BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: May 15, 2019

Total Value: $15.62B (99.4% shares, 0.6% debt)

Holdings (96)

Seattle Genetics, Inc. 23.9%
Value $3.739B Shares 51,049,760 Est. Cost $37.84 Unrealized
INCY Incyte Corporation 18.9%
Value $2.948B Shares 34,271,827 Est. Cost $73.07 Unrealized +11.4%
ONC BeiGene, Ltd. 10.1%
Value $1.579B Shares 11,959,824 Est. Cost $117.58 Unrealized
Alexion Pharmaceuticals, Inc. 7.4%
Value $1.157B Shares 8,558,068 Est. Cost $166.88 Unrealized
ACAD ACADIA Pharmaceuticals Inc. 6.8%
Value $1.066B Shares 39,713,842 Est. Cost $17.80 Unrealized +31.2%
Amarin Corporation plc 5.7%
Value $897M Shares 43,210,459 Est. Cost $8.93 Unrealized
Genomic Health, Inc. 4.6%
Value $714M Shares 10,198,943 Est. Cost $31.71 Unrealized
BMRN BioMarin Pharmaceutical Inc. 4.3%
Value $674M Shares 7,589,294 Est. Cost $81.02 Unrealized +14.4%
ASND Ascendis Pharma A/S 2.6%
Value $399M Shares 3,390,270 Est. Cost $44.21 Unrealized
Mirati Therapeutics, Inc. 1.2%
Value $184M Shares 2,513,462 Est. Cost $18.61 Unrealized
MDGL Madrigal Pharmaceuticals, Inc. 0.9%
Value $146M Shares 1,169,278 Est. Cost $110.87 Unrealized +12.1%
ARGX argenx SE 0.8%
Value $127M Shares 1,019,557 Est. Cost $59.75 Unrealized
BCRX BioCryst Pharmaceuticals, Inc. 0.8%
Value $123M Shares 15,118,081 Est. Cost $6.96 Unrealized +23.0%
HRTX Heron Therapeutics, Inc. 0.8%
Value $123M Shares 5,018,104 Est. Cost $17.34 Unrealized +51.0%
Clementia Pharmaceuticals Inc. 0.6%
Value $97.21M Shares 3,724,445 Est. Cost $12.34 Unrealized
NBIX Neurocrine Biosciences, Inc. 0.6%
Value $96.79M Shares 1,098,670 Est. Cost $57.33 Unrealized +45.8%
Array BioPharma Inc. 0.6%
Value $93.67M Shares 3,842,289 Est. Cost $10.76 Unrealized
Invitae Corporation 0.6%
Value $91.39M Shares 3,902,421 Est. Cost $14.39 Unrealized
Spark Therapeutics, Inc. 0.5%
Value $85.63M Shares 751,927 Est. Cost $76.99 Unrealized
CymaBay Therapeutics, Inc. 0.5%
Value $75.79M Shares 5,707,411 Est. Cost $9.54 Unrealized
RYTM Rhythm Pharmaceuticals, Inc. 0.5%
Value $74.23M Shares 2,708,200 Est. Cost $26.63 Unrealized +7.9%
GW Pharmaceuticals plc 0.5%
Value $72.21M Shares 428,345 Est. Cost $132.99 Unrealized
Neurocrine Biosciences, Inc. 0.5%
Value $71.99M Shares 53,270,000 Est. Cost $1.24 Unrealized
Tricida, Inc. 0.4%
Value $69.64M Shares 1,803,238 Est. Cost $30.88 Unrealized
CERS Cerus Corporation 0.4%
Value $66.97M Shares 10,749,937 Est. Cost $4.67 Unrealized +29.9%
Audentes Therapeutics, Inc. 0.4%
Value $66.93M Shares 1,715,183 Est. Cost $31.63 Unrealized
Principia Biopharma Inc. 0.4%
Value $60.78M Shares 1,787,807 Est. Cost $29.22 Unrealized
INSM Insmed Incorporated 0.4%
Value $60.4M Shares 2,077,601 Est. Cost $20.87 Unrealized +24.2%
KOD Kodiak Sciences Inc. 0.4%
Value $59.72M Shares 9,145,115 Est. Cost $8.85 Unrealized -16.5%
Kiniksa Pharmaceuticals, Ltd. 0.3%
Value $54.18M Shares 3,000,000 Est. Cost $17.35 Unrealized
MyoKardia, Inc. 0.3%
