Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 15, 2026

Total Value: $759M (100.0% shares, 0.0% debt)

Holdings (54)

HROW HARROW INC 13.2%
Value $99.86M Shares 2,832,230 Est. Cost $6.33 Unrealized +659.8%
LQDA LIQUIDIA CORPORATION 11.7%
Value $88.82M Shares 2,545,000 Est. Cost $13.06 Unrealized +190.4%
ETON ETON PHARMACEUTICALS INC 9.3%
Value $70.58M Shares 2,860,000 Est. Cost $5.71 Unrealized +180.0%
SLGL SOL-GEL TECHNOLOGIES LTD 5.2%
Value $39.61M Shares 500,000 Est. Cost $32.61 Unrealized +103.6%
RYTM RHYTHM PHARMACEUTICALS INC 4.7%
Value $35.32M Shares 123,000 Est. Cost $12.73 Unrealized +707.7%
APGE APOGEE THERAPEUTICS INC 4.3%
Value $32.83M Shares 390,000 Est. Cost $39.78 Unrealized +81.6%
IRON DISC MEDICINE INC 3.5%
Value $26.92M Shares 421,000 Est. Cost $63.70 Unrealized +16.2%
URGN UROGEN PHARMA LTD 3.4%
Value $25.71M Shares 1,430,000 Est. Cost $21.00 Unrealized -0.8%
CBIO CRESCENT BIOPHARMA INC. 3.2%
Value $24.11M Shares 1,312,615 Est. Cost $12.57 Unrealized -12.0%
STOK STOKE THERAPEUTICS INC 3.0%
Value $22.79M Shares 700,000 Est. Cost $11.23 Unrealized +183.5%
CATX PERSPECTIVE THERAPEUTICS INC 2.6%
Value $19.49M Shares 4,675,000 Est. Cost $3.59 Unrealized +7.0%
RZLT REZOLUTE INC 2.5%
Value $19.21M Shares 6,300,000 Est. Cost $7.31 Unrealized -58.1%
MGTX MEIRAGTX HLDGS PLC 2.4%
Value $18.39M Shares 2,123,259 Est. Cost $7.74 Unrealized -1.7%
TGTX TG THERAPEUTICS INC 2.3%
Value $17.77M Shares 535,000 Est. Cost $13.67 Unrealized +117.0%
SNWV SANUWAVE HEALTH INC 2.2%
Value $16.97M Shares 981,267 Est. Cost $28.49 Unrealized -6.4%
EWTX EDGEWISE THERAPEUTICS INC 2.1%
Value $15.75M Shares 500,000 Est. Cost $11.02 Unrealized +155.6%
ACOG ALPHA COGNITION INC 1.9%
Value $14.07M Shares 2,561,950 Est. Cost $6.32 Unrealized -10.3%
ANNX ANNEXON INC 1.7%
Value $12.92M Shares 2,331,761 Est. Cost $2.48 Unrealized +131.5%
ALMS ALUMIS INC 1.6%
Value $12.12M Shares 550,000 Est. Cost $5.26 Unrealized +362.7%
CDXS CODEXIS INC 1.5%
Value $11.06M Shares 6,785,000 Est. Cost $2.81 Unrealized -49.2%
PTGX PROTAGONIST THERAPEUTICS INC 1.4%
Value $10.54M Shares 100,000 Est. Cost $17.50 Unrealized +376.0%
RVMD REVOLUTION MEDICINES INC 1.3%
Value $9.725M Shares 100,000 Est. Cost $38.42 Unrealized +168.2%
XOMA XOMA ROYALTY CORPORATION 1.2%
Value $9.411M Shares 300,000 Est. Cost $14.38 Unrealized +81.7%
QTTB Q32 BIO INC 1.1%
Value $8.065M Shares 1,256,228 Est. Cost $3.75 Unrealized +5.1%
MBX MBX BIOSCIENCES INC 1.0%
Value $7.761M Shares 260,000 Est. Cost $11.09 Unrealized +232.1%
RLMD RELMADA THERAPEUTICS INC 0.9%
Value $6.508M Shares 935,000 Est. Cost $3.35 Unrealized +19.8%
CGON CG ONCOLOGY INC 0.8%
