BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q4 2018 (← Previous) (Next →)

Filing Date: Feb 13, 2019

Total Value: $12.21B (99.4% shares, 0.6% debt)

Holdings (93)

Seattle Genetics, Inc. 23.7%
Value $2.892B Shares 51,046,060 Est. Cost $37.84 Unrealized
INCY Incyte Corporation 17.8%
Value $2.178B Shares 34,251,607 Est. Cost $73.07 Unrealized -11.1%
ONC BeiGene, Ltd. 13.7%
Value $1.677B Shares 11,959,824 Est. Cost $117.58 Unrealized
Alexion Pharmaceuticals, Inc. 6.8%
Value $833M Shares 8,555,894 Est. Cost $166.88 Unrealized
Genomic Health, Inc. 6.2%
Value $756M Shares 11,744,010 Est. Cost $31.71 Unrealized
BMRN BioMarin Pharmaceutical Inc. 5.3%
Value $646M Shares 7,589,294 Est. Cost $81.02 Unrealized +17.4%
ACAD ACADIA Pharmaceuticals Inc. 5.3%
Value $642M Shares 39,713,842 Est. Cost $17.80 Unrealized +9.1%
Amarin Corporation plc 4.7%
Value $580M Shares 42,592,824 Est. Cost $8.76 Unrealized
ASND Ascendis Pharma A/S 1.5%
Value $178M Shares 2,837,352 Est. Cost $29.89 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 1.1%
Value $132M Shares 1,169,278 Est. Cost $110.87 Unrealized +39.6%
HRTX Heron Therapeutics, Inc. 1.1%
Value $130M Shares 5,018,104 Est. Cost $17.34 Unrealized +58.6%
BCRX BioCryst Pharmaceuticals, Inc. 1.0%
Value $122M Shares 15,103,081 Est. Cost $6.96 Unrealized +11.7%
Mirati Therapeutics, Inc. 0.9%
Value $107M Shares 2,513,462 Est. Cost $18.61 Unrealized
ARGX argenx SE 0.8%
Value $97.95M Shares 1,019,557 Est. Cost $59.75 Unrealized
Kiniksa Pharmaceuticals, Ltd. 0.7%
Value $84.27M Shares 3,000,000 Est. Cost $17.35 Unrealized
RYTM Rhythm Pharmaceuticals, Inc. 0.6%
Value $72.8M Shares 2,708,200 Est. Cost $26.63 Unrealized +3.8%
Array BioPharma Inc. 0.6%
Value $71.84M Shares 5,041,696 Est. Cost $10.76 Unrealized
KOD Kodiak Sciences Inc. 0.5%
Value $64.93M Shares 9,145,115 Est. Cost $8.85 Unrealized 0.0%
Neurocrine Biosciences, Inc. 0.5%
Value $63.43M Shares 53,270,000 Est. Cost $1.24 Unrealized
CERS Cerus Corporation 0.4%
Value $54.5M Shares 10,749,937 Est. Cost $4.67 Unrealized +24.2%
Spark Therapeutics, Inc. 0.4%
Value $54.17M Shares 1,384,130 Est. Cost $76.99 Unrealized
NBIX Neurocrine Biosciences, Inc. 0.4%
Value $52.16M Shares 730,355 Est. Cost $44.09 Unrealized +117.3%
Principia Biopharma Inc. 0.4%
Value $48.97M Shares 1,787,807 Est. Cost $29.22 Unrealized
Clementia Pharmaceuticals Inc. 0.4%
Value $43.8M Shares 3,724,445 Est. Cost $12.34 Unrealized
Invitae Corporation 0.4%
Value $43.16M Shares 3,902,421 Est. Cost $14.39 Unrealized
GW Pharmaceuticals plc 0.3%
Value $41.72M Shares 428,345 Est. Cost $132.99 Unrealized
CymaBay Therapeutics, Inc. 0.3%
Value $38.7M Shares 4,917,700 Est. Cost $8.94 Unrealized
Tricida, Inc. 0.3%
Value $37.73M Shares 1,600,000 Est. Cost $29.90 Unrealized
DBV Technologies S.A. 0.3%
Value $35.37M Shares 5,509,560 Est. Cost $32.87 Unrealized
Zymeworks Inc. 0.2%