Value $52.84M Shares 1,016,306 Est. Cost $48.30 Unrealized
DBV Technologies S.A. 0.3%
Value $42.48M Shares 5,509,560 Est. Cost $32.87 Unrealized
QURE uniQure N.V. 0.2%
Value $36.09M Shares 605,000 Est. Cost $18.33 Unrealized +143.7%
Aquinox Pharmaceuticals, Inc. 0.2%
Value $29.47M Shares 10,934,154 Est. Cost $13.36 Unrealized
Zymeworks Inc. 0.2%
Value $27.64M Shares 1,708,472 Est. Cost $14.76 Unrealized
KRYS Krystal Biotech, Inc. 0.2%
Value $25.82M Shares 784,674 Est. Cost $19.35 Unrealized +21.8%
Ra Pharmaceuticals, Inc. 0.1%
Value $18.44M Shares 823,113 Est. Cost $17.55 Unrealized
Merus N.V. 0.1%
Value $17.13M Shares 1,160,014 Est. Cost $8.27 Unrealized
AXSM Axsome Therapeutics, Inc. 0.1%
Value $17.08M Shares 1,200,000 Est. Cost $9.29 Unrealized 0.0%
BioMarin Pharmaceutical Inc. 0.1%
Value $15.38M Shares 15,000,000 Est. Cost $1.01 Unrealized
Aimmune Therapeutics, Inc. 0.1%
Value $15.06M Shares 673,908 Est. Cost $16.20 Unrealized
CPRX Catalyst Pharmaceuticals, Inc. 0.1%
Value $14.79M Shares 2,900,000 Est. Cost $2.70 Unrealized +8.8%
Aeglea BioTherapeutics, Inc. 0.1%
Value $13.79M Shares 1,713,604 Est. Cost $5.64 Unrealized
XNCR Xencor, Inc. 0.1%
Value $13.3M Shares 428,120 Est. Cost $11.07 Unrealized +200.7%
Idera Pharmaceuticals, Inc. 0.1%
Value $12.34M Shares 4,839,895 Est. Cost $1.32 Unrealized
Dermira, Inc. 0.1%
Value $12.29M Shares 906,943 Est. Cost $13.55 Unrealized
Marker Therapeutics, Inc. 0.1%
Value $9.9M Shares 1,500,000 Est. Cost $5.55 Unrealized
SGMO Sangamo Therapeutics, Inc. 0.1%
Value $9.538M Shares 999,823 Est. Cost $11.28 Unrealized -9.5%
Abeona Therapeutics Inc. 0.1%
Value $9.481M Shares 1,288,235 Est. Cost $7.28 Unrealized
Bellicum Pharmaceuticals, Inc. 0.1%
Value $9.024M Shares 2,677,818 Est. Cost $22.31 Unrealized
ANAB AnaptysBio, Inc. 0.1%
Value $8.261M Shares 113,086 Est. Cost $56.96 Unrealized +21.2%
Albireo Pharma, Inc. 0.1%
Value $8.053M Shares 250,000 Est. Cost $22.99 Unrealized
IFRX InflaRx N.V. 0.0%
Value $6.764M Shares 178,987 Est. Cost $21.73 Unrealized +71.4%
Spring Bank Pharmaceuticals, Inc. 0.0%
Value $6.432M Shares 613,144 Est. Cost $10.97 Unrealized
bluebird bio, Inc. 0.0%
Value $6.293M Shares 40,000 Est. Cost $41.25 Unrealized
APLS Apellis Pharmaceuticals, Inc. 0.0%
Value $6.118M Shares 313,725 Est. Cost $20.26 Unrealized -22.4%
Menlo Therapeutics Inc. 0.0%
Value $5.495M Shares 700,000 Est. Cost $37.58 Unrealized
MGNX MacroGenics, Inc. 0.0%
Value $5.441M Shares 302,600 Est. Cost $17.29 Unrealized 0.0%
Syros Pharmaceuticals, Inc. 0.0%
Value $5.254M Shares 574,835 Est. Cost $16.82 Unrealized
PTGX Protagonist Therapeutics, Inc. 0.0%
Value $5.077M Shares 403,893 Est. Cost $8.83 Unrealized 0.0%
AUTL Autolus Therapeutics plc 0.0%
Value $4.934M Shares 156,773 Est. Cost $26.79 Unrealized
HALO Halozyme Therapeutics, Inc. 0.0%
Value $4.83M Shares 299,969 Est. Cost $7.32 Unrealized +121.3%
VKTX Viking Therapeutics, Inc. 0.0%
Value $4.225M Shares 425,000 Est. Cost $11.90 Unrealized -29.7%
