BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q3 2018 (← Previous) (Next →)

Filing Date: Nov 14, 2018

Total Value: $15.18B (100.0% shares, 0.0% debt)

Holdings (97)

Seattle Genetics, Inc. 25.9%
Value $3.937B Shares 51,046,060 Est. Cost $37.84 Unrealized
INCY Incyte Corporation 15.6%
Value $2.366B Shares 34,251,309 Est. Cost $73.07 Unrealized -6.1%
ONC BeiGene, Ltd. 13.6%
Value $2.06B Shares 11,959,824 Est. Cost $117.58 Unrealized
Alexion Pharmaceuticals, Inc. 7.8%
Value $1.189B Shares 8,555,894 Est. Cost $166.88 Unrealized
Genomic Health, Inc. 6.4%
Value $968M Shares 13,790,970 Est. Cost $31.71 Unrealized
BMRN BioMarin Pharmaceutical Inc. 4.8%
Value $735M Shares 7,583,084 Est. Cost $81.02 Unrealized +23.2%
ACAD ACADIA Pharmaceuticals Inc. 3.9%
Value $590M Shares 28,439,114 Est. Cost $17.16 Unrealized -8.3%
Amarin Corporation plc 3.7%
Value $554M Shares 34,069,509 Est. Cost $7.54 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 1.6%
Value $250M Shares 1,169,278 Est. Cost $110.87 Unrealized +126.3%
ASND Ascendis Pharma A/S 1.3%
Value $201M Shares 2,837,352 Est. Cost $29.89 Unrealized
HRTX Heron Therapeutics, Inc. 1.0%
Value $159M Shares 5,025,298 Est. Cost $17.34 Unrealized +114.8%
Invitae Corporation 0.9%
Value $141M Shares 8,399,411 Est. Cost $14.39 Unrealized
DBV Technologies S.A. 0.8%
Value $124M Shares 5,509,560 Est. Cost $32.87 Unrealized
Mirati Therapeutics, Inc. 0.8%
Value $118M Shares 2,513,462 Est. Cost $18.61 Unrealized
NBIX Neurocrine Biosciences, Inc. 0.8%
Value $116M Shares 944,624 Est. Cost $44.09 Unrealized +157.3%
BCRX BioCryst Pharmaceuticals, Inc. 0.8%
Value $115M Shares 15,103,081 Est. Cost $6.96 Unrealized -3.5%
Array BioPharma Inc. 0.6%
Value $85.97M Shares 5,656,196 Est. Cost $10.76 Unrealized
Sage Therapeutics, Inc. 0.5%
Value $80.16M Shares 567,497 Est. Cost $92.31 Unrealized
RYTM Rhythm Pharmaceuticals, Inc. 0.5%
Value $79M Shares 2,708,200 Est. Cost $26.63 Unrealized +18.7%
CERS Cerus Corporation 0.5%
Value $77.51M Shares 10,749,937 Est. Cost $4.67 Unrealized +55.5%
ARGX argenx SE 0.5%
Value $77.32M Shares 1,019,557 Est. Cost $59.75 Unrealized
Kiniksa Pharmaceuticals, Ltd. 0.5%
Value $76.5M Shares 3,000,000 Est. Cost $17.35 Unrealized
Spark Therapeutics, Inc. 0.5%
Value $75.5M Shares 1,384,130 Est. Cost $76.99 Unrealized
GW Pharmaceuticals plc 0.5%
Value $68.53M Shares 396,700 Est. Cost $135.83 Unrealized
CymaBay Therapeutics, Inc. 0.4%
Value $54.49M Shares 4,917,700 Est. Cost $8.94 Unrealized
Principia Biopharma Inc. 0.3%
Value $52.24M Shares 1,787,807 Est. Cost $29.22 Unrealized
Tricida, Inc. 0.3%
Value $48.88M Shares 1,600,000 Est. Cost $29.90 Unrealized
Endocyte, Inc. 0.3%
Value $45.25M Shares 2,548,069 Est. Cost $7.96 Unrealized
Idera Pharmaceuticals, Inc. 0.3%
Value $43.07M Shares 4,833,897 Est. Cost $1.32 Unrealized
Corsicanto II Designated Activity Company 0.3%
Value $41.75M Shares 10,000,000 Est. Cost $1.10 Unrealized
INSM Insmed Incorporated 0.2%
Value $37.45M Shares 1,851,982 Est. Cost $20.25 Unrealized +11.6%