Value $25.08M Shares 1,708,472 Est. Cost $14.76 Unrealized
INSM Insmed Incorporated 0.2%
Value $24.3M Shares 1,851,982 Est. Cost $20.25 Unrealized -21.2%
Aquinox Pharmaceuticals, Inc. 0.2%
Value $23.62M Shares 10,934,154 Est. Cost $13.36 Unrealized
Audentes Therapeutics, Inc. 0.2%
Value $19.41M Shares 910,463 Est. Cost $25.09 Unrealized
QURE uniQure N.V. 0.1%
Value $17.44M Shares 605,000 Est. Cost $18.33 Unrealized +51.8%
KRYS Krystal Biotech, Inc. 0.1%
Value $16.31M Shares 784,674 Est. Cost $19.35 Unrealized +8.2%
Merus N.V. 0.1%
Value $16.24M Shares 1,160,014 Est. Cost $8.27 Unrealized
Aimmune Therapeutics, Inc. 0.1%
Value $16.12M Shares 673,908 Est. Cost $16.20 Unrealized
XNCR Xencor, Inc. 0.1%
Value $15.92M Shares 440,186 Est. Cost $11.07 Unrealized +231.6%
Solid Biosciences Inc. 0.1%
Value $15.76M Shares 587,884 Est. Cost $7.50 Unrealized
MyoKardia, Inc. 0.1%
Value $15.4M Shares 315,243 Est. Cost $40.09 Unrealized
Abeona Therapeutics Inc. 0.1%
Value $15.02M Shares 2,103,164 Est. Cost $7.28 Unrealized
Ra Pharmaceuticals, Inc. 0.1%
Value $14.98M Shares 823,113 Est. Cost $17.55 Unrealized
BioMarin Pharmaceutical Inc. 0.1%
Value $14.91M Shares 15,000,000 Est. Cost $1.01 Unrealized
Idera Pharmaceuticals, Inc. 0.1%
Value $13.4M Shares 4,836,237 Est. Cost $1.32 Unrealized
Aeglea BioTherapeutics, Inc. 0.1%
Value $12.84M Shares 1,713,604 Est. Cost $5.64 Unrealized
SGMO Sangamo Therapeutics, Inc. 0.1%
Value $11.48M Shares 999,823 Est. Cost $11.28 Unrealized +10.1%
ContraFect Corporation 0.1%
Value $10.94M Shares 7,153,076 Est. Cost $1.88 Unrealized
Novavax, Inc. 0.1%
Value $8.682M Shares 4,718,318 Est. Cost $1.88 Unrealized
Marker Therapeutics, Inc. 0.1%
Value $8.325M Shares 1,500,000 Est. Cost $5.55 Unrealized
Bellicum Pharmaceuticals, Inc. 0.1%
Value $7.819M Shares 2,677,818 Est. Cost $22.31 Unrealized
ANAB AnaptysBio, Inc. 0.1%
Value $7.214M Shares 113,086 Est. Cost $56.96 Unrealized +30.6%
IFRX InflaRx N.V. 0.1%
Value $6.51M Shares 178,987 Est. Cost $21.73 Unrealized +41.6%
Spring Bank Pharmaceuticals, Inc. 0.1%
Value $6.371M Shares 613,144 Est. Cost $10.97 Unrealized
Albireo Pharma, Inc. 0.1%
Value $6.133M Shares 250,000 Est. Cost $22.99 Unrealized
CPRX Catalyst Pharmaceuticals, Inc. 0.0%
Value $5.568M Shares 2,900,000 Est. Cost $2.70 Unrealized +6.0%
AUTL Autolus Therapeutics plc 0.0%
Value $5.148M Shares 156,773 Est. Cost $26.79 Unrealized
HALO Halozyme Therapeutics, Inc. 0.0%
Value $4.389M Shares 299,969 Est. Cost $7.32 Unrealized +117.9%
bluebird bio, Inc. 0.0%
Value $3.968M Shares 40,000 Est. Cost $41.25 Unrealized
CRNX Crinetics Pharmaceuticals, Inc. 0.0%
Value $3.936M Shares 131,250 Est. Cost $29.69 Unrealized -5.2%
Forty Seven, Inc. 0.0%
Value $3.93M Shares 250,000 Est. Cost $16.00 Unrealized
Acceleron Pharma Inc. 0.0%
Value $3.654M Shares 83,900 Est. Cost $37.72 Unrealized