Value $6.416M Shares 94,800 Est. Cost $27.46 Unrealized +90.9%
JBIO JADE BIOSCIENCES INC 0.8%
Value $6.008M Shares 427,608 Est. Cost $11.73 Unrealized +26.0%
OCUL OCULAR THERAPEUTIX INC 0.7%
Value $5.082M Shares 600,000 Est. Cost $5.10 Unrealized +92.9%
ASRT ASSERTIO HOLDINGS INC 0.7%
Value $5.064M Shares 265,707 Est. Cost $11.33 Unrealized 0.0%
EDIT EDITAS MEDICINE INC 0.6%
Value $4.76M Shares 1,926,997 Est. Cost $1.99 Unrealized 0.0%
STRO SUTRO BIOPHARMA INC 0.6%
Value $4.75M Shares 190,671 Est. Cost $9.49 Unrealized +58.9%
DERM JOURNEY MED CORP 0.6%
Value $4.502M Shares 960,000 Est. Cost $7.08 Unrealized +15.9%
VYGR VOYAGER THERAPEUTICS INC 0.6%
Value $4.439M Shares 1,150,000 Est. Cost $3.93 Unrealized
TRVI TREVI THERAPEUTICS INC 0.5%
Value $4.117M Shares 345,100 Est. Cost $2.06 Unrealized +431.9%
TECX TECTONIC THERAPEUTIC INC 0.5%
Value $3.802M Shares 123,000 Est. Cost $18.58 Unrealized +13.5%
CABA CABALETTA BIO INC 0.5%
Value $3.712M Shares 1,380,000 Est. Cost $2.08 Unrealized +25.9%
BDSX BIODESIX INC 0.5%
Value $3.452M Shares 238,047 Est. Cost $9.93 Unrealized 0.0%
RCKT ROCKET PHARMACEUTICALS INC 0.5%
Value $3.419M Shares 955,000 Est. Cost $3.42 Unrealized +5.5%
ZNTL ZENTALIS PHARMACEUTICALS INC 0.4%
Value $3.306M Shares 1,412,656 Est. Cost $1.88 Unrealized +39.2%
NTLA INTELLIA THERAPEUTICS INC 0.4%
Value $3.141M Shares 245,000 Est. Cost $12.40 Unrealized 0.0%
FBIO FORTRESS BIOTECH INC 0.4%
Value $2.907M Shares 1,042,000 Est. Cost $2.85 Unrealized +25.6%
IRD OPUS GENETICS INC 0.3%
Value $2.251M Shares 1,120,000 Est. Cost $1.13 Unrealized +143.4%
RIGL RIGEL PHARMACEUTICALS INC 0.2%
Value $1.893M Shares 70,000 Est. Cost $33.50 Unrealized +10.6%
AVIR ATEA PHARMACEUTICALS INC 0.2%
Value $1.736M Shares 322,600 Est. Cost $3.53 Unrealized +12.7%
LYEL LYELL IMMUNOPHARMA INC 0.2%
Value $1.587M Shares 79,097 Est. Cost $24.33 Unrealized 0.0%
ENTA ENANTA PHARMACEUTICALS INC 0.2%
Value $1.579M Shares 125,000 Est. Cost $13.02 Unrealized +3.6%
NXTC NEXTCURE INC 0.2%
Value $1.508M Shares 141,181 Est. Cost $12.58 Unrealized 0.0%
FDMT 4D MOLECULAR THERAPEUTICS IN 0.1%
Value $1.045M Shares 112,291 Est. Cost $8.57 Unrealized 0.0%
PERSPECTIVE THERAPEUTICS INC 0.1%
Value $834K Shares 200,000 Est. Cost $4.17 Unrealized
PLX PROTALIX BIOTHERAPEUTICS INC 0.1%
Value $738K Shares 340,000 Est. Cost $1.63 Unrealized +50.3%
BBOT BRIDGEBIO ONCOLOGY THERAPEUT 0.1%
Value $477K Shares 53,282 Est. Cost $8.95 Unrealized
LBRX LB PHARMACEUTICALS INC 0.0%
Value $358K Shares 14,506 Est. Cost $22.38 Unrealized 0.0%
ADGM ADAGIO MED HLDGS INC 0.0%
Value $21,211 Shares 18,444 Est. Cost $4.76 Unrealized -79.4%