | Syros Pharmaceuticals, Inc. | 574,835 | $5.869M | 0.0% | $16.82 | — | COM | 87184Q107 |
| — | Assembly Biosciences, Inc. | 148,587 | $5.826M | 0.0% | $20.45 | — | COM | 045396108 |
| — | Menlo Therapeutics Inc. | 700,000 | $5.684M | 0.0% | $37.58 | — | COM | 586858102 |
| — | Achillion Pharmaceuticals, Inc. | 1,943,620 | $5.5M | 0.0% | $6.34 | — | COM | 00448Q201 |
| — | ChemoCentryx, Inc. | 414,029 | $5.453M | 0.0% | $13.66 | — | COM | 16383L106 |
| ANAB | AnaptysBio, Inc. | 73,086 | $5.192M | 0.0% | $42.73 | +96.3% | COM | 032724106 |
| — | Sesen Bio, Inc. | 2,624,412 | $5.118M | 0.0% | $1.95 | — | COM | 817763105 |
| — | Acorda Therapeutics, Inc. | 173,100 | $4.968M | 0.0% | $28.70 | — | COM | 00484M106 |
| — | Versartis, Inc. | 2,426,310 | $4.913M | 0.0% | $14.17 | — | COM | 92529L102 |
| — | GlycoMimetics, Inc. | 291,214 | $4.697M | 0.0% | $8.53 | — | COM | 38000Q102 |
| — | La Jolla Pharmaceutical Company | 154,675 | $4.512M | 0.0% | $29.30 | — | COM PAR $.0001 2 | 503459604 |
| — | Aevi Genomic Medicine, Inc. | 4,055,142 | $4.501M | 0.0% | $2.12 | — | COM | 00835P105 |
| MGNX | MacroGenics, Inc. | 217,695 | $4.495M | 0.0% | $23.98 | -6.1% | COM | 556099109 |
| — | Adamas Pharmaceuticals, Inc. | 172,630 | $4.459M | 0.0% | $14.46 | — | COM | 00548A106 |
| — | Spring Bank Pharmaceuticals, Inc. | 373,144 | $4.422M | 0.0% | $10.28 | — | COM | 849431101 |
| APLS | Apellis Pharmaceuticals, Inc. | 196,078 | $4.314M | 0.0% | $22.98 | 0.0% | COM | 03753U106 |
| NTRA | Natera, Inc. | 228,676 | $4.304M | 0.0% | $13.15 | -7.5% | COM | 632307104 |
| ALKS | Alkermes plc | 100,251 | $4.126M | 0.0% | $70.02 | -35.0% | SHS | G01767105 |
| — | Aerie Pharmaceuticals, Inc. | 60,155 | $4.063M | 0.0% | $17.96 | — | COM | 00771V108 |
| — | Forty Seven, Inc. | 250,000 | $4M | 0.0% | $16.00 | — | COM | 34983P104 |
| — | Tetraphase Pharmaceuticals, Inc. | 935,000 | $3.338M | 0.0% | $6.84 | — | COM | 88165N105 |
| — | Nabriva Therapeutics plc | 938,235 | $3.265M | 0.0% | $9.04 | — | SHS | G63637105 |
| — | Tonix Pharmaceuticals Holdings Corp. | 699,500 | $3.113M | 0.0% | $4.61 | — | COM | 890260409 |
| — | Trillium Therapeutics Inc. | 511,763 | $3.071M | 0.0% | $12.19 | — | COM NEW | 89620X506 |
| KRYS | Krystal Biotech, Inc. | 200,000 | $2.974M | 0.0% | $10.08 | +11.3% | COM | 501147102 |
| — | Rigel Pharmaceuticals, Inc. | 1,041,612 | $2.948M | 0.0% | $2.56 | — | COM NEW | 766559603 |
| — | NewLink Genetics Corporation | 507,273 | $2.415M | 0.0% | $8.78 | — | COM | 651511107 |
| OVID | Ovid Therapeutics Inc. | 247,733 | $1.932M | 0.0% | $13.06 | -34.3% | COM | 690469101 |
| — | Ra Pharmaceuticals, Inc. | 177,952 | $1.771M | 0.0% | $15.19 | — | COM | 74933V108 |
| — | MediWound Ltd. | 226,000 | $1.559M | 0.0% | $11.38 | — | ORD SHS | M68830104 |
| RCUS | Arcus Biosciences, Inc. | 121,534 | $1.488M | 0.0% | $15.69 | 0.0% | COM | 03969F109 |
| CLLS | Cellectis S.A. | 50,000 | $1.415M | 0.0% | $34.58 | — | SPONSORED ADS | 15117K103 |
| — | Trevena, Inc. | 950,000 | $1.368M | 0.0% | $6.70 | — | COM | 89532E109 |
| ABUS | Arbutus Biopharma Corporation | 180,582 | $1.318M | 0.0% | $8.87 | -32.9% | COM | 03879J100 |
| — | Corbus Pharmaceuticals Holdings, Inc. | 247,450 | $1.25M | 0.0% | $7.10 | — | COM | 21833P103 |
| — | Selecta Biosciences, Inc. | 93,750 | $1.242M | 0.0% | $16.30 | — | COM | 816212104 |
| ADAPY | Adaptimmune Therapeutics plc | 100,000 | $1.187M | 0.0% | $18.33 | — | SPONSORED ADR | 00653A107 |
| — | Sunesis Pharmaceuticals, Inc. | 556,665 | $1.18M | 0.0% | $4.37 | — | COM PAR | 867328700 |
| — | Dynavax Technologies Corporation | 75,000 | $1.144M | 0.0% | $24.55 | — | COM NEW | 268158201 |
| INFIQ | Infinity Pharmaceuticals, Inc. | 580,400 | $1.109M | 0.0% | $1.54 | +31.5% | COM | 45665G303 |
| — | T2 Biosystems, Inc. | 100,000 | $774K | 0.0% | $4.20 | — | COM | 89853L104 |
| — | Jounce Therapeutics, Inc. | 100,000 | $766K | 0.0% | $21.99 | — | COM | 481116101 |
| — | Proteon Therapeutics, Inc. | 298,591 | $732K | 0.0% | $9.69 | — | COM | 74371L109 |
| — | Ritter Pharmaceuticals, Inc. | 279,999 | $720K | 0.0% | $2.72 | — | COM NEW | 767836307 |
| — | Stemline Therapeutics, Inc. | 44,524 | $715K | 0.0% | $16.60 | — | COM | 85858C107 |
| — | Affimed N.V. | 400,000 | $660K | 0.0% | $6.30 | — | COM | N01045108 |
| — | BioDelivery Sciences International, Inc. | 210,021 | $620K | 0.0% | $5.21 | — | COM | 09060J106 |
| FLGT | Fulgent Genetics, Inc. | 125,000 | $518K | 0.0% | $9.20 | -57.0% | COM | 359664109 |
| — | Molecular Templates, Inc. | 72,412 | $379K | 0.0% | $6.97 | — | COM | 608550109 |
| — | Akari Therapeutics, Plc | 58,770 | $115K | 0.0% | $16.83 | — | SPONSORED ADR | 00972G108 |
| — | Cyclacel Pharmaceuticals, Inc. | 13,253 | $89,000 | 0.0% | $7.20 | — | PFD CONV EX 6% | 23254L207 |
| — | BioTime, Inc. | 20,084 | $1,000 | 0.0% | $1.07 | — | *W EXP 10/1/201 | 09066L162 |