Assembly Biosciences, Inc. 0.0%
Value $3.361M Shares 148,587 Est. Cost $20.45 Unrealized
VKTX Viking Therapeutics, Inc. 0.0%
Value $3.251M Shares 425,000 Est. Cost $11.90 Unrealized +0.5%
Syros Pharmaceuticals, Inc. 0.0%
Value $3.202M Shares 574,835 Est. Cost $16.82 Unrealized
Menlo Therapeutics Inc. 0.0%
Value $2.884M Shares 700,000 Est. Cost $37.58 Unrealized
Aevi Genomic Medicine, Inc. 0.0%
Value $2.765M Shares 3,950,419 Est. Cost $2.12 Unrealized
Sierra Oncology, Inc. 0.0%
Value $2.64M Shares 2,000,000 Est. Cost $1.32 Unrealized
APLS Apellis Pharmaceuticals, Inc. 0.0%
Value $2.586M Shares 196,078 Est. Cost $22.98 Unrealized -33.2%
G1 Therapeutics, Inc. 0.0%
Value $2.437M Shares 127,236 Est. Cost $37.05 Unrealized
GLPG Galapagos NV 0.0%
Value $2.3M Shares 25,072 Est. Cost $51.50 Unrealized
ChemoCentryx, Inc. 0.0%
Value $2.259M Shares 207,029 Est. Cost $13.66 Unrealized
Y-mAbs Therapeutics, Inc. 0.0%
Value $2.091M Shares 102,800 Est. Cost $26.56 Unrealized
ALKS Alkermes plc 0.0%
Value $1.977M Shares 67,000 Est. Cost $70.02 Unrealized -47.3%
Orchard Therapeutics plc 0.0%
Value $1.966M Shares 125,000 Est. Cost $15.73 Unrealized
Foamix Pharmaceuticals Ltd. 0.0%
Value $1.788M Shares 498,189 Est. Cost $7.55 Unrealized
NTLA Intellia Therapeutics, Inc. 0.0%
Value $1.755M Shares 128,538 Est. Cost $26.35 Unrealized -29.5%
Achillion Pharmaceuticals, Inc. 0.0%
Value $1.742M Shares 1,095,359 Est. Cost $6.34 Unrealized
Adamas Pharmaceuticals, Inc. 0.0%
Value $1.474M Shares 172,630 Est. Cost $14.46 Unrealized
Galmed Pharmaceuticals Ltd. 0.0%
Value $1.473M Shares 215,594 Est. Cost $11.90 Unrealized
La Jolla Pharmaceutical Company 0.0%
Value $1.459M Shares 154,675 Est. Cost $29.30 Unrealized
Aravive, Inc. 0.0%
Value $1.423M Shares 404,384 Est. Cost $3.52 Unrealized
RCUS Arcus Biosciences, Inc. 0.0%
Value $1.309M Shares 121,534 Est. Cost $15.69 Unrealized -25.6%
Molecular Templates, Inc. 0.0%
Value $1.027M Shares 254,230 Est. Cost $5.84 Unrealized
Trillium Therapeutics Inc. 0.0%
Value $864K Shares 505,262 Est. Cost $12.19 Unrealized
Dynavax Technologies Corporation 0.0%
Value $686K Shares 75,000 Est. Cost $24.55 Unrealized
INFIQ Infinity Pharmaceuticals, Inc. 0.0%
Value $685K Shares 580,400 Est. Cost $1.54 Unrealized +17.1%
Proteon Therapeutics, Inc. 0.0%
Value $678K Shares 298,591 Est. Cost $9.69 Unrealized
AQST Aquestive Therapeutics, Inc. 0.0%
Value $627K Shares 99,600 Est. Cost $16.48 Unrealized -23.4%
Affimed N.V. 0.0%
Value $622K Shares 200,000 Est. Cost $6.30 Unrealized
Constellation Pharmaceuticals, Inc. 0.0%
Value $535K Shares 133,333 Est. Cost $6.73 Unrealized
FLGT Fulgent Genetics, Inc. 0.0%
Value $396K Shares 125,000 Est. Cost $9.20 Unrealized -61.8%
Sunesis Pharmaceuticals, Inc. 0.0%
Value $231K Shares 556,665 Est. Cost $4.37 Unrealized
Ritter Pharmaceuticals, Inc. 0.0%
Value $168K Shares 279,999 Est. Cost $2.72 Unrealized