Forty Seven, Inc. 0.0%
Value $4.04M Shares 250,000 Est. Cost $16.00 Unrealized
Acceleron Pharma Inc. 0.0%
Value $3.907M Shares 83,900 Est. Cost $37.72 Unrealized
Acorda Therapeutics, Inc. 0.0%
Value $3.882M Shares 292,134 Est. Cost $13.29 Unrealized
Sierra Oncology, Inc. 0.0%
Value $3.42M Shares 2,000,000 Est. Cost $1.32 Unrealized
La Jolla Pharmaceutical Company 0.0%
Value $3.249M Shares 505,240 Est. Cost $13.43 Unrealized
Achillion Pharmaceuticals, Inc. 0.0%
Value $3.242M Shares 1,095,359 Est. Cost $6.34 Unrealized
Aravive, Inc. 0.0%
Value $3.033M Shares 430,885 Est. Cost $3.74 Unrealized
CRNX Crinetics Pharmaceuticals, Inc. 0.0%
Value $2.987M Shares 131,250 Est. Cost $29.69 Unrealized -17.2%
GLPG Galapagos NV 0.0%
Value $2.953M Shares 25,072 Est. Cost $51.50 Unrealized
Assembly Biosciences, Inc. 0.0%
Value $2.926M Shares 148,587 Est. Cost $20.45 Unrealized
ChemoCentryx, Inc. 0.0%
Value $2.876M Shares 207,029 Est. Cost $13.66 Unrealized
Y-mAbs Therapeutics, Inc. 0.0%
Value $2.694M Shares 102,800 Est. Cost $26.56 Unrealized
ALKS Alkermes plc 0.0%
Value $2.445M Shares 67,000 Est. Cost $70.02 Unrealized -52.8%
Orchard Therapeutics plc 0.0%
Value $2.235M Shares 125,000 Est. Cost $15.73 Unrealized
NTLA Intellia Therapeutics, Inc. 0.0%
Value $2.195M Shares 128,538 Est. Cost $26.35 Unrealized -43.4%
G1 Therapeutics, Inc. 0.0%
Value $2.112M Shares 127,236 Est. Cost $37.05 Unrealized
CTMX CytomX Therapeutics, Inc. 0.0%
Value $2.09M Shares 194,377 Est. Cost $14.78 Unrealized 0.0%
Harpoon Therapeutics, Inc. 0.0%
Value $2.029M Shares 214,285 Est. Cost $9.47 Unrealized
Foamix Pharmaceuticals Ltd. 0.0%
Value $1.868M Shares 498,189 Est. Cost $7.55 Unrealized
Constellation Pharmaceuticals, Inc. 0.0%
Value $1.807M Shares 133,333 Est. Cost $6.73 Unrealized
Galmed Pharmaceuticals Ltd. 0.0%
Value $1.761M Shares 215,594 Est. Cost $11.90 Unrealized
RCUS Arcus Biosciences, Inc. 0.0%
Value $1.518M Shares 121,534 Est. Cost $15.69 Unrealized -30.8%
Molecular Templates, Inc. 0.0%
Value $1.477M Shares 254,230 Est. Cost $5.84 Unrealized
Adamas Pharmaceuticals, Inc. 0.0%
Value $1.227M Shares 172,630 Est. Cost $14.46 Unrealized
ContraFect Corporation 0.0%
Value $1.159M Shares 2,914,536 Est. Cost $1.88 Unrealized
INFIQ Infinity Pharmaceuticals, Inc. 0.0%
Value $1.091M Shares 580,400 Est. Cost $1.54 Unrealized -4.8%
Affimed N.V. 0.0%
Value $840K Shares 200,000 Est. Cost $6.30 Unrealized
FLGT Fulgent Genetics, Inc. 0.0%
Value $744K Shares 125,000 Est. Cost $9.20 Unrealized -50.3%
AQST Aquestive Therapeutics, Inc. 0.0%
Value $688K Shares 99,600 Est. Cost $16.48 Unrealized -57.5%
Sunesis Pharmaceuticals, Inc. 0.0%
Value $676K Shares 556,665 Est. Cost $4.37 Unrealized
Dynavax Technologies Corporation 0.0%
Value $548K Shares 75,000 Est. Cost $24.55 Unrealized
Trillium Therapeutics Inc. 0.0%
Value $333K Shares 505,262 Est. Cost $12.19 Unrealized
Ritter Pharmaceuticals, Inc. 0.0%
Value $244K Shares 279,999 Est. Cost $2.72 Unrealized