Aquinox Pharmaceuticals, Inc. 0.2%
Value $32.04M Shares 10,934,154 Est. Cost $13.36 Unrealized
Abeona Therapeutics Inc. 0.2%
Value $27.96M Shares 2,184,364 Est. Cost $7.28 Unrealized
Solid Biosciences Inc. 0.2%
Value $27.74M Shares 587,884 Est. Cost $7.50 Unrealized
GLPG Galapagos NV 0.2%
Value $26.67M Shares 237,191 Est. Cost $51.50 Unrealized
XNCR Xencor, Inc. 0.2%
Value $23.48M Shares 602,495 Est. Cost $11.07 Unrealized +268.5%
MyoKardia, Inc. 0.2%
Value $23.29M Shares 357,215 Est. Cost $40.09 Unrealized
Merus N.V. 0.2%
Value $22.9M Shares 1,160,014 Est. Cost $8.27 Unrealized
QURE uniQure N.V. 0.1%
Value $22.02M Shares 605,000 Est. Cost $18.33 Unrealized +102.9%
SGMO Sangamo Therapeutics, Inc. 0.1%
Value $21.76M Shares 1,283,923 Est. Cost $11.28 Unrealized +34.7%
Clementia Pharmaceuticals Inc. 0.1%
Value $21.56M Shares 1,933,624 Est. Cost $12.87 Unrealized
Zymeworks Inc. 0.1%
Value $20.58M Shares 1,311,085 Est. Cost $14.78 Unrealized
Aimmune Therapeutics, Inc. 0.1%
Value $18.38M Shares 673,908 Est. Cost $16.20 Unrealized
Neurocrine Biosciences, Inc. 0.1%
Value $17.06M Shares 10,000,000 Est. Cost $1.45 Unrealized
Bellicum Pharmaceuticals, Inc. 0.1%
Value $16.5M Shares 2,677,818 Est. Cost $22.31 Unrealized
BioMarin Pharmaceutical Inc. 0.1%
Value $15.82M Shares 15,000,000 Est. Cost $1.01 Unrealized
Audentes Therapeutics, Inc. 0.1%
Value $15.57M Shares 393,222 Est. Cost $30.05 Unrealized
ContraFect Corporation 0.1%
Value $14.81M Shares 7,153,076 Est. Cost $1.88 Unrealized
Aeglea BioTherapeutics, Inc. 0.1%
Value $13.28M Shares 1,387,872 Est. Cost $5.20 Unrealized
BioMarin Pharmaceutical Inc. 0.1%
Value $12.6M Shares 12,228,000 Est. Cost $1.06 Unrealized
ANAB AnaptysBio, Inc. 0.1%
Value $11.28M Shares 113,086 Est. Cost $56.96 Unrealized +45.7%
CPRX Catalyst Pharmaceuticals, Inc. 0.1%
Value $10.96M Shares 2,900,000 Est. Cost $2.70 Unrealized +16.0%
ERYTECH Pharma S.A. 0.1%
Value $9.307M Shares 1,085,969 Est. Cost $22.02 Unrealized
Novavax, Inc. 0.1%
Value $8.87M Shares 4,718,318 Est. Cost $1.88 Unrealized
bluebird bio, Inc. 0.1%
Value $8.678M Shares 59,441 Est. Cost $41.25 Unrealized
Albireo Pharma, Inc. 0.1%
Value $8.24M Shares 250,000 Est. Cost $22.99 Unrealized
HALO Halozyme Therapeutics, Inc. 0.1%
Value $8.176M Shares 449,969 Est. Cost $7.32 Unrealized +139.2%
Momenta Pharmaceuticals, Inc. 0.1%
Value $8.114M Shares 308,500 Est. Cost $18.15 Unrealized
VKTX Viking Therapeutics, Inc. 0.0%
Value $7.404M Shares 425,000 Est. Cost $11.90 Unrealized 0.0%
Spring Bank Pharmaceuticals, Inc. 0.0%
Value $7.388M Shares 613,144 Est. Cost $10.97 Unrealized
AUTL Autolus Therapeutics plc 0.0%
Value $7.216M Shares 235,294 Est. Cost $26.79 Unrealized
Menlo Therapeutics Inc. 0.0%
Value $6.895M Shares 700,000 Est. Cost $37.58 Unrealized
Syros Pharmaceuticals, Inc. 0.0%
Value $6.846M Shares 574,835 Est. Cost $16.82 Unrealized
G1 Therapeutics, Inc. 0.0%
Value $6.653M Shares 127,236 Est. Cost $37.05 Unrealized
IFRX InflaRx N.V. 0.0%
Value $6.143M Shares 178,987 Est. Cost $21.73 Unrealized +48.4%
Achillion Pharmaceuticals, Inc. 0.0%
Value $6.035M Shares 1,639,948 Est. Cost $6.34 Unrealized
ARWR Arrowhead Pharmaceuticals, Inc. 0.0%
Value $5.895M Shares 307,496 Est. Cost $16.41 Unrealized 0.0%
Assembly Biosciences, Inc. 0.0%
Value $5.519M Shares 148,587 Est. Cost $20.45 Unrealized
NTLA Intellia Therapeutics, Inc. 0.0%
Value $5.51M Shares 192,538 Est. Cost $26.35 Unrealized +10.4%
ChemoCentryx, Inc. 0.0%
Value $5.233M Shares 414,029 Est. Cost $13.66 Unrealized
Aevi Genomic Medicine, Inc. 0.0%
Value $4.859M Shares 3,950,419 Est. Cost $2.12 Unrealized
Acceleron Pharma Inc. 0.0%
Value $4.802M Shares 83,900 Est. Cost $37.72 Unrealized
Galmed Pharmaceuticals Ltd. 0.0%
Value $4.401M Shares 324,094 Est. Cost $11.90 Unrealized
ALKS Alkermes plc 0.0%
Value $4.255M Shares 100,251 Est. Cost $70.02 Unrealized -38.0%
Y-mAbs Therapeutics, Inc. 0.0%
Value $3.984M Shares 150,000 Est. Cost $26.56 Unrealized
Foamix Pharmaceuticals Ltd. 0.0%
Value $3.943M Shares 688,075 Est. Cost $7.55 Unrealized
CRNX Crinetics Pharmaceuticals, Inc. 0.0%
Value $3.76M Shares 131,250 Est. Cost $29.69 Unrealized 0.0%
Forty Seven, Inc. 0.0%
Value $3.73M Shares 250,000 Est. Cost $16.00 Unrealized
APLS Apellis Pharmaceuticals, Inc. 0.0%
Value $3.486M Shares 196,078 Est. Cost $22.98 Unrealized -19.5%
Adamas Pharmaceuticals, Inc. 0.0%
Value $3.456M Shares 172,630 Est. Cost $14.46 Unrealized
Versartis, Inc. 0.0%
Value $3.397M Shares 2,426,310 Est. Cost $14.17 Unrealized
Ra Pharmaceuticals, Inc. 0.0%
Value $3.219M Shares 177,952 Est. Cost $15.19 Unrealized
La Jolla Pharmaceutical Company 0.0%
Value $3.114M Shares 154,675 Est. Cost $29.30 Unrealized
Trillium Therapeutics Inc. 0.0%
Value $2.931M Shares 505,262 Est. Cost $12.19 Unrealized
KRYS Krystal Biotech, Inc. 0.0%
Value $2.016M Shares 114,674 Est. Cost $10.08 Unrealized +66.4%
AQST Aquestive Therapeutics, Inc. 0.0%
Value $1.744M Shares 99,600 Est. Cost $16.48 Unrealized 0.0%
RCUS Arcus Biosciences, Inc. 0.0%
Value $1.694M Shares 121,534 Est. Cost $15.69 Unrealized -18.7%
INFIQ Infinity Pharmaceuticals, Inc. 0.0%
Value $1.573M Shares 580,400 Est. Cost $1.54 Unrealized +34.7%
Molecular Templates, Inc. 0.0%
Value $1.37M Shares 254,230 Est. Cost $5.84 Unrealized
OVID Ovid Therapeutics Inc. 0.0%
Value $1.26M Shares 222,139 Est. Cost $13.06 Unrealized -41.9%
Sunesis Pharmaceuticals, Inc. 0.0%
Value $1.113M Shares 556,665 Est. Cost $4.37 Unrealized
Dynavax Technologies Corporation 0.0%
Value $930K Shares 75,000 Est. Cost $24.55 Unrealized
Constellation Pharmaceuticals, Inc. 0.0%
Value $897K Shares 133,333 Est. Cost $6.73 Unrealized
Affimed N.V. 0.0%
Value $870K Shares 200,000 Est. Cost $6.30 Unrealized
Proteon Therapeutics, Inc. 0.0%
Value $582K Shares 298,591 Est. Cost $9.69 Unrealized
Ritter Pharmaceuticals, Inc. 0.0%
Value $521K Shares 279,999 Est. Cost $2.72 Unrealized
FLGT Fulgent Genetics, Inc. 0.0%
Value $491K Shares 125,000 Est. Cost $9.20 Unrealized -53.6%